Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

November 1993

Volume 698 Breast Cancer: From Biology to Therapy–Pisa Symposia in Oncology

Pages xiii–xv, 1–435

    1. In Honor of Professor Francesco Squartini (pages xiii–xiv)

      G. Bevilacqua, P. F. Conte and A. Surbone

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17185.x

    2. Introduction (page xv)

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17186.x

  1. Part I. The Biology of Breast Cancer Growth

    1. Top of page
    2. Part I. The Biology of Breast Cancer Growth
    3. Part II. New Perspectives of Surgery and Radiation Therapy
    4. Part III. The Biological and Pharmacological Bases of Therapy
    5. Part IV. Medical Adjuvant Treatments
    6. Part V. Treatment of Advanced Disease
    7. Part VI. New Perspectives in Breast Cancer Treatment
    1. Critical Steps in Breast Carcinogenesis (pages 1–20)

      J. RUSSO, G. CALAF, N. SOHI, Q. TAHIN, P. L. ZHANG, M. E. ALVARADO, S. ESTRADA and I. H. RUSSO

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17187.x

    2. Frequent Mutations in Breast Cancer (pages 21–30)

      ROBERT CALLAHAN, DANIEL GALLAHAN, GILBERT SMITH, CRAIG CROPP, GIORGIO MERLO, FRANCESCA DIELLA, DANIEL LISCIA and ROSETTE LIDEREAU

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17188.x

    3. The Role of Tumor-associated Antigens in the Biology and Immunotherapy of Breast Cancer (pages 31–47)

      J. TAYLOR-PAPADIMITRIOU, B. D'SOUZA, J. BURCHELL, N. KYPRIANOU and F. BERDICHEVSKY

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17189.x

    4. Kinetic Concepts in the Treatment of Breast Cancer (pages 48–62)

      ANTONELLA SURBONE and LARRY NORTON

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17190.x

    5. Heparin-Binding Growth Factor Blockade with Pentosan Polysulfate (pages 63–70)

      S. SWAIN, A. WELLSTEIN, B. PARKER, M. LIPPMAN, C. STEAKLEY and R. DeLAP

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17191.x

    6. Angiogenesis in Breast Cancer : Regulation, Prognostic Aspects, and Implications for Novel Treatment Strategies (pages 71–84)

      ELIZABETH R. HORAK, ADRIAN L. HARRIS, NICHOLAS STUART and ROY BICKNELL

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17192.x

    7. Growth Factors : Clinical Implications in Breast Cancer (pages 85–101)

      J. G. M. KLIJN, P. M. J. J. BERNS, M. BONTENBAL and J. A. FOEKENS

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17193.x

    8. Reduction of RIα Subunit of cAMP-dependent Protein Kinase Expression Induces Growth Inhibition of Human Mammary Epithelial Cells Transformed by TGF-α, c-Ha-ras, and c-erbB-2 Genes (pages 102–107)

      FORTUNATO CIARDIELLO, GIAMPAOLO TORTORA, STEFANO PEPE, CATERINA BIANCO, GUSTAVO BALDASSARRE, ANGELA RUGGIERO, CATALDO BIANCO, MOUNA P. SELVAM and A. RAFFAELE BIANCO

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17194.x

    9. Growth Suppression of Normal Mammary Epithelial Cells by Wild-Type p53 (pages 108–113)

      GIORGIO R. MERLO, TIZIANA VENESIO, DANIELA TAVERNA, ROBERT CALLAHAN and NANCY E. HYNES

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17195.x

    10. p53 Mutations and Histologie Type of Invasive Breast Carcinoma : A Polymerase Chain Reaction-Single-Strand Conformation Polymorphism and Immunohistochemical Analysis (pages 114–119)

      ANTONIO MARCHETTI, FIAMMA BUTTITTA, SILVIA PELLEGRINI, FRANCESCA DIELLA, DANIELA CAMPANI, DENISE CECCHETTI, FRANCESCO SQUARTINI, ROBERT CALLAHAN and MARIA BISTOCCHI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17196.x

    11. A Locus on Chromosome 17P13.3, Associated with a High S-Phase Index Is Distinct from the p53 Gene in Breast Cancer (pages 120–125)

      DANIEL S. LISCIA, TIZIANA VENESIO, FRANCESCA DIELLA, AMELIA BERNARDI, ALBERTO P. M. CAPPA, ROBERT CALLAHAN and GIORGIO R. MERLO

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17197.x

    12. Production of Cytokines and Response to Them in Normal and Transformed Human Mammary Epithelial Cells (pages 126–130)

      F. BASOLO, S. CALVO, L. FIORE, C. SERRA, P. G. CONALDI, V. FALCONE, M. MORGANTI, F. SQUARTINI and A. TONIOLO

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17198.x

    13. Marker Expression and Differentiation in Human Breast Cancer (pages 143–147)

      CECILIA BALLARE, ALICIA I. BRAVO, VALERIA TURCHI, MARIANNA NUTI, ROBERTO YOMHA, JORGE SCHIAFFI and JOSE MORDOH

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17201.x

    14. Evidence of Epithelial Expression of Progesterone Receptor in Breast Cancers with Marked Fibrosis and Limited Metastatic Node Diffusion (pages 148–152)

      CLAUDIO GIANI, DANIELA CAMPANI, FERDINANDO De NEGRI, AGOSTINO GIGLIOTTI, RAFFAELLA FABBRI, ROSANNA BONACCI, PAOLA FIERABRACCI, CLAUDIA MAMMOLI, FRANCESCO SQUARTINI and ALDO PINCHERA

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17202.x

    15. Breast Carcinoma and the Role of Iron Metabolism : A Cytochemical, Tissue Culture, and Ultrastructural Study (pages 159–166)

      ROBERT L. ELLIOTT, MARY C. ELLIOTT, FEN WANG and JONATHAN F. HEAD

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17204.x

    16. Receptor Status, Proliferating Activity, and c-erbB2 Oncoprotein : An Immunocytochemical Evaluation in Breast Cancer (pages 167–173)

      DANIELA CAMPANI, ROBERTA SARNELLI, GABRIELLA FONTANINI, LEONARDO MARTINI, DENISE CECCHETTI, FILOMENA DE LUCA and FRANCESCO SQUARTINI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17205.x

    17. Cell Cycle Kinetic Effects of Tamoxifen on Human Breast Cancer Cells : Flow Cytometric Analyses of DNA Content, BrdU Labeling, Ki-67, PCNA, and Statin Expression (pages 174–181)

      MARCO DANOVA, CARLO PELLICCIARI, CARLO ZIBERA, ROSANNA MANGIAROTTI, NADIA GIBELLI, MONICA GIORDANO, EUGENIA WANG, GIULIANO MAZZINI and ALBERTO RICCARDI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17206.x

    18. Expression of the GSTπ Gene and Response to Tamoxifen Therapy in Locally Advanced Breast Carcinomas (pages 182–185)

      F. DORION-BONNET, N. QUÉNEL, J. M. COINDRE, L. MAURIAC, F. BONICHON, M. DURAND, J. WAFFLART, J. A. MOSCOW, K. H. COWAN and N. GUALDE

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17207.x

    19. Clinical Relevance of Cell Kinetics in Breast Cancer (pages 186–192)

      D. AMADORI, A. VOLPI, A. CALLEA, L. AMADUCCI, S. MORGAGNI, E. MAGNI and O. NANNI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17208.x

    20. Prognostic Value of the S-Phase Fraction of Breast Cancers Treated by Primary Radiotherapy or Neoadjuvant Chemotherapy (pages 193–203)

      Y. REMVIKOS, V. MOSSERI, A. ZAJDELA, A. FOURQUET, J.C. DURAND, P. POUILLART and H. MAGDELÉNAT

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17209.x

    21. Tumor Targeting Potential and Metabolism of 5-[125I]Iodo-2′-Deoxyuridine Injected Intratumorally in Patients with Breast Cancer (pages 204–211)

      G. MARIANI, P. COLLECCHI, L. GIULIANI, J. BARANOWSKA-KOKTYLEWICZ, L. DI LUCA, G. MEUCCI, P. VIACAVA, A. D. VAN DEN ABBEELE, P. A. SALVADORI, S. DI SACCO, S. J. ADELSTEIN, G. BEVILACQUA and A. I. KASSIS

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17210.x

  2. Part II. New Perspectives of Surgery and Radiation Therapy

    1. Top of page
    2. Part I. The Biology of Breast Cancer Growth
    3. Part II. New Perspectives of Surgery and Radiation Therapy
    4. Part III. The Biological and Pharmacological Bases of Therapy
    5. Part IV. Medical Adjuvant Treatments
    6. Part V. Treatment of Advanced Disease
    7. Part VI. New Perspectives in Breast Cancer Treatment
    1. Conservative Surgery in Breast Cancer (pages 212–218)

      UMBERTO VERONESI and ALBERTO COSTA

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17211.x

    2. The Impact of Reconstructive Surgery in Breast Cancer (pages 219–226)

      F. BADELLINO, G. CANAVESE, A. CATTURICH, C. VECCHIO, D. TOMEI, M. ESTIENNE, P. MESZAROS, M. MUGGIANU and S. PASTORINO

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17212.x

    3. Reconstructive Surgery in Operable Breast Cancer : Critical Evaluation (pages 227–245)

      L. DI MAKTINO, G. MURENU, B. DEMONTIS and S. LICHERI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17213.x

    4. Alternatives in Immediate and Delayed Breast Reconstruction : An Overview (pages 246–253)

      P. L. SANTI, S. FRANCHELLI, M. S. LEONE and P. BERRINO

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17214.x

    5. Radical Mastectomy and Immediate Reconstruction with Prosthesis : Experience with 250 Cases (pages 254–258)

      FRANCESCO D'ERRICO, ELENA FERRARIO and EMILIO BEVIGLIA

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17215.x

    6. Long-Term Results of Conservation Treatment of Operable Breast Cancer (pages 259–263)

      Y. AYME, R. AMALRIC, J. M. KURTZ and J. M. SPITALIER

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17216.x

  3. Part III. The Biological and Pharmacological Bases of Therapy

    1. Top of page
    2. Part I. The Biology of Breast Cancer Growth
    3. Part II. New Perspectives of Surgery and Radiation Therapy
    4. Part III. The Biological and Pharmacological Bases of Therapy
    5. Part IV. Medical Adjuvant Treatments
    6. Part V. Treatment of Advanced Disease
    7. Part VI. New Perspectives in Breast Cancer Treatment
    1. Biological Markers for Designing Clinical Protocols (pages 271–278)

      ROSELLA SILVESTRINI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17218.x

    2. Dose Intensity : The Neglected Variable in Clinical Trials (pages 279–288)

      ANTONELLA SURBONE and VINCENT T. DeVITA Jr.

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17219.x

    3. Antineoplastic Drug Resistance and Breast Cancer (pages 289–312)

      CHARLES S. MORROW and KENNETH H. COWAN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17220.x

    4. Endocrine Aspects of Adjuvant Treatment of Breast Cancer (pages 313–317)

      MICHAEL BAUM and ANTHONY COLLETTA

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17221.x

  4. Part IV. Medical Adjuvant Treatments

    1. Top of page
    2. Part I. The Biology of Breast Cancer Growth
    3. Part II. New Perspectives of Surgery and Radiation Therapy
    4. Part III. The Biological and Pharmacological Bases of Therapy
    5. Part IV. Medical Adjuvant Treatments
    6. Part V. Treatment of Advanced Disease
    7. Part VI. New Perspectives in Breast Cancer Treatment
    1. Endocrine Therapy of Breast Cancer : The Experience of the Italian Cooperative Group for Chemohormonal Therapy of Early Breast Cancer (GROCTA) (pages 318–328)

      FRANCESCO BOCCARDO, DOMENICO AMOROSO, ALESSANDRA RUBAGOTTI, PIERO SISMONDI, CORRADO DE SANCTIS, MARIO CAPPELLINI, PAOLO PACINI, LUIGI CASTAGNETTA, ADELE TRAINA, ANTONIO FARRIS, STEFANO IACOBELLI, GIORGIO MUSTACCHI, ITALO NENCI, ADRIANO PIFFANELLI, EUGENIO VILLA, DANIELA ALDRIGHETTI, LUIGI GALLO, MARIO MESITI, GIUSEPPE SCHIEPPATI and OTHER PARTICIPANTS IN THE GROCTA TRIALS

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17222.x

    2. Endocrine Factors in the Outcome of Systemic Adjuvant Therapy of Early Breast Cancer (pages 330–338)

      A. R. BIANCO, S. DE PLACIDO, F. PERRONE, C. CARLOMAGNO, M. DE LAURENTIIS, L. DEL MASTRO, R. LAURIA, A. MARINELLI and C. GALLO

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17223.x

    3. The EBCTCG Overview of Adjuvant Therapy of Breast Cancer : What Are the Implications for Future Studies? (pages 339–348)

      RICHARD GRAY, MIKE CLARKE, RORY COLLINS and RICHARD PETO

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17224.x

  5. Part V. Treatment of Advanced Disease

    1. Top of page
    2. Part I. The Biology of Breast Cancer Growth
    3. Part II. New Perspectives of Surgery and Radiation Therapy
    4. Part III. The Biological and Pharmacological Bases of Therapy
    5. Part IV. Medical Adjuvant Treatments
    6. Part V. Treatment of Advanced Disease
    7. Part VI. New Perspectives in Breast Cancer Treatment
    1. The Role of Lonidamine in the Treatment of Breast Cancer Patients (pages 349–356)

      R. ROSSO, G. GARDIN, P. PRONZATO, A. CAMORIANO, L. MERLINI, C. NASO, M. ROSSO, C. BARONE, O. NASCIMBEN, G. IANNIELLO, F. STURBA, A. CONTU, E. BALDINI, P. G. GIANNESSI and P. F. CONTE

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17225.x

    2. Somatuline and Tamoxifen in Postmenopausal Breast Cancer Patients (pages 362–366)

      LUCIANO CANOBBIO, DANIELA CANNATA, LOREDANA MIGLIETIA and FRANCESCO BOCCARDO

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17227.x

    3. Quality of Life-Before, During, and After Treatment (pages 372–377)

      RORI J. BELLETTIERI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17229.x

  6. Part VI. New Perspectives in Breast Cancer Treatment

    1. Top of page
    2. Part I. The Biology of Breast Cancer Growth
    3. Part II. New Perspectives of Surgery and Radiation Therapy
    4. Part III. The Biological and Pharmacological Bases of Therapy
    5. Part IV. Medical Adjuvant Treatments
    6. Part V. Treatment of Advanced Disease
    7. Part VI. New Perspectives in Breast Cancer Treatment
    1. High-Intensity Chemotherapy with Hematopoietic Support in Breast Cancer (pages 378–388)

      JOHN CROWN, LINDA VAHDAT, DAVID FENNELLY, PRUDENCE FRANCIS, CAROLYN WASSERHEIT, CLIFFORD HUDIS, ALAN KRITZ, JEFFREY SCHNEIDER, NICOLA HAMILTON, TERESA GILEWSKI and LARRY NORTON

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17230.x

    2. High Dose Intensity Chemotherapy without Bone Marrow Support: Role of Granulocyte-Macrophage Colony-Stimulating Factor (pages 389–397)

      M. VENTURINI, L. DEL MASTRO, A. ARDIZZONI, M. R. SERTOLI, G. L. MARIANI, M. C. PENNUCCI, O. GARRONE, S. SILVESTRO, G. F. ADDAMO, P. QUEIROLO and R. ROSSO

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17231.x

    3. Taxol and Recombinant Human Granulocyte Colony-Stimulating Factor, an Active Regimen as Initial Therapy for Metastatic Breast Cancer : A Preliminary Report (pages 398–402)

      BONNIE S. REICHMAN, ANDREW D. SEIDMAN, JOHN P. A. CROWN, ROBERT HEELAN, T. J. YAO, THOMAS B. HAKES, DAVID E. LEBWOHL, THERESA A. GILEWSKI, ANTONELLA SURBONE, VIOLANTE CURRIE, CLIFFORD A. HUDIS, SUSAN QUINLIVAN, REGINA BERKERY, FRIEDA TOOMASI, RENZO CANETTA, JASON FISHERMAN, SUSAN ARBUCK and LARRY NORTON

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17232.x

    4. Evaluation of Taxol Cardiotoxicity in Metastatic Breast Cancer (pages 403–405)

      O. BIADI, G. MENGOZZI, G. GHERARDUCCI, G. STRATA, M. MARIANI, F. BALDINI, P. G. GIANNESSI, A. SURBONE and P. F. CONTE

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17233.x

    5. Cancer Therapy Using Radioimmunoconjugates : Implications for Breast Cancer (pages 406–417)

      MARGARET TEMPERO, DAVID COLCHER, GLENN DALRYMPLE, KATHERINE HARRISON, KAREN HOLDEMAN, SHANTARAM JOSHI, SYED QUADRI, JAMES LINDER, SAM AUGUSTINE, ELIZABETH REED and PETER LEICHNER

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17234.x

    6. Stimulation of Human Breast Cancer in Vivo : Experimental Findings and Clinical Results (pages 418–422)

      E. BALDINI, G. GARDIN, C. NASO, P. PRONZATO, R. ROSSO, A. RUBAGOTTI, C. MONZEGLIO, F. BREMA, G. PASTORINO, D. AMADORI, P. GENTILINI, P. GALLOTTI, G. PAVANATO, F. TESTORE, C. LANFRANCO, P. G. GIANNESSI and P. F. CONTE

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17235.x

    7. Positron Emission Tomography of Glucose Metabolism in Breast Cancer : Potential for Tumor Detection, Staging, and Evaluation of Chemotherapy (pages 423–428)

      OMGO E. NIEWEG, WAI-HOI WONG, SONJA E. SINGLETARY, GABRIEL N. HORTOBAGYI and E. EDMUND KIM

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1993.tb17236.x

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