Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

December 2001

Volume 949 SELECTIVE ESTROGEN RECEPTOR MODULATORS (SERMs)

Pages xi–xiii, 1–383

  1. Frontmatter

    1. Top of page
    2. Frontmatter
    3. Selective Estrogen Receptor Modulators (SERMs): Part I. Basic Biology of SERMs
    4. Selective Estrogen Receptor Modulators (SERMs): Part II. Cancer Treatment and Prevention
    5. Selective Estrogen Receptor Modulators (SERMs): Part III. Cardiovascular Disease
    6. Selective Estrogen Receptor Modulators (SERMs): Part IV. Osteoporosis
    7. Selective Estrogen Receptor Modulators (SERMs): Part IV. Cognitive Function
    8. Selective Estrogen Receptor Modulators (SERMs): Part V. Reproductive and Related Endocrine Considerations
    9. Selective Estrogen Receptor Modulators (SERMs): Part VI. Addressing the Benefit/Risk Ratio in Taking SERMs from Laboratory to Clinic
    10. Selective Estrogen Receptor Modulators (SERMs): Part VII. SERM Development in Industry, Academia, the NIH, and the FDA
    11. Selective Estrogen Receptor Modulators (SERMs): Everything You Wanted to Know about SERMs
    1. Preface (pages xi–xiii)

      Sherry Sherman

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2001.tb03995.x

  2. Selective Estrogen Receptor Modulators (SERMs): Part I. Basic Biology of SERMs

    1. Top of page
    2. Frontmatter
    3. Selective Estrogen Receptor Modulators (SERMs): Part I. Basic Biology of SERMs
    4. Selective Estrogen Receptor Modulators (SERMs): Part II. Cancer Treatment and Prevention
    5. Selective Estrogen Receptor Modulators (SERMs): Part III. Cardiovascular Disease
    6. Selective Estrogen Receptor Modulators (SERMs): Part IV. Osteoporosis
    7. Selective Estrogen Receptor Modulators (SERMs): Part IV. Cognitive Function
    8. Selective Estrogen Receptor Modulators (SERMs): Part V. Reproductive and Related Endocrine Considerations
    9. Selective Estrogen Receptor Modulators (SERMs): Part VI. Addressing the Benefit/Risk Ratio in Taking SERMs from Laboratory to Clinic
    10. Selective Estrogen Receptor Modulators (SERMs): Part VII. SERM Development in Industry, Academia, the NIH, and the FDA
    11. Selective Estrogen Receptor Modulators (SERMs): Everything You Wanted to Know about SERMs
    1. The Basic Biology of SERMs : Introduction (pages 1–2)

      RONALD MARGOLIS

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2001.tb03996.x

    2. Structure-Function Relationships in Estrogen Receptors and the Characterization of Novel Selective Estrogen Receptor Modulators with Unique Pharmacological Profiles (pages 6–15)

      BENITA S. KATZENELLENBOGEN, JUN SUN, WILLIAM R. HARRINGTON, DENNIS M. KRAICHELY, DESHANIE GANESSUNKER and JOHN A. KATZENELLENBOGEN

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2001.tb03998.x

    3. Developing Animal Models for Analyzing SERM Activity (pages 36–43)

      JUDITH M. A. EMMEN and KENNETH S. KORACH

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2001.tb04000.x

    4. Androgen Receptor: Structural Domains and Functional Dynamics after Ligand-Receptor Interaction (pages 44–57)

      ARUN K. ROY, RAKESH K. TYAGI, CHUNG S. SONG, YAN LAVROVSKY, SOON C. AHN, TAE-SUNG OH and BANDANA CHATTERJEE

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2001.tb04001.x

    5. Tissue-Specific Estrogen Biosynthesis and Metabolism (pages 58–67)

      EVAN R. SIMPSON, COLIN CLYNE, CAROLINE SPEED, GARY RUBIN and SERDAR BULUN

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2001.tb04002.x

  3. Selective Estrogen Receptor Modulators (SERMs): Part II. Cancer Treatment and Prevention

    1. Top of page
    2. Frontmatter
    3. Selective Estrogen Receptor Modulators (SERMs): Part I. Basic Biology of SERMs
    4. Selective Estrogen Receptor Modulators (SERMs): Part II. Cancer Treatment and Prevention
    5. Selective Estrogen Receptor Modulators (SERMs): Part III. Cardiovascular Disease
    6. Selective Estrogen Receptor Modulators (SERMs): Part IV. Osteoporosis
    7. Selective Estrogen Receptor Modulators (SERMs): Part IV. Cognitive Function
    8. Selective Estrogen Receptor Modulators (SERMs): Part V. Reproductive and Related Endocrine Considerations
    9. Selective Estrogen Receptor Modulators (SERMs): Part VI. Addressing the Benefit/Risk Ratio in Taking SERMs from Laboratory to Clinic
    10. Selective Estrogen Receptor Modulators (SERMs): Part VII. SERM Development in Industry, Academia, the NIH, and the FDA
    11. Selective Estrogen Receptor Modulators (SERMs): Everything You Wanted to Know about SERMs
    1. Cancer Treatment and Prevention : Introduction (pages 68–71)

      BARBARA K. DUNN and BARRY KRAMER

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2001.tb04003.x

    2. Use of SERMs for the Adjuvant Therapy of Early-Stage Breast Cancer (pages 80–88)

      ANTONIO C. WOLFF and NANCY E. DAVIDSON

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2001.tb04005.x

    3. The Italian Breast Cancer Prevention Trial with Tamoxifen : Findings and New Perspectives (pages 113–122)

      ALIANA GUERRIERI-GONZAGA, ARIANNA GALLI, NICOLE ROTMENSZ and ANDREA DECENSI

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2001.tb04009.x

  4. Selective Estrogen Receptor Modulators (SERMs): Part III. Cardiovascular Disease

    1. Top of page
    2. Frontmatter
    3. Selective Estrogen Receptor Modulators (SERMs): Part I. Basic Biology of SERMs
    4. Selective Estrogen Receptor Modulators (SERMs): Part II. Cancer Treatment and Prevention
    5. Selective Estrogen Receptor Modulators (SERMs): Part III. Cardiovascular Disease
    6. Selective Estrogen Receptor Modulators (SERMs): Part IV. Osteoporosis
    7. Selective Estrogen Receptor Modulators (SERMs): Part IV. Cognitive Function
    8. Selective Estrogen Receptor Modulators (SERMs): Part V. Reproductive and Related Endocrine Considerations
    9. Selective Estrogen Receptor Modulators (SERMs): Part VI. Addressing the Benefit/Risk Ratio in Taking SERMs from Laboratory to Clinic
    10. Selective Estrogen Receptor Modulators (SERMs): Part VII. SERM Development in Industry, Academia, the NIH, and the FDA
    11. Selective Estrogen Receptor Modulators (SERMs): Everything You Wanted to Know about SERMs
    1. Cardiovascular Trials of Estrogen Replacement Therapy (pages 153–162)

      DAVID M. HERRINGTON and KAREN POTVIN KLEIN

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2001.tb04014.x

  5. Selective Estrogen Receptor Modulators (SERMs): Part IV. Osteoporosis

    1. Top of page
    2. Frontmatter
    3. Selective Estrogen Receptor Modulators (SERMs): Part I. Basic Biology of SERMs
    4. Selective Estrogen Receptor Modulators (SERMs): Part II. Cancer Treatment and Prevention
    5. Selective Estrogen Receptor Modulators (SERMs): Part III. Cardiovascular Disease
    6. Selective Estrogen Receptor Modulators (SERMs): Part IV. Osteoporosis
    7. Selective Estrogen Receptor Modulators (SERMs): Part IV. Cognitive Function
    8. Selective Estrogen Receptor Modulators (SERMs): Part V. Reproductive and Related Endocrine Considerations
    9. Selective Estrogen Receptor Modulators (SERMs): Part VI. Addressing the Benefit/Risk Ratio in Taking SERMs from Laboratory to Clinic
    10. Selective Estrogen Receptor Modulators (SERMs): Part VII. SERM Development in Industry, Academia, the NIH, and the FDA
    11. Selective Estrogen Receptor Modulators (SERMs): Everything You Wanted to Know about SERMs
    1. Prevention and Treatment of Osteoporosis : Introduction (pages 186–187)

      SARALYN MARK and JHUMKA GUPTA

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2001.tb04019.x

  6. Selective Estrogen Receptor Modulators (SERMs): Part IV. Cognitive Function

    1. Top of page
    2. Frontmatter
    3. Selective Estrogen Receptor Modulators (SERMs): Part I. Basic Biology of SERMs
    4. Selective Estrogen Receptor Modulators (SERMs): Part II. Cancer Treatment and Prevention
    5. Selective Estrogen Receptor Modulators (SERMs): Part III. Cardiovascular Disease
    6. Selective Estrogen Receptor Modulators (SERMs): Part IV. Osteoporosis
    7. Selective Estrogen Receptor Modulators (SERMs): Part IV. Cognitive Function
    8. Selective Estrogen Receptor Modulators (SERMs): Part V. Reproductive and Related Endocrine Considerations
    9. Selective Estrogen Receptor Modulators (SERMs): Part VI. Addressing the Benefit/Risk Ratio in Taking SERMs from Laboratory to Clinic
    10. Selective Estrogen Receptor Modulators (SERMs): Part VII. SERM Development in Industry, Academia, the NIH, and the FDA
    11. Selective Estrogen Receptor Modulators (SERMs): Everything You Wanted to Know about SERMs
    1. SERMs, Estrogen, and Cognitive Function : Introduction (page 202)

      ANDREW A. MONJAN

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2001.tb04022.x

    2. Estrogen Replacement Therapy for the Potential Treatment or Prevention of Alzheimer's Disease (pages 223–234)

      MARILYN M. MILLER, ANDREW A. MONJAN and NEIL S. BUCKHOLTZ

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2001.tb04025.x

  7. Selective Estrogen Receptor Modulators (SERMs): Part V. Reproductive and Related Endocrine Considerations

    1. Top of page
    2. Frontmatter
    3. Selective Estrogen Receptor Modulators (SERMs): Part I. Basic Biology of SERMs
    4. Selective Estrogen Receptor Modulators (SERMs): Part II. Cancer Treatment and Prevention
    5. Selective Estrogen Receptor Modulators (SERMs): Part III. Cardiovascular Disease
    6. Selective Estrogen Receptor Modulators (SERMs): Part IV. Osteoporosis
    7. Selective Estrogen Receptor Modulators (SERMs): Part IV. Cognitive Function
    8. Selective Estrogen Receptor Modulators (SERMs): Part V. Reproductive and Related Endocrine Considerations
    9. Selective Estrogen Receptor Modulators (SERMs): Part VI. Addressing the Benefit/Risk Ratio in Taking SERMs from Laboratory to Clinic
    10. Selective Estrogen Receptor Modulators (SERMs): Part VII. SERM Development in Industry, Academia, the NIH, and the FDA
    11. Selective Estrogen Receptor Modulators (SERMs): Everything You Wanted to Know about SERMs
    1. The Effect of SERMs on the Endometrium (pages 237–242)

      STEVEN R. GOLDSTEIN

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2001.tb04027.x

  8. Selective Estrogen Receptor Modulators (SERMs): Part VI. Addressing the Benefit/Risk Ratio in Taking SERMs from Laboratory to Clinic

    1. Top of page
    2. Frontmatter
    3. Selective Estrogen Receptor Modulators (SERMs): Part I. Basic Biology of SERMs
    4. Selective Estrogen Receptor Modulators (SERMs): Part II. Cancer Treatment and Prevention
    5. Selective Estrogen Receptor Modulators (SERMs): Part III. Cardiovascular Disease
    6. Selective Estrogen Receptor Modulators (SERMs): Part IV. Osteoporosis
    7. Selective Estrogen Receptor Modulators (SERMs): Part IV. Cognitive Function
    8. Selective Estrogen Receptor Modulators (SERMs): Part V. Reproductive and Related Endocrine Considerations
    9. Selective Estrogen Receptor Modulators (SERMs): Part VI. Addressing the Benefit/Risk Ratio in Taking SERMs from Laboratory to Clinic
    10. Selective Estrogen Receptor Modulators (SERMs): Part VII. SERM Development in Industry, Academia, the NIH, and the FDA
    11. Selective Estrogen Receptor Modulators (SERMs): Everything You Wanted to Know about SERMs
    1. Translation of Basic Research: Finding the Perfect SERM : Introduction (pages 259–260)

      FRANCIS L. BELLINO and LORETTA FINNEGAN

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2001.tb04030.x

    2. What Would Be the Properties of an Ideal SERM? (pages 261–278)

      MARIETTA ANTHONY, J. KOUDY WILLIAMS and BARBARA K. DUNN

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2001.tb04031.x

    3. Raloxifene: Risks and Benefits (pages 295–303)

      ELIZABETH BARRETT-CONNOR

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2001.tb04036.x

    4. Defining Benefits and Risks for SERMs in Clinical Trials and Clinical Practice (pages 304–314)

      SUSAN R. JOHNSON, BARBARA K. DUNN and MARIETTA ANTHONY

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2001.tb04037.x

  9. Selective Estrogen Receptor Modulators (SERMs): Part VII. SERM Development in Industry, Academia, the NIH, and the FDA

    1. Top of page
    2. Frontmatter
    3. Selective Estrogen Receptor Modulators (SERMs): Part I. Basic Biology of SERMs
    4. Selective Estrogen Receptor Modulators (SERMs): Part II. Cancer Treatment and Prevention
    5. Selective Estrogen Receptor Modulators (SERMs): Part III. Cardiovascular Disease
    6. Selective Estrogen Receptor Modulators (SERMs): Part IV. Osteoporosis
    7. Selective Estrogen Receptor Modulators (SERMs): Part IV. Cognitive Function
    8. Selective Estrogen Receptor Modulators (SERMs): Part V. Reproductive and Related Endocrine Considerations
    9. Selective Estrogen Receptor Modulators (SERMs): Part VI. Addressing the Benefit/Risk Ratio in Taking SERMs from Laboratory to Clinic
    10. Selective Estrogen Receptor Modulators (SERMs): Part VII. SERM Development in Industry, Academia, the NIH, and the FDA
    11. Selective Estrogen Receptor Modulators (SERMs): Everything You Wanted to Know about SERMs
    1. FDA Review Practices and Priorities for Drugs Used in Cancer Treatmenta (pages 341–344)

      KEN KOBAYASHI and ROBERT J. DELAP

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2001.tb04042.x

    2. Conclusions : Considerations Regarding SERMs (pages 352–365)

      BARBARA K. DUNN, MARIETTA ANTHONY, SHERRY SHERMAN and JOSEPH P. COSTANTINO

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2001.tb04045.x

    3. Opportunities for Future Research (pages 366–374)

      SHERRY SHERMAN and BARBARA K. DUNN

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2001.tb04046.x

  10. Selective Estrogen Receptor Modulators (SERMs): Everything You Wanted to Know about SERMs

    1. Top of page
    2. Frontmatter
    3. Selective Estrogen Receptor Modulators (SERMs): Part I. Basic Biology of SERMs
    4. Selective Estrogen Receptor Modulators (SERMs): Part II. Cancer Treatment and Prevention
    5. Selective Estrogen Receptor Modulators (SERMs): Part III. Cardiovascular Disease
    6. Selective Estrogen Receptor Modulators (SERMs): Part IV. Osteoporosis
    7. Selective Estrogen Receptor Modulators (SERMs): Part IV. Cognitive Function
    8. Selective Estrogen Receptor Modulators (SERMs): Part V. Reproductive and Related Endocrine Considerations
    9. Selective Estrogen Receptor Modulators (SERMs): Part VI. Addressing the Benefit/Risk Ratio in Taking SERMs from Laboratory to Clinic
    10. Selective Estrogen Receptor Modulators (SERMs): Part VII. SERM Development in Industry, Academia, the NIH, and the FDA
    11. Selective Estrogen Receptor Modulators (SERMs): Everything You Wanted to Know about SERMs
    1. Action of SERMs in Target Tissues (page 383)

      Article first published online: 25 JAN 2006 | DOI: 10.1111/j.1749-6632.2001.tb04050.x

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