Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

September 1995

Volume 764 Immunoglobulin Gene Expression in Development and Disease

Pages xv–xvi, 1–582

  1. Preface

    1. Top of page
    2. Preface
    3. Part I. B-Cell Development and Ig V Gene Expression
    4. Part II. Genomic Organization of Ig V Segments
    5. Part III. V(D)J Gene Recombination and Ig Class Switch
    6. Part IV. Somatic Diversification in Human Ig V Genes
    7. Part V. Early and Adult Ig V Gene Repertoire Development
    8. Part VI. Structural Antibody Correlates for Antigen Binding
    9. Part VII. Ig V Genes and Cellular Origin of Autoantibodies
    10. Part VIII. Ig Gene Expression in B-Cell Neoplasias
    11. Part IX. Approaches to Recombinant Human Ig Gene Expression
    1. Preface (pages xv–xvi)

      PAOLO CASALI and LESLIE E. SILBERSTEIN

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55797.x

  2. Part I. B-Cell Development and Ig V Gene Expression

    1. Top of page
    2. Preface
    3. Part I. B-Cell Development and Ig V Gene Expression
    4. Part II. Genomic Organization of Ig V Segments
    5. Part III. V(D)J Gene Recombination and Ig Class Switch
    6. Part IV. Somatic Diversification in Human Ig V Genes
    7. Part V. Early and Adult Ig V Gene Repertoire Development
    8. Part VI. Structural Antibody Correlates for Antigen Binding
    9. Part VII. Ig V Genes and Cellular Origin of Autoantibodies
    10. Part VIII. Ig Gene Expression in B-Cell Neoplasias
    11. Part IX. Approaches to Recombinant Human Ig Gene Expression
    1. Human B-Cell Development (pages 1–8)

      LINDA G. BILLIPS, KAISS LASSOUED, CESAR NUÑEZ, JIYANG WANG, HIROMI KUBAGAWA, G. LARRY GARTLAND, PETER D. BURROWS and MAX D. COOPER

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55798.x

    2. In Vitro Studies of Human B Lymphopoiesis (pages 9–18)

      JULIE R. PRIBYL, BONNIE N. DITTEL and TUCKER W. LEBIEN

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55799.x

    3. B-Lineage Differentiation Stages Resolved by Multiparameter Flow Cytometry (pages 19–24)

      RICHARD R. HARDY and KYOKO HAYAKAWA

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55800.x

    4. Identification of Genes Specifically Expressed at Discrete Stages of B-Cell Development (pages 25–26)

      YU ZHANG, IAN McDERMOTT, MICHAEL ATKINSON and CHRISTOPHER PAIGE

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55801.x

    5. The Role of Bruton's Tyrosine Kinase in B-Cell Development and Function in Mice and Man (pages 27–38)

      WASIF N. KHAN, PASCHALIS SIDERAS, FRED S. ROSEN and FREDERICK W. ALT

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55802.x

    6. Ig μ Heavy Chains with VH81X Variable Regions Do Not Associate with λ5 (pages 39–42)

      ULRIKE KEYNA, STEVEN E. APPLEQUIST, JAN JONGSTRA, GABRIELE B. BECK-ENGESER and HANS-MARTIN JÄCK

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55803.x

  3. Part II. Genomic Organization of Ig V Segments

    1. Top of page
    2. Preface
    3. Part I. B-Cell Development and Ig V Gene Expression
    4. Part II. Genomic Organization of Ig V Segments
    5. Part III. V(D)J Gene Recombination and Ig Class Switch
    6. Part IV. Somatic Diversification in Human Ig V Genes
    7. Part V. Early and Adult Ig V Gene Repertoire Development
    8. Part VI. Structural Antibody Correlates for Antigen Binding
    9. Part VII. Ig V Genes and Cellular Origin of Autoantibodies
    10. Part VIII. Ig Gene Expression in B-Cell Neoplasias
    11. Part IX. Approaches to Recombinant Human Ig Gene Expression
    1. A Complete Map of the Human Immunoglobulin VH Locus (pages 43–46)

      IAN M. TOMLINSON, GRAHAM P. COOK, GERALD WALTER, NIGEL P. CARTER, HAROLD RIETHMAN, LAKJAYA BULUWELA, TERENCE H. RABBITTS and GREG WINTER

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55804.x

    2. LIGM-DB/IMGT: An Integrated Database of Ig and TcR, Part of the Immunogenetics Database (page 47)

      M.-P. LEFRANC, V. GIUDICELLI, C. BUSIN, A. MALIK, I. MOUGENOT, P. DÉHAIS and D. CHAUME

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55805.x

    3. Polymorphism and Utilization of Human VH Genes (pages 50–61)

      ERIC C. B. MILNER, WENDY O. HUFNAGLE, ANNUSKA M. GLAS, IVY SUZUKI and CATHERINE ALEXANDER

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55806.x

    4. Characterization and Genomic Mapping of a Novel Leader Peptide Associated with the Human VH4–21 (VH4–34) Gene Segment (pages 62–71)

      GEORGE F. WIDHOPF II, VIRGINIA PASCUAL, RICHARD BAER and J. DONALD CAPRA

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55807.x

    5. Ethnic Differences in VH Gene Polymorphism (pages 72–73)

      E. H. SASSO, J. H. BUCKNER and L. A. SUZUKI

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55808.x

    6. Expression and Hypermutation of Human Immunoglobulin k Genes (pages 74–83)

      RALPH KLEIN and HANS G. ZACHAU

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55809.x

    7. Regulation of Human λ Light Chain Gene Expression (pages 84–98)

      BONNIE B. BLOMBERG, MICHELE A. GLOZAK and MARY E. DONOHOE

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55810.x

  4. Part III. V(D)J Gene Recombination and Ig Class Switch

    1. Top of page
    2. Preface
    3. Part I. B-Cell Development and Ig V Gene Expression
    4. Part II. Genomic Organization of Ig V Segments
    5. Part III. V(D)J Gene Recombination and Ig Class Switch
    6. Part IV. Somatic Diversification in Human Ig V Genes
    7. Part V. Early and Adult Ig V Gene Repertoire Development
    8. Part VI. Structural Antibody Correlates for Antigen Binding
    9. Part VII. Ig V Genes and Cellular Origin of Autoantibodies
    10. Part VIII. Ig Gene Expression in B-Cell Neoplasias
    11. Part IX. Approaches to Recombinant Human Ig Gene Expression
    1. V(D)J Recombination: Double-Strand Break Repair Gene Products Used in the Joining Mechanism (pages 99–111)

      DAVID WEAVER, NIKOLAI BOUBNOV, ZACHARY WILLS, KATHRYN HALL and JANE STAUNTON

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55811.x

    2. Regulation of N-Region Diversity in Ig Heavy Chain Transcripts Expressed by Murine Fetal Liver Cells Cultured with IL-7 (pages 112–115)

      PIERETTE M. APPASAMY, ALBERT B. DELEO, YEHUA WENG, THOMAS W. KENNISTON JR., LIN TANG and MEGHAN A. BURKE

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55812.x

    3. Mutations in Immunoglobulin V Gene Promoters May Cause Reduced Germline Transcription and Diminished Recombination Frequencies (pages 116–120)

      B. J. NICLAS STIERNHOLM and NEIL L. BERINSTEIN

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55813.x

    4. High Frequency of Normal IgH Rearrangement in scid Mice (pages 121–122)

      JACQUELINE PENNYCOOK, AARON MARSHALL, YENHUI CHANG, ROBERT A. PHILLIPS and GILLIAN E. WU

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55814.x

    5. Human Immunoglobulin Isotype Switching : Studies at the DNA Level (pages 136–147)

      E. E. MAX, F. C. MILLS and N. HARINDRANATH

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55816.x

    6. Role of Oct-2 in Immunoglobulin Gene Silencing (pages 148–150)

      HANNA S. RADOMSKA, MARIA D. HINES and LAUREL A. ECKHARDT

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55817.x

    7. Molecular Evidence That in Vivo Isotype Switching Occurs within the Germinal Centers (pages 151–154)

      HÉCTOR MARTINEZ-VALDEZ, FLORENCE MALISAN, ODETTE DE BOUTEILLER, CHRISTIANE GURET, JACQUES BANCHEREAU and YONG JUN LIU

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55818.x

    8. Diversification of Bovine λ-Light Chain Genes (pages 155–157)

      CHUEN-LEI PARNG, SUSAN HANSAL, RICHARD A. GOLDSBY and BARBARA A. OSBORNE

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55819.x

  5. Part IV. Somatic Diversification in Human Ig V Genes

    1. Top of page
    2. Preface
    3. Part I. B-Cell Development and Ig V Gene Expression
    4. Part II. Genomic Organization of Ig V Segments
    5. Part III. V(D)J Gene Recombination and Ig Class Switch
    6. Part IV. Somatic Diversification in Human Ig V Genes
    7. Part V. Early and Adult Ig V Gene Repertoire Development
    8. Part VI. Structural Antibody Correlates for Antigen Binding
    9. Part VII. Ig V Genes and Cellular Origin of Autoantibodies
    10. Part VIII. Ig Gene Expression in B-Cell Neoplasias
    11. Part IX. Approaches to Recombinant Human Ig Gene Expression
    1. Somatic Mutation of Human Immunoglobulin V Genes: Bias, Rate, and Regulation (pages 158–169)

      RICHARD A. INSEL, WILLIAM S. VARADE, YU-WAYE CHU, ELIDES MARIN, RAMSAY FULEIHAN and RAIF S. GEHA

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55820.x

    2. Comparison of the Human Germline and Rearranged VH Repertoire Reveals Complementarity between Germline Variability and Somatic Mutation (pages 180–182)

      GERALD WALTER, IAN M. TOMLINSON, PAUL H. DEAR, ERIK L. L. SONNHAMMER, GRAHAM P. COOK and GREG WINTER

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55822.x

    3. Analysis of Somatic Mutation with a Reporter Gene Construct (pages 183–186)

      ESTHER M. CHUN, PATTY ZWOLLO, PHILLIP WONG, CHERI LOVE, ANTHONY DOFT and ROBERTA R. POLLOCK

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55823.x

    4. Mechanistic Properties of Immunoglobulin Somatic Mutation (pages 187–188)

      JOHN E. FORD, MICHAEL G. MCHEYZER-WILLIAMS and MICHAEL R. LIEBER

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55824.x

    5. Analysis of Hypermutation in a Mixed T-Cell Receptor β/Immunoglobulin Heavy Chain Passenger Transgene (pages 192–194)

      J. M. JOHNSTON, S. R. IHYER, K-F. TAI, R. S. SMITH, N. L. NADON and W. L. CARROLL

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55826.x

    6. Pattern of Usage of the VH4–21 Gene by B Lymphocytes in a Patient with EBV Infection Indicates Ongoing Mutation and Class Switching (pages 195–197)

      CAROLINE CHAPMAN, MYFANWY SPELLERBERG, TERRY HAMBLIN and FREDA STEVENSON

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55827.x

  6. Part V. Early and Adult Ig V Gene Repertoire Development

    1. Top of page
    2. Preface
    3. Part I. B-Cell Development and Ig V Gene Expression
    4. Part II. Genomic Organization of Ig V Segments
    5. Part III. V(D)J Gene Recombination and Ig Class Switch
    6. Part IV. Somatic Diversification in Human Ig V Genes
    7. Part V. Early and Adult Ig V Gene Repertoire Development
    8. Part VI. Structural Antibody Correlates for Antigen Binding
    9. Part VII. Ig V Genes and Cellular Origin of Autoantibodies
    10. Part VIII. Ig Gene Expression in B-Cell Neoplasias
    11. Part IX. Approaches to Recombinant Human Ig Gene Expression
    1. Development of the Antibody Repertoire in Rabbits (pages 198–206)

      KATHERINE L. KNIGHT and MARY A. CRANE

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55828.x

    2. Development of the Mouse B-Cell Repertoire (pages 207–221)

      FLAVIUS MARTIN, XINJIAN CHEN, FENGYU SHU and JOHN F. KEARNEY

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55829.x

    3. Analysis of Immunoglobulin Gene Rearrangement in Fetal B-Cell Progenitors Developing in Vivo or in Vitro (pages 222–223)

      AARON J. MARSHALL, BARBARA L. KEE, CHRISTOPHER J. PAIGE and GILLIAN E. WU

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55830.x

    4. Development of the Antibody Repertoire as Revealed by Single-Cell PCR of FACS-Sorted B-Cell Subsets (pages 224–227)

      AARON B. KANTOR, CYNTHIA E. MERRILL, JOHN D. MACKENZIE, LEONORE A. HERZENBERG and JAN L. HILLSON

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55831.x

    5. Analysis of DHQ52 Gene Segment Transcription and Rearrangement During B-Cell Development in Human Fetal Bone Marrow (pages 228–230)

      F. E. BERTRAND III, L. G. BILLIPS and H. W. SCHROEDER JR.

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55832.x

    6. Fetal versus Adult PreB or B Cells: The Human VH Repertoire (pages 231–241)

      CÉCILE TONNELLE, ANNE MARIE CUISINIER, LAURENT GAUTHIER, VALÉRIE GUELPA-FONLUPT, MICHÉLE MILILI, CLAUDINE SCHIFF and MICHEL FOUGEREAU

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55833.x

    7. Developmental Regulation of the Human Antibody Repertoire (pages 242–260)

      HARRY W. SCHROEDER JR., FRANK MORTARI, SATOSHI SHIOKAWA, PERRY M. KIRKHAM, ROTEM A. ELGAVISH and F. E. BERTRAND III

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55834.x

    8. Human IgH-V Gene Repertoire in Neonatal Cord Blood, Adult Peripheral Blood, and EBV-Transformed Cells (pages 261–264)

      YOUNGNIM CHOI, MICHAEL H. RICKERT, MARK BALLOW and STEVEN J. GREENBERG

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55835.x

    9. The Expressed Heavy Chain V Gene Repertoire of Circulating B Cells in Normal Adults (pages 265–274)

      B. DAVID STOLLAR

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55836.x

    10. Molecular Analysis of VH Regions Expressed in the Adult B-Cell Repertoire (pages 275–284)

      NIENKE VAN DER STOEP, SASKIA B. EBELING and TON LOGTENBERG

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55837.x

    11. VH4.21 Expression in the Normal Human B-Cell Repertoire (page 285)

      DAVID F. FRIEDMAN, PIOTR KRAJ and LESLIE E. SILBERSTEIN

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55838.x

    12. A Complete Preimmune Human VH3 Repertoire (pages 293–295)

      WENDY O. HUFNAGLE, SHU-CAI HUANG, IVY SUZUKI and ERIC C. B. MILNER

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55839.x

    13. Contribution of the Vλ Light Chain to the Development of the Primary Antibody Repertoire (pages 296–300)

      A. NANGPAL, J. KNOTT, V. LIPSANEN, C. BONA and A. KAUSHIK

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55840.x

    14. Analysis of V kI and VLDII Light Chain Genes in the Expressed B-Cell Repertoire (pages 301–311)

      AUDREY MANHEIMER-LORY, MACARENA IRIGOYEN, BRUCE GAYNOR, RASHEL MONHIAN, ADAM SPLAVER and BETTY DIAMOND

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55841.x

    15. Anomalous Diversification of the Antibody Repertoire following Bone Marrow Transplantation (pages 312–314)

      ANNUSKA M. GLAS, WENDY O. HUFNAGLE, IVY SUZUKI, LAURIE PFISTER, P. SAMBASIVA RAO, CAROL NOTTENBURG and ERIC C. B. MILNER

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55842.x

  7. Part VI. Structural Antibody Correlates for Antigen Binding

    1. Top of page
    2. Preface
    3. Part I. B-Cell Development and Ig V Gene Expression
    4. Part II. Genomic Organization of Ig V Segments
    5. Part III. V(D)J Gene Recombination and Ig Class Switch
    6. Part IV. Somatic Diversification in Human Ig V Genes
    7. Part V. Early and Adult Ig V Gene Repertoire Development
    8. Part VI. Structural Antibody Correlates for Antigen Binding
    9. Part VII. Ig V Genes and Cellular Origin of Autoantibodies
    10. Part VIII. Ig Gene Expression in B-Cell Neoplasias
    11. Part IX. Approaches to Recombinant Human Ig Gene Expression
    1. Structure and Thermodynamics of Antigen Recognition by Antibodies (pages 315–327)

      BRADFORD C. BRADEN, ANA CAUERHFF, WILLIAM DALL'ACQUA, BARRY A. FIELDS, FERNANDO A. GOLDBAUM, EMILIO L. MALCHIODI, ROY A. MARIUZZA, ROBERTO J. POLJAK, FREDERICK P. SCHWARZ, XAVIER YSERN and T. N. BHAT

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55843.x

    2. Unconventional B-Cell Antigens and Human Immune Repertoires (pages 342–355)

      GREGG J. SILVERMAN

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55845.x

    3. Effect of a Putative B Cell Superantigen on Complement (pages 356–358)

      LISA M. KOZLOWSKI, JOHN D. LAMBRIS and ARNOLD I. LEVINSON

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55846.x

    4. Structure—Function Studies of Human Monoclonal Antibodies to Pneumococcus Type 3 Polysaccharide (pages 370–373)

      DENISE R. SHAW, PERRY KIRKHAM, HARRY W. SCHROEDER JR., PAUL ROBEN and GREGG J. SILVERMAN

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55849.x

    5. The Immunoglobulin Gene Repertoire to Haemophilus influenzae Type b (pages 374–377)

      WILLIAM L. CARROLL, PENELOPE G. SHACKELFORD and ELISABETH E. ADDERSON

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55850.x

    6. Patterns of V-Region Gene Segment Association in the Human Antibody Response to Haemophilus influenzae Type B Capsular Polysaccharide (pages 378–380)

      GEORGE V. PINCHUK, CAROL NOTTENBURG and ERIC C. B. MILNER

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55851.x

    7. Generation of Diversity in a Human Anti-Viral Response (pages 381–383)

      JOHN D. RIOUX, BERNARD R. BRODEUR, YOLANDE LAROSE, MATS OHLIN, CARL A. K. BORREBAECK and MARIANNA M. NEWKIRK

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55852.x

  8. Part VII. Ig V Genes and Cellular Origin of Autoantibodies

    1. Top of page
    2. Preface
    3. Part I. B-Cell Development and Ig V Gene Expression
    4. Part II. Genomic Organization of Ig V Segments
    5. Part III. V(D)J Gene Recombination and Ig Class Switch
    6. Part IV. Somatic Diversification in Human Ig V Genes
    7. Part V. Early and Adult Ig V Gene Repertoire Development
    8. Part VI. Structural Antibody Correlates for Antigen Binding
    9. Part VII. Ig V Genes and Cellular Origin of Autoantibodies
    10. Part VIII. Ig Gene Expression in B-Cell Neoplasias
    11. Part IX. Approaches to Recombinant Human Ig Gene Expression
    1. Origins of Anti-DNA Antibodies and Their Implications for B-Cell Tolerance (pages 384–396)

      MARKO Z. RADIC and MARTIN WEIGERT

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55853.x

    2. B-1 Cells and Autoimmunity (pages 402–409)

      MASAO MURAKAMI and TASUKU HONJO

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55855.x

    3. The Importance of the Diversity Region YYGS Motif in Anti-DNA Antibody Binding to DNA (pages 424–426)

      MAHMOUD MAHMOUDI, DAVID A. BELL and EWA CAIRNS

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55857.x

    4. Dual Recognition of Lipid A and DNA by Human Antibodies Encoded by the VH4-21 Gene A Possible Link between Infection and Lupus (pages 427–432)

      MYFANWY SPELLERBERG, CAROLINE CHAPMAN, TERRY HAMBLIN and FREDA STEVENSON

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55858.x

    5. Immunoglobulin Gene Use by Naturally Occurring Cold Agglutinins (pages 433–435)

      LEIGH C. JEFFERIES, CATHERINE M. CARCHIDI and LESLIE E. SILBERSTEIN

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55859.x

    6. Human Pathogenic Autoantibodies and Their Escape from Deletion (pages 436–439)

      MONCEF ZOUALI

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55860.x

    7. V-GENE Repertoire and Hypermutation of Rheumatoid Factors Produced in Rheumatoid Synovial Inflammation and Immunized Healthy Donors (pages 440–449)

      KEITH M. THOMPSON, MARIE BØRRETZEN, INGRID RANDEN, ØYSTEIN FØRRE and JACOB B. NATVIG

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55861.x

    8. Analysis of Immunoglobulin Gamma Heavy Chains from Rheumatoid Arthritis Synovium Evidence of Antigen-Driven Selection (pages 450–460)

      S. LOUIS BRIDGES JR., BJÖRN E. CLAUSEN, JOHN C. LAVELLE, PRISCILLA G. FOWLER, WILLIAM J. KOOPMAN and HARRY W. SCHROEDER JR.

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55862.x

    9. In Situ Hybridization Analysis of Immunoglobulin VH Gene Family Expression in Rheumatoid Arthritis (pages 453–456)

      CHARLES H. RUNDLE, HARRY W. SCHROEDER JR. and WILLIAM J. KOOPMAN

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55863.x

    10. Immunoglobulin Gene Usage in Diabetes-Associated Human Monoclonal Antibodies Recognizing Glutamate Decarboxylase (pages 457–460)

      WILTRUD RICHTER, KARIN M. JURY, DANIELA LOEFFLER, THOMAS H. EIERMANN and BERNHARD O. BOEHM

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55864.x

    11. Expression and Regulation of Clonally Ignorant B Cells (pages 461–462)

      JAMES W. THOMAS and CHRYS HULBERT

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55865.x

  9. Part VIII. Ig Gene Expression in B-Cell Neoplasias

    1. Top of page
    2. Preface
    3. Part I. B-Cell Development and Ig V Gene Expression
    4. Part II. Genomic Organization of Ig V Segments
    5. Part III. V(D)J Gene Recombination and Ig Class Switch
    6. Part IV. Somatic Diversification in Human Ig V Genes
    7. Part V. Early and Adult Ig V Gene Repertoire Development
    8. Part VI. Structural Antibody Correlates for Antigen Binding
    9. Part VII. Ig V Genes and Cellular Origin of Autoantibodies
    10. Part VIII. Ig Gene Expression in B-Cell Neoplasias
    11. Part IX. Approaches to Recombinant Human Ig Gene Expression
    1. Analysis of Immunoglobulin VH Gene Repertoire by an Anchored PCR-Elisa (pages 463–473)

      LAURA Z. RASSENTI, HITOSHI KOHSAKA and THOMAS J. KIPPS

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55866.x

    2. Expression of Immunoglobulin Heavy Chain Variable Genes in B-Chronic Lymphocytic Leukemia (pages 474–477)

      PABLO BERTIN, CONCEPCIÓN RISUEÑO and CLAUDIA MELLER

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55867.x

    3. In Vivo Isotype Class Switching in CD5+ Chronic Lymphocytic Leukemia B Cells (pages 478–481)

      MARIELLA DONO, SHIORI HASHIMOTO, MANLIO FERRARINI and NICHOLAS CHIORAZZI

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55868.x

    4. Clonal Heterogeneity in Membrane Expression of CD5 in a Patient with Chronic Lymphocytic Leukemia (pages 482–484)

      SHIORI HASHIMOTO, MARIELLA DONO, VINCENT VINCIGUERRA, JACK SILVER and NICHOLAS CHIORAZZI

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55869.x

    5. Clonal Analysis of IgM+ CD5+ CLL B Cells (pages 485–491)

      EDWARD W. SCHETTINO, ELIZABETH W. NEWCOMB, MILAN POTMESIL, GIORGIO INGHIRAMI and PAOLO CASALI

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55870.x

    6. Surface Phenotype and Immunoglobulin Heavy Chain Gene Usage in Chronic B-Cell Leukemias (pages 492–495)

      WATARU IKEMATSU, HIDEYUKI IKEMATSU, TERUHISA OTSUKA, SEIICHI OKAMURA, SEIZABURO KASHIWAGI and YOSHIYUKI NIHO

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55871.x

    7. Different Clonal Origin of B-Cell Populations of Chronic Lymphocytic Leukemia and Large-Cell Lymphoma in Richter's Syndrome (pages 496–503)

      ANDRÁS MATOLCSY, PAOLO CASALI and DANIEL M. KNOWLES

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55872.x

    8. VH Gene Repertoire of Mantle Cell Lymphomas (pages 504–506)

      W. VARADE, E. MARIN, M. MILANO, R. INSEL, S. SWERDLOW and M. WILLIAMS

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55873.x

    9. VH Gene Use by CD5+ AIDS-Associated B-Cell Lymphoproliferations (pages 507–508)

      VALERIE L. NG, MARK H. HURT, BRIAN G. HERNDIER and MICHAEL S. McGRATH

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55874.x

    10. Cellular Origin, Antigen Reactivity, and VH Segment Structure of IgM mAbs from AIDS Lymphomas (pages 509–518)

      PIERSANDRO RIBOLDI, GIANLUCA GAIDANO, EDWARD W. SCHETTINO, DANIEL M. KNOWLES, RICCARDO DALLA-FAVERA and PAOLO CASALI

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55875.x

    11. Analysis of Multiple Myeloma Third Complementarity-Determining Regions Reveals Characteristics of Prenatal B Cells (pages 519–522)

      L. A. KUNKEL, R. VESCIO, J. CAO, C. H. HONG, A. KIM, G. J. SCHILLER, A. K. LICHTENSTEIN and J. R. BERENSON

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55876.x

    12. Hodgkin's Disease: Clonal Ig Gene Rearrangements in Hodgkin and Reed-Sternberg Cells Picked from Histological Sections (pages 523–524)

      RALF KÜPPERS, KLAUS RAJEWSKY, MIN ZHAO, GÜNTHER SIMONS, RALF LAUMANN, ROBERT FISCHER and MARTIN-LEO HANSMANN

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55877.x

  10. Part IX. Approaches to Recombinant Human Ig Gene Expression

    1. Top of page
    2. Preface
    3. Part I. B-Cell Development and Ig V Gene Expression
    4. Part II. Genomic Organization of Ig V Segments
    5. Part III. V(D)J Gene Recombination and Ig Class Switch
    6. Part IV. Somatic Diversification in Human Ig V Genes
    7. Part V. Early and Adult Ig V Gene Repertoire Development
    8. Part VI. Structural Antibody Correlates for Antigen Binding
    9. Part VII. Ig V Genes and Cellular Origin of Autoantibodies
    10. Part VIII. Ig Gene Expression in B-Cell Neoplasias
    11. Part IX. Approaches to Recombinant Human Ig Gene Expression
    1. Production of Antigen-Specific Human Antibodies from Mice Engineered with Human Heavy and Light Chain YACs (pages 525–535)

      AYA JAKOBOVITS, LARRY L. GREEN, MARGARET C. HARDY, CATHERINE E. MAYNARD-CURRIE, HIROHISA TSUDA, DONNA M. LOUIE, MICHAEL J. MENDEZ, HADI ABDERRAHIM, MASATO NOGUCHI, DOUGLAS H. SMITH, YONGJUN ZENG, NATHANIEL E. DAVID, HITOSHI SASAI, DAN GARZA, DANIEL G. BRENNER, JOANNA F. HALES, RYAN P. MCGUINNESS, DANIEL J. CAPON and SUE KLAPHOLZ

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55878.x

    2. Class Switching in Human Immunoglobulin Transgenic Mice (pages 536–546)

      FIONA A. HARDING and NILS LONBERG

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55879.x

    3. Isolation of Human Anti-Red Blood Cell Antibodies by Repertoire Cloning (pages 547–558)

      DON L. SIEGEL

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55880.x

    4. Genetic and Functional Characterization of Human Autoantibodies Using Combinatorial Phage Display Libraries (pages 559–564)

      MARIA ZEIDEL, ELENA REY, JOE TAMI, MICHAEL FISCHBACH and IÑAKI SANZ

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55881.x

    5. Repertoire Cloning of Human Lupus Autoantibodies (pages 565–566)

      G. J. SILVERMAN, S. BARBAS, P. ROBEN and D. R. BURTON

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55882.x

    6. Substrate-Driven Formation of a Proteolytic Antibody Light Chain (pages 567–569)

      QING-SHENG GAO, MEI SUN, SONIA TYUTYULKOVA, DAVID WEBSTER, ANTHONY REES, ALFONSO TRAMONTANO, RICHARD J. MASSEY and SUDHIR PAUL

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55883.x

    7. Catalytic Activity of Anti-Thyroglobulin Antibodies (pages 570–572)

      LAN LI, SRINIVAS KAVERI, SONIA TYUTYULKOVA, MICHEL D. KAZATCHKINE and SUDHIR PAUL

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55884.x

    8. Localization of Protease Activity in Antibody Subunit (pages 573–575)

      MEI SUN, LAN LI, QING-SHENG GAO and SUDHIR PAUL

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55885.x

    9. Use of a Phage Expression System to Produce Fabs from Human Autoanti-DNA Antibodies Encoded by the VH4–21 Gene Segment (pages 576–579)

      C. J. CHAPMAN, C. I. MOCKRIDGE, M. B. SPELLERBERG, D. A. ISENBERG, T. J. HAMBLIN and F. K. STEVENSON

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55886.x

    10. The Development of a Bacteriophage Expression Vector for Cloning Immunoglobulin Variable Region Genes from B-Cell Genomic DNA (pages 580–582)

      GREGORY A. DENOMME, ZHILI SONG and JOHN G. KELTON

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1749-6632.1995.tb55887.x

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