Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

November 1999

Volume 884 OTOTOXICITY: Basic Science and Clinical Applications

Pages ix–xi, 19–436

  1. Frontmatter

    1. Top of page
    2. Frontmatter
    3. Ototoxicity: Basic Science and Clinical Applicationsa: Part 1: Introduction
    4. Ototoxicity: Basic Science and Clinical Applicationsa: Part 2: Aminoglycosides
    5. Ototoxicity: Basic Science and Clinical Applicationsa: Part 3: Cisplatin
    6. Ototoxicity: Basic Science and Clinical Applicationsa: Part 4: Ischemia and Excitotoxicity
    7. Ototoxicity: Basic Science and Clinical Applicationsa: Part 5: General Protection Approaches
    8. Ototoxicity: Basic Science and Clinical Applicationsa: Part 6: Future Directions
    1. Introduction (pages ix–xi)

      S. IURATO, D. HENDERSON, A. QUARANTA and R. J. SALVI

      Article first published online: 6 FEB 2006 | DOI: 10.1111/j.1749-6632.1999.tb08632.x

  2. Ototoxicity: Basic Science and Clinical Applicationsa: Part 1: Introduction

    1. Top of page
    2. Frontmatter
    3. Ototoxicity: Basic Science and Clinical Applicationsa: Part 1: Introduction
    4. Ototoxicity: Basic Science and Clinical Applicationsa: Part 2: Aminoglycosides
    5. Ototoxicity: Basic Science and Clinical Applicationsa: Part 3: Cisplatin
    6. Ototoxicity: Basic Science and Clinical Applicationsa: Part 4: Ischemia and Excitotoxicity
    7. Ototoxicity: Basic Science and Clinical Applicationsa: Part 5: General Protection Approaches
    8. Ototoxicity: Basic Science and Clinical Applicationsa: Part 6: Future Directions
    1. Free Radicals and Hearing: Cause, Consequence, and Criteria (pages 19–40)

      PATRICIA EVANS and BARRY HALLIWELL

      Article first published online: 6 FEB 2006 | DOI: 10.1111/j.1749-6632.1999.tb08633.x

  3. Ototoxicity: Basic Science and Clinical Applicationsa: Part 2: Aminoglycosides

    1. Top of page
    2. Frontmatter
    3. Ototoxicity: Basic Science and Clinical Applicationsa: Part 1: Introduction
    4. Ototoxicity: Basic Science and Clinical Applicationsa: Part 2: Aminoglycosides
    5. Ototoxicity: Basic Science and Clinical Applicationsa: Part 3: Cisplatin
    6. Ototoxicity: Basic Science and Clinical Applicationsa: Part 4: Ischemia and Excitotoxicity
    7. Ototoxicity: Basic Science and Clinical Applicationsa: Part 5: General Protection Approaches
    8. Ototoxicity: Basic Science and Clinical Applicationsa: Part 6: Future Directions
    1. Acute and Chronic Effects of Aminoglycosides on Cochlear Hair Cells (pages 60–68)

      JEAN-MARIE ARAN, JEAN-PAUL ERRE, DEISE LIMA DA COSTA, IKRAM DEBBARH and DIDIER DULON

      Article first published online: 6 FEB 2006 | DOI: 10.1111/j.1749-6632.1999.tb08636.x

    2. Normal and Altered Cytoarchitecture of the Inner Ear (pages 69–84)

      A. SERRA, D. L. GRASSO, S. COCUZZA, L. TROMBETTA and I. LA MANTIA

      Article first published online: 6 FEB 2006 | DOI: 10.1111/j.1749-6632.1999.tb08637.x

    3. An Animal Model Based on the Sprague Dawley Rat for the Evaluation of Ototoxicity (pages 85–98)

      A. MARTINI, S. HATZOPOULOS, R. RUBINI, M. DI STEFANO, A. ALBERTIN and E. GOVONI

      Article first published online: 6 FEB 2006 | DOI: 10.1111/j.1749-6632.1999.tb08638.x

    4. Genetic Factors in Aminoglycoside Toxicity (pages 99–109)

      NATHAN FISCHEL-GHODSIAN

      Article first published online: 6 FEB 2006 | DOI: 10.1111/j.1749-6632.1999.tb08639.x

  4. Ototoxicity: Basic Science and Clinical Applicationsa: Part 3: Cisplatin

    1. Top of page
    2. Frontmatter
    3. Ototoxicity: Basic Science and Clinical Applicationsa: Part 1: Introduction
    4. Ototoxicity: Basic Science and Clinical Applicationsa: Part 2: Aminoglycosides
    5. Ototoxicity: Basic Science and Clinical Applicationsa: Part 3: Cisplatin
    6. Ototoxicity: Basic Science and Clinical Applicationsa: Part 4: Ischemia and Excitotoxicity
    7. Ototoxicity: Basic Science and Clinical Applicationsa: Part 5: General Protection Approaches
    8. Ototoxicity: Basic Science and Clinical Applicationsa: Part 6: Future Directions
    1. Selective Loss of Inner Hair Cells and Type-I Ganglion Neurons in Carboplatin-Treated Chinchillas: Mechanisms of Damage and Protection (pages 152–170)

      D.-L. DING, J. WANG, R. SALVI, D. HENDERSON, B.-H. HU, S. L. McFADDEN and M. MUELLER

      Article first published online: 6 FEB 2006 | DOI: 10.1111/j.1749-6632.1999.tb08640.x

    2. A Radical Demise: Toxins and Trauma Share Common Pathways in Hair Cell Death (pages 171–191)

      RICHARD KOPKE, KEITH A. ALLEN, DONALD HENDERSON, MICHAEL HOFFER, DOROTHY FRENZ and THOMAS VAN DE WATER

      Article first published online: 6 FEB 2006 | DOI: 10.1111/j.1749-6632.1999.tb08641.x

    3. Protection and Spontaneous Recovery from Cisplatin-Induced Hearing Loss (pages 192–210)

      GUIDO F. SMOORENBURG, JOHN C. M. J. DE GROOT, FRANK P. T. HAMERS and SJAAK F. L. KLIS

      Article first published online: 6 FEB 2006 | DOI: 10.1111/j.1749-6632.1999.tb08642.x

    4. Evaluation of Cisplatin Ototoxicity in a Rat Animal Model (pages 211–225)

      S. HATZOPOULOS, M. DI STEFANO, A. ALBERTIN and A. MARTINI

      Article first published online: 6 FEB 2006 | DOI: 10.1111/j.1749-6632.1999.tb08643.x

  5. Ototoxicity: Basic Science and Clinical Applicationsa: Part 4: Ischemia and Excitotoxicity

    1. Top of page
    2. Frontmatter
    3. Ototoxicity: Basic Science and Clinical Applicationsa: Part 1: Introduction
    4. Ototoxicity: Basic Science and Clinical Applicationsa: Part 2: Aminoglycosides
    5. Ototoxicity: Basic Science and Clinical Applicationsa: Part 3: Cisplatin
    6. Ototoxicity: Basic Science and Clinical Applicationsa: Part 4: Ischemia and Excitotoxicity
    7. Ototoxicity: Basic Science and Clinical Applicationsa: Part 5: General Protection Approaches
    8. Ototoxicity: Basic Science and Clinical Applicationsa: Part 6: Future Directions
    1. Mechanisms of Alterations in the Microcirculation of the Cochlea (pages 226–232)

      MICHAEL D. SEIDMAN, WAYNE S. QUIRK and NAJEEB A. SHIRWANY

      Article first published online: 6 FEB 2006 | DOI: 10.1111/j.1749-6632.1999.tb08644.x

    2. Recovery of Kainic Acid Excitotoxicity in Chinchilla Cochlea (pages 255–269)

      XIANG YANG ZHENG, RICHARD J. SALVI, SANDRA L. McFADDEN, DA LIAN DING and DONALD HENDERSON

      Article first published online: 6 FEB 2006 | DOI: 10.1111/j.1749-6632.1999.tb08647.x

  6. Ototoxicity: Basic Science and Clinical Applicationsa: Part 5: General Protection Approaches

    1. Top of page
    2. Frontmatter
    3. Ototoxicity: Basic Science and Clinical Applicationsa: Part 1: Introduction
    4. Ototoxicity: Basic Science and Clinical Applicationsa: Part 2: Aminoglycosides
    5. Ototoxicity: Basic Science and Clinical Applicationsa: Part 3: Cisplatin
    6. Ototoxicity: Basic Science and Clinical Applicationsa: Part 4: Ischemia and Excitotoxicity
    7. Ototoxicity: Basic Science and Clinical Applicationsa: Part 5: General Protection Approaches
    8. Ototoxicity: Basic Science and Clinical Applicationsa: Part 6: Future Directions
    1. Glial Cell Line-Derived Neurotrophic Factor: Potential for Otoprotection (pages 270–291)

      R. KUANG, G. HEVER, G. ZAJIC, Q. YAN, F. COLLINS, J.-C. LOUIS, E. KEITHLEY and E. MAGAL

      Article first published online: 6 FEB 2006 | DOI: 10.1111/j.1749-6632.1999.tb08648.x

    2. Neurotrophic Factors in the Auditory Periphery (pages 292–304)

      LIANG XING QUN, ULLA PIRVOLA, MART SAARMA and JUKKA YLIKOSKI1

      Article first published online: 6 FEB 2006 | DOI: 10.1111/j.1749-6632.1999.tb08649.x

    3. Rescue and Regrowth of Sensory Nerves Following Deafferentation by Neurotrophic Factors (pages 305–311)

      R. A. ALTSCHULER, Y. CHO, J. YLIKOSKI, U. PIRVOLA, E. MAGAL and J. M. MILLER

      Article first published online: 6 FEB 2006 | DOI: 10.1111/j.1749-6632.1999.tb08650.x

    4. Treatment of Acoustic Trauma (pages 328–344)

      CHRISTINE D'ALDIN, LILY CHERNY, FRANCIS DEVRIÈRE and A. DANCER

      Article first published online: 6 FEB 2006 | DOI: 10.1111/j.1749-6632.1999.tb08652.x

    5. Gene Therapy in the Inner Ear: Mechanisms and Clinical Implications (pages 345–360)

      THOMAS R. VAN DE WATER, HINRICH STAECKER, MARC W. HALTERMAN and HOWARD J. FEDEROFF

      Article first published online: 6 FEB 2006 | DOI: 10.1111/j.1749-6632.1999.tb08653.x

    6. Protective Effect of the Cochlear Efferent System During Noise Exposure (pages 361–367)

      GIUSEPPE ATTANASIO, MAURIZIO BARBARA, GIUSEPPE BUONGIORNO, ALDO CORDIER, BARBARA MAFERA, FEDERICO PICCOLI, GABRIELE NOSTRO and ROBERTO FILIPO

      Article first published online: 6 FEB 2006 | DOI: 10.1111/j.1749-6632.1999.tb08654.x

    7. The Role of Antioxidants in Protection from Impulse Noise (pages 368–380)

      D. HENDERSON, S. L. MCFADDEN, C. C. LIU, N. HIGHT and X. Y. ZHENG

      Article first published online: 6 FEB 2006 | DOI: 10.1111/j.1749-6632.1999.tb08655.x

    8. Gender-Specific Effects of Drugs on Hearing Levels of Older Persons (pages 381–388)

      JOHN H. MILLS, LOIS J. MATTHEWS, FU-SHING LEE, JUDY R. DUBNO, BRADLEY A. SCHULTE and PETER C. WEBER

      Article first published online: 6 FEB 2006 | DOI: 10.1111/j.1749-6632.1999.tb08656.x

    9. Dynamic Studies of Ototoxicity in Mature Avian Auditory Epithelium (pages 389–409)

      KEIKO HIROSE, LESNICK E. WESTRUM, JENNIFER S. STONE, LANCE ZIRPEL and EDWIN W RUBEL

      Article first published online: 6 FEB 2006 | DOI: 10.1111/j.1749-6632.1999.tb08657.x

  7. Ototoxicity: Basic Science and Clinical Applicationsa: Part 6: Future Directions

    1. Top of page
    2. Frontmatter
    3. Ototoxicity: Basic Science and Clinical Applicationsa: Part 1: Introduction
    4. Ototoxicity: Basic Science and Clinical Applicationsa: Part 2: Aminoglycosides
    5. Ototoxicity: Basic Science and Clinical Applicationsa: Part 3: Cisplatin
    6. Ototoxicity: Basic Science and Clinical Applicationsa: Part 4: Ischemia and Excitotoxicity
    7. Ototoxicity: Basic Science and Clinical Applicationsa: Part 5: General Protection Approaches
    8. Ototoxicity: Basic Science and Clinical Applicationsa: Part 6: Future Directions
    1. Cochlear Effects of Mesna Application into the Middle Ear (pages 425–432)

      V. VINCENTI, M. MONDAIN, E. PASANISI, F. PIAZZA, J.-L. PUEL, S. BACCIU, N. QUARANTA, A. UZIEL and C. ZINI

      Article first published online: 6 FEB 2006 | DOI: 10.1111/j.1749-6632.1999.tb08659.x

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