Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

September 2000

Volume 919 TOXICOLOGY FOR THE NEXT MILLENNIUM

Pages ix–xii, 1–321

  1. Frontmatter

    1. Top of page
    2. Frontmatter
    3. Toxicology for the Next Millennium: Part I. Molecular Technologies
    4. Toxicology for the Next Millennium: Part II. Cellular/Organismal Technologies
    5. Toxicology for the Next Millennium: Part III. Genomics/Proteomics
    6. Toxicology for the Next Millennium: Part IV. Computer Modeling/Bioinformatics
    7. Toxicology for the Next Millennium: Part V. Cancer
    8. Toxicology for the Next Millennium: Part VI. Neurotoxicology
    9. Toxicology for the Next Millennium: Part VII. Acute Toxicology
    10. Toxicology for the Next Millennium: Part VIII. Immunotoxicology
    11. Toxicology for the Next Millennium: Part IX. Developmental Toxicology
    12. Toxicology for the Next Millennium: Part X. Poster Papers
    1. Introduction (pages ix–x)

      ROBERT J. ISFORT

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06859.x

    2. What's Important about Toxicology? (pages xi–xii)

      JOSHUA LEDERBERG

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06860.x

  2. Toxicology for the Next Millennium: Part I. Molecular Technologies

    1. Top of page
    2. Frontmatter
    3. Toxicology for the Next Millennium: Part I. Molecular Technologies
    4. Toxicology for the Next Millennium: Part II. Cellular/Organismal Technologies
    5. Toxicology for the Next Millennium: Part III. Genomics/Proteomics
    6. Toxicology for the Next Millennium: Part IV. Computer Modeling/Bioinformatics
    7. Toxicology for the Next Millennium: Part V. Cancer
    8. Toxicology for the Next Millennium: Part VI. Neurotoxicology
    9. Toxicology for the Next Millennium: Part VII. Acute Toxicology
    10. Toxicology for the Next Millennium: Part VIII. Immunotoxicology
    11. Toxicology for the Next Millennium: Part IX. Developmental Toxicology
    12. Toxicology for the Next Millennium: Part X. Poster Papers
    1. Use of Oligonucleotide Arrays to Analyze Drug Toxicity (pages 1–8)

      NAFTALI KAMINSKI, JOHN ALLARD and RENU A. HELLER

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06861.x

    2. Analysis of Drug Pharmacology towards Predicting Drug Behavior by Expression Profiling Using High-Density Oligonucleotide Arrays (pages 9–15)

      JING-SHAN HU, MARK DURST, REINHOLD KERB, VIVI TRUONG, JING-TYAN MA, ELINA KHURGIN, DAVID BALABAN, THOMAS R. GINGERAS and BRIAN B. HOFFMAN

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06862.x

  3. Toxicology for the Next Millennium: Part II. Cellular/Organismal Technologies

    1. Top of page
    2. Frontmatter
    3. Toxicology for the Next Millennium: Part I. Molecular Technologies
    4. Toxicology for the Next Millennium: Part II. Cellular/Organismal Technologies
    5. Toxicology for the Next Millennium: Part III. Genomics/Proteomics
    6. Toxicology for the Next Millennium: Part IV. Computer Modeling/Bioinformatics
    7. Toxicology for the Next Millennium: Part V. Cancer
    8. Toxicology for the Next Millennium: Part VI. Neurotoxicology
    9. Toxicology for the Next Millennium: Part VII. Acute Toxicology
    10. Toxicology for the Next Millennium: Part VIII. Immunotoxicology
    11. Toxicology for the Next Millennium: Part IX. Developmental Toxicology
    12. Toxicology for the Next Millennium: Part X. Poster Papers
    1. Fluorometric High-Throughput Screening for Inhibitors of Cytochrome P450 (pages 26–32)

      VAUGHN P. MILLER, DAVID M. STRESSER, ANDREW P. BLANCHARD, STEPHANIE TURNER and CHARLES L. CRESPI

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06864.x

  4. Toxicology for the Next Millennium: Part III. Genomics/Proteomics

    1. Top of page
    2. Frontmatter
    3. Toxicology for the Next Millennium: Part I. Molecular Technologies
    4. Toxicology for the Next Millennium: Part II. Cellular/Organismal Technologies
    5. Toxicology for the Next Millennium: Part III. Genomics/Proteomics
    6. Toxicology for the Next Millennium: Part IV. Computer Modeling/Bioinformatics
    7. Toxicology for the Next Millennium: Part V. Cancer
    8. Toxicology for the Next Millennium: Part VI. Neurotoxicology
    9. Toxicology for the Next Millennium: Part VII. Acute Toxicology
    10. Toxicology for the Next Millennium: Part VIII. Immunotoxicology
    11. Toxicology for the Next Millennium: Part IX. Developmental Toxicology
    12. Toxicology for the Next Millennium: Part X. Poster Papers
    1. Quantitative Proteome Analysis: Methods and Applications (pages 33–47)

      RUEDI AEBERSOLD, BEATE RIST and STEVEN P. GYGI

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06865.x

    2. Pharmaceutical Proteomics (pages 48–51)

      SANDRA STEINER and N. LEIGH ANDERSON

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06866.x

  5. Toxicology for the Next Millennium: Part IV. Computer Modeling/Bioinformatics

    1. Top of page
    2. Frontmatter
    3. Toxicology for the Next Millennium: Part I. Molecular Technologies
    4. Toxicology for the Next Millennium: Part II. Cellular/Organismal Technologies
    5. Toxicology for the Next Millennium: Part III. Genomics/Proteomics
    6. Toxicology for the Next Millennium: Part IV. Computer Modeling/Bioinformatics
    7. Toxicology for the Next Millennium: Part V. Cancer
    8. Toxicology for the Next Millennium: Part VI. Neurotoxicology
    9. Toxicology for the Next Millennium: Part VII. Acute Toxicology
    10. Toxicology for the Next Millennium: Part VIII. Immunotoxicology
    11. Toxicology for the Next Millennium: Part IX. Developmental Toxicology
    12. Toxicology for the Next Millennium: Part X. Poster Papers
    1. Gene Expression Microarray Data Analysis for Toxicology Profiling (pages 52–67)

      M. J. CUNNINGHAM, S. LIANG, S. FURMAN, J. J. SEILHAMER and R. SOMOGYI

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06867.x

    2. In Silico Toxicology (pages 68–74)

      SAMUEL HOLTZMAN

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06868.x

    3. Toxicity Testing: The FDA Perspective (pages 75–78)

      JANE E. HENNEY

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06869.x

  6. Toxicology for the Next Millennium: Part V. Cancer

    1. Top of page
    2. Frontmatter
    3. Toxicology for the Next Millennium: Part I. Molecular Technologies
    4. Toxicology for the Next Millennium: Part II. Cellular/Organismal Technologies
    5. Toxicology for the Next Millennium: Part III. Genomics/Proteomics
    6. Toxicology for the Next Millennium: Part IV. Computer Modeling/Bioinformatics
    7. Toxicology for the Next Millennium: Part V. Cancer
    8. Toxicology for the Next Millennium: Part VI. Neurotoxicology
    9. Toxicology for the Next Millennium: Part VII. Acute Toxicology
    10. Toxicology for the Next Millennium: Part VIII. Immunotoxicology
    11. Toxicology for the Next Millennium: Part IX. Developmental Toxicology
    12. Toxicology for the Next Millennium: Part X. Poster Papers
  7. Toxicology for the Next Millennium: Part VI. Neurotoxicology

    1. Top of page
    2. Frontmatter
    3. Toxicology for the Next Millennium: Part I. Molecular Technologies
    4. Toxicology for the Next Millennium: Part II. Cellular/Organismal Technologies
    5. Toxicology for the Next Millennium: Part III. Genomics/Proteomics
    6. Toxicology for the Next Millennium: Part IV. Computer Modeling/Bioinformatics
    7. Toxicology for the Next Millennium: Part V. Cancer
    8. Toxicology for the Next Millennium: Part VI. Neurotoxicology
    9. Toxicology for the Next Millennium: Part VII. Acute Toxicology
    10. Toxicology for the Next Millennium: Part VIII. Immunotoxicology
    11. Toxicology for the Next Millennium: Part IX. Developmental Toxicology
    12. Toxicology for the Next Millennium: Part X. Poster Papers
    1. Culture Models of Neurodegenerative Disease (pages 106–118)

      D. A. FIGLEWICZ, L. DONG, M. MLODZIENSKI and J. C. TURCOTTE

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06873.x

  8. Toxicology for the Next Millennium: Part VII. Acute Toxicology

    1. Top of page
    2. Frontmatter
    3. Toxicology for the Next Millennium: Part I. Molecular Technologies
    4. Toxicology for the Next Millennium: Part II. Cellular/Organismal Technologies
    5. Toxicology for the Next Millennium: Part III. Genomics/Proteomics
    6. Toxicology for the Next Millennium: Part IV. Computer Modeling/Bioinformatics
    7. Toxicology for the Next Millennium: Part V. Cancer
    8. Toxicology for the Next Millennium: Part VI. Neurotoxicology
    9. Toxicology for the Next Millennium: Part VII. Acute Toxicology
    10. Toxicology for the Next Millennium: Part VIII. Immunotoxicology
    11. Toxicology for the Next Millennium: Part IX. Developmental Toxicology
    12. Toxicology for the Next Millennium: Part X. Poster Papers
    1. Transgenic Zebrafish as Sentinels for Aquatic Pollution (pages 133–147)

      MICHAEL J. CARVAN III, TIMOTHY P. DALTON, GARY W. STUART and DANIEL W. NEBERT

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06875.x

    2. “Gene-Swap Knock-in” Cassette in Mice to Study Allelic Differences in Human Genes (pages 148–170)

      DANIEL W. NEBERT, TIMOTHY P. DALTON, GARY W. STUART and MICHAEL J. CARVAN III

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06876.x

    3. The Use of Explant Lens Culture to Assess Cataractogenic Potential (pages 171–187)

      MICHAEL D. ALEO, MICHAEL J. AVERY, WILLIAM P. BEIERSCHMITT, CYNTHIA A. DRUPA, JAY H. FORTNER, ADAM H. KAPLAN, KIMBERLY A. NAVETTA, RICHARD M. SHEPARD and COLLEEN M. WALSH

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06877.x

    4. In Vitro Percutaneous Absorption Models (pages 188–191)

      ROBERT L. BRONAUGH

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06878.x

    5. In Vitro and Human Testing Strategies for Skin Irritation (pages 192–204)

      MICHAEL K. ROBINSON, ROSEMARIE OSBORNE and MARY A. PERKINS

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06879.x

  9. Toxicology for the Next Millennium: Part VIII. Immunotoxicology

    1. Top of page
    2. Frontmatter
    3. Toxicology for the Next Millennium: Part I. Molecular Technologies
    4. Toxicology for the Next Millennium: Part II. Cellular/Organismal Technologies
    5. Toxicology for the Next Millennium: Part III. Genomics/Proteomics
    6. Toxicology for the Next Millennium: Part IV. Computer Modeling/Bioinformatics
    7. Toxicology for the Next Millennium: Part V. Cancer
    8. Toxicology for the Next Millennium: Part VI. Neurotoxicology
    9. Toxicology for the Next Millennium: Part VII. Acute Toxicology
    10. Toxicology for the Next Millennium: Part VIII. Immunotoxicology
    11. Toxicology for the Next Millennium: Part IX. Developmental Toxicology
    12. Toxicology for the Next Millennium: Part X. Poster Papers
    1. New Technologies to Prevent and Treat Contact Hypersensitivity Responses (pages 205–213)

      AKIRA TAKASHIMA, MARK MUMMERT, TOSHIYUKI KITAJIMA and HIROYUKI MATSUE

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06880.x

    2. The Role of Tumor Necrosis Factor α in Chemical-Induced Hepatotoxicity (pages 214–220)

      MICHAEL I. LUSTER, PETIA P. SIMEONOVA, RANDLE M. GALLUCCI, ALEX BRUCCOLERI, MARK E. BLAZKA, BERRAN YUCESOY and JOANNA M. MATHESON

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06881.x

    3. Aging and Resistance to Trichinella spiralis Infection following Xenobiotic Exposure (pages 221–229)

      ROBERT W. LUEBKE, CAREY B. COPELAND and DEBORA L. ANDREWS

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06882.x

    4. Animal Models to Assess the Effects of Air Pollutants on Allergic Lung Disease (pages 230–238)

      MARYJANE K. SELGRADE, AMY L. LAMBERT, MARSHA D. W. WARD and M. IAN GILMOUR

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06883.x

  10. Toxicology for the Next Millennium: Part IX. Developmental Toxicology

    1. Top of page
    2. Frontmatter
    3. Toxicology for the Next Millennium: Part I. Molecular Technologies
    4. Toxicology for the Next Millennium: Part II. Cellular/Organismal Technologies
    5. Toxicology for the Next Millennium: Part III. Genomics/Proteomics
    6. Toxicology for the Next Millennium: Part IV. Computer Modeling/Bioinformatics
    7. Toxicology for the Next Millennium: Part V. Cancer
    8. Toxicology for the Next Millennium: Part VI. Neurotoxicology
    9. Toxicology for the Next Millennium: Part VII. Acute Toxicology
    10. Toxicology for the Next Millennium: Part VIII. Immunotoxicology
    11. Toxicology for the Next Millennium: Part IX. Developmental Toxicology
    12. Toxicology for the Next Millennium: Part X. Poster Papers
    1. From Developmental Biology to Developmental Toxicology (pages 239–245)

      RUDI BALLING and MARTIN HRABÉ DE ANGELIS

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06884.x

    2. Genetic Basis of Susceptibility to Environmentally Induced Neural Tube Defects (pages 261–277)

      RICHARD H. FINNELL, JANEE GELINEAU-VAN WAES, GREGORY D. BENNETT, ROBERT C. BARBER, BOGDAN WLODARCZYK, GARY M. SHAW, EDWARD J. LAMMER, JORGE A. PIEDRAHITA and JAMES H. EBERWINE

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06886.x

    3. Transient Modulation of Gene Expression in the Neurulation Staged Mouse Embryo (pages 278–283)

      E. SIDNEY HUNTER III and PHILLIP HARTIG

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06887.x

  11. Toxicology for the Next Millennium: Part X. Poster Papers

    1. Top of page
    2. Frontmatter
    3. Toxicology for the Next Millennium: Part I. Molecular Technologies
    4. Toxicology for the Next Millennium: Part II. Cellular/Organismal Technologies
    5. Toxicology for the Next Millennium: Part III. Genomics/Proteomics
    6. Toxicology for the Next Millennium: Part IV. Computer Modeling/Bioinformatics
    7. Toxicology for the Next Millennium: Part V. Cancer
    8. Toxicology for the Next Millennium: Part VI. Neurotoxicology
    9. Toxicology for the Next Millennium: Part VII. Acute Toxicology
    10. Toxicology for the Next Millennium: Part VIII. Immunotoxicology
    11. Toxicology for the Next Millennium: Part IX. Developmental Toxicology
    12. Toxicology for the Next Millennium: Part X. Poster Papers
    1. Use of Bone Marrow Chimeras to Identify Cell Targets in the Immune System for the Actions of Chemicals (pages 300–303)

      THOMAS A. GASIEWICZ, T. SCOTT THURMOND, J. ERIN STAPLES, FRANCIS G. MURANTE and ALLEN E. SILVERSTONE

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06890.x

    2. The Effects of Lead on PKC Isoforms (pages 304–306)

      ALDO A. COPPI, JACOB LESNIAK, DIANE ZIEBA and FRANCIS A. X. SCHANNE

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06891.x

    3. Lead-Induced Activation of Protein Kinase C in Rat Brain Cortical Synaptosomes (pages 307–311)

      CHRISTOPHER D. TOSCANO and FRANCIS A.X. SCHANNE

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06892.x

    4. Toxicity of Ethylene Glycol Metabolites in Normal Human Kidney Cells (pages 315–317)

      K. E. McMARTIN and T. A. CENAC

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06894.x

    5. Concluding Remarks (page 321)

      ROBERT J. ISFORT

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06896.x

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