Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

July 1991

Volume 629 Advances in the Understanding andTreatment of Asthma

Pages xi–xi, 1–459

  1. Preface

    1. Top of page
    2. Preface
    3. Part I. Clinical Background
    4. Part II. Contribution of Cells to the Pathophysiology of Asthma
    5. Part III. Putative Mediators of Asthma
    6. Part IV. Pulmonary Neuropepeptides in Astma
    7. Poster Papers
    1. Preface (page xi)

      Priscillu J. Piper

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37953.x

  2. Part I. Clinical Background

    1. Top of page
    2. Preface
    3. Part I. Clinical Background
    4. Part II. Contribution of Cells to the Pathophysiology of Asthma
    5. Part III. Putative Mediators of Asthma
    6. Part IV. Pulmonary Neuropepeptides in Astma
    7. Poster Papers
    1. Control of Asthma with Emphasis on Prevention of Fatalities (pages 1–6)

      ROY PATTERSON and PAUL A. GREENBERGER

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37954.x

    2. Asthma—a United Kingdom View; Treatment and Its Implications (pages 7–14)

      JOHN F. COSTELLO

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37955.x

    3. Epidemiology and Treatment of Asthma: the European View (pages 15–25)

      JEAN BOUSQUET and FRANÇOIS B. MICHEL

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37956.x

    4. Asthma, Atopy, and Genetic Linkage (pages 26–30)

      J. M. HOPKIN, W. O. C. M. COOKSON and R. P. YOUNG

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37957.x

  3. Part II. Contribution of Cells to the Pathophysiology of Asthma

    1. Top of page
    2. Preface
    3. Part I. Clinical Background
    4. Part II. Contribution of Cells to the Pathophysiology of Asthma
    5. Part III. Putative Mediators of Asthma
    6. Part IV. Pulmonary Neuropepeptides in Astma
    7. Poster Papers
    1. Gene Expression in Different Populations of Mouse Mast Cells (pages 31–37)

      RICHARD L. STEVENS

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37958.x

    2. Platelets and Asthma (pages 38–47)

      C. P. PAGE

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37959.x

    3. The Role of Basophils in Asthma (pages 48–61)

      LAWRENCE M. LICHTENSTEIN and BRUCE S. BOCHNER

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37960.x

    4. The Role of Eosinophils in the Pathophysiology of Asthma (pages 62–72)

      WILLIAM J. CALHOUN, JULIE SEDGWICK and WILLIAM W. BUSSE

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37961.x

    5. Neutrophils in Asthma (pages 73–81)

      T. J. WILLIAMS, A. DAS, C. von UEXKULL and S. NOURSHARGH

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37962.x

    6. Airway Epithelial Cells in the Pathophysiology of Asthma (pages 82–88)

      KEITH J. MORRISON and PAUL M. VANHOUTTE

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37963.x

  4. Part III. Putative Mediators of Asthma

    1. Top of page
    2. Preface
    3. Part I. Clinical Background
    4. Part II. Contribution of Cells to the Pathophysiology of Asthma
    5. Part III. Putative Mediators of Asthma
    6. Part IV. Pulmonary Neuropepeptides in Astma
    7. Poster Papers
    1. Cysteinyl Leukotrienes

      Leukotriene Biosynthesis (pages 89–99)

      BENGT SAMUELSSON, JESPER Z. HAEGGSTRÖM and ANDERS WETTERHOLM

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37964.x

    2. Generation and Metabolism of Cysteinyl Leukotrienes in Vivo (pages 100–104)

      DIETRICH KEPPLER, ALBRECHT GUHLMANN, FRANZ OBERDORFER, KATJA KRAUSS, JULIANE MÜLLER, HERMANN OSTERTAG and MICHAEL HUBER

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37965.x

    3. Appearance of Urinary Metabolites of LTE4 in Human Subjects (pages 105–111)

      ROBERT C. MURPHY, ANGELO SALA, NORBERT VOELKEL and JACQUES MACLOUF

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37966.x

    4. Leukotrienes and Inflammatory Lung Disease (pages 112–119)

      P. J. PIPER, D. M. CONROY, J. F. COSTELLO, J. M. EVANS, C. P. GREEN, J. F. PRICE, A. P. SAMPSON and D. A. SPENCER

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37967.x

    5. Leukotriene Receptors and Mechanisms of Signal Transduction (pages 120–124)

      STANLEY T. CROOKE, BRETT P. MONIA, MING YI CHIANG and C. FRANK BENNETT

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37968.x

    6. Pharmacology of Peptide Leukotriene Receptor Antagonists (pages 125–132)

      DAVID AHARONY and ROBERT D. KRELL

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37969.x

    7. Inhibition of Leukotriene Biosynthesis (pages 133–142)

      A. W. FORD-HUTCHINSON

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37970.x

    8. Initial Results with Oral Administration of ICI 204,219 (pages 143–147)

      MITCHELL GLASS

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37971.x

    9. The Preclinical and Clinical Pharmacology of SK&F 104353, a Potent and Selective Peptidoleukotriene Receptor Antagonist (pages 157–167)

      T. J. TORPHY, I. FAIFERMAN, J. G. GLEASON, R. F. HALL, M. A. LEWIS, C. BROOM, H. M. HELFRICH, J. F. NEWTON and D. W. P. HAY

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37973.x

    10. Platelet Activating Factor

      Metabolism of Platelet Activating Factor in Lung (pages 168–175)

      FRED SNYDER, MERLE L. BLANK and TEN-CHING LEE

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37974.x

    11. Platelet Activating Factor and Asthma (pages 193–204)

      PETER J. BARNES

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37976.x

    12. Other Putative Mediators

      Adenosine: a Positive Modulator of Airway Inflammation in Asthma (pages 227–236)

      S. T. HOLGATE, M. K. CHURCH and R. POLOSA

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37979.x

    13. Airway Bradykinin Receptors (pages 237–249)

      STEPHEN G. FARMER and RONALD M. BURCH

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37980.x

    14. The Role of Cytokines in Asthma (pages 250–261)

      ANNE S. HAMBLIN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37981.x

    15. Lipoxins and Other Lipoxygenase Products with Relevance to Inflammatory Reactions in the Lung (pages 262–273)

      SVEN-ERIK DAHLÉN, MARIA KUMLIN, THURE BJÖRCK, JOHAN RAUD, EVA WIKSTRÖM and PER HEDQVIST

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37982.x

    16. Contribution of Leukotriene B4 to Airway Inflammation and the Effect of Antagonists (pages 274–287)

      IVAN M. RICHARDS, FRANK F. SUN, BRUCE M. TAYLOR, SHARON K. SHIELDS, ROBERT L. GRIFFIN, JOEL MORRIS, DONN G. WISHKA, HERMAN W. SMITH, ROY A. JOHNSON and COLIN J. DUNN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37983.x

  5. Part IV. Pulmonary Neuropepeptides in Astma

    1. Top of page
    2. Preface
    3. Part I. Clinical Background
    4. Part II. Contribution of Cells to the Pathophysiology of Asthma
    5. Part III. Putative Mediators of Asthma
    6. Part IV. Pulmonary Neuropepeptides in Astma
    7. Poster Papers
    1. Localization of Peptides in the Lung (pages 288–304)

      D. R. SPRINGALL and J. M. POLAK

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37984.x

    2. Vasoactive Intestinal Polypeptide (VIP) in Asthma (pages 305–318)

      SAMI I. SAID

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37985.x

    3. Biology of Mast Cell Tryptase and Chymase (pages 319–331)

      JAY A. NADEL

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37986.x

    4. Pulmonary Physiology and Pharmacology of Neuropeptides (pages 332–339)

      JAN M. LUNDBERG, KJELL ALVING and REGIS MATRAN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37987.x

    5. Pharmacological Studies of Tachykinin Receptors Mediating Contraction of Isolated Airway Smooth Muscle (pages 340–358)

      C. K. BUCKNER, S. V. GHANEKAR, J. S. KAYS, R. D. KRELL, R. I. FISHLEDER, J. A. WILL and J. M. VANN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37988.x

    6. Sensory Nerves, Neuropeptides, and Asthma (pages 359–370)

      PETER J. BARNES

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37989.x

    7. The Bronchoconstrictor Effect of Sensory Neuropeptides in Man (pages 371–382)

      G. F. JOOS and R. A. PAUWELS

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37990.x

  6. Poster Papers

    1. Top of page
    2. Preface
    3. Part I. Clinical Background
    4. Part II. Contribution of Cells to the Pathophysiology of Asthma
    5. Part III. Putative Mediators of Asthma
    6. Part IV. Pulmonary Neuropepeptides in Astma
    7. Poster Papers
    1. Measurement of Specific Markers in the Monitoring of the Bronchial Inflammation in Asthma (pages 383–387)

      P. MATSSON, S. AHLSTEDT, I. ENANDER, C. G. B. PETERSON and P. VENGE

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37991.x

    2. Guinea Pig Pulmonary Responses to Serotonin (5-HT) and Related Agonists (pages 392–393)

      C. K. BUCKNER, D. DEA, N. LIBERATI and R. D. KRELL

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37993.x

    3. Effect of the Prostaglandin Endoperoxide Antagonist AA-2414 on Experimental Allergic Asthma (pages 394–395)

      Y. ASHIDA, T. MATSUMOTO, H. KURIKI and T. SAIJO

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37994.x

    4. BAY u3405 Is a Potent and Competitive Antagonist of U466l9, PGD2 and 9α, 11β PGF-Induced Contractions of Airway Smooth Muscle (pages 396–398)

      P. NORMAN, N. J. CUTHBERT, P. J. GARDINER and M. G. McKENNIFF

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37995.x

    5. The Thromboxane Receptor Antagonist BAY u3405 Reverses Prostaglandin D2 (PGD2)-Induced Bronchoconstriction in the Anaesthetised Guinea Pig (pages 399–401)

      H. P. FRANCIS, T. G. MORRIS, A. M. THOMPSON, U. P. PATEL and P. J. GARDINER

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37996.x

    6. BAY u9773—an LTC4 Antagonist in the Guinea Pig Trachea (pages 402–404)

      N. J. CUTHBERT, S. R. TUDHOPE, P. J. GARDINER, T. S. ABRAM, P. NORMAN, A. M. THOMPSON, R. J. MAXEY and M. A. JENNINGS

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37997.x

    7. Leukotriene Receptors in Sheep Respiratory Tissue (pages 405–406)

      N. J. CUTHBERT, T. S. ABRAM and P. J. GARDINER

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37998.x

    8. Effect of DP-1904, a New Thromboxane A2 Synthetase Inhibitor, on Guinea Pig Experimental Asthma (pages 407–409)

      M. TAKAMI, Y. TAKATA, K. MATSUMOTO, S. ONO and W. TSUKADA

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb37999.x

    9. Metabolism of LTB4 by Isolated Hepatocytes: New Metabolites and Effect of Ethanol (pages 410–412)

      MICHAEL A. SHIRLEY and ROBERT C. MURPHY

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb38000.x

    10. hrIL-8-Induced Hyperresponsiveness in Guinea Pig Perfused Lungs (pages 419–421)

      A. D. MEDHURST, J. WESTWICK and P. J. PIPER

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb38003.x

    11. The Effects of a 5-Lipoxygenase Inhibitor, BW A4C, on the Acute Response to Inhaled PAF in Man (pages 430–431)

      D. A. SPENCER, A. P. SAMPSON, J. M. EVANS, L. G. GARLAND, P. J. PIPER and J. F. COSTELLO

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb38007.x

    12. Large Versus Small Airways Functions in Asthmatic Patients (pages 434–435)

      M. K. ELSOROUGI, A. A. AL HELALY, M. M. SHARAF EL DIN, A. ABOU YOUSSEF HODA, A. M. HATEM and S. A. EISSA

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb38009.x

    13. Leukotriene (LT) D4 Is Involved in Antigen-Induced Asthma: a Study with the LTD4 Receptor Antagonist, MK-571 (page 436)

      J. B. RASMUSSEN, D. J. MARGOLSKEE, L. O. ERIKSSON, V. C. WILLIAMS and K. E. ANDERSSON

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb38010.x

    14. Leukotrienes in the Blood and Urine of Children with Acute Asthma (pages 437–439)

      A. P. SAMPSON, C. P. GREEN, D. A. SPENCER, P. J. PIPER and J. F. PRICE

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb38011.x

    15. Comparison of Airway Responsiveness to Prostaglandin D2 and Histamine, Methacholine or Exercise in Healthy and Asthmatic Subjects (pages 442–445)

      DENNIS NOWAK, KERSTIN TEMPLIN, RUDOLF JÖRRES and HELGO MAGNUSSEN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb38013.x

    16. Bronchoalveolar Lavage (BAL) Cell Profiles in Mild Asthmatic and Nonasthmatic Subjects (pages 446–448)

      MAIKE OLDIGS, DENNIS NOWAK, ANDREAS MEYER and HELGO MAGNUSSEN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb38014.x

    17. The Clinical Outcome of Asthma in the Elderly: a 7-Year Follow-Up Study (pages 449–450)

      SIDNEY S. BRAMAN, WILLIAM M. CORRAO and JOHN T. KAEMMERLEN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb38015.x

    18. In Vitro Hyperresponsiveness to Adenosine in Bronchi from Asthmatics (pages 458–459)

      THURE BJÖRCK, LARS E. GUSTAFSSON, EVA WIKSTRÖM, BARBRO DAHLÉN, OLLE ZETTERSTRÖM and SVEN-ERIK DAHLÉN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb38018.x

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