Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

May 1993

Volume 679 Markers of Neuronal Injury and Degeneration

Pages xi–xii, 1–430

    1. Preface (pages xi–xii)

      JAN N. JOHANNESSEN and M. ANTHONY VERITY

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18284.x

  1. Part I. Intracellular Calcium and Neuronal Injury

    1. Top of page
    2. Part I. Intracellular Calcium and Neuronal Injury
    3. Part II. Changes in Protein Structure and Function
    4. Part III. Altered Gene Expression
    5. Part IV. Non-neuronal Markers of Neuronal Injury
    6. Part V. Poster Presentations Section I. Markers of Neuronal Degeneration in Vitro
    7. Section II. Markers of Neuronal Injury in Vivo
    8. Section III. Markers of Metabolic Damage
    9. Section IV. Altered Gene Expression in Neuronal Injury and Degeneration
    1. Altered Calcium Signaling and Neuronal Injury: Stroke and Alzheimer's Disease as Examples (pages 1–21)

      M. P. MATTSON, R. E. RYDEL, I. LIEBERBURG and V. L. SMITH-SWINTOSKY

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18285.x

    2. Calcium Influx and Neurodegeneration (pages 22–33)

      SIMON J. GIBBONS, JAMES R. BRORSON, DAVID BLEAKMAN, PAUL S. CHARD and RICHARD J. MILLER

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18286.x

    3. Examination of the Role of Calcium in Neuronal Death (pages 34–42)

      JANET M. DUBINSKY

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18287.x

  2. Part II. Changes in Protein Structure and Function

    1. Top of page
    2. Part I. Intracellular Calcium and Neuronal Injury
    3. Part II. Changes in Protein Structure and Function
    4. Part III. Altered Gene Expression
    5. Part IV. Non-neuronal Markers of Neuronal Injury
    6. Part V. Poster Presentations Section I. Markers of Neuronal Degeneration in Vitro
    7. Section II. Markers of Neuronal Injury in Vivo
    8. Section III. Markers of Metabolic Damage
    9. Section IV. Altered Gene Expression in Neuronal Injury and Degeneration
    1. Changes in Protein Phosphorylation in Cultured Neurons after Exposure to Methyl Mercury (pages 65–77)

      THEODORE A. SARAFIAN and M. ANTHONY VERITY

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18289.x

    2. Spectrin Proteolysis in the Hippocampus: A Biochemical Marker for Neuronal Injury and Neuroprotection (pages 78–86)

      JILL M. ROBERTS-LEWIS and ROBERT SIMAN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18290.x

    3. The Lysosomal System in Neuronal Cell Death: A Review (pages 87–109)

      RALPH A. NIXON and ANNE M. CATALDO

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18291.x

    4. Mechanisms of Phospholipase A2 Activation and Neuronal Injury (pages 110–120)

      M. ANTHONY VERITY

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18292.x

    5. Neurotrophic Factor Deprivation-induced Death (pages 121–131)

      THOMAS L. DECKWERTH and EUGENE M. JOHNSON JR.

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18293.x

  3. Part III. Altered Gene Expression

    1. Top of page
    2. Part I. Intracellular Calcium and Neuronal Injury
    3. Part II. Changes in Protein Structure and Function
    4. Part III. Altered Gene Expression
    5. Part IV. Non-neuronal Markers of Neuronal Injury
    6. Part V. Poster Presentations Section I. Markers of Neuronal Degeneration in Vitro
    7. Section II. Markers of Neuronal Injury in Vivo
    8. Section III. Markers of Metabolic Damage
    9. Section IV. Altered Gene Expression in Neuronal Injury and Degeneration
    1. Glutamate, Immediate-Early Genes, and Cell Death in the Nervous System (pages 132–141)

      MONTSERRAT VENDRELL, TOM CURRAN and JAMES I. MORGAN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18294.x

    2. Synthesis of Heat Shock/Stress Proteins during Cellular Injury (pages 142–156)

      THADDEUS S. NOWAK JR.

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18295.x

    3. Molecular Mechanisms of Selective Neurotoxicants: Studies on Organotin Compounds (pages 157–177)

      STEPHANIE M. TOGGAS, J. KYLE KRADY, THERESA A. THOMPSON and MELVIN L. BILLINGSLEY

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18296.x

    4. Heterogeneity of Brain Gene Expression in Alzheimer's Disease (pages 178–187)

      JOHN R. DUGUID, CHRISTOPHER TRZEPACZ, THOMAS KEMPER, WALLACE W. TOURTELLOTE and LADISLAV VOLICER

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18297.x

    5. Polyubiquitin Gene Expression following Cerebral Ischemia (pages 188–194)

      CORNELIO G. CADAY, ROBERT M. SKLAR, DAVID J. BERLOVE, AHMED KEMMOU, ROBERT H. BROWN JR. and SETH P. FINKLESTEIN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18298.x

  4. Part IV. Non-neuronal Markers of Neuronal Injury

    1. Top of page
    2. Part I. Intracellular Calcium and Neuronal Injury
    3. Part II. Changes in Protein Structure and Function
    4. Part III. Altered Gene Expression
    5. Part IV. Non-neuronal Markers of Neuronal Injury
    6. Part V. Poster Presentations Section I. Markers of Neuronal Degeneration in Vitro
    7. Section II. Markers of Neuronal Injury in Vivo
    8. Section III. Markers of Metabolic Damage
    9. Section IV. Altered Gene Expression in Neuronal Injury and Degeneration
    1. Quantitative Features of Reactive Gliosis following Toxicant-induced Damage of the CNS (pages 195–210)

      JAMES P. O'CALLAGHAN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18299.x

    2. Quinolinic Acid and Inflammation (pages 211–216)

      MELVYN P. HEYES

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18300.x

    3. Release of Membrane-associated Growth Factors during Neural Injury (pages 217–225)

      GEORGE H. De VRIES, TIMOTHY J. NEUBERGER, ROOPA R. Baichwal, JOHN W. BIGBEE, LEE ZANE and JUN E. YOSHINO

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18301.x

    4. Trophic Factor Production by Reactive Astrocytes in Injured Brain (pages 226–234)

      JOAN P. SCHWARTZ, JIN GEN SHENG, KUNIHIKO Mitsuo, SUSUMU Shirabe and NOBUYOSHI Nishiyama

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18302.x

    5. Sulfated Glycoprotein-2: An Emerging Molecular Marker for Neurodegeneration (pages 235–244)

      PATRICK C. MAY

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18303.x

  5. Part V. Poster Presentations Section I. Markers of Neuronal Degeneration in Vitro

    1. Top of page
    2. Part I. Intracellular Calcium and Neuronal Injury
    3. Part II. Changes in Protein Structure and Function
    4. Part III. Altered Gene Expression
    5. Part IV. Non-neuronal Markers of Neuronal Injury
    6. Part V. Poster Presentations Section I. Markers of Neuronal Degeneration in Vitro
    7. Section II. Markers of Neuronal Injury in Vivo
    8. Section III. Markers of Metabolic Damage
    9. Section IV. Altered Gene Expression in Neuronal Injury and Degeneration
    1. Neurotoxic Effect of Okadaic Acid, A Seafood-related Toxin, on Cultured Cerebellar Neurons (pages 260–269)

      MARÍA TERESA FERNÁNDEZ, VLADIMIR ZITKO, SANTIAGO GASCÓN, ANGELES TORREBLANCA and ANTONELLO NOVELLI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18306.x

    2. Effects of ORG 2766, a Neurotrophic ACTH4–9 Analogue, in Neuroblastoma Cells (pages 270–275)

      R. MURRY, J. A. McLANE and G. GRUENER

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18307.x

    3. Use of Neurite Outgrowth as an in Vitro Method of Assessing Neurotoxicity (pages 276–279)

      ELIZABETH McFARLANE ABDULLA and IAIN C. CAMPBELL

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18308.x

    4. Preliminary Observations on the in Vitro Toxicity of N-Butylbenzenesulfonamide: A Newly Discovered Neurotoxin (pages 280–287)

      V. R. NERURKAR, I. WAKAYAMA, T. ROWE, R. YANAGIHARA and R. M. GARRUTO

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18309.x

  6. Section II. Markers of Neuronal Injury in Vivo

    1. Top of page
    2. Part I. Intracellular Calcium and Neuronal Injury
    3. Part II. Changes in Protein Structure and Function
    4. Part III. Altered Gene Expression
    5. Part IV. Non-neuronal Markers of Neuronal Injury
    6. Part V. Poster Presentations Section I. Markers of Neuronal Degeneration in Vitro
    7. Section II. Markers of Neuronal Injury in Vivo
    8. Section III. Markers of Metabolic Damage
    9. Section IV. Altered Gene Expression in Neuronal Injury and Degeneration
    1. Heat Shock Proteins Used to Show that Haloperidol Prevents Neuronal Injury Produced by Ketamine, MK801, and Phencyclidine (pages 288–290)

      FRANK R. SHARP, MICHAEL BUTMAN, SHU WANG, JARI KOISTINAHO, STEVEN H. GRAHAM, STEPHEN M. SAGAR, PAUL BERGER and FRANK M. LONGO

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18310.x

    2. Light- and Electron-Microscopic Studies of Identified Septohippocampal Neurons Surviving Axotomy (pages 291–297)

      GARY M. PETERSON, THOMAS NAUMANN and MICHAEL FROTSCHER

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18311.x

    3. The Effects of Intraseptal Brain-derived Neurotrophic Factor on Cognition in Rats with MS/DB Lesions (pages 299–305)

      MARY ANN PELLEYMOUNTER and MARY JANE CULLEN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18312.x

    4. The Goldfish as a Drug Discovery Vehicle for Parkinson's Disease and Other Neurodegenerative Disorders (pages 317–320)

      HARVEY B. POLLARD, MARTENS ADEYEMO, KULDEEP DHARIWAL, MARK LEVINE, HUNG CAOHUY, SANFORD MARKEY, CAROL J. MARKEY and MOUSSA B. H. YOUDIM

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18314.x

    5. Calpain Activity in Organophosphorus-induced Delayed Neuropathy (OPIDN): Effects of a Phenylalkylamine Calcium Channel Blocker (pages 325–329)

      HASSAN A. N. EL-FAWAL and MARION F. EHRICH

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18316.x

    6. Tirilazad Mesylate Attenuates the Accumulation of Neutrophils in Ischemic Gerbil Brain (pages 330–335)

      LAWRENCE R. WILLIAMS and JO A. OOSTVEEN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18317.x

    7. Detection of Early Axonal Degeneration in the Mammalian Central Nervous System by Magnetization Transfer Techniques in Magnetic Resonance Imaging (pages 336–340)

      FRANK J. LEXA, ROBERT I. GROSSMAN and ALAN C. ROSENQUIST

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18318.x

    8. Silver Staining Methods: Their Role in Detecting Neurotoxicity (pages 341–348)

      ROBERT C. SWITZER III

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18319.x

    9. Elevation of Nerve Growth Factor Receptor-truncated in the Urine of Patients with Diabetic Neuropathy (pages 349–351)

      ROBERT E. HRUSKA, M. M. CHERTACK and D. KRAVIS

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18320.x

  7. Section III. Markers of Metabolic Damage

    1. Top of page
    2. Part I. Intracellular Calcium and Neuronal Injury
    3. Part II. Changes in Protein Structure and Function
    4. Part III. Altered Gene Expression
    5. Part IV. Non-neuronal Markers of Neuronal Injury
    6. Part V. Poster Presentations Section I. Markers of Neuronal Degeneration in Vitro
    7. Section II. Markers of Neuronal Injury in Vivo
    8. Section III. Markers of Metabolic Damage
    9. Section IV. Altered Gene Expression in Neuronal Injury and Degeneration
    1. Oxidative Damage in Double-stranded Genomic DNA as Measured by GC/MS Assay of a Thymine Glycol Derivative (pages 352–357)

      S. P. MARKEY, C. J. MARKEY and T.-C. L. WANG

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18321.x

    2. Free Radical and Lipid Peroxidation in Manganese-induced Neuronal Cell Injury (pages 358–363)

      A. Y. SUN, W. L. YANG and H. D. KIM

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18322.x

    3. Glutathione Disulfide (GSSG) as a Marker of Oxidative Injury to Brain Mitochondria (pages 364–369)

      PETER WERNER and GERALD COHEN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18323.x

    4. Hydroxyl Free Radical (·OH) Formation Reflected by Salicylate Hydroxylation and Neuromelanin : In Vivo Markers for Oxidant Injury of Nigral Neurons (pages 370–375)

      C. C. CHIUEH, D. L. MURPHY, H. MIYAKE, K. LANG, P. K. TULSI and S.-J. HUANG

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18324.x

    5. Manganese Transport and Na/K/Cl Cotransport in PC-12 Cell (pages 376–381)

      H. D. KIM, G. Y. SUN and A. Y. SUN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18325.x

  8. Section IV. Altered Gene Expression in Neuronal Injury and Degeneration

    1. Top of page
    2. Part I. Intracellular Calcium and Neuronal Injury
    3. Part II. Changes in Protein Structure and Function
    4. Part III. Altered Gene Expression
    5. Part IV. Non-neuronal Markers of Neuronal Injury
    6. Part V. Poster Presentations Section I. Markers of Neuronal Degeneration in Vitro
    7. Section II. Markers of Neuronal Injury in Vivo
    8. Section III. Markers of Metabolic Damage
    9. Section IV. Altered Gene Expression in Neuronal Injury and Degeneration
    1. Effects of Focal Cerebral Ischemia on Expression and Activity of Inositol 1,4,5-Trisphosphate 3-Kinase in Rat Cortex (pages 382–387)

      G. Y. SUN, T-A. LIN, P. WIXOM, R. T. ZOELLER, T-N. LIN, Y. Y. HE and C. Y. HSU

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18326.x

    2. The Neuronal Cytoskeleton in Disorders of Late Onset and Slow Progression (pages 388–393)

      MICHAEL J. STRONG, IKURO WAKAYAMA and RALPH M. GARRUTO

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18327.x

    3. Long-term Changes in Glial Fibrillary Acidic Protein and Calcium Levels in Rat Hippocampus after a Single Systemic Dose of Kainic Acid (pages 394–401)

      KORNELIS J. VAN DEN BERG and JAN BERT P. GRAMSBERGEN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18328.x

    4. Glial Fibrillary Acidic Protein (GFAP) Indicates in Vivo Exposure to Environmental Contaminants: PCBs in the Atlantic Tomcod (pages 402–406)

      H. L. EVANS, A. R. LITTLE, Z. L. GONG, J. S. DUFFY, I. WIRGIN and H. A. N. EL-FAWAL

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18329.x

    5. The Expression of B-50/GAP-43 in Schwann Cells (pages 412–417)

      L. C. PLANTINGA, J. VERHAAGEN and W. H. GISPEN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18331.x

    6. Insulin-like Growth Factors and Cerebral Ischemia (pages 418–422)

      WEI-HUA LEE and CAROLYN BONDY

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18332.x

    7. Gene Expression in Brain Injury: Identification of a New cDNA Structurally Related to Adhesive and Trophic Agents (pages 423–430)

      TAM THANH QUACH, BRUCE K. SCHRIER and ANNE-MARIE DUCHEMIN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb18333.x

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