Annals of the New York Academy of Sciences

© The New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

October 1996

Volume 795 Interleukin 12: Cellular and Molecular Immunology of an Important Regulatory Cytokine

Pages xiii–xix, 1–454

    1. Introduction (pages xiii–xix)

      MICHAEL T. LOTZE

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52649.x

  2. Part I. Opening Plenary Session

    1. Top of page
    2. Part I. Opening Plenary Session
    3. Part II. Molecular Immunology of Interleukin-12
    4. Part III. Interleukins 10 and 12: Production by Various Cells During Inflammation
    5. Part IV. Interaction of Interleukin-12 with Other Immunoregulatory Cytokines
    6. Part V. Interleukin-12 Development of Cellular Immunity and Its Role in Hematopoiesis
    7. Part VI. Autoimmunity and Infectious Disease
    8. Part VII. Interleukin-12 Neoplastic Diseases: Preclinical Studies
    9. Part VIII. Poster Papers
    1. Interleukin-12 Antagonist Activity of Mouse Interleukin-12 p40 Homodimer in Vitro and in Vivo (pages 1–12)

      MAURICE K. GATELY, DAISY M. CARVAJAL, SUZANNE E. CONNAUGHTON, SILKE GILLESSEN, RAJEEV R. WARRIER, KENNETH D. KOLINSKY, VICTORIA L. WILKINSON, CYNTHIA M. DWYER, GEORGE F. HIGGINS JR., FRANK J. PODLASKI, DENISE A. FAHERTY, PHILIP C. FAMILLETTI, ALVIN S. STERN and DAVID H. PRESKY

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52650.x

    2. Regulation of Interleukin-12 Production (pages 13–25)

      XIAOJING MA, MIGUEL ASTE-AMEZAGA and GIORGIO TRINCHIERI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52651.x

    3. Interleukin-12 as Vaccine Adjuvant : Characteristics of Primary, Recall, and Long-Term Responses (pages 26–35)

      JUDY BLISS, RICHARD MAYLOR, KEYA STOKES, KRISTIN S. MURRAY, MARA A. KETCHUM and STANLEY F. WOLF

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52652.x

  3. Part II. Molecular Immunology of Interleukin-12

    1. Top of page
    2. Part I. Opening Plenary Session
    3. Part II. Molecular Immunology of Interleukin-12
    4. Part III. Interleukins 10 and 12: Production by Various Cells During Inflammation
    5. Part IV. Interaction of Interleukin-12 with Other Immunoregulatory Cytokines
    6. Part V. Interleukin-12 Development of Cellular Immunity and Its Role in Hematopoiesis
    7. Part VI. Autoimmunity and Infectious Disease
    8. Part VII. Interleukin-12 Neoplastic Diseases: Preclinical Studies
    9. Part VIII. Poster Papers
    1. Molecular Biology of lnterleukin-12 Receptors (pages 36–40)

      UELI GUBLER and DAVID H. PRESKY

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52653.x

    2. Signal Transduction by Interleukin-12 and Interleukin-2 : A Comparison and Contrast (pages 41–59)

      CHRIS M. BACON, SARAH S. CHO and JOHN J. O'SHEA

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52654.x

    3. IL-12-Deficient Mice Are Defective but Not Devoid of Type 1 Cytokine Responses (pages 60–70)

      JEANNE MAGRAM, JESSICA SFARRA, SUZANNE CONNAUGHTON, DENISE FAHERTY, RAJEEV WARRIER, DAISY CARVAJAL, CHANG-YOU WU, COLIN STEWART, ULLA SARMIENTO and MAURICE K. GATELY

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52655.x

    4. CD2-CD58 Interaction and the Control of T-Cell Interleukin-12 Responsiveness : Adhesion Molecules Link Innate and Acquired Immunity (pages 71–81)

      JARED A. GOLLOB and JEROME RITZ

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52656.x

  4. Part III. Interleukins 10 and 12: Production by Various Cells During Inflammation

    1. Top of page
    2. Part I. Opening Plenary Session
    3. Part II. Molecular Immunology of Interleukin-12
    4. Part III. Interleukins 10 and 12: Production by Various Cells During Inflammation
    5. Part IV. Interaction of Interleukin-12 with Other Immunoregulatory Cytokines
    6. Part V. Interleukin-12 Development of Cellular Immunity and Its Role in Hematopoiesis
    7. Part VI. Autoimmunity and Infectious Disease
    8. Part VII. Interleukin-12 Neoplastic Diseases: Preclinical Studies
    9. Part VIII. Poster Papers
    1. Production of Interleukin-12 by Keratinocytes and Its Role in Contact Hypersensitivity (pages 82–87)

      THOMAS SCHWARZ

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52657.x

    2. Effects of IL-12 in Memory CD4+ T Lymphocyte Responses (pages 88–99)

      DALE T. UMETSU, RANDY GIENI and ROSEMARIE H. DeKRUYFF

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52658.x

    3. Enhancement of Humoral Immunity by Interleukin-12 (pages 100–115)

      DENNIS W. METZGER, J. MATTHEW BUCHANAN, JOHN T. COLLINS, TERRY L. LESTER, KRISTIN S. MURRAY, VICTOR H. VAN CLEAVE, LAURA A. VOGEL and WESLEY A. DUNNICK

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52659.x

    4. Interleukin-12 Production by Dendritic Cells : The Role of CD40–CD40L Interactions in Thl T-Cell Responses (pages 116–126)

      BRIAN L. KELSALL, ECKHARD STÜBER, MARKUS NEURATH and WARREN STROBER

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52660.x

    5. Interleukin-12 Activates Interferon-γ Production by Targeted Activation of CD30+ T cells (pages 127–136)

      MORTIMER ALZONA, HANS-MARTIN JÄCK, PATRICIA E. SIMMS and THOMAS M. ELLIS

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52661.x

  5. Part IV. Interaction of Interleukin-12 with Other Immunoregulatory Cytokines

    1. Top of page
    2. Part I. Opening Plenary Session
    3. Part II. Molecular Immunology of Interleukin-12
    4. Part III. Interleukins 10 and 12: Production by Various Cells During Inflammation
    5. Part IV. Interaction of Interleukin-12 with Other Immunoregulatory Cytokines
    6. Part V. Interleukin-12 Development of Cellular Immunity and Its Role in Hematopoiesis
    7. Part VI. Autoimmunity and Infectious Disease
    8. Part VII. Interleukin-12 Neoplastic Diseases: Preclinical Studies
    9. Part VIII. Poster Papers
    1. Role of Tl and T2 Cytokines in the Response to Mycobacterium tuberculosis (pages 137–146)

      JOANNE L. FLYNN and BARRY R. BLOOM

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52662.x

    2. Regulation of IL-12 Production by Human Monocytes and the Influence of Prostaglandin E2 (pages 147–157)

      T. C. T. M. van der POUW KRAAN, L. C. M. BOEIJE, A. SNIJDERS, R. J. T. SMEENK, J. WIJDENES and L. A. AARDEN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52663.x

    3. A Role for the Interferon-Inducible Protein 10 in Inhibition of Angiogenesis by Interleukin-12 (pages 158–167)

      ANNE L. ANGIOLILLO, CECILIA SGADARI and GIOVANNA TOSATO

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52664.x

    4. Both IL-2 and IL-4 Synergize with IL-12 to Induce a CTL Response, a Response Completely Blocked by TGF-β (pages 168–180)

      STEVEN HERRMANN and KAVEH ABDI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52665.x

  6. Part V. Interleukin-12 Development of Cellular Immunity and Its Role in Hematopoiesis

    1. Top of page
    2. Part I. Opening Plenary Session
    3. Part II. Molecular Immunology of Interleukin-12
    4. Part III. Interleukins 10 and 12: Production by Various Cells During Inflammation
    5. Part IV. Interaction of Interleukin-12 with Other Immunoregulatory Cytokines
    6. Part V. Interleukin-12 Development of Cellular Immunity and Its Role in Hematopoiesis
    7. Part VI. Autoimmunity and Infectious Disease
    8. Part VII. Interleukin-12 Neoplastic Diseases: Preclinical Studies
    9. Part VIII. Poster Papers
    1. Effects of IL-12 on Human Natural Killer Cell Differentiation (pages 181–188)

      IAN M. BENNETT and BICE PERUSSIA

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52666.x

    2. Interleukin- 12-Induced Interferon- γ Inhibits Hematopoiesis in Vivo in Mice (pages 189–195)

      VALERIE F. J. QUESNIAUX and BERNHARD RYFFEI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52667.x

    3. Role of Interleukin-12 in the Maturation of Naive Human CD4 T Cells (pages 196–201)

      G. DELESPESSE, L.-P. YANG, U. SHU, D. G. BYUN, C. E. DEMEURE, Y. OHSHIMA, C. Y. WU and M. SARFATI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52668.x

  7. Part VI. Autoimmunity and Infectious Disease

    1. Top of page
    2. Part I. Opening Plenary Session
    3. Part II. Molecular Immunology of Interleukin-12
    4. Part III. Interleukins 10 and 12: Production by Various Cells During Inflammation
    5. Part IV. Interaction of Interleukin-12 with Other Immunoregulatory Cytokines
    6. Part V. Interleukin-12 Development of Cellular Immunity and Its Role in Hematopoiesis
    7. Part VI. Autoimmunity and Infectious Disease
    8. Part VII. Interleukin-12 Neoplastic Diseases: Preclinical Studies
    9. Part VIII. Poster Papers
    1. An IL-12-Based Vaccine Approach for Preventing Immunopathology in Schistosomiasis (pages 202–207)

      ALAN SHER, DRAGANA JANKOVIC, ALLEN CHEEVER and THOMAS WYNN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52669.x

    2. The Role of IL-12 in the Pathogenesis of Thl Cell-Mediated Autoimmune Diseases (pages 208–215)

      LUCIANO ADORINI, SILVIA GREGORI, JEANNE MAGRAM and SYLVIE TREMBLEAU

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52670.x

    3. Regulation of Experimental Autoimmune Encephalomyelitis by Interleukin-12 (pages 216–226)

      JOHN P. LEONARD, KRISTINE E. WALDBURGER and SAMUEL J. GOLDMAN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52671.x

    4. Characterization of the Adjuvant Effect of IL-12 and Efficacy of IL-12 Inhibitors in Type II Collagen-Induced Arthritis (pages 227–240)

      TIENO GERMANN, HENRY HESS, JACEK SZELIGA and ERWIN RÜDE

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52672.x

    5. Prevention of a Thl Disease by a Thl, Cytokine: IL-12 and Diabetes in, NOD Mice (pages 241–249)

      RICHARD M. O'HARA JR., SHERYL L. HENDERSON and ANNMARIE NAGELIN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52673.x

    6. The Role of IL-12 in Regulation of T Helper Cell Subsets in Vivo : Lessons from Experimental Cutaneous Leishmaniasis (pages 250–256)

      PHILLIP SCOTT, BRIAN HONDOWICZ, ASHLYN EATON and TANYA SCHARTON-KERSTEN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52674.x

    7. Interleukin-12 Promotes Enhanced Recovery from Viral Infection of Neurons in the Central Nervous System (pages 257–265)

      CAROL S. REISS, TAKASHI KOMATSU, MARIA BARNA and ZHENGBIAO BI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52675.x

  8. Part VII. Interleukin-12 Neoplastic Diseases: Preclinical Studies

    1. Top of page
    2. Part I. Opening Plenary Session
    3. Part II. Molecular Immunology of Interleukin-12
    4. Part III. Interleukins 10 and 12: Production by Various Cells During Inflammation
    5. Part IV. Interaction of Interleukin-12 with Other Immunoregulatory Cytokines
    6. Part V. Interleukin-12 Development of Cellular Immunity and Its Role in Hematopoiesis
    7. Part VI. Autoimmunity and Infectious Disease
    8. Part VII. Interleukin-12 Neoplastic Diseases: Preclinical Studies
    9. Part VIII. Poster Papers
    1. Interleukin-12: Murine Models of a Potent Antitumor Agent (pages 266–274)

      MICHAEL J. BRUNDA, LEOPOLDO LUISTRO, LEONID RUMENNIK, ROSEMARY B. WRIGHT, JON M. WIGGINTON, ROBERT H. WILTROUT, JILL A. HENDRZAK and ALICIA V. PALLERONI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52676.x

    2. Murine Models of Cancer Cytokine Gene Therapy Using Interleukin-12 (pages 275–283)

      HIDEAKI TAHARA, LAURENCE ZITVOGEL, WALTER J. STORKUS, PAUL D. ROBBINS and MICHAEL T. LOTZE

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52677.x

    3. IL-12-Engineered Dendritic Cells Serve as Effective Tumor Vaccine Adjuvants in Vivo (pages 284–293)

      LAURENCE ZITVOGEL, BETTINA COUDERC, JOSE I. MAYORDOMO, PAUL D. ROBBINS, MICHAEL T. LOTZE and WALTER J. STORKUS

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52678.x

    4. Cellular and Molecular Mechanisms Underlying IL-12-Induced Tumor Regression (pages 294–309)

      HIROMI FUJIWARA, STEVEN C. CLARK and TOSHIYUKI HAMAOKA

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52679.x

    5. The Potential Therapeutic Role of Interleukin-12 in Cutaneous T-Cell Lymphoma (pages 310–318)

      ALAIN H. ROOK, MAREK RUBIN, FLOYD E. FOX, ZHUTIAN NIU, MAUREEN CASSIN, BENJAMIN R. VOWELS, SCOTT L. GOTTLEIB, ERIC C. VONDERHEID, STUART R. LESSIN and GIORGIO TRINCHIERF

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52680.x

  9. Part VIII. Poster Papers

    1. Top of page
    2. Part I. Opening Plenary Session
    3. Part II. Molecular Immunology of Interleukin-12
    4. Part III. Interleukins 10 and 12: Production by Various Cells During Inflammation
    5. Part IV. Interaction of Interleukin-12 with Other Immunoregulatory Cytokines
    6. Part V. Interleukin-12 Development of Cellular Immunity and Its Role in Hematopoiesis
    7. Part VI. Autoimmunity and Infectious Disease
    8. Part VII. Interleukin-12 Neoplastic Diseases: Preclinical Studies
    9. Part VIII. Poster Papers
    1. Regulation by Interleukin-10 of Staphylococcus aureus- and Lipopolysaccharide-Indueed Interleukin-12 Gene Expression in Human Peripheral Blood Mononuclear Cells (pages 319–320)

      M. ASTE-AMEZAGA, X. MA and G. TRINCHIERI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52681.x

    2. Human Interleukin-12 Upregulates Proliferation and Interferon- γ Production by Parasite Antigen-Stimulated Th Cell Clones and γ/δ T Cells of Cattle (pages 321–324)

      WENDY C. BROWN, WILLIAM C. DAVIS and WENBIN TUO

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52682.x

    3. Tumor Cells Transfected with B7-1 and Interleukin-12 cDNA Induce Protective Immunity (pages 325–327)

      PETER W. CHEN, DAVID C. GEER, ECKHARD R. PODACK and BRUCE R. KSANDER

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52683.x

    4. Astrocytes and Microglia Produce Interleukin-12 p40 (pages 328–333)

      C. S. CONSTANTINESCU, K. FREI, M. WYSOCKA, G. TRINCHIERI, U. MALIPIERO, A. ROSTAMI and A. FONTANA

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52684.x

    5. Characterization of Monoclonal Antibodies against Human Interleukin-12 and Their Use in an Elisa for the Measurement of This Cytokine (pages 334–336)

      F. FAUCHET, M. JADOUL, J. D. FRANSSEN, J. ZHANG and D. DE GROOTE

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52685.x

    6. Retinoids Synergize with IL-2 to Increase Interferon- γ Production by Peripheral Blood Mononuclear Cells via Induction of IL-12 (pages 337–340)

      F. E. FOX, M. CASSIN, S. GOTTLIEB, S. S. FAKHARZADEH, M. KUBIN, G. TRINCHIERI, K. COOPER and A. H. ROOK

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52686.x

    7. Retroviral Vectors for Production of Interleukin-12 in the Bone Marrow to Induce a Graft-Versus-Leukemia Effect (pages 341–345)

      ROBERT G. HAWLEY, FRANCIS H. L. LIEU, ANDREW Z. C. FONG, SAMUEL J. GOLDMAN, JOHN P. LEONARD and TERESA S. HAWLEY

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52687.x

    8. Modulation of lnterleukin-12 mRNA Expression in Leukocytes of Cancer Patients Treated with CM101 (pages 346–348)

      CARL G. HELLERQVIST, R. STEPHEN LLOYD, ENZE WANG and SMRITI BARDHAN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52688.x

    9. Accessory Cell-Derived Interleukin-12 and Prostaglandin E2 Determine the Level of Interferon- γ Produced by Activated Human CD4+ T Cells (pages 349–350)

      CATHARIEN HILKENS, ALIES SNIJDERS, HANS VERMEULEN, PETER van der MEIDE, EDDY WIERENGA and MARTIEN KAPSENBERG

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52689.x

    10. The Release of Interleukin-12 in Escherichia co/i-Induced Lethal and Sublethal Primate Sepsis (pages 351–353)

      PATTY M. JANSEN, TINEKE C. T. M. van der POUW KRAAN, IRMA W. de JONG, GERARD van MIERLO, JOHN WUDENES, LUCIEN AARDEN, ALVIN A. CHANGE, FLETCHER B. TAYLOR JR. and C. ERIK HACK

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52690.x

    11. Co-therapy with Suboptimal Doses of Interleukin-12 and Interferon-α Promotes Synergistic Protection against Herpes Virus Infection (pages 354–356)

      JANE A. L. ROGERSON, DAVID S. POLE, JACKIE A. CARR, NOEL A. ROBERTS and ALAN G. LAMONT

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52691.x

    12. A Novel ets-2-Related Nuclear Factor Is Involved in Transcriptional Activation of the Human Interleukin-12 p40 Gene Promoter in Response to Interferon- γ and LPS Stimulation of Monocytic Cells (pages 357–360)

      XIAOJING MA, GIORGIA GRI and GIORGIO TRINCHIERI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52692.x

    13. Interleukin-12 Alters Helper T-Cell Subsets and Antibody Profiles Induced by the Mucosal Adjuvant Cholera Toxin (pages 361–365)

      MARIAROSARIA MARINARO, PROSPER N. BOYAKA, RAYMOND J. JACKSON, FRED D. FINKELMAN, HIROSHI KIYONO and JERRY R. McGHEE

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52693.x

    14. Does Interleukin-12 Play a Role in the Viral Immune Response? (pages 366–367)

      JUANITA MONTEIRO and GIORGIO TRINCHIERI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52694.x

    15. Effects of IL-12 and Antibodies to IL-12 on Established Granulomatous Colitis in Mice (pages 368–370)

      MARKUS F. NEURATH, IVAN FUSS, BRIAN KELSALL, K.-H. MEYER zum BÜSCHENFELDE and WARREN STROBER

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52695.x

    16. The Therapeutic Effect of Interleukin-12 or Its Antagonist in Transplantation Immunity (pages 371–374)

      TAKASHI NISHIMURA, AKIKO SADATA, CHIE YAHAGI, KAZUKI SANTA, KENZO OTSUKI, KAZUHITO WATANABE, TAKASHI YAHATA and SONOKO HABU

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52696.x

    17. The Application of IL-12 to Cytokine Therapy and Gene Therapy for Tumors (pages 375–378)

      TAKASHI NISHIMURA, KAZUHITO WATANABE, TAKASHI YAHATA, TOSHIMITSU UEDE, IKUO SAIKI, STEVE H. HERRMANN, MICHIKO KOBAYASHI and SONOKO HABU

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52697.x

    18. Interleukin-12 as Adjuvant in Peptide Vaccines (pages 379–381)

      MARGOT O'TOOLE, JOSEPH WOOTERS, EUGENE BROWN, HOLLY SWINIARSKI, GRANT CULL, LENA LEGER and STEVEN HERRMANN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52698.x

    19. Effect of Interleukin-12 on the Cytokine Profile of Human CD4 and CD8 T-Cell Clones (pages 382–383)

      CARLA PAGANIN, FRANCA GEROSA, DAVID PERITT, FIORENZA PAIOLA, MARIA TERESA SCUPOLI, MIGUEL ASTE-AMEZAGA, IAN FRANK and GIORGIO TRINCHIERI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52699.x

    20. Detection of the p35 and p40 Subunits of Interleukin-12 in Melanoma and Bladder Cancer Cell Lines (pages 384–386)

      A. J. STANLEY, R. W. CARTER, E. INGHAM, P. M. PATEL, R. E. BANKS and P. J. SELBY

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52700.x

    21. Interleukin-10 Induction by IL-12: A Possible Modulatory Mechanism? (pages 387–389)

      DAVID PERITT, MIGUEL ASTE-AMEZAGA, FRANCA GEROSA, CARLA PAGANIN and GIORGIO TRINCHIERP

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52701.x

    22. Evidence for Multiple Sites of Interaction between IL-12 and Its Receptor (pages 390–393)

      D. H. PRESKY, L. J. MINETTI, S. GILLESSEN, U. GUBLER, R. CHIZZONITE, A. S. STERN and M. K. GATELY

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52702.x

    23. Neutrophils Producing Interleukin-10 Antagonize the Effect of Interleukin-12 in Mice with Candidiasis (pages 394–396)

      A. MENCACCI, E. CENCI, R. SPACCAPELO, L. TONNETTI, G. del SERO, C. Fè D'OSTIANI, F. BISTONI and L. ROMANI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52703.x

    24. Interleukin-12 Gene Expression Mediates the Accelerating Effect of Cyclophosphamide in Autoimmune Disease (pages 397–399)

      HELGA ROTHE, VOLKER BURKART, ANTJE FAUST and HUBERT KOLB

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52704.x

    25. Leishmania major Metacyclogenesis Modulates Ability to Induce IL-12 (pages 400–402)

      ALEXANDRINA SARTORI, PHIL SCOTT and GIORGIO TRINCHIERI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52705.x

    26. Reversal of Orally Induced T-Cell Tolerance by Subcutaneous Administration of Interleukin-12 at the Site of Attempted Sensitization (pages 403–409)

      RIK J. SCHEPER, B. MARY E.von BLOMBERG, JAN de GROOT, DANIELLE A. E. WOLVERS, GEORG KRAAL and ANKE M. E. CLAESSEN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52706.x

    27. Serum Levels of Interleukin-10 and Interleukin-12 in Patients with Colorectal Cancer (pages 410–412)

      MASAHIKO SHIBATA, TAKESHI NEZU, MOTOO TAKEKAWA, HIDEHIRO TAKIZAWA, KATSUYUKI ANDO, HIROSHI MIYAKE, SADAO AMANO and YASUHIKO KUROSU

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52707.x

    28. Structure of the Mouse IL-12R01 Chain and Regulation of Its Expression in BCG/LPS-Treated Mice (pages 413–415)

      LOUISE C. SHOWE, MARIA WYSOCKA, BEI WANG, DONNA LINEMAN-WILLIAMS, DAVID PERITT, MICHAEL K. SHOWE and GIORGIO TRINCHIERI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52708.x

    29. Interleukin-12 as an Adjuvant in the Generation of Protective Immunity to an Intracellular Pathogen (pages 416–419)

      MARIANNE J. SKEEN, MARK A. MILLER and H. KIRK ZIEGLER

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52709.x

    30. Apoptosis Induced by Interleukin-12 Measured by DNA Electrophoresis and in Situ End Labeling in Leukemia (pages 420–421)

      K. C. STINE, B. A. WARREN and D. L. BECTON

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52710.x

    31. Acute Ethanol Treatment Augments Interleukin-12 Production in Activated Human Monocytes (pages 422–425)

      GYONGYI SZABO, LINDA GIROUARD, PRANOTI MANDREKAR and DONNA CATALANO

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52711.x

    1. The Effect of IL-12 on Immune Privilege of the Eye (pages 426–428)

      TOSHIHIKO UNO, J. WAYNE STREILEIN and BRUCE R. KSANDER

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52712.x

    2. Mechanism of the Induction of Anti-Tumor Immunity by B7.1 and Interleukin-12 (pages 429–433)

      MARIA WYSOCKA, CHRISTINA M. COUGHLIN, HOLLY L. KURZAWA, GIORGIO TRINCHIERI, STEPHEN L. ECK and WILLIAM M. F. LEE

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52713.x

    3. Evaluation of the Antitumor Activity of the Interleukin-12/Pulse Interleukin-2 Combination (pages 434–439)

      JON M. WIGGINTON, KRISTIN L. KOMSCHLIES, JEFFREY E. GREEN, GEORGE W. COX, CHERYL L. JORCYK, TIMOTHY C. BACK, JOSÉ L. FRANCO, MICHAEL J. BRUNDA and ROBERT H. WILTROUT

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52714.x

    4. Cytokine Gene Therapy of Cancer Using Interleukin-12: Murine and Clinical Trials (pages 440–454)

      MICHAEL T. LOTZE, LAURENCE ZITVOGEL, RONNA CAMPBELL, PAUL D. ROBBINS, ELAINE ELDER, CATHY HALUSZCZAK, DINA MARTIN, THERESA L. WHITESIDE, WALTER J. STORKUS and HIDEAKI TAHARA

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1996.tb52715.x

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