Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

December 1992

Volume 674 Proteases and Protease Inhibitors in Alzheimer's Disease Pathogenesis

Pages ix–x, 1–252

    1. Preface (pages ix–x)

      Carl D. B. Banner and Ralph A. Nixon

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb27471.x

    2. Cellular Proteolysis An Overview (pages 1–15)

      A. J. BARRETT

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb27472.x

    3. Protein Metabolism in the Brain (pages 16–26)

      ABEL LAJTHA, MIRIAM BANAY-SCHWARTZ and DAVID DUNLOP

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb27473.x

    4. Translocation of Proteins across and Integration of Membrane Proteins into the Rough Endoplasmic Reticulum (pages 27–37)

      REID GILMORE and KENNAN V. KELLARIS

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb27474.x

    5. Sorting of Chromogranin B into Immature Secretory Granules in Pheochromocytoma (PCI2) Cells (pages 38–52)

      MARK GRIMES and REGIS B. KELLY

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb27475.x

    6. Secretion of the β-Amyloid Precursor Protein (pages 53–57)

      SANGRAM S. SISODIA

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb27476.x

    7. Selective Degradation of Cytosolic Proteins by Lysosomes (pages 58–64)

      J. FRED DICE

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb27477.x

    8. The Lysosomal System in Neurons : Involvement at Multiple Stages of Alzheimer's Disease Pathogenesis (pages 65–88)

      RALPH A. NIXON, ANNE M. CATALDO, PETER A. PASKEVICH, DEBORAH J. HAMILTON, TIMOTHY R. WHEELOCK and LISA KANALEY-ANDREWS

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb27478.x

    9. An Endosomal-Lysosomal Pathway for Degradation of Amyloid Precursor Protein (pages 103–117)

      GREG M. COLE, LLORAINE BELL, QUANG B. TRUONG and TSUNAO SAITOH

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb27480.x

    10. The Alzheimer's Amyloid Precursor Is Cleaved Intracellularly in the Trans-Golgi Network or in a Post-Golgi Compartment (pages 118–128)

      K. SAMBAMURTI, L. M. REFOLO, J. SHIOI, M. A. PAPPOLLA and N. K. ROBAKIS

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb27481.x

    11. Amyloid β/A4 Precursor Protein (APP) Processing in Lysosomes (pages 129–137)

      KAZUHIKO TAGAWA, KEI MARUYAMA and SHOICHI ISHIURA

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb27482.x

    12. Ubiquitin, Lysosomes, and Neurodegenerative Diseases (pages 149–160)

      R. JOHN MAYER, LAJOS LASZLO, MICHAEL LANDON, JAMES HOPE and JAMES LOWE

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb27484.x

    13. The Involvement of Proteases, Protease Inhibitors, and an Acute Phase Response in Alzheimer's Disease (pages 161–173)

      HUNTINGTON POTTER, ROBERT B. NELSON, SAUMYA DAS, ROBERT SIMAN, USAMAH S. KAYYALI and DAVID DRESSLER

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb27485.x

    14. Purification and Cloning of Brain Proteases Capable of Degrading the β-Amyloid Precursor Protein (pages 174–179)

      CARMELA R. ABRAHAM, BRONWYN L. RAZZABONI, GREGORY PAPASTOITSIS, ELIOT PICARD, KAZUTOMI KANEMARU, BARBARA MECKELEIN and LENNART MUCKE

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb27486.x

    15. Degradation of Proteins in the Membrane-Cytoskeleton Complex in Alzheimer's Disease : Might Amyloidogenic APP Processing Be Just the Tip of the Iceberg? (pages 180–192)

      TSUNAO SAITOH, ELIEZER MASLIAH, LARRY BAUM, MARY SUNDSMO, LISA FLANAGAN, RAMKUMAR VIKRAMKUMAR and MARGUERITE M. B. KAY

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb27487.x

    16. Proteolytic Mechanism for the Neurodegeneration of Alzheimer's Disease (pages 193–202)

      ROBERT SIMAN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb27488.x

    17. Characterization of Alternative Routes for Processing of the Alzheimer β/A4-Amyloid Precursor Protein : Differential Effects of Phorbol Esters and Chloroquine (pages 203–217)

      SAMUEL E. GANDY, GREGG L. CAPORASO, TRIPRAYAR V. RAMABHADRAN, TOSHIHARU SUZUKI, JOSEPH D. BUXBAUM, CHRISTER NORDSTEDT, KERSTIN IVERFELDT, ANDREW J. CZERNIK, ANGUS C. NAIRN and PAUL GREENGARD

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb27489.x

    18. Modulation of Cellular Signals by Calpain (pages 218–227)

      KOICHI SUZUKI, TAKAOMI C. SAIDO and SHUICHI HIRAI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb27490.x

    19. Regulation of Neuronal Cells and Astrocytes by Protease Nexin-1 and Thrombin (pages 228–236)

      DENNIS D. CUNNINGHAM

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb27491.x

    20. Relevance of the Balance between Glia-Derived Nexin and Thrombin following Lesion in the Nervous System (pages 237–242)

      DENIS MONARD, HANA S. SUIDAN and CORDULA NITSCH

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb27492.x

    21. Potential Role of Protease Nexin-2/Amyloid β-Protein Precursor as a Cerebral Anticoagulant (pages 243–252)

      WILLIAM E. VAN NOSTRAND, ALVIN H. SCHMAIER and STEVEN L. WAGNER

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1992.tb27493.x

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