Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

May 1992

Volume 648 Neurotoxins and Neurodegenerative Disease

Pages xi–xvi, 1–382

  1. Preface

    1. Top of page
    2. Preface
    1. Preface (pages xi–xiii)

      J. WILLIAM LANGSTON

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24516.x

    1. Richard E. Heikkila: A Tribute (pages xv–xvi)

      Roger Dwoisin

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24517.x

    2. Theories of Neurodegeneration (pages 1–5)

      D. B. CALNE, F. H. HOCHBERG, B. J. SNOW and T. NYGAARD

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24518.x

    3. Neuropathologic Features of Parkinson's, Huntington's, and Alzheimer's Diseases (pages 6–16)

      LYSIA S. FORNO

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24519.x

    4. Ca2+ and Cell Death (pages 17–27)

      PIERLUIGI NICOTERA and STEN ORRENIUS

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24520.x

    5. Mitochondrial Mechanisms of Neurotoxicity (pages 28–36)

      WILLIAM J. NICKLAS, MICHAEL SAPORITO, ALIE BASMA, HERBERT M. GELLER and RICHARD E. HEIKKILA

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24521.x

    6. Antioxidative Therapeutic Strategies for Parkinson's Disease (pages 37–41)

      IRA SHOULSON

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24522.x

    7. Midbrain Dopaminergic Cell Loss in Parkinson's Disease and MPTP-Induced Parkinsonism: Sparing of Calbindin-D25k—Containing Cells (pages 42–62)

      DWIGHT C. GERMAN, KEBRETEN F. MANAYE, PATRICIA K. SONSALLA and BARBARA A. BROOKS

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24523.x

    8. Cholinergic Toxins and Alzheimer's Disease (pages 63–70)

      ISRAEL HANIN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24524.x

    9. Neurochemical Responses to 6-Hydroxydopamine and L-Dopa Therapy: Implications for Parkinson's Disease (pages 71–86)

      MICHAEL J. ZIGMOND, TERESA G. HASTINGS and ELIZABETH D. ABERCROMBIE

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24525.x

    10. Comparison of MPTP and Amphetamines as Dopaminergic Neurotoxins (pages 87–95)

      RAY W. FULLER

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24526.x

    11. Features of the Dopaminergic Neurotoxin MPTP (pages 96–104)

      IRWIN J. KOPIN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24527.x

    12. Genetic Causes of Neuronal Cell Death (pages 105–118)

      SUZANNE ROFFLER-TARLOV

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24528.x

    13. Ovarian Steroid and Neurotoxin Models of Brain Aging in Rodents (pages 119–124)

      CALEB E. FINCH, STEVEN G. KOHAMA and GIULIO M. PASINETTI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24529.x

    14. Modulation of NMDA Excitotoxicity by Redox Reagents (pages 125–131)

      ELIAS AIZENMAN and IAN J. REYNOLDS

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24530.x

    15. Excitotoxins: Possible Mechanisms of Action (pages 132–139)

      STEVEN M. ROTHMAN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24531.x

    16. Kynurenic Acid: A Potential Pathogen in Brain Disorders (pages 140–153)

      ROBERT SCHWARCZ, FU DU, WERNER SCHMIDT, WALDEMAR A. TURSKI, JAN BERT P. GRAMSBERGEN, ETSUO OKUNO and ROSALINDA C. ROBERTS

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24532.x

    17. Are Human Neurodegenerative Disorders Linked to Environmental Chemicals with Excitotoxic Properties? (pages 154–160)

      PETER S. SPENCER, ALBERT C. LUDOLPH and GLEN E. KISBY

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24533.x

    18. Huntington's Disease and Neurotoxins (pages 169–175)

      JOSEPH B. MARTIN and M. FLINT BEAL

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24535.x

    19. The Etiology of Alzheimer's Disease: The Pathogenesis of Dementiaa The Role of Neurotoxins (pages 176–184)

      DAVID A. DRACHMAN and CAROL F. LIPPA

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24536.x

    20. Overview of Parkinson's Disease (pages 187–193)

      ROGER C. DUVOISIN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24537.x

    21. Pharmacologic Properties of NMDA Receptors (pages 194–204)

      MARK L. MAYER, MORRIS BENVENISTE, DORIS K. PATNEAU and LADISLAV VYKLICKY JR.

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24538.x

    22. Comparative Pharmacology of Kainate-Stimulated Single-Channel Activity in Outside-Out Patches Is Consistent with a Multiplicity of Non-NMDA Receptors (pages 205–206)

      CORNELIA POULOPOULOU, JANET L. CHRISTIANSEN and LINDA M. NOWAK

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24539.x

    23. Neurotoxin-Related Research: From the Laboratory to the Clinic (pages 207–218)

      L. IVERSEN, A. C. FOSTER, R. G. HILL, S. D. IVERSEN, J. A. KEMP, P. D. LEESON, N. M. J. RUPNIAK, K. SAYWELL, M. D. TRICKLEBANK and B. J. WILLIAMS

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24540.x

    24. Role of Astrocytes in MPTP Metabolism and Toxicity (pages 219–228)

      DONATO A. Di MONTE, ELLEN Y. WU and J. WILLIAM LANGSTON

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24541.x

    25. Characteristics of Dopaminergic Neurotoxicity Produced by MPTP and Methamphetamine (pages 229–238)

      PATRICIA K. SONSALLA, ANDREW GIOVANNI, BETH-ANNE SIEBER, KAREN DELLE DONNE and LAWRENCE MANZINO

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24542.x

    26. MPP+ Redox Cycling: A New Mechanism Involving Hydride Transfer (pages 239–240)

      JAMES D. ADAMS, LORI K. KLAIDMAN and ENRIQUE CADENAS

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24543.x

    27. Creation of Transgenic Mice that Overexpress Monoamine Oxidase-B Neuronally (pages 241–243)

      J. K. ANDERSEN, K. HERRUP and X. O. BREAKEFIELD

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24544.x

    28. Biochemical Basis of Structural Electivity of MPTP-like Neurotoxicity (pages 248–250)

      S. O. BACHURIN, N. N. LERMONTOVA, S. O. SABLIN, L. S. SOLYAKOV and S. E. TKACHENKO

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24546.x

    29. Modulatory Action of Kainic Acid on Glutamate Release from Rat Brain Cortical Synaptosomes (pages 251–253)

      L. S. SOLYAKOV, O. A. DRANY, L. N. PETROVA and S. O. BACHURIN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24547.x

    30. Differential Effect of Excitotoxins in the Basal Forebrain on Choline Acetyltransferase Activity in the Cortex and Amygdala (pages 254–255)

      R. J. BOEGMAN, K. JHAMANDAS and J. COCKHILL

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24548.x

    31. The Potential Neurotoxin 2-OH-Dopamine Is an Inhibitor of Arylsulfatase (pages 256–259)

      THOMAS A. CAWLEY JR. and TIMOTHY J. SHICKLEY

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24549.x

    32. Excitatory Amino Acid Receptors in Human Spinal Cord Evaluation in Amyotrophic Lateral Sclerosis Patients (pages 260–262)

      H. ALLAOUA, I. CHAUDIEU, P. BOKSA, T. L. PERRY, C. KRIEGER and R. QUIRION

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24550.x

    33. Indole-N-Methylation of β-Carbolines: The Brain's Bioactivation Route to Toxins in Parkinson's Disease? (pages 263–265)

      MICHAEL A. COLLINS, EDWARD J. NEAFSEY, KAZUO MATSUBARA, ROBERT COBUZZI JR., RUDOLPH ALBORES JR., JEREMY FIELDS and HANS ROLLEMA

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24551.x

    34. Manganese as Possible Ecoetiologic Factor in Parkinson's Disease (pages 266–267)

      ROBERT G. FELDMAN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24552.x

    35. Pharmacologic Modulation of MPTP Toxicity: MK 801 in Prevention of Dopaminergic Cell Death in Monkeys and Mice (pages 268–271)

      ALESSANDRO ZUDDAS, FRANCESCA VAGLINI, FRANCESCO FORNAI, FLAVIA FASCETTI, ANTONIO SAGINARIO and GIOVANNI U. CORSINI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24553.x

    36. Neurotoxicity of an MPTP Analogue, 2/CH3-MPTP, on Monoaminergic Systems in the Mouse Brain (pages 283–285)

      M. GUPTA and X. L. CHEN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24557.x

    37. Effects of Prolonged Chronic Dietary Treatment with AlCl3 on Selected Metabolisms and Memory in Rats (pages 289–290)

      MARTIN CLAUBERG and JAYANT G. JOSHI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24559.x

    38. Stimulation of Glutamate Receptors Increases Expression of Brain-Derived Neurotrophic Factor mRNA in Rat Hippocampus (pages 296–299)

      NILS LINDEFORS, MONTSERRAT BALLARIN, PATRIK ERNFORS, TORKEL FALKENBERG and HÅKAN PERSSON

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24561.x

    39. ATP Deficits and Neuronal Degeneration Induced by 3-Nitropropionic Acid (pages 300–302)

      A. C. LUDOLPH, M. SEELIG, A. G. LUDOLPH, M. I. SABRI and P. S. SPENCER

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24562.x

    40. Hypoxic Neurodegeneration in Culture: Calcium Influx, Electron Microscopy, and Neuroprotection with Excitatory Amino Acid Antagonists (pages 303–305)

      FRANK W. MARCOUX, MARK L. WEBER, ALBERT W. PROBERT Jr. and MARK A. DOMINICK

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24563.x

    41. MPTP-Induced ATP Loss in Mouse Brain (pages 306–308)

      PIU CHAN, LOUIS E. DeLANNEY, IAN IRWIN, J. WILLIAM LANGSTON and DONATO Di MONTE

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24564.x

    42. The Neurotoxicant 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Alters Immune Function When Given in Combination with Diethyldithiocarbamate (DDC) (pages 309–311)

      DIANE B. MILLER, ROBERT W. LUEBKE, JOHN F. REINHARD Jr. and J. P. O'CALLAGHAN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24565.x

    43. Neuropathologies Associated with Dideoxycytosine: A Preliminary Assessment (pages 312–316)

      DAVID E. MORSE, GARY EVONIUK, PAUL L. BLACK and MICHAEL A. USSERY

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24566.x

    44. MK-801 Prevents Methamphetamine-Induced Striatal Dopamine Damage and Reduces Extracellular Dopamine Overflow (pages 317–319)

      STEVEN J. O'DELL, FREDRIC B. WEIHMULLER and JOHN F. MARSHALL

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24567.x

    45. Generic Inhibition of Mitochondrial Electron Transport by MPP+ and Other Charge-Shielded Lipophilic Cations (pages 320–322)

      B. C. PRESSMAN, Y-F. SHI and C. CALDERON-HIGGINSON

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24568.x

    46. Subcellular Compartmentation of 2′Methyl MPP+ Can Explain Differences in Toxicity to Adrenal Chromaffin Cells (pages 323–325)

      JOHN F. REINHARD Jr. and ALEJANDRO J. DANIELS

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24569.x

    47. On the Possible Role of Iron-Induced Free Radical Peroxidation in Neural Degeneration in Alzheimer's Disease (pages 326–327)

      J. S. RICHARDSON, KALA V. SUBBARAO and L. C. ANG

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24570.x

    48. Characterization of [3H]MK-801 Binding in LA-N-2 Neuroblastoma Cells (pages 328–329)

      U. I. RICHARDSON and R. J. WURTMAN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24571.x

    49. Patterns of Fos Expression Suggest Similar Mechanisms of Action for the Excitotoxins Domoic and Kainic Acid (pages 330–334)

      HAROLD ROBERTSON, KENNETH RENTON, JUDY KOHN and THOMAS WHITE

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24572.x

    50. Inhibition of Cocaine Intoxication by Excitatory Amino Acid Receptor Antagonists (pages 335–337)

      R. W. ROCKHOLD, R. S. SURRETT, G. ODEN, C. G. ACUFF, T. ZHANG, J. M. FARLEY, B. HOSKINS and I. K. HO

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24573.x

    51. Analysis of the Protective Effects of 21-Aminosteroids in MPP+-Induced Neurotoxicity to Dopaminergic Neurons in Mesencephalic Cultures (pages 338–339)

      JUAN R. SANCHEZ-RAMOS, SHIJE SONG, JILL OPPENHEIMER, DEBORAH MASH and WILLIAM J. WEINER

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24574.x

    52. Age and Dietary Factors in Hippocampal Sensitivity to Trimethyltin (pages 340–342)

      ANDREW C. SCALLET, WILLIAM SLIKKER Jr., SYED F. ALI, JOHN F. BOWYER, R. ROBERT HOLSON, GEORGE W. LIPE, JOHN C. LIPSCOMB, ROBERT L. ROUNTREE, CHRISTOPHER W. STEWART and JOHN C. MATTHEWS

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24575.x

    53. L-Dopa Potentiates the Neurotoxicity of Some Amphetamine Analogues (pages 343–344)

      CHRISTOPHER J. SCHMIDT

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24576.x

    54. The Platelet Plasma Membrane Serotonin Transporter Catalyzes Exchange between Neurotoxic Amphetamines and Serotonin (pages 345–347)

      GARY RUDNICK and STEPHEN C. WALL

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24577.x

    55. Brain-Derived Neurotrophic Factor Protects Dopaminergic Cells from 6-Hydroxydopamine Toxicity (pages 348–350)

      MARY BETH SPINA, CAROLYN HYMAN, STEPHEN SQUINTO and RONALD M. LINDSAY

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24578.x

    56. The Interaction of a Kainate Receptor from Goldfish Brain with a Pertussis Toxin-Sensitive GTP Binding Protein (pages 351–352)

      JAMES M. WILLARD, CYNTHIA J. ZIEGRA and ROBERT E. OSWALD

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24579.x

    57. A Slow Voltage-Dependent Increase in N-Methyl-D-Aspartate Open-Channel Probability (pages 353–354)

      J. M. WRIGHT and L. M. NOWAK

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24580.x

    58. Excitatory Amino Acid-Evoked Calcium Influx and Calcium-Dependent Neurotoxicity in Rat Cortical Cultures (pages 355–357)

      W. C. ZINKAND, C. THOMPSON, A. I. SALAMA and J. PATEL

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24581.x

    59. Evidence for a Common Mechanism of Serotonin Release Induced by Substituted Amphetamines in Vitro (pages 358–360)

      URS V. BERGER, XI F. GU, JEROEN W. L. van LANGE and EFRAIN C. AZMITIA

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24582.x

    60. Comparison of the Release of Exogenous and Endogenous Excitatory Amino Acids from Rat Cerebral Cortex (pages 361–364)

      A. M. PALMER, C. T. REITER and M. BOTSCHELLER

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24583.x

    61. NMDA Receptors, Cellular Edema, and Metabolic Stress (pages 368–370)

      GAIL D. ZEEVALK and WILLIAM J. NICKLAS

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24585.x

    62. Neurotoxic Amphetamine Analogues: Effects in Monkeys and Implications for Humans (pages 371–382)

      GEORGE A. RICAURTE and UNA D. McCANN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb24586.x

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