Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

September 1993

Volume 695 Alzheimer's Disease: Amyloid Precursor Proteins, Signal Transduction, and Neuronal Transplantation

Pages xiii–xiv, 1–336

  1. Preface

    1. Top of page
    2. Preface
    3. Part I. Principles of Neural Transmission, Signal Transduction, and Metabolism in Aging and Dementia
    4. Part II. Amyloid Precursor Proteins: Metabolism, Function, and Potential Rate in Alzheimer's Disease
    5. Part III. Animal Models
    1. Preface (pages xiii–xiv)

      ROGER M. NITSCH, SUZANNE CORKIN, JOHN H. GROWDON and RICHARD J. WURTMAN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23017.x

  2. Part I. Principles of Neural Transmission, Signal Transduction, and Metabolism in Aging and Dementia

    1. Top of page
    2. Preface
    3. Part I. Principles of Neural Transmission, Signal Transduction, and Metabolism in Aging and Dementia
    4. Part II. Amyloid Precursor Proteins: Metabolism, Function, and Potential Rate in Alzheimer's Disease
    5. Part III. Animal Models
    1. Principles of Synaptic Transmission (pages 1–9)

      ROBERT Y. MOORE

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23018.x

    2. Second Messengers in Neuronal Signaling (pages 10–14)

      BERNARD W. AGRANOFF

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23019.x

    3. Neurotransmitters and Second Messengers in Aging and Alzheimer's Disease (pages 19–26)

      PAUL T. FRANCIS, M-T. WEBSTER, I. P. CHESSELL, C. HOLMES, G. C. STRATMANN, A. W. PROCTER, ALAN J. CROSS, A. R. GREEN and DAVID M. BOWEN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23021.x

    4. Hyperactivation of Signal Transduction Systems in Alzheimer's Disease (pages 34–41)

      TSUNAO SAITOH, KAREN HORSBURGH and ELIEZER MASLIAH

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23023.x

    5. Changes in G Protein-mediated Signal Transduction in Aging and Alzheimer's Disease (pages 42–45)

      J. A. JOSEPH, R. CUTLER and G. S. ROTH

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23024.x

    6. Aberrant Phosphoinositide Metabolism in Alzheimer's Disease (pages 46–49)

      SHUN SHIMOHAMA, SADAKI FUJIMOTO, NANCY TRESSER, PEGGY RICHEY, GEORGE PERRY, PETER J. WHITEHOUSE, YOSHIMI HOMMA, TADAOMI TAKENAWA, TAKASHI TANIGUCHI, TOSHIHIKO SUENAGA and JUN KIMURA

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23025.x

    7. NMDA Receptor Status in Elderly Normal Individuals and Those with Alzheimer's Disease (pages 50–53)

      R. H. P. PORTER, P. J. ROBERTS and R. S. J. BRIGGS

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23026.x

    8. Synaptic Pathology of Alzheimer's Disease (pages 59–64)

      H. LASSMANN, P. FISCHER and K. JELLINGER

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23028.x

    9. Transmitters in the Developing and Senescent Human Brain (pages 69–72)

      ELAINE K. PERRY, MARGARET A. PIGGOTT, JENNIFER A. COURT, MARY JOHNSON and ROBERT H. PERRY

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23030.x

    10. Free Radicals in the Genesis of Alzheimer's Disease (pages 73–76)

      J. STEVEN RICHARDSON

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23031.x

  3. Part II. Amyloid Precursor Proteins: Metabolism, Function, and Potential Rate in Alzheimer's Disease

    1. Top of page
    2. Preface
    3. Part I. Principles of Neural Transmission, Signal Transduction, and Metabolism in Aging and Dementia
    4. Part II. Amyloid Precursor Proteins: Metabolism, Function, and Potential Rate in Alzheimer's Disease
    5. Part III. Animal Models
    1. Regulation and Expression of the Alzheimer's β/A4 Amyloid Protein Precursor in Health, Disease, and Down's Syndrome (pages 91–102)

      KONRAD BEYREUTHER, PETER POLLWEIN, GERD MULTHAUP, URSULA MÖNNING, GERHARD KÖNIG, THOMAS DYRKS, WALTER SCHUBERT and COLIN L. MASTERS

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23035.x

    2. Normal Cellular Processing of the β-Amyloid Precursor Protein Results in the Secretion of the Amyloid β Peptide and Related Molecules (pages 109–116)

      CHRISTIAN HAASS, ALBERT Y. HUNG, MICHAEL G. SCHLOSSMACHER, TILMAN OLTERSDORF, DAVID B. TEPLOW and DENNIS J. SELKOE

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23037.x

    3. Protein Phosphorylation Regulates Relative Utilization of Processing Pathways for Alzheimer β/A4 Amyloid Precursor Protein (pages 117–121)

      SAMUEL E. GANDY, GREGG L. CAPORASO, JOSEPH D. BUXBAUM, ODETE DA CRUZ E SILVA, KERSTIN IVERFELDT, CHRISTER NORDSTEDT, TOSHI SUZUKI, ANDREW J. CZERNIK, ANGUS C. NAIRN and PAUL GREENGARD

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23038.x

    4. Receptor-coupled Amyloid Precursor Protein Processing (pages 122–127)

      ROGER M. NITSCH, BARBARA E. SLACK, STEVEN A. FARBER, PAUL R. BORGHESANI, JOACHIM G. SCHULZ, CINDY KIM, CHRISTIAN C. FELDER, JOHN H. GROWDON and RICHARD J. WURTMAN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23039.x

    5. Regulation of Amyloid Precursor Protein Release By Protein Kinase C in Swiss 3T3 Fibroblasts (pages 128–131)

      BARBARA E. SLACK, ROGER M. NITSCH, ETTA LIVNEH, GEORGE M. KUNZ JR., HAGIT ELDAR and RICHARD J. WURTMAN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23040.x

    6. Cellular Processing and Proteoglycan Nature of Amyloid Precursor Proteins (pages 132–138)

      NIKOLAOS K. ROBAKIS, DIDO VASSILACOPOULOU, SPIROS EFTHIMIOPOULOS, KUMAR SAMBAMURTI, LAWRENCE M. REFOLO and JUNICHI SHIOI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23041.x

    7. Sequestration of Amyloid β-Peptide (pages 139–143)

      D. GOLDGABER, A. I. SCHWARZMAN, R. BHASIN, L. GREGORI, D. SCHMECHEL, A. M. SAUNDERS, A. D. ROSES and W. J. STRITTMATTER

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23042.x

    8. The C-Terminus of the β Protein is Critical in Amyloidogenesis (pages 144–148)

      JOSEPH T. JARRETT, ELIZABETH P. BERGER and PETER T. LANSBURY JR.

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23043.x

    9. Biologically Active Domain of the Secreted Form of the Amyloid β/A4 Protein Precursor (pages 149–157)

      JEAN-MARC ROCH, LEE-WAY JIN, HARUAKI NINOMIYA, DAVID SCHUBERT and TSUNAO SAITOH

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23044.x

    10. β-Amyloid Precursor Protein Mismetabolism and Loss of Calcium Homeostasis in Alzheimer's Disease (pages 158–164)

      S. W. BARGER, V. L. SMITH-SWINTOSKY, R. E. RYDEL and M. P. MATTSON

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23045.x

    11. The Role of Extracellular Matrix in the Processing of the Amyloid Protein Precursor of Alzheimer's Disease (pages 169–174)

      DAVID H. SMALL, VICTOR NURCOMBE, HEIDI CLARRIS, KONRAD BEYREUTHER and COLIN L. MASTERS

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23047.x

    12. The βA4 Amyloid Protein Precursor in Human Circulation (pages 175–182)

      ASHLEY I. BUSH, KONRAD BEYREUTHER and COLIN L. MASTERS

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23048.x

    13. Expression of L-APP mRNA in Brain Cells (pages 183–189)

      RUPERT SANDBRINK, RICHARD BANATI, COLIN L. MASTERS, KONRAD BEYREUTHER and GERHARD KÖNIG

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23049.x

    14. The Amyloid Precursor Protein in Ischemic Brain Injury and Chronic Hypoperfusion (pages 190–193)

      R. N. KALARIA, S. U. BHATTI, W. D. LUST and G. PERRY

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23050.x

    15. Alzheimer's Disease Families with Amyloid Precursor Protein Mutations (pages 198–202)

      M. N. ROSSOR, S. NEWMAN, R. S. J. FRACKOWIAK, P. LANTOS and A. M. KENNEDY

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23052.x

    16. Search for the Genes Responsible for Familial Alzheimer's Disease (pages 203–208)

      WILMA WASCO, JEFFREY PEPPERCORN and RUDOLPH E. TANZI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23053.x

    17. Microtubule-associated Protein Tau, Paired Helical Filaments, and Phosphorylation (pages 209–216)

      E.-M. MANDELKOW, J. BIERNAT, G. DREWES, B. STEINER, B. LICHTENBERG-KRAAG, H. WILLE, N. GUSTKE and E. MANDELKOW

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23054.x

  4. Part III. Animal Models

    1. Top of page
    2. Preface
    3. Part I. Principles of Neural Transmission, Signal Transduction, and Metabolism in Aging and Dementia
    4. Part II. Amyloid Precursor Proteins: Metabolism, Function, and Potential Rate in Alzheimer's Disease
    5. Part III. Animal Models
    1. Transgenic Animal Models for Alzheimer's Disease (pages 217–223)

      KEN-ICHIRO FUKUCHI, CHARLES E. OGBURN, ANNETTE C. SMITH, DENNIS D. KUNKEL, CLEMENT E. FURLONG, SAMIR S. DEEB, DAVID NOCHLIN, S. MARK SUMI and GEORGE M. MARTIN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23055.x

    2. Experimental Induction of β-Amyloid Plaques and Cerebral Angiopathy in Primates (pages 228–231)

      H. F. BAKER, R. M. RIDLEY, L. W. DUCHEN, T. J. CROW and C. J. BRUTON

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23057.x

    3. Cholinergic and Non-cholinergic Synaptic Mechanisms in the Aged Rat Hippocampus (pages 236–240)

      B. POTIER, Y. LAMOUR and P. DUTAR

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23059.x

    4. Phospholipid and Phospholipid Metabolites in Rat Frontal Cortex Are Decreased following Nucleus Basalis Lesions (pages 241–243)

      TODD C. HOLMES, ROGER M. NITSCH, ANDREAS ERFURTH and RICHARD J. WURTMAN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23060.x

    5. Decreased Density of Forebrain Cholinergic Neurons and Disintegration of the Spatial Organization of Behavior in Experimental Autoimmune Dementia (EAD) (pages 244–248)

      DANIEL M. MICHAELSON, VLADIMIR DUBOVIK, MARIA FAIGON, DAVID EILAM and JORAM FELDON

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23061.x

    6. Age-related Increase in Galanin-binding Sites in the Rat Brain: Correlation with Behavioral Impairment (pages 249–253)

      P. KRZYWKOWSKI, I. LAGNY, F. JAZAT, Y. LAMOUR and J. EPELBAUM

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23062.x

    7. Neural Transplantation for Neurodegenerative Diseases: Past, Present, and Future (pages 258–266)

      D. EUGENE REDMOND JR., ROBERT H. ROTH, DENNIS D. SPENCER, FREDERICK NAFTOLIN, CSABA LERANTH, RICHARD J. ROBBINS, KENNETH L. MAREK, JOHN D. ELSWORTH, KIMBERLEE J. SASS, JANE R. TAYLOR and JOHN R. SLADEK JR.

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23064.x

    8. Basal Forebrain Grafts in the Hippocampus and Neocortex: Regulation of Acetylcholine Release (pages 267–273)

      OLA G. NILSSON, GIAMPIERO LEANZA, CARL ROSENBLAD and ANDERS BJÖRKLUND

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23065.x

    9. Behavioral Effects of Cholinergic Grafts (pages 274–277)

      R. M. RIDLEY and H. F. BAKER

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23066.x

    10. Cells Engineered to Produce Acetylcholine: Therapeutic Potential for Alzheimer's Disease (pages 278–284)

      LISA J. FISHER, HEATHER K. RAYMON and FRED H. GAGE

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23067.x

    11. Neural Stem Cells for CNS Transplantation (pages 285–291)

      E. EDWARD BAETGE

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23068.x

    12. Neurotrophic Strategies for Treating Alzheimer's Disease: Lessons from Basic Neurobiology and Animal Models (pages 292–299)

      VASSILIS E. KOLIATSOS, DONALD L. PRICE, RICHARD E. CLATTERBUCK, ALICJA L. MARKOWSKA, DAVID S. OLTON and BARBARA J. WILCOX

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23069.x

    13. Selective Signaling via Unique Ml Muscarinic Agonists (pages 300–303)

      ABRAHAM FISHER, ELIAHU HELDMAN, DAVID GURWITZ, RACHEL HARING, DOV BARAK, HAIM MESHULAM, DANIELE MARCIANO, RACHEL BRANDEIS, ZIPORA PITTEL, MENAHEM SEGAL, ZVI VOGEL and YISHAI KARTON

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23070.x

    14. Natural and Synthetic Huperzine A: Effect on Cholinergic Function in Vitro and in Vivo (pages 304–306)

      ISRAEL HANIN, XI-CAN TANG, GISELA L. KINDEL and ALAN P. KOZIKOWSKI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23071.x

    15. PKC Translocation in Rat Brain Cortex Is Promoted in Vivo and in Vitro by α-Glycerylphosphorylcholine, a Cognition-enhancing Drug (pages 307–310)

      S. GOVONI, F. BATTAINI, L. LUCCHI, A. PASCALE and M. TRABUCCHI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23072.x

    16. Gangliosides and Neurotrophic Factors in Neurodegenerative Diseases: From Experimental Findings to Clinical Perspectives (pages 314–317)

      M. FUSCO, G. VANTINI, N. SCHIAVO, A. ZANOTTI, R. ZANONI, L. FACCI and S. D. SKAPER

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23074.x

    17. Oral Cytidine 5′-Diphosphate Choline Administration to Rats Increases Brain Phospholipid Levels (pages 318–320)

      J. AGUT, I. LOPEZ G.-COVIELLA, J. A. ORTIZ and R. J. WURTMAN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23075.x

    18. Effect of CDP-Choline on Cognition and Immune Function in Alzheimer's Disease and Multi-Infarct Dementia (pages 321–323)

      R. CACABELOS, X. A. ALVAREZ, A. FRANCO-MASIDE, L. FERNÁNDEZ-NOVOA and J. CAAMAÑO

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23076.x

    19. Acetyl-l-Carnitine and Alzheimer's Disease: Pharmacological Considerations beyond the Cholinergic Sphere (pages 324–326)

      A. CARTA, M. CALVANI, D BRAVI and S. NÍ BHUACHALLA

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23077.x

    20. Activation PET as an Instrument to Determine Therapeutic Efficacy in Alzheimer's Disease (pages 327–331)

      W. D. HEISS, J. KESSLER, I. SLANSKY, R. MIELKE, B. SZELIES and K. HERHOLZ

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23078.x

    21. The Use of the Computerized Neuropsychological Test Battery (CNTB) in an Efficacy and Safety Trial of BMY 21,502 in Alzheimer's Disease (pages 332–336)

      NEAL R. CUTLER, RAJESH C. SHROTRIYA, JOHN J. SRAMEK, AMY E. VEROFF, RANDALL D. SEIFERT, LINDA A. REICH and DENISE YEE HIRONAKA

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb23079.x

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