Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

May 1991

Volume 624 Pulmonary Emphysema: The Rationale for Therapeutic Intervention

Pages xi–xii, 1–367

    1. Preface (pages xi–xii)

      George Weinbaum, Ralph E. Giles and Robert D. Krell

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb16999.x

  1. Part 1. Epidemiology, Risk Factors, and Approaches to Therapy

    1. Top of page
    2. Part 1. Epidemiology, Risk Factors, and Approaches to Therapy
    3. Part 2. Putative Etiologies of Emphysema: Proteases/Inhibitors/Modulators
    4. Part 3. New Approaches to the Monitoring of Emphysema
    5. Part 4. The Present: Approaches to Emphysema Therapy
    6. Part 5. The Future: Potential Involvement of Proteases in Pulmonary Pathology Other Than Emphysema
    7. Part 6. Poster Papers
    1. Emphysema Before and After 1963 : Historic Perspectives (pages 1–6)

      STEN ERIKSSON

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17000.x

    2. Risk Factors Associated with Chronic Obstructive Lung Disease (pages 7–17)

      MILLICENT HIGGINS

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17001.x

    3. Neutrophil Kinetics in Normal and Emphysematous Regions of Human Lungs (pages 30–39)

      M. L. BRUMWELL, W. MacNEE, C. M. DOERSCHUK, B. WIGGS and J. C. HOGG

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17003.x

    4. Nonsteroidal Antiinflammatory Drugs (pages 40–44)

      STEVEN B. ABRAMSON

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17004.x

  2. Part 2. Putative Etiologies of Emphysema: Proteases/Inhibitors/Modulators

    1. Top of page
    2. Part 1. Epidemiology, Risk Factors, and Approaches to Therapy
    3. Part 2. Putative Etiologies of Emphysema: Proteases/Inhibitors/Modulators
    4. Part 3. New Approaches to the Monitoring of Emphysema
    5. Part 4. The Present: Approaches to Emphysema Therapy
    6. Part 5. The Future: Potential Involvement of Proteases in Pulmonary Pathology Other Than Emphysema
    7. Part 6. Poster Papers
    1. Putative Role of Neutrophil Elastase in the Pathogenesis of Emphysema (pages 45–59)

      GORDON L. SNIDER, DAVID E. CICCOLELLA, SHIRLEY M. MORRIS, PHILLIP J. STONE and EDGAR C. LUCEY

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17005.x

    2. Proteinase-3 (PR-3): A Polymorphonuclear Leukocyte Serine Proteinase (pages 60–68)

      N. V. RAO, NANCY G. WEHNER, BRUCE C. MARSHALL, ANNE B. STURROCK, THOMAS P. HUECKSTEADT, GOPNA V. RAO, BEULAH H. GRAY and JOHN R. HOIDAL

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17006.x

    3. Elastin Degradation by Mononuclear Phagocytes (pages 69–80)

      STEVEN D. SHAPIRO, EDWARD J. CAMPBELL, HOWARD G. WELGUS and ROBERT M. SENIOR

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17007.x

    4. Neutrophil Proteinases : Caution Signs in Designing Inhibitors Against Enzymes with Possible Multiple Functions (pages 81–86)

      JAMES TRAVIS, ADAM DUBIN, JAN POTEMPA, WIESLAW WATOREK and ANNA KURDOWSKA

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17008.x

    5. Role of Enzyme Receptors and Inhibitors in Regulating Proteolytic Activities of Macrophages (pages 87–96)

      HAROLD A. CHAPMAN JR.

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17009.x

    6. Role of Antileukoprotease in the Human Lung (pages 97–108)

      J. A. KRAMPS, A. RUDOLPHUS, J. STOLK, L. N. A. WILLEMS and J. H. DIJKMAN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17010.x

    7. Secreted Inhibitors of Mammalian Metalloproteinases (pages 109–115)

      MICHAEL J. BANDA and ERIC W. HOWARD

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17011.x

    8. Regulation of Elastin Gene Expression (pages 116–136)

      JOEL ROSENBLOOM, MUHAMMAD BASHIR, HELENA YEH, JOAN ROSENBLOOM, NORMA ORNSTEIN-GOLDSTEIN, MICHAEL FAZIO, VELI-MATTI KAHARI and JOUNI UITTO

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17012.x

    9. Elastin Synthesis and Fiber Assembly (pages 137–146)

      ROBERT P. MECHAM

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17013.x

  3. Part 3. New Approaches to the Monitoring of Emphysema

    1. Top of page
    2. Part 1. Epidemiology, Risk Factors, and Approaches to Therapy
    3. Part 2. Putative Etiologies of Emphysema: Proteases/Inhibitors/Modulators
    4. Part 3. New Approaches to the Monitoring of Emphysema
    5. Part 4. The Present: Approaches to Emphysema Therapy
    6. Part 5. The Future: Potential Involvement of Proteases in Pulmonary Pathology Other Than Emphysema
    7. Part 6. Poster Papers
    1. Measurement of Elastin-Derived Peptides (pages 147–153)

      G. WEINBAUM, U. KUCICH, P. KIMBEL, S. METTE, S. AKERS and J. ROSENBLOOM

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17014.x

    2. Development and Application of Assays for Elastase-Specific Fibrinogen Fragments (pages 154–166)

      JEFFREY I. WEITZ

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17015.x

    3. Direct Assay of Aα(1–21), a PMN Elastase-Specific Cleavage Product of Fibrinogen, in the Chimpanzee (pages 167–178)

      RICHARD A. MUMFORD, HOLLIS WILLIAMS, JENNIFER MAO, MARY ELLEN DAHLGREN, DALE FRANKENFIELD, THOMAS NOLAN, LINDA SCHAFFER, JAMES B. DOHERTY, DANIEL FLETCHER, KAREN HAND, ROBERT BONNEY, JOHN L. HUMES, STEPHEN PACHOLOK, WILLIAM HANLON and PHILIP DAVIES

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17016.x

    4. Quantifying Emphysema by CT Scanning : Clinicopathologic Correlates (pages 179–194)

      WILLIAM MacNEE, GRAHAM GOULD and DAVID LAMB

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17017.x

    5. The Feasibility of an Outcome Trial in the Preventive Therapy of Emphysema (pages 195–208)

      MITCHELL GLASS

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17018.x

  4. Part 4. The Present: Approaches to Emphysema Therapy

    1. Top of page
    2. Part 1. Epidemiology, Risk Factors, and Approaches to Therapy
    3. Part 2. Putative Etiologies of Emphysema: Proteases/Inhibitors/Modulators
    4. Part 3. New Approaches to the Monitoring of Emphysema
    5. Part 4. The Present: Approaches to Emphysema Therapy
    6. Part 5. The Future: Potential Involvement of Proteases in Pulmonary Pathology Other Than Emphysema
    7. Part 6. Poster Papers
    1. Lung Transplantation for Chronic Obstructive Lung Disease (pages 209–211)

      JOEL D. COOPER

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17019.x

    2. Recombinant Elastase Inhibitors for Therapy (pages 212–218)

      HANS PETER SCHNEBLI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17020.x

    3. The Discovery and Biologic Properties of Cephalosporin-Based Inhibitors of PMN Elastase (pages 219–229)

      PHILIP DAVIES, B. M. ASHE, R. J. BONNEY, C. DORN, P. FINKE, D. FLETCHER, W. A. HANLON, J. L. HUMES, A. MAYCOCK, R. A. MUMFORD, M. A. NAVIA, E. E. OPAS, S. PACHOLOK, S. SHAH, M. ZIMMERMAN and J. B. DOHERTY

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17021.x

    4. Biochemistry and Pharmacology of ICI 200,880, a Synthetic Peptide Inhibitor of Human Neutrophil Elastase (pages 230–243)

      JOSEPH C. WILLIAMS, ROSS L. STEIN, RALPH E. GILES and ROBERT D. KRELL

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17022.x

    5. Reduction of Neutrophil Elastase Load in the Lungs of Patients with Emphysema by Reducing Neutrophil Enzyme Secretion or Chemotaxis (pages 244–256)

      ALLEN B. COHEN, WILLIAM GIRARD, JERRY McLARTY, BARRY STARCHER, DORIS DAVIS, MICHAEL STEVENS, JOEL ROSENBLOOM and UMBERTO KUCICH

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17023.x

  5. Part 5. The Future: Potential Involvement of Proteases in Pulmonary Pathology Other Than Emphysema

    1. Top of page
    2. Part 1. Epidemiology, Risk Factors, and Approaches to Therapy
    3. Part 2. Putative Etiologies of Emphysema: Proteases/Inhibitors/Modulators
    4. Part 3. New Approaches to the Monitoring of Emphysema
    5. Part 4. The Present: Approaches to Emphysema Therapy
    6. Part 5. The Future: Potential Involvement of Proteases in Pulmonary Pathology Other Than Emphysema
    7. Part 6. Poster Papers
    1. Proteinases in Chronic Lung Infection (pages 257–266)

      R. A. STOCKLEY, S. L. HILL and D. BURNETT

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17024.x

    2. Protease Mechanisms in the Pathogenesis of Acute Lung Injury (pages 267–277)

      THOMAS L. PETTY

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17025.x

    3. Protease Injury in Airways Disease (pages 278–285)

      STEPHEN I. RENNARD, KATHLEEN RICKARD, JOE D. BECKMANN, GUILLERMO HUERTA, SEKIYA KOYAMA, RICHARD A. ROBBINS, DEBRA ROMBERGER, JOHN SPURZEM and AUSTIN B. THOMPSON

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17026.x

    4. Protease Actions on Airway Secretions : Relevance to Cystic Fibrosis (pages 286–296)

      JAY A. NADEL

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17027.x

    5. Potential Role of Proteases in Pulmonary Fibrosis (pages 297–306)

      MOISÉS SELMAN and ANNIE PARDO

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17028.x

    6. Conference Summary : Pulmonary Emphysema: The Rationale for Therapeutic Intervention (pages 307–314)

      ALLEN B. COHEN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17029.x

  6. Part 6. Poster Papers

    1. Top of page
    2. Part 1. Epidemiology, Risk Factors, and Approaches to Therapy
    3. Part 2. Putative Etiologies of Emphysema: Proteases/Inhibitors/Modulators
    4. Part 3. New Approaches to the Monitoring of Emphysema
    5. Part 4. The Present: Approaches to Emphysema Therapy
    6. Part 5. The Future: Potential Involvement of Proteases in Pulmonary Pathology Other Than Emphysema
    7. Part 6. Poster Papers
    1. Neutrophil Sequestration in Rat Lungs (pages 316–317)

      G. M. BROWN, E. DROST, C. SELBY, K. DONALDSON and W. MacNEE

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17031.x

    2. Synergistic Effect of Elastase and 60 Percent Oxygen on Pulmonary Airspace Enlargement (pages 318–320)

      JEROME O. CANTOR, STEPHEN KELLER, JOSEPH M. CERRETA and GERARD M. TURINO

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17032.x

    3. Eglin C and Heparin Inhibition of Platelet Activation Induced by Cathepsin G or Human Neutrophils (pages 321–324)

      P. RENESTO, P. FERRER-LOPEZ and M. CHIGNARD

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17033.x

    4. Does Cigarette Smoke Enhance the Proteolytic Activity of Neutrophils? (pages 325–327)

      K. DONALDSON, G. M. BROWN, E. DROST, C. SELBY and W. MacNEE

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17034.x

    5. Bronchial Inhibitor in Human Lung (page 328)

      B. FOX, T. B. BULL, A. GUZ and T. D. TETLEY

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17035.x

    6. Different Evolution of Emphysema in Two Strains of Mice with Similar Serum Antielastase Deficit (pages 329–330)

      C. GARDI, P. A. MARTORANA, M. M. de SANTI, P. van EVEN, P. CALZONI and G. LUNGARELLA

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17036.x

    7. Pulmonary Hemorrhage Induced by Intratracheal Administration of Human Leukocyte Elastase in Hamsters (pages 331–333)

      ROBERT J. GORDON, EDWARD FERGUSON, RICHARD DUNLAP, CATHERINE FRANKE and PAUL J. SILVER

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17037.x

    8. Purification of Elastin Antigen(s) from the Urine of Patients with Emphysema (pages 334–336)

      U. KUCICH, J. HAMILTON, S. AKERS, P. KIMBEL, S. METTE, J. ROSENBLOOM and G. WEINBAUM

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17038.x

    9. Relationship between Intraalveolar Macrophage Population and Microscopic Emphysema (pages 337–338)

      D. LAMB, A. McLEAN and W. WALLACE

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17039.x

    10. Microscopic Emphysema and Its Variations with Age, Smoking, and Site within the Lungs (pages 339–340)

      D. LAMB, M. GILLOOLY and A. S. J. FARROW

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17040.x

    11. A Polymer-Bound Elastase Inhibitor Is Effective in Preventing Human Neutrophil Elastase-Induced Emphysema (pages 341–342)

      E. C. LUCEY, P. J. STONE, G. A. DIGENIS and G. L. SNIDER

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17041.x

    12. On the Activity of MR 889, a New Synthetic Proteinase Inhibitor (pages 343–344)

      M. LUISETTI, P. D. PICCIONI, M. DONNINI, R. ALESINA, A. M. DONNETTA and V. PEONA

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17042.x

    13. Development of Cor Pulmonale in Tight-Skin Mice with Genetic Emphysema (pages 345–347)

      P. A. MARTORANA, M. WILKINSON, M. M. de SANTI, P. van EVEN, C. GARDI and G. LUNGARELLA

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17043.x

    14. The in Vitro and in Vivo Recovery of PMN Elastase:Beta-Lactam Inhibitor Complexes by Cation Exchange Chromatography (pages 348–349)

      E. E. OPAS, P. S. DELLEA, D. S. FLETCHER, P. DAVIES and J. L. HUMES

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17044.x

    15. Neutrophil Traffic Through the Lungs in Man (pages 353–354)

      C. SELBY, E. DROST, P. K. WRAITH and W. MacNEE

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17046.x

    16. Isolation of Urinary Desmosine by HPLC, Amino Acid Analysis, and Quantification by Isotope Dilution (pages 355–357)

      P. J. STONE, E. C. LUCEY, J. BRYAN-RHADFI, G. L. SNIDER and C. FRANZBLAU

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17047.x

    17. The Blotchy Mouse, Lung Desmosine, and Emphysema (page 358)

      T. D. TETLEY, G. J. PHILLIPS, A. GUZ and B. FOX

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17048.x

    18. Ten-Year Changes of Protease Inhibitors in the Sons of Patients with COPD (pages 359–361)

      A. YOSHIOKA, H. NAGATA, M. YAMAMOTO, Y. AKIYAMA, M. NISHIMURA, K. MIYAMOTO, F. KISHI and Y. KAWAKAMI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17049.x

    19. Early Diagnosis of Pulmonary Emphysema in Smokers (pages 362–364)

      JAIME W. FIDALGO-GARRIDO and JOSÉ L. MARTINEZ-CARRASCO

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17050.x

    20. Rapid Screening for Human Alpha1-Proteinase Inhibitor Deficiency (pages 365–367)

      C. A. LLOYD and K. D. ARBTAN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb17051.x

SEARCH

SEARCH BY CITATION