Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

November 1993

Volume 696 Immunosuppressive and Anti-Inflammatory Drugs

Pages xi–xx, 1–421

  1. Part I. Immunobiology of Cyclosporins, FK-506, and Rapamycin

    1. Top of page
    2. Part I. Immunobiology of Cyclosporins, FK-506, and Rapamycin
    3. Part II. Novel Immunosuppressive Drugs
    4. Part III. Novel Antiinflammatory Strategies
    5. Part IV. Immunosuppressive Drugs for Transplantation
    6. Part V. Clinical Applications of Immunosuppressive and Antiinflammatory Drugs
    7. Part VI. Treatment of Insulin-Dependent Diabetes Mellitus
    8. Poster Papers
    1. Immunosuppressive Profile of Rapamycin (pages 1–8)

      SUREN N. SEHGAL

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17136.x

    2. The Mechanism of Action of FK-506 and Cyclosporin A (pages 9–19)

      GREG WIEDERRECHT, ELSA LAM, SHIRLEY HUNG, MARY MARTIN and NOLAN SIGAL

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17137.x

    3. Rapamycin Inhibits p34cdc2 Expression and Arrests T Lymphocyte Proliferation at the G1/S Transition (pages 31–36)

      W. MICHAEL FLANAGAN and GERALD R. CRABTREE

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17139.x

    4. Proline Isomerases in Microorganisms and Small Eukaryotes (pages 38–43)

      CHARLES HEMENWAY and JOSEPH HEITMAN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17140.x

    5. Cyclosporins : Structure-Activity Relationships (pages 47–53)

      HANS FLIRI, GOETZ BAUMANN, ALBERT ENZ, JUERG KALLEN, MARCEL LUYTEN, VINCENT MIKOL, RAO MOVVA, VALERIE QUESNIAUX, MAX SCHREIER, MALCOLM WALKINSHAW, ROLAND WENGER, GERHARD ZENKE and MAURO ZURINI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17141.x

    6. An FKBP-Rapamycin-Sensitive, Cyclin-Dependent Kinase Activity that Correlates with the FKBP-Rapamycin-Induced G1 Arrest Point in MG-63 Cells (pages 54–62)

      MARK W. ALBERS, ERIC J. BROWN, AKITO TANAKA, RICHARD T. WILLIAMS, FREDERICK L. HALL and STUART L. SCHREIBER

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17142.x

  2. Part II. Novel Immunosuppressive Drugs

    1. Top of page
    2. Part I. Immunobiology of Cyclosporins, FK-506, and Rapamycin
    3. Part II. Novel Immunosuppressive Drugs
    4. Part III. Novel Antiinflammatory Strategies
    5. Part IV. Immunosuppressive Drugs for Transplantation
    6. Part V. Clinical Applications of Immunosuppressive and Antiinflammatory Drugs
    7. Part VI. Treatment of Insulin-Dependent Diabetes Mellitus
    8. Poster Papers
    1. Mechanisms of Action of Mycophenolic Acid (pages 63–87)

      ANTHONY C. ALLISON, W. JOSEPH KOWALSKI, CHRISTIAN D. MULLER and ELSIE M. EUGUI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17143.x

    2. Human Type I and II IMP Dehydrogenases as Drug Targets (pages 88–93)

      YUTAKA NATSUMEDA and STEPHEN F. CARR

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17144.x

    3. Immunosuppression by Discodermolide (pages 94–107)

      ROSS E. LONGLEY, SARATH P. GUNASEKERA, DENISE FAHERTY, JOHN MCLANE and FRANCIS DUMONT

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17145.x

    4. Brequinar Sodium, Mycophenolic Acid, and Cyclosporin A Inhibit Different Stages of IL-4- or IL-13-Induced Human IgG4 and IgE Production In Vitro (pages 108–122)

      CHIA-CHUN J. CHANG, GREGORIO AVERSA, JUHA PUNNONEN, HANS YSSEL and JAN E. de VRIES

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17146.x

  3. Part III. Novel Antiinflammatory Strategies

    1. Top of page
    2. Part I. Immunobiology of Cyclosporins, FK-506, and Rapamycin
    3. Part II. Novel Immunosuppressive Drugs
    4. Part III. Novel Antiinflammatory Strategies
    5. Part IV. Immunosuppressive Drugs for Transplantation
    6. Part V. Clinical Applications of Immunosuppressive and Antiinflammatory Drugs
    7. Part VI. Treatment of Insulin-Dependent Diabetes Mellitus
    8. Poster Papers
    1. The IL-1β Converting Enzyme as a Therapeutic Target (pages 133–148)

      DOUGLAS K. MILLER, JIMMY R. CALAYCAY, KEVIN T. CHAPMAN, ANDREW D. HOWARD, MATTHEW J. KOSTURA, SUSAN M. MOLINEAUX and NANCY A. THORNBERRY

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17148.x

    2. Bicyclic Imidazoles as a Novel Class of Cytokine Biosynthesis Inhibitors (pages 149–170)

      J. C. LEE, A. M. BADGER, D. E. GRISWOLD, D. DUNNINGTON, A. TRUNEH, B. VOTTA, J. R. WHITE, P. R. YOUNG and P. E. BENDER

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17149.x

    3. Coordinate Inhibition by Some Antioxidants of TNFα, IL-1β, and IL-6 Production by Human Peripheral Blood Mononuclear Cells (pages 171–184)

      ELSIE M. EUGUI, BARBARA DELUSTRO, SUSSAN ROUHAFZA, ROBERT WILHELM and ANTHONY C. ALLISON

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17150.x

    4. Cyclooxygenase Gene Expression in Inflammation and Angiogenesis (pages 197–204)

      TIMOTHY HLA, ARI RISTIMÄKI, SUSAN APPLEBY and JAVIER G. BARRIOCANAL

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17152.x

    5. Preclinical and Clinical Activity of Zileuton and A-78773 (pages 205–215)

      R. L. BELL, C. LANNI, P. E. MALO, D. W. BROOKS, A. O. STEWART, R. HANSEN, P. RUBIN and G. W. CARTER

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17153.x

  4. Part IV. Immunosuppressive Drugs for Transplantation

    1. Top of page
    2. Part I. Immunobiology of Cyclosporins, FK-506, and Rapamycin
    3. Part II. Novel Immunosuppressive Drugs
    4. Part III. Novel Antiinflammatory Strategies
    5. Part IV. Immunosuppressive Drugs for Transplantation
    6. Part V. Clinical Applications of Immunosuppressive and Antiinflammatory Drugs
    7. Part VI. Treatment of Insulin-Dependent Diabetes Mellitus
    8. Poster Papers
    1. The Use of Brequinar Sodium for Transplantation (pages 216–226)

      DONALD V. CRAMER, FRANCES A. CHAPMAN and LEONARD MAKOWKA

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17154.x

    2. Cytidine Potentiates the Inhibitory Effect of Brequinar Sodium on Xeno-MLR, Antibody Production, and Concordant Hamster to Rat Cardiac Xenograft Survival (pages 227–234)

      JACKY WOO, LUIS A. VALDIVIA, FAN PAN, SUSANNA CELLI, JOHN J. FUNG and ANGUS W. THOMSON

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17155.x

    3. Efficacy of FK506 in Renal Transplantation (pages 235–244)

      SHIRO TAKAHARA

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17156.x

    4. Incidence of CD4+ IL-2Rα+ and CD4+ CD45RA+ T-Cells in Progressive Multiple Sclerosis and the Influence of Short-Term (3 Months) FK 506 Therapy (pages 245–246)

      ANGUS W. THOMSON, JACKY WOO, BONNIE LEMSTER, WILLIAM IRISH, LINDA L. HUANG, PATRICIA B. CARROLL, HORATIO R. RILO, KAREEM ABU-ELMAGD and BENJAMIN EIDELMAN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17157.x

    5. FK 506 Inhibits Cytokine Gene and Adhesion Molecule Expression in Psoriatic Skin Lesions (pages 250–256)

      B. LEMSTER, H. R. RILO, P. B. CARROLL, M. A. NALESNIK and A. W. THOMSON

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17158.x

    6. Inhibitory Effect of FK 506 on Autoimmune Thyroid Disease in the PVG Rat (pages 257–262)

      K. TAMURA, J. WOO, N. MURASE, M. NALESNIK and A. W. THOMSON

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17159.x

    7. Deoxyspergualin : Mode of Action and Clinical Trials (pages 263–269)

      SEIICHI SUZUKI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17160.x

    8. Combination of Immunosuppressive Drugs for Organ Transplantation (pages 270–280)

      TAKENORI OCHIAI, YOSHIO GUNJI, MATSUO NAGATA and KAICHI ISONO

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17161.x

    9. Immunosuppressant Combinations in Primate Cardiac Xenografts : A Review (pages 281–284)

      ROBERT P. McMANUS, DANIEL P. O'HAIR, RICHARD KOMOROWSKI and J. PAUL SCOTT

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17162.x

  5. Part V. Clinical Applications of Immunosuppressive and Antiinflammatory Drugs

    1. Top of page
    2. Part I. Immunobiology of Cyclosporins, FK-506, and Rapamycin
    3. Part II. Novel Immunosuppressive Drugs
    4. Part III. Novel Antiinflammatory Strategies
    5. Part IV. Immunosuppressive Drugs for Transplantation
    6. Part V. Clinical Applications of Immunosuppressive and Antiinflammatory Drugs
    7. Part VI. Treatment of Insulin-Dependent Diabetes Mellitus
    8. Poster Papers
    1. Optimizing Combination Chemotherapy for Rheumatoid Arthritis (pages 285–291)

      DANIEL E. FURST

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17163.x

    2. Effects of Nonsteroidal Antiinflammatory Drugs on Bone Loss in Chronic Inflammatory Disease (pages 292–302)

      MARJORIE K. JEFFCOAT, MICHAEL S. REDDY, LARRY W. MORELAND and WILLIAM J. KOOPMAN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17164.x

    3. Cyclooxygenase Inhibitors Vary Widely in Potency for Preventing Cytokine-Induced Bone Resorption (pages 303–306)

      ANTHONY C. ALLISON, RUEI-CHEN CHIN and YVONNE CHENG

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17165.x

    4. Treatment of Autoimmune Uveitis (pages 307–318)

      SCOTT M. WHITCUP and ROBERT B. NUSSENBLATT

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17166.x

    5. Immunosuppressive Treatment of Chronic Liver Disease (pages 319–327)

      E. ANTHONY JONES and NORA VALERIA BERGASA

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17167.x

  6. Part VI. Treatment of Insulin-Dependent Diabetes Mellitus

    1. Top of page
    2. Part I. Immunobiology of Cyclosporins, FK-506, and Rapamycin
    3. Part II. Novel Immunosuppressive Drugs
    4. Part III. Novel Antiinflammatory Strategies
    5. Part IV. Immunosuppressive Drugs for Transplantation
    6. Part V. Clinical Applications of Immunosuppressive and Antiinflammatory Drugs
    7. Part VI. Treatment of Insulin-Dependent Diabetes Mellitus
    8. Poster Papers
    1. Mycophenolate Mofetil Can Prevent the Development of Diabetes in BB Rats (pages 328–332)

      LIMING HAO, SIU-MEI CHAN and KEVIN J. LAFFERTY

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17168.x

    2. The Use of Nicotinamide in the Prevention of Type 1 Diabetes (pages 333–341)

      R. B. ELLIOTT, C. C. PILCHER, A. STEWART, D. FERGUSSON and M. A. McGREGOR

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17169.x

    3. Early Diagnosis and Specific Treatment of Insulin-Dependent Diabetes (pages 342–350)

      NOEL MACLAREN, ANDREW MUIR, JANET SILVERSTEIN, YAO-HUA SONG, JIN XIONG SHE, JEFFREY KRISCHER, MARK ATKINSON and DESMOND SCHATZ

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17170.x

    4. Strategies in Immunotherapy of Insulin-Dependent Diabetes Mellitus (pages 364–376)

      JEAN-FRANÇOIS BACH

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17172.x

    5. New Strategies for Clinical Islet Transplantation : The Role of Purified Grafts and Immunosuppressive Therapy (pages 377–389)

      PAUL F. GORES, DIXON B. KAUFMAN and DAVID E. R. SUTHERLAND

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17173.x

  7. Poster Papers

    1. Top of page
    2. Part I. Immunobiology of Cyclosporins, FK-506, and Rapamycin
    3. Part II. Novel Immunosuppressive Drugs
    4. Part III. Novel Antiinflammatory Strategies
    5. Part IV. Immunosuppressive Drugs for Transplantation
    6. Part V. Clinical Applications of Immunosuppressive and Antiinflammatory Drugs
    7. Part VI. Treatment of Insulin-Dependent Diabetes Mellitus
    8. Poster Papers
    1. A Powerful Antiinflammatory Therapy Is Effective in the Treatment of Idiopathic Thrombocytopenia (pages 390–391)

      ADRIANA MENICHELLI and DOMENICO DEL PRINCIPE

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17174.x

    2. Interaction of Diltiazem and Rapamycin on Survival of Rat Cardiac Allografts (pages 392–395)

      LOUIS DUMONT, HUIFANG CHEN, DASHENG XU and PIERRE DALOZE

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17175.x

    3. Antioxidants Inhibit Activation of Transcription Factors and Cytokine Gene Transcription in Monocytes (pages 396–398)

      MARIOLA ILNICKA, SIMON W. LEE and ELSIE M. EUGUI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17176.x

    4. Hydrogen Peroxide Primes Promonocytic U937 Cells to Produce IL-1β (pages 399–401)

      SIMON W. LEE and MARIOLA ILNICKA

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17177.x

    5. Effects of Cyclosporine-A and Cyclosporine-G on ADP-Stimulated Aggregation of Human Platelets (pages 404–407)

      MARIANA S. MARKELL, JULIO FERNANDEZ, ULHAS P. NAIK, YIGAL EHRLICH and ELIZABETH KORNECKI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17179.x

    6. Relationship of Ionized Magnesium and Cyclosporine Level in Renal Transplant Recipients (pages 408–411)

      MARIANA S. MARKELL, BELLA T. ALTURA, YVONNE SARN, RANDALL BARBOUR, ELI A. FRIEDMAN and BURTON M. ALTURA

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17180.x

    7. Studies on the Interaction of the Immunosuppressant 15-Deoxyspergualin with Heat Shock Proteins (pages 412–414)

      STEVEN G. NADLER, JEFFREY CLEAVELAND, MARK A. TEPPER, CHRISTOPHER WALSH and KARI NADEAU

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17181.x

    8. 4-Thiazolidinones, Potent Antioxidants, as Antiinflammatory Agents (pages 415–416)

      J. A. PANETTA, J. K. SHADLE, M. L. PHILLIPS, D. N. BENSLAY and P. P. K. HO

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17182.x

    9. CMT/NSAID Combination Increases Bone CMT Uptake and Inhibits Bone Resorption (pages 420–421)

      N. RAMAMURTHY, M. LEUNG, S. MOAK, R. GREENWALD and L. GOLUB

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17184.x

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