Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

June 1993

Volume 685 Immunomodulating Drugs

Pages xv–xvi, 1–812

    1. Preface (pages xv–xvi)

      VASSIL ST. GEORGIEV and HIDEYO YAMAGUCHI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35843.x

  1. Part I. FK-506: Chemistry and Biological Evaluation

    1. Top of page
    2. Part I. FK-506: Chemistry and Biological Evaluation
    3. Part II. Immunosuppressive Properties of Rapamycin
    4. Part III. 15-Deoxyspergualin: Chemistry and Immunosuppressive Action
    5. Part IV. Guanine Arabinoside and Purine Nucleoside Phosphorylase Inhibitors
    6. Part V. Immunomodulating Activity of Experimental Therapeutics
    7. CONFERENCE LECTURESHIPS: The Edmrd Jenner Lecture
    8. Part VI. Immunomodulating Activities of Anti-Infectious Drugs
    9. Part VII. Treatment of Infectious Diseases and Sepsis: Intervention by Immune Regulation
    10. Part VIII. Immunomodulating Properties of Peptides in Allergic and Autoimmune Diseases
    11. Part IX. Kamp Medicine (Japanese Herbal Medicine) and Its Imrnunomodulating Effects with Special Reference to Intractable Asthma
    12. Part X. Cytokines and Regulation of the Immune Response
    13. Part XI. Drug Metabolizing Enzymes and the Immune System
    14. Part XII. Novel Strategies for Immunotherapy
    15. Part XIII. Vaccines: Recent Progress in Development
    1. Immunomodulating Drugs: Major Advances in Research and Development (pages 1–10)

      VASSIL ST. GEORGIEV

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35844.x

    2. FK-506: Its Role in Immunosuppression (pages 11–12)

      B. G. CHRISTENSEN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35845.x

    3. Discovery of FK-506 and Update (pages 13–21)

      TORU KINO and TOSHIO GOTO

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35846.x

    4. FK-506–A Novel Immunosuppressant (pages 22–36)

      WILLIAM H. PARSONS, NOLAN H. SIGAL and MATTHEW J. WYVRATT

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35847.x

    5. Structural Studies of Complexed FK-506 Binding Protein (pages 37–45)

      JON CLARDY

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35848.x

    6. Allograft and Xenograft Acceptance under FK-506 and Other Immunosuppressant Treatment (pages 46–51)

      THOMAS E. STARZL, NORIKO MURASE, ANTHONY J. DEMETRIS, SUZANNE ILDSTAD, CAMILLO RICORDI and MASSIMO TRUCCO

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35849.x

    7. FK-506 Inhibits the IL-2-Independent Induction of the Activation Antigen CD 69 (pages 52–54)

      GABRIELLE H. REEM, YONG SHI and SOUMAYA el ROUBY

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35850.x

    8. Comparison of FK-506, Rapamycin, Ascomycin, and Cyclosporine in Mouse Models of Host-versus-Graft Disease and Heterotopic Heart Transplantation (pages 55–57)

      K. W. MOLLISON, T. A. FEY, R. A. KRAUSE, V. A. THOMAS, A. P. MEHTA and J. R. LULY

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35851.x

  2. Part II. Immunosuppressive Properties of Rapamycin

    1. Top of page
    2. Part I. FK-506: Chemistry and Biological Evaluation
    3. Part II. Immunosuppressive Properties of Rapamycin
    4. Part III. 15-Deoxyspergualin: Chemistry and Immunosuppressive Action
    5. Part IV. Guanine Arabinoside and Purine Nucleoside Phosphorylase Inhibitors
    6. Part V. Immunomodulating Activity of Experimental Therapeutics
    7. CONFERENCE LECTURESHIPS: The Edmrd Jenner Lecture
    8. Part VI. Immunomodulating Activities of Anti-Infectious Drugs
    9. Part VII. Treatment of Infectious Diseases and Sepsis: Intervention by Immune Regulation
    10. Part VIII. Immunomodulating Properties of Peptides in Allergic and Autoimmune Diseases
    11. Part IX. Kamp Medicine (Japanese Herbal Medicine) and Its Imrnunomodulating Effects with Special Reference to Intractable Asthma
    12. Part X. Cytokines and Regulation of the Immune Response
    13. Part XI. Drug Metabolizing Enzymes and the Immune System
    14. Part XII. Novel Strategies for Immunotherapy
    15. Part XIII. Vaccines: Recent Progress in Development
    1. Rapamycin: In Vitro Profile of a New Immunosuppressive Macrolide. (pages 58–67)

      S. N. SEHGAL and C. C. BANSBACH

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35852.x

    2. Rapamycin Prolongs Survival of Murine Recipients of Fully Allogeneic Donor Grafts When Administered during the Graft-versus-Host Disease Process (pages 73–85)

      BRUCE R. BLAZAR, PATRICIA A. TAYLOR, SUREN N. SEHGAL and DANIEL A. VALLERA

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35854.x

    3. Effects of Orally Administered Rapamycin in Animal Models of Arthritis and Other Autoimmune Diseases (pages 86–113)

      RICHARD P. CARLSON, WILLIAM L. BAEDER, ROBERT G. CACCESE, LINDA M. WARNER and SUREN N. SEHGAL

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35855.x

    4. Rapamycin's Inhibition of Thymocyte Proliferation, Unlike That of Cyclosporin A or Prednisolone, Is Not Associated with Cytotoxicity (pages 114–116)

      CATHERINE C. BANSBACH, DAVID WANCIO, ROBERT G. CACCESE, C. FRANK SHEN and SUREN N. SEHGAL

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35856.x

    5. Rapamycin's Inhibition Lymphocyte Proliferation in a Poplked Lymph Node Model via an IL-2-Independent Mechanism (pages 117–120)

      L. M. WARNER, G. M. LEWIS, B. M. WEICHMAN and S. N. SEHGAL

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35857.x

    6. Rapamycin in a Porcine Renal Transplant Model (pages 121–122)

      P. S. ALMOND, A. MOSS, R. NAKHLEH, M. MELIN, S. CHEN, A. SALAZAR, K. SHIRABE and A. MATAS

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35858.x

  3. Part III. 15-Deoxyspergualin: Chemistry and Immunosuppressive Action

    1. Top of page
    2. Part I. FK-506: Chemistry and Biological Evaluation
    3. Part II. Immunosuppressive Properties of Rapamycin
    4. Part III. 15-Deoxyspergualin: Chemistry and Immunosuppressive Action
    5. Part IV. Guanine Arabinoside and Purine Nucleoside Phosphorylase Inhibitors
    6. Part V. Immunomodulating Activity of Experimental Therapeutics
    7. CONFERENCE LECTURESHIPS: The Edmrd Jenner Lecture
    8. Part VI. Immunomodulating Activities of Anti-Infectious Drugs
    9. Part VII. Treatment of Infectious Diseases and Sepsis: Intervention by Immune Regulation
    10. Part VIII. Immunomodulating Properties of Peptides in Allergic and Autoimmune Diseases
    11. Part IX. Kamp Medicine (Japanese Herbal Medicine) and Its Imrnunomodulating Effects with Special Reference to Intractable Asthma
    12. Part X. Cytokines and Regulation of the Immune Response
    13. Part XI. Drug Metabolizing Enzymes and the Immune System
    14. Part XII. Novel Strategies for Immunotherapy
    15. Part XIII. Vaccines: Recent Progress in Development
    1. Synthesis and Background Chemistry of 15-Deoxyspergualin (pages 123–135)

      KENJI MAEDA, YOSHIHISA UMEDA and TETSUSHI SAINO

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35859.x

    2. 15-Deoxyspergualin, a Novel Immunosuppressive Drug: Studies of the Mechanism of Action (pages 136–147)

      MARK A. TEPPER, STEVEN NADLER, CHARLES MAZZUCCO, CHERRY SINGH and SUSAN L. KELLEY

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35860.x

    3. Successful Treatment with a Novel Immunosuppressive Agent, Deoxyspergualin, in Type II Collagen-Induced Arthritis in Mice (pages 148–154)

      KYUICHI NEMOTO, TAKAKO MAE, FUMINORI ABE and TOMIO TAKEUCHI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35861.x

    4. Preclinical Studies with 15-Deoxyspergualin in Various Animal Models for Autoimmune Diseases (pages 155–174)

      HANS-ULRICH SCHORLEMMER and GERHARD DICKNEITE

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35862.x

    5. 15-Deoxyspergualin: A Novel Immunosuppressive Drug with Clinical Potential (pages 175–192)

      FRANCIS T. THOMAS, MARK A. TEPPER, JUDITH M. THOMAS and CARL E. HAISCH

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35863.x

    6. Deoxyspergualin: Clinical Trials in Renal Graft Rejection (pages 196–201)

      HIROSHI AMEMIYAa for the JAPAN COLLABORATIVE TRANSPLANT Study of Deoxyspergualin

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35865.x

  4. Part IV. Guanine Arabinoside and Purine Nucleoside Phosphorylase Inhibitors

    1. Top of page
    2. Part I. FK-506: Chemistry and Biological Evaluation
    3. Part II. Immunosuppressive Properties of Rapamycin
    4. Part III. 15-Deoxyspergualin: Chemistry and Immunosuppressive Action
    5. Part IV. Guanine Arabinoside and Purine Nucleoside Phosphorylase Inhibitors
    6. Part V. Immunomodulating Activity of Experimental Therapeutics
    7. CONFERENCE LECTURESHIPS: The Edmrd Jenner Lecture
    8. Part VI. Immunomodulating Activities of Anti-Infectious Drugs
    9. Part VII. Treatment of Infectious Diseases and Sepsis: Intervention by Immune Regulation
    10. Part VIII. Immunomodulating Properties of Peptides in Allergic and Autoimmune Diseases
    11. Part IX. Kamp Medicine (Japanese Herbal Medicine) and Its Imrnunomodulating Effects with Special Reference to Intractable Asthma
    12. Part X. Cytokines and Regulation of the Immune Response
    13. Part XI. Drug Metabolizing Enzymes and the Immune System
    14. Part XII. Novel Strategies for Immunotherapy
    15. Part XIII. Vaccines: Recent Progress in Development
    1. Enzymes of the Purine Metabolism: Inhibition and Therapeutic Potential (pages 207–216)

      VASSIL ST. GEORGIEV

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35868.x

    2. IMP Dehydrogenase Inhibitors as Immunomodulators (pages 217–224)

      BEVERLY S. MITCHELL, JENNIFER S. DAYTON, LAURENCE A. TURKA and CRAIG B. THOMPSON

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35869.x

    3. Guanine Arabinoside as a Bone Marrow-Purging Agent (pages 225–236)

      JOANNE KURTZBERG

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35870.x

    4. Application of X-Ray Crystallographic Methods in the Design of Purine Nucleoside Phosphorylase Inhibitors (pages 237–247)

      STEVEN E. EALICK, Y. S. BABU, CHARLES E. BUGG, MARK D. ERION, WAYNE G. GUIDA, JOHN A. MONTGOMERY and JOHN A. SECRIST III

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35871.x

    5. Activities of Two 9-Deazaguanine Analogue Inhibitors of Purine Nucleoside Phosphorylase, CI-972 and PD 141955, in Vitro and in Vivo (pages 248–251)

      R. B. GILBERTSEN, M. K. DONG, U. JOSYULA, J. C. SIRCAR, D. J. WILBURN and M. C. CONROY

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35872.x

  5. Part V. Immunomodulating Activity of Experimental Therapeutics

    1. Top of page
    2. Part I. FK-506: Chemistry and Biological Evaluation
    3. Part II. Immunosuppressive Properties of Rapamycin
    4. Part III. 15-Deoxyspergualin: Chemistry and Immunosuppressive Action
    5. Part IV. Guanine Arabinoside and Purine Nucleoside Phosphorylase Inhibitors
    6. Part V. Immunomodulating Activity of Experimental Therapeutics
    7. CONFERENCE LECTURESHIPS: The Edmrd Jenner Lecture
    8. Part VI. Immunomodulating Activities of Anti-Infectious Drugs
    9. Part VII. Treatment of Infectious Diseases and Sepsis: Intervention by Immune Regulation
    10. Part VIII. Immunomodulating Properties of Peptides in Allergic and Autoimmune Diseases
    11. Part IX. Kamp Medicine (Japanese Herbal Medicine) and Its Imrnunomodulating Effects with Special Reference to Intractable Asthma
    12. Part X. Cytokines and Regulation of the Immune Response
    13. Part XI. Drug Metabolizing Enzymes and the Immune System
    14. Part XII. Novel Strategies for Immunotherapy
    15. Part XIII. Vaccines: Recent Progress in Development
    1. Levamisole-Induced Neopterin Synthesis (pages 252–258)

      JOHN JANIK, WILLIAM C. KOPP, JOHN W. SMITH II, DAN L. LONGO, W. GREGORY ALVORD and WALTER J. URBA

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35873.x

    2. Recent Clinical Trials with Levamisole (pages 269–277)

      MICHAEL R. KURMAN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35875.x

    3. Sex Hormones as Immunomodulators of Disease (pages 278–287)

      ROBERT G. LAHITA

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35876.x

    4. Corticosteroids as Immunomodulators (pages 288–292)

      HENRY N. CLAMAN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35877.x

    5. Androstenediol Regulates Systemic Resistance against Lethal Infections in Mice (pages 293–295)

      ROGER M. LORIA and DAVID A. PADGETT

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35878.x

    6. Bropirimine in Bladder Cancer: Clinical Studies (pages 301–308)

      MICHAEL F. SAROSDY

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35880.x

    7. Immunosuppressive Activity of Mycophenolate Mofetil (pages 309–329)

      ELSIE M. EUGUI and ANTHONY C. ALLISON

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35881.x

    8. Molecular Mechanisms of Immunosuppression by Cyclosporins (pages 330–335)

      GERHARD ZENKE, GÖTZ BAUMANN, ROLAND WENGER, PETER HIESTAND, VALERIE QUESNIAUX, ELSEBETH ANDERSEN and MAX H. SCHREIER

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35882.x

    9. Study of the Immunosuppressive Properties of Cyclosporine Analogues (pages 336–338)

      G. H. REEM, S. el ROUBY and Y. SHI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35883.x

    10. Suppression of Alloantigen Presentation by Prodigiosin, a T Cell-Specific Immunosuppressant (pages 339–340)

      JUNJI MAGAE, MASAHIRO YAMASHITA and KAZUO NAGAI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35884.x

    11. In Vivo and in Vitro Efficacy of Fusidic Acid in HIV Infection (pages 341–343)

      GIUSEPPE FAMULARO, CLAUDIO DE SIMONE, SONIA TZANTZOGLOU, VITO TRINCHIERI, SONIA MORETTI and GIORGIO TONIETTI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35885.x

    12. In Vivo Antitumor Activity of the Hypoxanthine Derivatives ST 789 and ST 689 (pages 344–346)

      CLAUDIO De SIMONEad, GIUSEPPE FAMULARO, PIETRO FORESTA, CLAUDIO ALBERTONI and EDOARDO ARRIGONI MARTELLI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35886.x

    13. Immunomodulating Activity of Myelopeptides: Clinical Trials (pages 351–361)

      REM V. PETROV

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35888.x

    14. Structural Nature and Functions of Transfer Factors (pages 362–368)

      CHARLES H. KIRKPATRICK

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35889.x

    15. Effect of Oral Administration of Heat-Killed Enterococcus faecalis FK-23 on the Leukocyte-Reconstituting Capacity in Immunosuppressed Dogs (pages 369–371)

      TAKASHI HASEGAWA, HIROMI KANASUGI, MASAKAZU HIDAKA, SUSUMU MAKIMURA, KATSUYUKI MIYATA, SHIGERU ABE and HIDEYO YAMAGUCHI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35890.x

    16. Antitumor and Antimicrobial Activities of Enterococcal Preparation Orally Administered to Mice (pages 372–374)

      SHIGERU ABE, KAZUTOMO OHASHI, KASTUHISA UCHIDA, TATSUO IKEDA, SADAO KIMURA and HIDEYO YAMAGUCHI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35891.x

    17. Immunostimulating Peptide Derived from Soybean Protein (pages 375–376)

      MASAAKI YOSHIKAWA, KATSUKI KISHI, MASAKAZU TAKAHASHI, AKIHIRO WATANABE, TSUYOSHI MIYAMURA, MASATOSHI YAMAZAKI and HIDEO CHIBA

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35892.x

    18. Two Simple Glucose Derivatives with Opposite Immunoactivities (pages 377–382)

      MEI-LING SHEN, SHI-KANG ZHAI, ZHEN-WEI LU and DAVID W. OU

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35893.x

    19. Immunopharmacologic Study of Glucofructan from Symphytum asperum Roots (pages 383–387)

      M. MAKHATADZE, M. BOSTOGANASHVILI, V. BARBAKADZE, E. KEMERTELIDZE and H. DEKANOSIDZE

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35894.x

  6. CONFERENCE LECTURESHIPS: The Edmrd Jenner Lecture

    1. Top of page
    2. Part I. FK-506: Chemistry and Biological Evaluation
    3. Part II. Immunosuppressive Properties of Rapamycin
    4. Part III. 15-Deoxyspergualin: Chemistry and Immunosuppressive Action
    5. Part IV. Guanine Arabinoside and Purine Nucleoside Phosphorylase Inhibitors
    6. Part V. Immunomodulating Activity of Experimental Therapeutics
    7. CONFERENCE LECTURESHIPS: The Edmrd Jenner Lecture
    8. Part VI. Immunomodulating Activities of Anti-Infectious Drugs
    9. Part VII. Treatment of Infectious Diseases and Sepsis: Intervention by Immune Regulation
    10. Part VIII. Immunomodulating Properties of Peptides in Allergic and Autoimmune Diseases
    11. Part IX. Kamp Medicine (Japanese Herbal Medicine) and Its Imrnunomodulating Effects with Special Reference to Intractable Asthma
    12. Part X. Cytokines and Regulation of the Immune Response
    13. Part XI. Drug Metabolizing Enzymes and the Immune System
    14. Part XII. Novel Strategies for Immunotherapy
    15. Part XIII. Vaccines: Recent Progress in Development
    1. Biological Spinoffs of Organ Transplantation (pages 389–399)

      JOSEPH E. MURRAY

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35895.x

    2. THE GEORGE HTCHINGS AND GERTRUDE ELION LECTURE (page 400)

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35896.x

    3. The Pharmacology of Azathioprine (pages 401–407)

      GERTRUDE B. ELION

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35897.x

    4. THE JULES BORDET LECTURE (page 408)

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35898.x

    5. Immunopathogenesis of HIV Infection (pages 409–419)

      ANTHONY S. FAUCI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35899.x

    6. THE GERHARD DOMAGK LECTURE (page 420)

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35900.x

    7. Transcription Factors in Lymphoid Development (pages 421–428)

      DAVID BALTIMORE

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35901.x

    8. THE EMIL VON BEHRING LECTURE (page 429)

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35902.x

  7. Part VI. Immunomodulating Activities of Anti-Infectious Drugs

    1. Top of page
    2. Part I. FK-506: Chemistry and Biological Evaluation
    3. Part II. Immunosuppressive Properties of Rapamycin
    4. Part III. 15-Deoxyspergualin: Chemistry and Immunosuppressive Action
    5. Part IV. Guanine Arabinoside and Purine Nucleoside Phosphorylase Inhibitors
    6. Part V. Immunomodulating Activity of Experimental Therapeutics
    7. CONFERENCE LECTURESHIPS: The Edmrd Jenner Lecture
    8. Part VI. Immunomodulating Activities of Anti-Infectious Drugs
    9. Part VII. Treatment of Infectious Diseases and Sepsis: Intervention by Immune Regulation
    10. Part VIII. Immunomodulating Properties of Peptides in Allergic and Autoimmune Diseases
    11. Part IX. Kamp Medicine (Japanese Herbal Medicine) and Its Imrnunomodulating Effects with Special Reference to Intractable Asthma
    12. Part X. Cytokines and Regulation of the Immune Response
    13. Part XI. Drug Metabolizing Enzymes and the Immune System
    14. Part XII. Novel Strategies for Immunotherapy
    15. Part XIII. Vaccines: Recent Progress in Development
    1. Immunomodulating Drugs: Whence and Whither (pages 430–431)

      GEORGE DE STEVENS

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35903.x

    2. Immunomodulator Effects on the Friend Virus Infection in Genetically Defined Mice (pages 432–446)

      R. W. SIDWELL, J. D. MORREY, K. M. OKLEBERRY, R. A. BURGER and R. P. WARREN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35904.x

    3. Immunomodulating Activity of Antifungal Drugs (pages 447–457)

      HIDEYO YAMAGUCHI, SHIGERU ABE and YOSHIKO TOKUDA

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35905.x

    4. Immunopharmacologic Properties of Inosine 5'-Methyl Monophosphate (MIMP) (pages 458–463)

      M. SOSA, A. SAHA, A. GINER-SOROLLA, E. HADDEN and J. W. HADDEN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35906.x

    5. Immunomodulatory Properties of AZT (pages 464–466)

      ROBERT J. McKALLIP, MITZI NAGARKATTI and PRAKASH NAGARKATTI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35907.x

  8. Part VII. Treatment of Infectious Diseases and Sepsis: Intervention by Immune Regulation

    1. Top of page
    2. Part I. FK-506: Chemistry and Biological Evaluation
    3. Part II. Immunosuppressive Properties of Rapamycin
    4. Part III. 15-Deoxyspergualin: Chemistry and Immunosuppressive Action
    5. Part IV. Guanine Arabinoside and Purine Nucleoside Phosphorylase Inhibitors
    6. Part V. Immunomodulating Activity of Experimental Therapeutics
    7. CONFERENCE LECTURESHIPS: The Edmrd Jenner Lecture
    8. Part VI. Immunomodulating Activities of Anti-Infectious Drugs
    9. Part VII. Treatment of Infectious Diseases and Sepsis: Intervention by Immune Regulation
    10. Part VIII. Immunomodulating Properties of Peptides in Allergic and Autoimmune Diseases
    11. Part IX. Kamp Medicine (Japanese Herbal Medicine) and Its Imrnunomodulating Effects with Special Reference to Intractable Asthma
    12. Part X. Cytokines and Regulation of the Immune Response
    13. Part XI. Drug Metabolizing Enzymes and the Immune System
    14. Part XII. Novel Strategies for Immunotherapy
    15. Part XIII. Vaccines: Recent Progress in Development
    1. Modulation of Cytokine Responses in Sepsis (pages 471–482)

      STEPHEN F. LOWRY and LYLE L. MOLDAWER

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35909.x

    2. Interventions for the Treatment of Septic Shock (pages 483–487)

      IRENE S. FIGARI and MICHAEL A. PALLADINO

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35910.x

    3. Pleiotropic Effects of Transforming Growth Factor-β on Cells of the Immune System (pages 488–500)

      FRANCIS RUSCETTI, LUIGI VARESIO, AUGUSTO OCHOA and JOHN ORTALDO

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35911.x

    4. TGFβ and HIV Infection (pages 501–511)

      MARTIN LOTZ and PRADEEP SETH

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35912.x

  9. Part VIII. Immunomodulating Properties of Peptides in Allergic and Autoimmune Diseases

    1. Top of page
    2. Part I. FK-506: Chemistry and Biological Evaluation
    3. Part II. Immunosuppressive Properties of Rapamycin
    4. Part III. 15-Deoxyspergualin: Chemistry and Immunosuppressive Action
    5. Part IV. Guanine Arabinoside and Purine Nucleoside Phosphorylase Inhibitors
    6. Part V. Immunomodulating Activity of Experimental Therapeutics
    7. CONFERENCE LECTURESHIPS: The Edmrd Jenner Lecture
    8. Part VI. Immunomodulating Activities of Anti-Infectious Drugs
    9. Part VII. Treatment of Infectious Diseases and Sepsis: Intervention by Immune Regulation
    10. Part VIII. Immunomodulating Properties of Peptides in Allergic and Autoimmune Diseases
    11. Part IX. Kamp Medicine (Japanese Herbal Medicine) and Its Imrnunomodulating Effects with Special Reference to Intractable Asthma
    12. Part X. Cytokines and Regulation of the Immune Response
    13. Part XI. Drug Metabolizing Enzymes and the Immune System
    14. Part XII. Novel Strategies for Immunotherapy
    15. Part XIII. Vaccines: Recent Progress in Development
    1. Cytokines and Modulation of Diseases of Immediate Hypersensitivity (pages 512–520)

      MARSHALL PLAUT

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35913.x

    2. Antigen Presentation by the Murine Renal Proximal Tubule: A Mechanism of Self Tolerance? (pages 525–528)

      DAVID T. HAGERTY and PAUL M. ALLEN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35915.x

  10. Part IX. Kamp Medicine (Japanese Herbal Medicine) and Its Imrnunomodulating Effects with Special Reference to Intractable Asthma

    1. Top of page
    2. Part I. FK-506: Chemistry and Biological Evaluation
    3. Part II. Immunosuppressive Properties of Rapamycin
    4. Part III. 15-Deoxyspergualin: Chemistry and Immunosuppressive Action
    5. Part IV. Guanine Arabinoside and Purine Nucleoside Phosphorylase Inhibitors
    6. Part V. Immunomodulating Activity of Experimental Therapeutics
    7. CONFERENCE LECTURESHIPS: The Edmrd Jenner Lecture
    8. Part VI. Immunomodulating Activities of Anti-Infectious Drugs
    9. Part VII. Treatment of Infectious Diseases and Sepsis: Intervention by Immune Regulation
    10. Part VIII. Immunomodulating Properties of Peptides in Allergic and Autoimmune Diseases
    11. Part IX. Kamp Medicine (Japanese Herbal Medicine) and Its Imrnunomodulating Effects with Special Reference to Intractable Asthma
    12. Part X. Cytokines and Regulation of the Immune Response
    13. Part XI. Drug Metabolizing Enzymes and the Immune System
    14. Part XII. Novel Strategies for Immunotherapy
    15. Part XIII. Vaccines: Recent Progress in Development
    1. Immunologic Aspects of Kampo Medicine (pages 529–542)

      IKURO KIMURA

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35916.x

    2. Effects of Saiboku-to (TJ-96) on the Production of Platelet-Activating Factor in Human Neutrophils (pages 572–579)

      TSUNEYOSHI NAKAMURA, MOTOAKI KURIYAMA, ERI KOSUGE, KEIKO ISHIHARA and KOJI ITO

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35920.x

  11. Part X. Cytokines and Regulation of the Immune Response

    1. Top of page
    2. Part I. FK-506: Chemistry and Biological Evaluation
    3. Part II. Immunosuppressive Properties of Rapamycin
    4. Part III. 15-Deoxyspergualin: Chemistry and Immunosuppressive Action
    5. Part IV. Guanine Arabinoside and Purine Nucleoside Phosphorylase Inhibitors
    6. Part V. Immunomodulating Activity of Experimental Therapeutics
    7. CONFERENCE LECTURESHIPS: The Edmrd Jenner Lecture
    8. Part VI. Immunomodulating Activities of Anti-Infectious Drugs
    9. Part VII. Treatment of Infectious Diseases and Sepsis: Intervention by Immune Regulation
    10. Part VIII. Immunomodulating Properties of Peptides in Allergic and Autoimmune Diseases
    11. Part IX. Kamp Medicine (Japanese Herbal Medicine) and Its Imrnunomodulating Effects with Special Reference to Intractable Asthma
    12. Part X. Cytokines and Regulation of the Immune Response
    13. Part XI. Drug Metabolizing Enzymes and the Immune System
    14. Part XII. Novel Strategies for Immunotherapy
    15. Part XIII. Vaccines: Recent Progress in Development
    1. Cytokines and Their Role as Growth Factors and in Regulation of Immune Responses (pages 584–602)

      VASSIL ST. GEORGIEV and JOSEPH F. ALBRIGHT

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35922.x

    2. The Interleukin-2 Receptor: A Target for Immunotherapy (pages 603–610)

      THOMAS A. WALDMANN, CAROLYN GOLDMAN, LOIS TOP, ANGUS GRANT, JACK BURTON, RICHARD BAMFORD, ERICH ROESSLER, IVAN HORAK, SARA ZAKNOEN, CLAUDE KASTEN-SPORTES, JEFFREY WHITE, RICHARD ENGLAND, EVA HORAK, JEAN MARTINUCCI, SIKIRU A. TINUBU, BIBHUTI MISHRA, RICHARD JUNGHANS, MICHAEL DIPRE, JORGE CARRASQUILLO, JAMES REYNOLDS, OTTO GANSOW and DAVID NELSON

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35923.x

    3. The Role of the T Cell Receptor α Chain in Antigen-Specific Immune Suppression (pages 611–613)

      MICHAEL C. BYRNE, RICHARD M. O'HARA Jr., VIJAY K. KUCHROO, SUNDARARAJAN JAYARAMAN, ANJANA RAO, MARTIN E. DORF and MARY COLLINS

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35924.x

    4. Increased Levels of Leukotriene B4 and Interleukin-8 in Psoriatic Skin (pages 614–617)

      RENZA DEGIULIO, CATERINA MONTEMARTINI, ANTONINO MAZZONE, DAVIDE PASOTTI, ANTONIO DONADINI and GIOVANNI RICEVUTI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35925.x

  12. Part XI. Drug Metabolizing Enzymes and the Immune System

    1. Top of page
    2. Part I. FK-506: Chemistry and Biological Evaluation
    3. Part II. Immunosuppressive Properties of Rapamycin
    4. Part III. 15-Deoxyspergualin: Chemistry and Immunosuppressive Action
    5. Part IV. Guanine Arabinoside and Purine Nucleoside Phosphorylase Inhibitors
    6. Part V. Immunomodulating Activity of Experimental Therapeutics
    7. CONFERENCE LECTURESHIPS: The Edmrd Jenner Lecture
    8. Part VI. Immunomodulating Activities of Anti-Infectious Drugs
    9. Part VII. Treatment of Infectious Diseases and Sepsis: Intervention by Immune Regulation
    10. Part VIII. Immunomodulating Properties of Peptides in Allergic and Autoimmune Diseases
    11. Part IX. Kamp Medicine (Japanese Herbal Medicine) and Its Imrnunomodulating Effects with Special Reference to Intractable Asthma
    12. Part X. Cytokines and Regulation of the Immune Response
    13. Part XI. Drug Metabolizing Enzymes and the Immune System
    14. Part XII. Novel Strategies for Immunotherapy
    15. Part XIII. Vaccines: Recent Progress in Development
    1. Immune Dysfunction Related to Drug-Metabolizing Enzymes (pages 620–623)

      JOSEPH F. ALBRIGHT

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35927.x

    2. Role of the Ah Receptor and the Dioxin-Inducible [Ah] Gene Battery in Toxicity, Cancer, and Signal Transduction (pages 624–640)

      DANIEL W. NEBERT, ALVARO PUGA and VASILIS VASILIOU

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35928.x

    3. Autoantibodies against Cytochromes P-450 in Drug-Induced Autoimmune Hepatitis (pages 641–645)

      P. H. BEAUNE and M. BOURDI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35929.x

    4. Immunity to Halothane Metabolite-Modified Proteins in Halothane Hepatitis (pages 646–661)

      J. GERALD KENNA, TRUDY L. KNIGHT and FRANK N. A. M. van PELT

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35930.x

    5. Effects of Small Doses of Dioxins on the Immune System of Marmosets and Rats (pages 662–686)

      REINHARD NEUBERT, RALF STAHLMANN, MARIA KORTE, HENK van LOVEREN, JOSEPH G. VOS, GEORG GOLOR, JESSIE R. WEBB, HANS HELGE and DIETHER NEUBERT

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35931.x

  13. Part XII. Novel Strategies for Immunotherapy

    1. Top of page
    2. Part I. FK-506: Chemistry and Biological Evaluation
    3. Part II. Immunosuppressive Properties of Rapamycin
    4. Part III. 15-Deoxyspergualin: Chemistry and Immunosuppressive Action
    5. Part IV. Guanine Arabinoside and Purine Nucleoside Phosphorylase Inhibitors
    6. Part V. Immunomodulating Activity of Experimental Therapeutics
    7. CONFERENCE LECTURESHIPS: The Edmrd Jenner Lecture
    8. Part VI. Immunomodulating Activities of Anti-Infectious Drugs
    9. Part VII. Treatment of Infectious Diseases and Sepsis: Intervention by Immune Regulation
    10. Part VIII. Immunomodulating Properties of Peptides in Allergic and Autoimmune Diseases
    11. Part IX. Kamp Medicine (Japanese Herbal Medicine) and Its Imrnunomodulating Effects with Special Reference to Intractable Asthma
    12. Part X. Cytokines and Regulation of the Immune Response
    13. Part XI. Drug Metabolizing Enzymes and the Immune System
    14. Part XII. Novel Strategies for Immunotherapy
    15. Part XIII. Vaccines: Recent Progress in Development
    1. Immunologic Approaches to the Therapy of HIV-1 Infection (pages 687–696)

      MICHAEL C. SNELLER and H. CLIFFORD LANE

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35932.x

    2. Gene Transfer for Therapy and Prophylaxis of HIV-1 Infection (pages 697–712)

      MARK L. ROHRBAUGH and JOHN J. McGOWAN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35933.x

    3. Pseudomonas Exotoxin and Recombinant Immunotoxins Derived from It (pages 740–745)

      DAVID FITZGERALD and IRA PASTAN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35935.x

    4. Superantigens in Infectious Diseases, Including AIDS (pages 746–755)

      JEFFREY LAURENCE, ANDREW S. HODTSEV and DAVID N. POSNETT

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35936.x

    5. RNA Drug Therapy Acting via the 2–5A Synthetase/RNase L Pathway (pages 756–757)

      ROBERT J. SUHADOLNIK, NANCY L. REICHENBACH, PATRICIA M. HITZGES, DHARAM V. ABLASHI, DAVID R. STRAYER and WILLIAM A. CARTER

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35937.x

    6. Specific RNA Drug Therapy of Hepatitis Viruses (pages 758–761)

      WILLIAM A. CARTER, ROBERT J. SUHADOLNIK, WERNER E. G. MÜLLER, BRENT E. KORBA, HOWARD R. HUBBELL, GABRIEL GARCIA and DAVID R. STRAYER

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35938.x

    7. Immunorehabilitation in Patients with Herpes Simplex (pages 762–764)

      TENGIZ TSERTSVADZE, NIKOLAI SHAVDIA, IRAKLI MEBONIA, TSISANA SHARTAVA, MANANA GVABERIDZE and MALVINA ALADASHVILI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35939.x

    8. Role of Increase of Opiod Receptors in Granulocyte CDllb/CD18 Dysfunction (pages 770–773)

      ANTONINO MAZZONE, GIOVANNI RICEVUTI, DAVIDE PASOTTI, GIANLUCA FOSSATI, IOLANDA MAZZUCCHELLI, PAOLA CAVIGLIANO, SERGIO LECCHINI, GIANMARIO FRIGO and ANTONIA NOTARIO

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35941.x

    9. Immunosuppressive Effects of Lymphocyte-Specific Histamine Congener Treatment of an Adoptive Transfer Model (pages 774–776)

      NINA K. GARLIE, PARISA KHOSROPOUR and KENNETH L. MELMON

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35942.x

  14. Part XIII. Vaccines: Recent Progress in Development

    1. Top of page
    2. Part I. FK-506: Chemistry and Biological Evaluation
    3. Part II. Immunosuppressive Properties of Rapamycin
    4. Part III. 15-Deoxyspergualin: Chemistry and Immunosuppressive Action
    5. Part IV. Guanine Arabinoside and Purine Nucleoside Phosphorylase Inhibitors
    6. Part V. Immunomodulating Activity of Experimental Therapeutics
    7. CONFERENCE LECTURESHIPS: The Edmrd Jenner Lecture
    8. Part VI. Immunomodulating Activities of Anti-Infectious Drugs
    9. Part VII. Treatment of Infectious Diseases and Sepsis: Intervention by Immune Regulation
    10. Part VIII. Immunomodulating Properties of Peptides in Allergic and Autoimmune Diseases
    11. Part IX. Kamp Medicine (Japanese Herbal Medicine) and Its Imrnunomodulating Effects with Special Reference to Intractable Asthma
    12. Part X. Cytokines and Regulation of the Immune Response
    13. Part XI. Drug Metabolizing Enzymes and the Immune System
    14. Part XII. Novel Strategies for Immunotherapy
    15. Part XIII. Vaccines: Recent Progress in Development
    1. Issues in the Development of a Prophylactic HIV Vaccine (pages 777–783)

      DANIEL F. HOTH

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35943.x

    2. T Cell Vaccines for Autoimmune Diseases (pages 784–787)

      FELIX MOR and IRUN R. COHEN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35944.x

    3. Vaccines Based on Synthetic Polyions and Peptides (pages 788–802)

      RAKHIM M. KHAITOV

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35945.x

    4. Advances in Influenza Virus Vaccine Research (pages 803–812)

      ROBERT B. COUCH

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb35946.x

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