Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

November 2002

Volume 973 CELL SIGNALING, TRANSCRIPTION, AND TRANSLATION AS THERAPEUTIC TARGETS

Pages xv–xv, 1–598

  1. Frontmatter

    1. Top of page
    2. Frontmatter
    3. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part I. Signal Transduction in Health and Disease
    4. Article: Part I. Signal Transduction in Health and Disease
    5. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part I. Signal Transduction in Health and Disease
    6. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part II. Apoptosis Pathways as Targets for Therapeutic Applications
    7. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part III. Cell Cycle Control
    8. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part IV. Signal Transduction, Stress Response, and Aging
    9. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part V. Kinases as Targets for Novel Therapeutic Applications
    10. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VI. Transcriptional Regulation Paradigms
    11. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VII. Thiols, Protein Thiolation, and Cell Signaling
    12. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VIII. Signaling by Cell Adhesion Molecules
    1. Preface (page xv)

      Marc Diederich

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04594.x

  2. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part I. Signal Transduction in Health and Disease

    1. Top of page
    2. Frontmatter
    3. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part I. Signal Transduction in Health and Disease
    4. Article: Part I. Signal Transduction in Health and Disease
    5. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part I. Signal Transduction in Health and Disease
    6. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part II. Apoptosis Pathways as Targets for Therapeutic Applications
    7. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part III. Cell Cycle Control
    8. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part IV. Signal Transduction, Stress Response, and Aging
    9. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part V. Kinases as Targets for Novel Therapeutic Applications
    10. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VI. Transcriptional Regulation Paradigms
    11. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VII. Thiols, Protein Thiolation, and Cell Signaling
    12. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VIII. Signaling by Cell Adhesion Molecules
    1. Molecular Chaperones in the Regulation of Signal Transduction (pages 3–4)

      SIMON ALBERTI and JÖRG HÖHFELD

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04596.x

    2. The Role of PPAR-γ/RXR-α Heterodimers in the Regulation of Human Trophoblast Invasion (pages 26–30)

      THIERRY FOURNIER, LAETITIA PAVAN, ANNE TARRADE, KRISTINA SCHOONJANS, JOHAN AUWERX, CECILE ROCHETTE-EGLY and DANIELE EVAIN-BRION

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04601.x

    3. Ultraviolet-B Irradiation and Matrix Metalloproteinases : From Induction via Signaling to Initial Events (pages 31–43)

      PETER BRENNEISEN, HELMUT SIES and KARIN SCHARFFETTER-KOCHANEK

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04602.x

    4. Doxorubicin Increases Intracellular Diacylglycerol by the Mobilization of Choline-Enriched Phospholipids in Rat Hepatocytes (pages 49–51)

      ROSA MARTÍNEZ, ROSAURA NAVARRO, CÉSAR MARTÍN, IGOR AURREKOETXEA, M. LUISA HERNÁNDEZ, MERCEDES LACORT, JOSÉ IGNACIO RUIZ-SANZ and M. BEGOÑA RUIZ-LARREA

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04604.x

    5. Intracellular Diacylglycerol Accumulation Induced by Doxorubicin in Rat Hepatocytes : Potential Involvement of Phospholipases C and D (pages 52–56)

      ROSA MARTÍNEZ, ROSAURA NAVARRO, CÉSAR MARTÍN, IGOR AURREKOETXEA, M. LUISA HERNÁNDEZ, MERCEDES LACORT, JOSÉ IGNACIO RUIZ-SANZ and M. BEGOÑA RUIZ-LARREA

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04605.x

    6. Dual Role of Cytochalasin D in the Regulation of Connective Tissue Growth Factor (pages 57–59)

      MARGARETE GOPPELT-STRUEBE, JULIANE HEUSINGER-RIBEIRO and BARBARA FISCHER

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04606.x

    7. Expression of the Chemokine Receptor CXCR4 and Its Ligand Stromal Cell-Derived Factor 1 in Human Brain Tumors and Their Involvement in Glial Proliferation in Vitro (pages 60–69)

      SIMONE BARBERO, ADRIANA BAJETTO, RUDY BONAVIA, CAROLA PORCILE, PATRIZIA PICCIOLI, PAOLO PIRANI, JEAN LOUIS RAVETTI, GIANLUIGI ZONA, RENATO SPAZIANTE, TULLIO FLORIO and GENNARO SCHETTINI

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04607.x

    8. Signaling Pathways Mediate the Neuroprotective Effects of GDNF (pages 70–74)

      F. NEFF, C. NOELKER, K. EGGERT and J. SCHLEGEL

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04608.x

    9. Space Flight and Insulin-like Growth Factor-I Signaling in Rat Osteoblasts (pages 75–78)

      YASUHIRO KUMEI, HIROSHI NAKAMURA, SADAO MORITA, HIDEO AKIYAMA, MASAHIKO HIRANO, KEI'ICHI OHYA, KEN'ICHI SHINOMIYA and HITOYATA SHIMOKAWA

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04609.x

    10. Suppressor of Cytokine Signaling-1 Inhibits Interferon-g-Induced Activation of Human Keratinocytes (pages 79–82)

      CRISTINA ALBANESI, MONICA FEDERICI, MARIA L. GIUSTIZIERI, CLAUDIA SCARPONI and GIAMPIERO GIROLOMONI

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04610.x

    11. Expression of Steroidogenic Acute Regulatory Protein in Cultured Schwann Cells and Its Regulation by cAMP (pages 83–87)

      Y. BENMESSAHEL, R. GUENNOUN, F. CADEPOND, E. E. BAULIEU, M. SCHUMACHER and G. GROYER

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04611.x

    12. Hepatic Insulin-like Growth Factor-I Binding Protein 3 Gene Expression in Rats with Endotoxic Shock: The Role of Glucocorticoids (pages 88–90)

      T. PRIEGO, I. IBAÑEZ de CÁCERES, A. I. MARTÍN, M. A. VILLANÚA and A. LÓPEZ-CALDERÓN

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04612.x

    13. Further Immunohistochemical Evidence for Impaired NO Signaling in the Hypothalamus of Depressed Patients (pages 91–93)

      H.-G. BERNSTEIN, A. HEINEMANN, D. KRELL, C. MAWRIN, H. BIELAU, P. DANOS, S. DIEKMANN, G. KEILHOFF, B. BOGERTS and B. BAUMANN

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04613.x

    14. Nitric Oxide Production Stimulated by the Basic Fibroblast Growth Factor Requires the Synthesis of Ceramide (pages 94–104)

      SARA ARENA, ALESSANDRA PATTAROZZI, STEFANO THELLUNG, VALENTINA VILLA, ALESSANDRO CORSARO, ALESSANDRO MASSA, FABRIZIO DIANA, GIUSEPPE SPOTO, SABRINA FORCELLA, GIANLUCA DAMONTE, MIRELLA FILOCAMO, UMBERTO BENATTI, GENNARO SCHETTINI and TULLIO FLORIOA

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04614.x

  3. Article: Part I. Signal Transduction in Health and Disease

    1. Top of page
    2. Frontmatter
    3. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part I. Signal Transduction in Health and Disease
    4. Article: Part I. Signal Transduction in Health and Disease
    5. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part I. Signal Transduction in Health and Disease
    6. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part II. Apoptosis Pathways as Targets for Therapeutic Applications
    7. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part III. Cell Cycle Control
    8. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part IV. Signal Transduction, Stress Response, and Aging
    9. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part V. Kinases as Targets for Novel Therapeutic Applications
    10. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VI. Transcriptional Regulation Paradigms
    11. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VII. Thiols, Protein Thiolation, and Cell Signaling
    12. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VIII. Signaling by Cell Adhesion Molecules
    1. Involvement of RAS-ERK Signaling in Multiple Biological Responses to HGF/SF (pages 105–108)

      DAVID TULASNE, REJANE PAUMELLE, CATHERINE LEROY, SYLVIE REVENEAU, BERNARD VANDENBUNDER and VERONIQUE FAFEUR

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04615.x

  4. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part I. Signal Transduction in Health and Disease

    1. Top of page
    2. Frontmatter
    3. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part I. Signal Transduction in Health and Disease
    4. Article: Part I. Signal Transduction in Health and Disease
    5. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part I. Signal Transduction in Health and Disease
    6. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part II. Apoptosis Pathways as Targets for Therapeutic Applications
    7. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part III. Cell Cycle Control
    8. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part IV. Signal Transduction, Stress Response, and Aging
    9. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part V. Kinases as Targets for Novel Therapeutic Applications
    10. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VI. Transcriptional Regulation Paradigms
    11. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VII. Thiols, Protein Thiolation, and Cell Signaling
    12. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VIII. Signaling by Cell Adhesion Molecules
    1. Structure of the Amino-Terminal Nuclear Export Domain of the APC Tumor Suppressor Protein (pages 109–111)

      LARA TICKENBROCK, JANINA CRAMER, INGRID VETTER and OLIVER MÜLLER

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04616.x

    2. Antagonistic Signaling Pathways Regulate Alternative Splicing of CD44 in T Cells (pages 112–115)

      S. WEG-REMERS, H. PONTA, P. HERRLICH and H. KÖNIG

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04617.x

    3. Denervation Is Not a Primary Cause of Prion Protein Down-Regulation Occurring in the Spinal Cord of a Transgenic Model of Amyotrophic Lateral Sclerosis (pages 116–119)

      LUC DUPUIS, FRÉDÉRIQUE RENE, FRANCK DI SCALA, JOSE-LUIS GONZALEZ de AGUILAR, MARC de TAPIA and JEAN-PHILIPPE LOEFFLER

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04618.x

    4. The F-Actin Content of Multiple Myeloma Cells as a Measure of Their Migration (pages 124–136)

      ELINE MENU, FILIP BRAET, MAARTEN TIMMERS, IVAN Van RIET, BEN Van CAMP and KARIN VANDERKERKEN

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04620.x

    5. Cloning and Characterization of a New Ral-GEF Expressed in Mouse Testis (pages 135–137)

      ENZO MARTEGANI, MICHELA CERIANI, RENATA TISI and GIOVANNA BERRUTI

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04621.x

    6. β-Arrestin 1 Couples Thrombin to the Rapid Activation of the Akt Pathway (pages 138–141)

      REEMA GOEL and JOSEPH J. BALDASSARE

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04622.x

    7. α-Thrombin Activates Akt via a Nonreceptor Tyrosine Kinase in IIC9 Cells (pages 142–144)

      POLLY J. PHILLIPS-MASON, REEMA GOEL and JOSEPH J. BALDASSARE

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04623.x

    8. Activation of ERK, Controlled by Rac1 and Cdc42 via Akt, Is Required for Anoikis (pages 145–148)

      WILFRID RUL, OLIVIER ZUGASTI, PIERRE ROUX, CAROLE PEYSSONNAUX, ALAIN EYCHENE, THOMAS F. FRANKE, PHILIPPE LENORMAND, PHILIPPE FORT and URSZULA HIBNER

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04624.x

    9. Decorin Affects Endothelial Cells by Akt-Dependent and -Independent Pathways (pages 149–152)

      E. SCHÖNHERR, B. LEVKAU, L. SCHAEFER, H. KRESSE and K. WALSH

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04625.x

  5. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part II. Apoptosis Pathways as Targets for Therapeutic Applications

    1. Top of page
    2. Frontmatter
    3. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part I. Signal Transduction in Health and Disease
    4. Article: Part I. Signal Transduction in Health and Disease
    5. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part I. Signal Transduction in Health and Disease
    6. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part II. Apoptosis Pathways as Targets for Therapeutic Applications
    7. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part III. Cell Cycle Control
    8. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part IV. Signal Transduction, Stress Response, and Aging
    9. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part V. Kinases as Targets for Novel Therapeutic Applications
    10. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VI. Transcriptional Regulation Paradigms
    11. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VII. Thiols, Protein Thiolation, and Cell Signaling
    12. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VIII. Signaling by Cell Adhesion Molecules
    1. Activation of the p38 MAPK and ERK1/2 Pathways Is Required for Fas-Induced IL-8 Production in Colonic Epithelial Cells (pages 161–165)

      DARREN O'BRIEN, TERRY O'CONNOR, FERGUS SHANAHAN and JOE O'CONNELL

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04627.x

    2. Treating Crohn's Disease by Inducing T Lymphocyte Apoptosis (pages 166–180)

      JAN M. H. VAN DEN BRANDE, MAIKEL P. PEPPELENBOSCH and SANDER J. H. VAN DEVENTER

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04628.x

    3. Signaling Pathways Leading to Apoptosis or Survival in Immature and Mature B Cells (pages 181–185)

      G. SÁRMAY, G. KONCZ, Cs. BODOR, D. KÖVESDI, R. GÁTI and J. GERGELY

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04629.x

    4. Extracellular ATP Induces Phosphatidylserine Externalization Earlier than Nuclear Apoptotic Events in Thymocytes (pages 186–189)

      MARIE-PIERRE COURAGEOT, SANDRINE LEPINE, FRANCOISE GIRAUD and JEAN-CLAUDE SULPICE

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04630.x

    5. Involvement of Sphingosine in Dexamethasone-Induced Thymocyte Apoptosis (pages 190–193)

      SANDRINE LÉPINE, BORIS LAKATOS, PIERRE MAZIERE, MARIE-PIERRE COURAGEOT, JEAN-CLAUDE SULPICE and FRANCOISE GIRAUD

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04631.x

    6. TNF-α Potentiates IL-4/IL-13-Induced IL-13Rα2 Expression (pages 207–209)

      MURIEL DAVID, JACQUES BERTOGLIO and JOSIANE PIERRE

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04633.x

    7. Epidermal Growth Factor Receptor Ligands and Tumor Necrosis Factor-α Coregulate Chemokine Expression in Human Keratinocytes (pages 210–213)

      SAVERIA PASTORE, FRANCESCA MASCIA, VALENTINA MARIANI and GIAMPIERO GIROLOMONI

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04634.x

    8. Hepatocytes Transgenic for the Full Hepatitis C Virus Open Reading Frame Are Resistant to Fas-Induced Cell Death (pages 214–217)

      OLIVIER DISSON, MICHAEL HAHNE, URSZULA HIBNER and HERVÉ LERAT

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04635.x

    9. Involvement of Protein Kinase C in Fluoride-Induced Apoptosis in Different Types of Lung Cells (pages 218–220)

      M. REFSNES, H. KERSTEN, P. E. SCHWARZE and M. LÅG

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04636.x

    10. Selenite Inhibits Apoptosis via Activation of the PI3-K/Akt Pathway (pages 221–223)

      SANG-OH YOON, SOO-JIN PARK and AN-SIK CHUNG

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04637.x

    11. Activation of the c-Jun N Terminal Kinase Pathway in an Animal Model of Parkinson's Disease (pages 237–240)

      METTE GEORGI WILLESEN, STEEN GAMMELTOFT and ELISABETTA VAUDANO

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04640.x

    12. The Role of Mitogen-Activated Protein Kinases and Their Relationship with NF-κB and PPARγ in Indomethacin-Induced Apoptosis of Colon Cancer Cells (pages 241–245)

      TAE IL KIM, SOO HYUN JIN, EUN HYE KANG, SUNG KWAN SHIN, KANG YELL CHOI and WON HO KIM

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04641.x

    13. Curcumin Induces Caspase-3-Independent Apoptosis in Human Multidrug-Resistant Cells (pages 250–254)

      KATARZYNA PIWOCKA, ANNA BIELAK-MIJEWSKA and EWA SIKORA

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04643.x

    14. Low-Dose Radiation-Induced Adaptive Response in the Murine System (pages 255–257)

      JINSIL SEONG, SUNG HEE KIM, HONG RYUL PYO, EUN JI CHUNG and CHANG OK SUH

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04644.x

    15. Nucleolus and Apoptosis (pages 258–264)

      M. HORKÝ, V. KOTALA, M. ANTON and J. WESIERSKA-GADEK

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04645.x

  6. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part III. Cell Cycle Control

    1. Top of page
    2. Frontmatter
    3. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part I. Signal Transduction in Health and Disease
    4. Article: Part I. Signal Transduction in Health and Disease
    5. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part I. Signal Transduction in Health and Disease
    6. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part II. Apoptosis Pathways as Targets for Therapeutic Applications
    7. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part III. Cell Cycle Control
    8. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part IV. Signal Transduction, Stress Response, and Aging
    9. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part V. Kinases as Targets for Novel Therapeutic Applications
    10. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VI. Transcriptional Regulation Paradigms
    11. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VII. Thiols, Protein Thiolation, and Cell Signaling
    12. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VIII. Signaling by Cell Adhesion Molecules
    1. Activation and Phosphorylation on Thr-160 of Nuclear-Targeted CDK2 Is ERK Dependent (pages 265–267)

      NATHAN H. LENTS, SUSAN M. KEENAN, CLIFFORD BELLONE and JOSEPH J. BALDASSARE

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04646.x

    2. Association of Bcl-2 with Cyclin A/Cdk-2 Complex and Its Effects on Cdk-2 Activity (pages 268–271)

      ELVIRA CRESCENZI, MARIA SANNINO, GILDA TONZIELLO and GIUSEPPE PALUMBO

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04647.x

    3. Dynamic Localization/Association of Protein Kinase CK2 Subunits in Living Cells : A Role in Its Cellular Regulation? (pages 272–277)

      VÉRONIQUE MARTEL, ODILE FILHOL, ARSENIO NUEDA and CLAUDE COCHET

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04648.x

    4. Cigarette Smoke-Induced Oxidative Stress and TGF-β1 Increase p21waf1/cip1 Expression in Alveolar Epithelial Cells (pages 278–283)

      JOHN A. MARWICK, PAUL KIRKHAM, PETER S. GILMOUR, KENNETH DONALDSON, WILLIAM MacNEE and IRFAN RAHMAN

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04649.x

    5. Assessment of p16, p21, and p27 in Granulocytic Differentiation of Human Promyelocytic HL-60 Cell Line (pages 284–286)

      RUTA NAVAKAUSKIENE, GRAZINA TREIGYTE, ARUNAS GINEITIS and KARL-ERIC MAGNUSSON

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04650.x

  7. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part IV. Signal Transduction, Stress Response, and Aging

    1. Top of page
    2. Frontmatter
    3. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part I. Signal Transduction in Health and Disease
    4. Article: Part I. Signal Transduction in Health and Disease
    5. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part I. Signal Transduction in Health and Disease
    6. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part II. Apoptosis Pathways as Targets for Therapeutic Applications
    7. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part III. Cell Cycle Control
    8. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part IV. Signal Transduction, Stress Response, and Aging
    9. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part V. Kinases as Targets for Novel Therapeutic Applications
    10. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VI. Transcriptional Regulation Paradigms
    11. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VII. Thiols, Protein Thiolation, and Cell Signaling
    12. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VIII. Signaling by Cell Adhesion Molecules
    1. Metamorphosis of the Selenoprotein PHGPx during Spermatogenesis (pages 287–288)

      LEOPOLD FLOHÉ, CARLO FORESTA, ANDREA GAROLLA, MATILDE MAIORINO, ANTONELLA ROVERI and FULVIO URSINI

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04651.x

    2. Detection and Characterization of Membrane-Bound Selenoproteins in the Kidney of the Rat (pages 289–292)

      A. KYRIAKOPOULOS, H. BERTELSMANN, A. GRAEBERT, B. HOPPE, M. KÜHBACHER and D. BEHNE

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04652.x

    3. Decreased Expression of Glucose Transport Protein (Glut3) in Aging and Vitamin E Deficiency (pages 293–296)

      PATRIZIA FATTORETTI, CARLO BERTONI-FREDDARI, TIZIANA CASOLI, GIUSEPPINA DI STEFANO, MORENO SOLAZZI and BELINDA GIORGETTI

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04653.x

    4. Implication of Copper Zinc Superoxide Dismutase (SOD-1) in Human Placenta Development (pages 297–301)

      JEAN-LOUIS FRENDO, PATRICE THÉROND, JEAN GUIBOURDENCHE, MICHEL VIDAUD and DANIèLE EVAIN-BRIONA

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04654.x

    5. The Role of Lipid Rafts in T Lymphocyte Signal Transduction with Aging (pages 302–304)

      TAMAS FULOP JR., NADINE DOUZIECH, ANIS LARBI and GILLES DUPUIS

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04655.x

    6. The Role of Mcl-1 and Bax Expression Alteration in the Decreased Rescue of Human Neutrophils from Apoptosis by GM-CSF with Aging (pages 305–308)

      TAMAS FULOP JR., ANIS LARBI, ANNIE LINTEAU, SÉBASTIEN DESGEORGES and NADINE DOUZIECH

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04656.x

    7. Proteasome Inhibition Enhances Lipofuscin Formation (pages 309–312)

      ALEXEI TERMAN and SARA SANDBERG

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04657.x

    8. Effects of Ethanol on GAP-43 Levels in Hippocampus and Cerebellum of Aged Rats (pages 313–316)

      T. CASOLI, G. DI STEFANO, P. FATTORETTI, A. DELFINO, M. SOLAZZI and C. BERTONI-FREDDARI

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04658.x

    9. Signal Transduction through Tyrosine-Phosphorylated Carboxy-Terminal Fragments of APP via an Enhanced Interaction with Shc/Grb2 Adaptor Proteins in Reactive Astrocytes of Alzheimer's Disease Brain (pages 323–333)

      CLAUDIO RUSSO, VIRGINIA DOLCINI, SERENA SALIS, VALENTINA VENEZIA, ELISABETTA VIOLANI, PIA CARLO, NICOLA ZAMBRANO, TOMMASO RUSSO and GENNARO SCHETTINI

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04660.x

    10. The Role of the Carboxyl-Terminal Fragments of Amyloid Precursor Protein in Alzheimer's Disease (pages 334–339)

      D. K. LAHIRI, G. J. KOTWAL, M. R. FARLOW, A. SIMA, W. KUPSKY, F. H. SARKAR and K. SAMBAMURTI

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04661.x

  8. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part V. Kinases as Targets for Novel Therapeutic Applications

    1. Top of page
    2. Frontmatter
    3. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part I. Signal Transduction in Health and Disease
    4. Article: Part I. Signal Transduction in Health and Disease
    5. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part I. Signal Transduction in Health and Disease
    6. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part II. Apoptosis Pathways as Targets for Therapeutic Applications
    7. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part III. Cell Cycle Control
    8. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part IV. Signal Transduction, Stress Response, and Aging
    9. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part V. Kinases as Targets for Novel Therapeutic Applications
    10. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VI. Transcriptional Regulation Paradigms
    11. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VII. Thiols, Protein Thiolation, and Cell Signaling
    12. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VIII. Signaling by Cell Adhesion Molecules
    1. From Extracellular to Intracellular Targets, Inhibiting MAP Kinases in Treatment of Crohn's Disease (pages 349–358)

      BERNT VAN DEN BLINK, TESSA ten HOVE, GIJS R. VAN DEN BRINK, MAIKEL P. PEPPELENBOSCH and SANDER J.H. VAN DEVENTER

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04664.x

    2. Elucidation of Transcriptional Elements and the Genomic Structure of DAP-like Kinase (pages 363–367)

      HARRY ENGEMANN, D. KÖGEL, S. MANDERSCHEID, U. PREUSS and K. H. SCHEIDTMANN

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04666.x

    3. Modulation of Kinase Activity by Polyphenols (pages 368–370)

      MIRELLA NARDINI, CRISTINA SCACCINI and FABIO VIRGILI

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04667.x

    4. Enhancement of Radioresponse of Murine Tumors by ERK Inhibitor (pages 371–373)

      JINSIL SEONG, SUNG HEE KIM and CHANG OK SUH

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04668.x

  9. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VI. Transcriptional Regulation Paradigms

    1. Top of page
    2. Frontmatter
    3. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part I. Signal Transduction in Health and Disease
    4. Article: Part I. Signal Transduction in Health and Disease
    5. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part I. Signal Transduction in Health and Disease
    6. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part II. Apoptosis Pathways as Targets for Therapeutic Applications
    7. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part III. Cell Cycle Control
    8. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part IV. Signal Transduction, Stress Response, and Aging
    9. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part V. Kinases as Targets for Novel Therapeutic Applications
    10. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VI. Transcriptional Regulation Paradigms
    11. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VII. Thiols, Protein Thiolation, and Cell Signaling
    12. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VIII. Signaling by Cell Adhesion Molecules
    1. Regulation of p53 : Intricate Loops and Delicate Balances (pages 374–383)

      MOSHE OREN, ALEXANDER DAMALAS, TANYA GOTTLIEB, DAN MICHAEL, JAN TAPLICK, JUAN FERNANDO MARTINEZ LEAL, RUTH MAYA, MIRI MOAS, RONY SEGER, YOICHI TAYA and AVRI BEN-ZE'EV

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04669.x

    2. Proteasome Inhibitors Induce Cerebellar Granule Cell Death : Inhibition of Nuclear Factor-kB Activation (pages 402–413)

      CAROLA PORCILE, PATRIZIA PICCIOLI, SABRINA STANZIONE, ADRIANA BAJETTO, RUDY BONAVIA, SIMONE BARBERO, TULLIO FLORIO and GENNARO SCHETTINIA

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04673.x

    3. Thalidomide Suppresses the Interleukin 1β-Induced NFκB Signaling Pathway in Colon Cancer Cells (pages 414–418)

      SOO HYUN JIN, TAE IL KIM, DONG SOO HAN, SUNG KWAN SHIN and WON HO KIM

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04674.x

    4. Rapid Estradiol Activation of AP-1 and CREB in Rat White Adipocytes (pages 423–425)

      D. LACASA, E. GARCIA DOS SANTOS, M. N. DIEUDONNE and Y. GIUDICELLI

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04676.x

    5. Multiple Degradation Pathways for Fos Family Proteins (pages 426–434)

      CLAIRE ACQUAVIVA, GUILLAUME BOSSIS, PATRIZIA FERRARA, FRÉDÉRIQUE BROCKLY, ISABELLE JARIEL-ENCONTRE and MARC PIECHACZYK

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04677.x

    6. Constitutive Repression of E2F1 Transcriptional Activity through HDAC Proteins Is Essential for Neuronal Survival (pages 438–442)

      ANNE-LAURENCE BOUTILLIER, EMMANUELLE TRINH and JEAN-PHILIPPE LOEFFLER

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04679.x

    7. ERK and Calcium in Activation of HIF-1 (pages 448–453)

      DENIS MOTTET, GAETAN MICHEL, PATRICIA RENARD, NOELLE NINANE, MARTINE RAES and CARINE MICHIELS

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04681.x

    8. Transcription of the Human Prolactin Gene in Mammary Cells (pages 454–458)

      A. BAUDHUIN, I. MANFROID, C. VAN DE WEERDT, J. A. MARTIAL and M. MULLER

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04682.x

    9. Transcriptional Inhibition of CYP24 by Genistein (pages 459–462)

      HESSO FARHAN and HEIDE S. CROSS

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04683.x

    10. Transcriptional Regulation of the Human MDR1 Gene at the Level of the Inverted MED-1 Promoter Region (pages 468–471)

      STEPHANE LABIALLE, LANDRY GAYET, ERIC MARTHINET, DOMINIQUE RIGAL and LORIS G. BAGGETTO

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04685.x

    11. Steroid Receptors in Various Glial Cell Lines Expression and Functional Studies (pages 484–487)

      FRANÇOISE CADEPOND, CHARBEL MASSAAD, AMALIA TROUSSON, JULIEN GRENIER, GHISLAINE GROYER, ETIENNE BAULIEU and MICHAEL SCHUMACHER

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04689.x

  10. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VII. Thiols, Protein Thiolation, and Cell Signaling

    1. Top of page
    2. Frontmatter
    3. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part I. Signal Transduction in Health and Disease
    4. Article: Part I. Signal Transduction in Health and Disease
    5. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part I. Signal Transduction in Health and Disease
    6. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part II. Apoptosis Pathways as Targets for Therapeutic Applications
    7. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part III. Cell Cycle Control
    8. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part IV. Signal Transduction, Stress Response, and Aging
    9. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part V. Kinases as Targets for Novel Therapeutic Applications
    10. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VI. Transcriptional Regulation Paradigms
    11. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VII. Thiols, Protein Thiolation, and Cell Signaling
    12. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VIII. Signaling by Cell Adhesion Molecules
    1. Glutathione in Defense and Signaling : Lessons from a Small Thiol (pages 488–504)

      DALE A. DICKINSON and HENRY JAY FORMAN

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04690.x

    2. Redox Control by Dithiol-Disulfide Exchange in Plants : I. The Chloroplastic Systems (pages 508–519)

      JEAN-PIERRE JACQUOT, NICOLAS ROUHIER and ERIC GELHAYE

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04692.x

    3. Redox Control by Dithiol-Disulfide Exchange in Plants : II. The Cytosolic and Mitochondrial Systems (pages 520–528)

      NICOLAS ROUHIER, ERIC GELHAYE and JEAN-PIERRE JACQUOT

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04693.x

    4. Contribution of Covalent Protein Modification to the Antiinflammatory Effects of Cyclopentenone Prostaglandins (pages 533–536)

      DOLORES PÉREZ-SALA, EVA CERNUDA-MOROLLÓN, ESTELA PINEDA-MOLINA and F. JAVIER CAÑADA

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04695.x

    5. Reactive Oxygen Species Accumulation Induced by Homocysteine in Human Platelets (pages 546–549)

      MARIA GRAZIA SIGNORELLO, RAFFAELE PASCALE and GIULIANA LEONCINI

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04698.x

    6. Effects of Homocysteine on the Cellular Responses of Murine Endothelial Cells Cultured in Vitro (pages 550–554)

      A. TACHENY, S. DOS SANTOS, A.-C. HUET, M. VAN STEENBRUGGE, C. MICHIELS, P. HOLVOET and M. RAES

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04699.x

  11. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VIII. Signaling by Cell Adhesion Molecules

    1. Top of page
    2. Frontmatter
    3. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part I. Signal Transduction in Health and Disease
    4. Article: Part I. Signal Transduction in Health and Disease
    5. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part I. Signal Transduction in Health and Disease
    6. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part II. Apoptosis Pathways as Targets for Therapeutic Applications
    7. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part III. Cell Cycle Control
    8. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part IV. Signal Transduction, Stress Response, and Aging
    9. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part V. Kinases as Targets for Novel Therapeutic Applications
    10. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VI. Transcriptional Regulation Paradigms
    11. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VII. Thiols, Protein Thiolation, and Cell Signaling
    12. Cell Signaling, Transcription, and Translation as Therapeutic Targets: Part VIII. Signaling by Cell Adhesion Molecules
    1. HERG K+ Channels and β1 Integrins Interact through the Assembly of a Macromolecular Complex (pages 559–561)

      A. CHERUBINI, S. PILLOZZI, G. HOFMANN, O. CROCIANI, L. GUASTI, E. LASTRAIOLI, S. POLVANI, A. MASI, A. BECCHETTI, E. WANKE, M. OLIVOTTO and A. ARCANGELI

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04701.x

    2. Regulation of the Metastatic Process by E-Selectin and Stress-Activated Protein Kinase-2/p38 (pages 562–572)

      JULIE LAFERRIÈRE, FRANÇOIS HOULE and JACQUES HUOT

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04702.x

    3. Intercellular Adhesion Molecule-1 in the Heart (pages 573–585)

      HANS W. M. NIESSEN, PAUL A. J. KRIJNEN, CEES A. VISSER, CHRIS J. L. M. MEIJER and C. ERIK HACK

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04703.x

    4. Analysis of in Vivo Endothelial Cell Activation Applying RT-PCR following Endothelial Cell Isolation by Laser Dissection Microscopy (pages 586–589)

      S. A. ÁSGEIRSDÓTTIR, N. WERNER, G. HARMS, A. van den BERG and G. MOLEMA

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04704.x

    5. The Signaling Pathway for β1-Integrin/ERKs Is Involved in the Adaptation of Adipocyte Functions to Cell Size (pages 594–598)

      C. FARNIER, S. KRIEF, M. BLACHE, F. DIOT-DUPUY, G. MORY, P. FERRE and R. BAZIN

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2002.tb04706.x

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