Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

December 2000

Volume 920 THE MOLECULAR BASIS OF DEMENTIA

Pages xi–xii, 1–335

  1. Frontmatter

    1. Top of page
    2. Frontmatter
    3. The Molecular Basis of Dementia: Part I. α-Synuclein in Neurodegenerative Disease
    4. The Molecular Basis of Dementia: Part II. Novel Mutations in Dementia
    5. The Molecular Basis of Dementia: Part III. Transgenic and Knockout Approaches to Neurodegenerative Diseases
    6. The Molecular Basis of Dementia: Part IV. Proteases in Alzheimer's Disease
    7. The Molecular Basis of Dementia: Part V. Therapies for Alzheimer's Disease beyond AChE Inhibitors
    1. Preface (pages xi–xii)

      John H. Growdon, Richard J. Wurtman, Suzanne Corkin and Roger M. Nitsch

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06897.x

  2. The Molecular Basis of Dementia: Part I. α-Synuclein in Neurodegenerative Disease

    1. Top of page
    2. Frontmatter
    3. The Molecular Basis of Dementia: Part I. α-Synuclein in Neurodegenerative Disease
    4. The Molecular Basis of Dementia: Part II. Novel Mutations in Dementia
    5. The Molecular Basis of Dementia: Part III. Transgenic and Knockout Approaches to Neurodegenerative Diseases
    6. The Molecular Basis of Dementia: Part IV. Proteases in Alzheimer's Disease
    7. The Molecular Basis of Dementia: Part V. Therapies for Alzheimer's Disease beyond AChE Inhibitors
    1. Clinical Lewy Body Syndromes (pages 1–8)

      I. G. McKEITH

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06898.x

    2. Clinical and Neuropathological Correlates of Dementia with Lewy Bodies (pages 9–15)

      E. GÓMEZ-TORTOSA, M. C. IRIZARRY, T. GÓMEZ-ISLA and B. T. HYMAN

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06899.x

    3. Genetics of Parkinson's Disease (pages 28–32)

      MIHAEL H. POLYMEROPOULOS

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06901.x

    4. Accelerated Oligomerization by Parkinson's Disease Linked α-Synuclein Mutants (pages 42–45)

      K. A. CONWAY, S.-J LEE, J.-C ROCHET, T. T. DING, J. D. HARPER, R. E. WILLIAMSON and P. T. LANSBURY JR.

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06903.x

  3. The Molecular Basis of Dementia: Part II. Novel Mutations in Dementia

    1. Top of page
    2. Frontmatter
    3. The Molecular Basis of Dementia: Part I. α-Synuclein in Neurodegenerative Disease
    4. The Molecular Basis of Dementia: Part II. Novel Mutations in Dementia
    5. The Molecular Basis of Dementia: Part III. Transgenic and Knockout Approaches to Neurodegenerative Diseases
    6. The Molecular Basis of Dementia: Part IV. Proteases in Alzheimer's Disease
    7. The Molecular Basis of Dementia: Part V. Therapies for Alzheimer's Disease beyond AChE Inhibitors
    1. Classification and Description of Frontotemporal Dementias (pages 46–51)

      D. NEARY, J. S. SNOWDEN and D. M.A. MANN

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06904.x

    2. Progress in Hereditary Tauopathies: A Mutation in the Tau Gene (G389R) Causes a Pick Disease-like Syndrome (pages 52–62)

      BERNARDINO GHETTI, JILL R. MURRELL, PAOLO ZOLO, MARIA GRAZIA SPILLANTINI and MICHEL GOEDERT

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06905.x

    3. Amyloidogenesis in Familial British Dementia Is Associated with a Genetic Defect on Chromosome 13 (pages 84–92)

      J. GHISO, R. VIDAL, A. ROSTAGNO, L. MIRAVALLE, J. L. HOLTON, S. MEAD, T. RÉVÉSZ, G. PLANT and B. FRANGIONE

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06908.x

    4. Familial British Dementia: Expression and Metabolism of BRI (pages 93–99)

      SEONG-HUN KIM, RONG WANG, DAVID J. GORDON, JOSEPH BASS, DONALD F. STEINER, GOPAL THINAKARAN, DAVID G. LYNN, STEPHEN C. MEREDITH and SANGRAM S. SISODIA

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06909.x

    5. High Frequency of Mutations in Four Different Disease Genes in Early-Onset Dementia (pages 100–106)

      ULRICH FINCKH, TOMAS MÜLLER-THOMSEN, ULRIKE MANN, CHRISTIAN EGGERS, JOSEF MARKSTEINER, WOLFGANG MEINS, GIULIANO BINETTI, ANTONELLA ALBERICI, PETER SONDEREGGER, CHRISTOPH HOCK, ROGER M. NITSCH and ANDREAS GAL

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06910.x

    6. Pathological Tau Phenotypes: The Weight of Mutations, Polymorphisms, and Differential Neuronal Vulnerabilities (pages 107–114)

      CHRISTEL MAILLIOT, THIERRY BUSSIÈRE, MALIKA HAMDANE, NICOLAS SERGEANT, MARIE-LAURE CAILLET, ANDRÉ DELACOURTE and LUC BUÉE

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06911.x

    7. Coexistent Tau and Amyloid Pathology in Hereditary Frontotemporal Dementia with Tau Mutations (pages 115–119)

      S. M. ROSSO, W. KAMPHORST, R. RAVID and J. C. Van SWIETEN

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06912.x

    8. The Clinical Spectrum of Guam ALS and Parkinson-Dementia Complex: 1997–1999 (pages 120–125)

      DOUGLAS GALASKO, DAVID SALMON, ULLA-KATRINA CRAIG and WIGBERT WIEDERHOLT

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06913.x

  4. The Molecular Basis of Dementia: Part III. Transgenic and Knockout Approaches to Neurodegenerative Diseases

    1. Top of page
    2. Frontmatter
    3. The Molecular Basis of Dementia: Part I. α-Synuclein in Neurodegenerative Disease
    4. The Molecular Basis of Dementia: Part II. Novel Mutations in Dementia
    5. The Molecular Basis of Dementia: Part III. Transgenic and Knockout Approaches to Neurodegenerative Diseases
    6. The Molecular Basis of Dementia: Part IV. Proteases in Alzheimer's Disease
    7. The Molecular Basis of Dementia: Part V. Therapies for Alzheimer's Disease beyond AChE Inhibitors
    1. In Vivo Analysis of Wild-type and FTDP-17 Tau Transgenic Mice (pages 126–133)

      J. GÖTZ, R. BARMETTLER, A. FERRARI, M. GOEDERT, A. PROBST and R. M. NITSCH

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06914.x

    2. Pathogenic Mechanisms of Alzheimer's Disease Analyzed in the APP23 Transgenic Mouse Model (pages 134–139)

      CHRISTINE STURCHLER-PIERRAT and MATTHIAS STAUFENBIEL

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06915.x

    3. Prions: Pathogenesis and Reverse Genetics (pages 140–157)

      ADRIANO AGUZZI, MICHAEL A. KLEIN, FABIO MONTRASIO, VLADIMIR PEKARIK, SEBASTIAN BRANDNER, HISAKO FURUKAWA, PASCAL KÄSER, CHRISTIANE RÖCKL and MARKUS GLATZEL

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06916.x

    4. Presenilin Function in APP Processing (pages 158–164)

      WIM ANNAERT, PHILIPPE CUPERS, PAUL SAFTIG and BART DE STROOPER

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06917.x

    5. Role of Presenilin-1 in Murine Neural Development (pages 165–170)

      XUDONG YANG, MELISSA HANDLER and JIE SHEN

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06918.x

    6. Modulation of Aβ Deposition in APP Transgenic Mice by an Apolipoprotein E Null Background (pages 171–178)

      M. C. IRIZARRY, G. W. REBECK, B. CHEUNG, K. BALES, S. M PAUL, D. HOLZMAN and B. T. HYMAN

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06919.x

    7. The Value of Transgenic Models for the Study of Neurodegenerative Diseases (pages 179–191)

      DONALD L. PRICE, PHILIP C. WONG, ALICJA L. MARKOWSKA, MICHAEL K. LEE, GOPAL THINAKAREN, DONALD W. CLEVELAND, SANGRAM S. SISODIA and DAVID R. BORCHELT

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06920.x

  5. The Molecular Basis of Dementia: Part IV. Proteases in Alzheimer's Disease

    1. Top of page
    2. Frontmatter
    3. The Molecular Basis of Dementia: Part I. α-Synuclein in Neurodegenerative Disease
    4. The Molecular Basis of Dementia: Part II. Novel Mutations in Dementia
    5. The Molecular Basis of Dementia: Part III. Transgenic and Knockout Approaches to Neurodegenerative Diseases
    6. The Molecular Basis of Dementia: Part IV. Proteases in Alzheimer's Disease
    7. The Molecular Basis of Dementia: Part V. Therapies for Alzheimer's Disease beyond AChE Inhibitors
    1. Toward the Characterization and Identification of γ-Secretases Using Transition-state Analogue Inhibitors (pages 197–205)

      CHAD L. MOORE, THEKLA S. DIEHL, DENNIS J. SELKOE and MICHAEL S. WOLFE

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06922.x

    2. Recent Advances in the Understanding of the Processing of APP to Beta Amyloid Peptide (pages 206–208)

      S. SINHA, J. ANDERSON, V. JOHN, L. McCONLOGUE, G. BASI, E. THORSETT and D. SCHENK

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06923.x

    3. Presenilin-1: A Component of Synaptic and Endothelial Adherens Junctions (pages 209–214)

      ANASTASIOS GEORGAKOPOULOS, PHILIPPE MARAMBAUD, VICTOR L. FRIEDRICH JR., JUNICHI SHIOI, SPIROS EFTHIMIOPOULOS and NIKOLAOS K. ROBAKIS

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06924.x

    4. α-Secretase Activity of the Disintegrin Metalloprotease ADAM 10: Influences of Domain Structure (pages 215–222)

      FALK FAHRENHOLZ, SANDRA GILBERT, ELZBIETA KOJRO, SVEN LAMMICH and ROLF POSTINA

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06925.x

    5. Rapid Notch1 Nuclear Translocation after Ligand Binding Depends on Presenilin-associated γ-Secretase Activity (pages 223–226)

      OKSANA BEREZOVSKA, CHRISTINE JACK, PAMELA McLEAN, JON C. ASTER, CAROL HICKS, WEIMING XIA, MICHAEL S. WOLFE, GERRY WEINMASTER, DENNIS J. SELKOE and BRADLEY T. HYMAN

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06926.x

    6. An Empirical Model of γ-Secretase Activity (pages 233–240)

      M. P. MURPHY, R. WANG, P. E. FRASER, A. FAUQ and T. E. GOLDE

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06928.x

    7. Overexpression of Presenilin-2 Enhances Apoptotic Death of Cultured Cortical Neurons (pages 241–244)

      W. ARAKI, K. YUASA, S. TAKEDA, K. SHIROTANI, K. TAKAHASHI and T. TABIRA

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06929.x

    8. α1-Antichymotrypsin Inhibits Aβ Degradation in Vitro and in Vivo (pages 245–248)

      CARMELA R. ABRAHAM, WALKER T. McGRAW, FRANCHOT SLOT and RINA YAMIN

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06930.x

    9. Activated Mitogenic Signaling Induces a Process of Dedifferentiation in Alzheimer's Disease That Eventually Results in Cell Death (pages 249–255)

      THOMAS ARENDT, MAX HOLZER, ANDREA STÖBE, ULRICH GÄRTNER, HANS-JOACHIM LÜTH, MARTINA K. BRÜCKNER and UWE UEBERHAM

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06931.x

    10. Inhibition of the Neuronal Insulin Receptor An in Vivo Model for Sporadic Alzheimer Disease? (pages 256–258)

      SIEGFRIED HOYER, SAE KYUNG LEE, THOMAS LÖFFLER and REINHARD SCHLIEBS

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06932.x

    11. Cytoplasmic Presenilin Aggregates in Proteasome Inhibitor-treated Cells (pages 259–260)

      L.A. MacKENZIE INGANO, K. M. LENTINI, I. KOVACS, R. E. TANZI and D. M. KOVACS

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06933.x

  6. The Molecular Basis of Dementia: Part V. Therapies for Alzheimer's Disease beyond AChE Inhibitors

    1. Top of page
    2. Frontmatter
    3. The Molecular Basis of Dementia: Part I. α-Synuclein in Neurodegenerative Disease
    4. The Molecular Basis of Dementia: Part II. Novel Mutations in Dementia
    5. The Molecular Basis of Dementia: Part III. Transgenic and Knockout Approaches to Neurodegenerative Diseases
    6. The Molecular Basis of Dementia: Part IV. Proteases in Alzheimer's Disease
    7. The Molecular Basis of Dementia: Part V. Therapies for Alzheimer's Disease beyond AChE Inhibitors
    1. Prevention and Reduction of AD-type Pathology in PDAPP Mice Immunized with Aβ1–42 (pages 274–284)

      DORA GAMES, FREDERIQUE BARD, HENRY GRAJEDA, TERRY GUIDO, KAREN KHAN, FERDIE SORIANO, NICKI VASQUEZ, NANCY WEHNER, KELLY JOHNSON-WOOD, TED YEDNOCK, PETER SEUBERT and DALE SCHENK

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06936.x

    2. Treatment with the Selective Muscarinic Agonist Talsaclidine Decreases Cerebrospinal Fluid Levels of Total Amyloid β-Peptide in Patients with Alzheimer's Disease (pages 285–291)

      C. HOCK, A. MADDALENA, I. HEUSER, D. NABER, W. OERTEL, H. VON DER KAMMER, M. WIENRICH, A. RASCHIG, M. DENG, J. H. GROWDON and R. M. NITSCH

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06937.x

    3. Metal Chelation as a Potential Therapy for Alzheimer's Disease (pages 292–304)

      MATH P. CUAJUNGCO, KYLE Y. FAGÉT, XUDONG HUANG, RUDOLPH E. TANZI and ASHLEY I. BUSH

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06938.x

    4. Regulation of Gene Expression by Muscarinic Acetylcholine Receptors: A Comprehensive Approach for the Identification of Regulated Genes (pages 305–308)

      HEINZ VON DER KAMMER, MANUEL MAYHAUS, CLAUDIA ALBRECHT, BARBARA ANDRESEN, JAROSLAV KLAUDINY, CÜNEYT DEMIRALAY and ROGER M. NITSCH

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06939.x

    5. M1 Muscarinic Agonists as Potential Disease-Modifying Agents in Alzheimer's Disease: Rationale and Perspectives (pages 315–320)

      A. FISHER, D.M. MICHAELSON, R. BRANDEIS, R. HARING, S. CHAPMAN and Z. PITTEL

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06941.x

    6. Nasal Aβ Treatment Induces Anti-Aβ Antibody Production and Decreases Cerebral Amyloid Burden in PD-APP Mice (pages 328–331)

      C.A. LEMERE, R. MARON, E.T. SPOONER, T.J. GRENFELL, C. MORI, R. DESAI, W. W. HANCOCK, H. L. WEINER and D. J. SELKOE

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2000.tb06943.x

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