Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

December 2003

Volume 1002 THERAPEUTIC OLIGONUCLEOTIDES: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips

Pages ix–xii, 1–271

  1. Frontmatter

    1. Top of page
    2. Frontmatter
    3. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part I. Antisense, Chemistry, Sequence Specificity, and Prodrug
    4. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part II. Interference RNA and Gene Repair
    5. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part III. Antisense Delivery and Gene Therapy
    6. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part IV. CpG Immune Modulators
    7. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part V. DNA Chips, Enhancer Decoys, Triple-Helix, Imaging Gene Expression, and Morpholino Antisense
    8. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part VI. Antisense Targets and Combination Strategies
    9. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part VII. Antisense Drug Development
    1. Foreword (pages ix–x)

      J. CARL BARRETT

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1281.001

    2. Introduction (pages xi–xii)

      YOON S. CHO-CHUNG, ALAN M. GEWIRTZ and CY A. STEIN

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1281.002

  2. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part I. Antisense, Chemistry, Sequence Specificity, and Prodrug

    1. Top of page
    2. Frontmatter
    3. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part I. Antisense, Chemistry, Sequence Specificity, and Prodrug
    4. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part II. Interference RNA and Gene Repair
    5. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part III. Antisense Delivery and Gene Therapy
    6. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part IV. CpG Immune Modulators
    7. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part V. DNA Chips, Enhancer Decoys, Triple-Helix, Imaging Gene Expression, and Morpholino Antisense
    8. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part VI. Antisense Targets and Combination Strategies
    9. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part VII. Antisense Drug Development
    1. Conceptual “Heat-Driven” Approach to the Synthesis of DNA Oligonucleotides on Microarrays (pages 1–11)

      A. GRAJKOWSKI, J. CIEŚLAK, M. K. CHMIELEWSKI, V. MARCHÁN, L. R. PHILLIPS, A. WILK and S. L. BEAUCAGE

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1281.003

    2. Reading, Writing, and Modulating Genetic Information with Boranophosphate Mimics of Nucleotides, DNA, and RNA (pages 12–29)

      BARBARA RAMSAY SHAW, MIKHAIL DOBRIKOV, XIN WANG, JING WAN, KAIZHANG HE, JIN-LAI LIN, PING LI, VLADIMIR RAIT, ZINAIDA A. SERGUEEVA and DMITRI SERGUEEV

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1281.004

  3. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part II. Interference RNA and Gene Repair

    1. Top of page
    2. Frontmatter
    3. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part I. Antisense, Chemistry, Sequence Specificity, and Prodrug
    4. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part II. Interference RNA and Gene Repair
    5. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part III. Antisense Delivery and Gene Therapy
    6. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part IV. CpG Immune Modulators
    7. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part V. DNA Chips, Enhancer Decoys, Triple-Helix, Imaging Gene Expression, and Morpholino Antisense
    8. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part VI. Antisense Targets and Combination Strategies
    9. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part VII. Antisense Drug Development
    1. RNA-Mediated Inhibition of HIV in a Gene Therapy Setting (pages 63–71)

      ALESSANDRO MICHIENZI, DANIELA CASTANOTTO, NANCY LEE, SHIRLEY LI, JOHN A. ZAIA and JOHN J. ROSSI

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1281.008

  4. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part III. Antisense Delivery and Gene Therapy

    1. Top of page
    2. Frontmatter
    3. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part I. Antisense, Chemistry, Sequence Specificity, and Prodrug
    4. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part II. Interference RNA and Gene Repair
    5. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part III. Antisense Delivery and Gene Therapy
    6. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part IV. CpG Immune Modulators
    7. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part V. DNA Chips, Enhancer Decoys, Triple-Helix, Imaging Gene Expression, and Morpholino Antisense
    8. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part VI. Antisense Targets and Combination Strategies
    9. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part VII. Antisense Drug Development
    1. Therapeutic Potentialities of EWS-Fli-1 mRNA-Targeted Vectorized Antisense Oligonucleotides (pages 72–77)

      A. MAKSIMENKO, G. LAMBERT, J. R. BERTRAND, E. FATTAL, P. COUVREUR and C. MALVY

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1281.017

    2. HER-2-Targeted Antisense Oligonucleotide Results in Sensitization of Head and Neck Cancer Cells to Chemotherapeutic Agents (pages 78–89)

      ANTONINA S. RAIT, KATHLEEN F. PIROLLO, DAVID ULICK, KEVIN CULLEN and ESTHER H. CHANG

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1281.018

  5. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part IV. CpG Immune Modulators

    1. Top of page
    2. Frontmatter
    3. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part I. Antisense, Chemistry, Sequence Specificity, and Prodrug
    4. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part II. Interference RNA and Gene Repair
    5. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part III. Antisense Delivery and Gene Therapy
    6. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part IV. CpG Immune Modulators
    7. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part V. DNA Chips, Enhancer Decoys, Triple-Helix, Imaging Gene Expression, and Morpholino Antisense
    8. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part VI. Antisense Targets and Combination Strategies
    9. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part VII. Antisense Drug Development
    1. The Therapeutic Potential of Antigen-Oligonucleotide Conjugates (pages 105–111)

      SANDIP K. DATTA, KENJI TAKABAYASHI and EYAL RAZ

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1281.022

    2. Regulation of CpG-Induced Immune Activation by Suppressive Oligodeoxynucleotides (pages 112–123)

      DENNIS M. KLINMAN, RAINALD ZEUNER, HIROSHI YAMADA, MAYDA GURSEL, DEBBIE CURRIE and IHSAN GURSEL

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1281.023

  6. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part V. DNA Chips, Enhancer Decoys, Triple-Helix, Imaging Gene Expression, and Morpholino Antisense

    1. Top of page
    2. Frontmatter
    3. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part I. Antisense, Chemistry, Sequence Specificity, and Prodrug
    4. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part II. Interference RNA and Gene Repair
    5. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part III. Antisense Delivery and Gene Therapy
    6. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part IV. CpG Immune Modulators
    7. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part V. DNA Chips, Enhancer Decoys, Triple-Helix, Imaging Gene Expression, and Morpholino Antisense
    8. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part VI. Antisense Targets and Combination Strategies
    9. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part VII. Antisense Drug Development
    1. Antigene Radiotherapy : Targeted Radiodamage with 125I-Labeled Triplex-Forming Oligonucleotides (pages 134–140)

      I. G. PANYUTIN, O. A. SEDELNIKOVA, V. N. KARAMYCHEV and R. D. NEUMANN

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1281.012

    2. Gene Targeting by Triple Helix-Forming Oligonucleotides (pages 141–153)

      ALOKES MAJUMDAR, NITIN PURI, NICHOLAS McCOLLUM, SALLY RICHARDS, BERNARD CUENOUD, PAUL MILLER and MICHAEL M. SEIDMAN

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1281.013

    3. Imaging Oncogene Expression (pages 165–188)

      XIAOBING TIAN, MOHAN R. ARUVA, PONUGOTI S. RAO, WENYI QIN, PAUL READ, EDWARD R. SAUTER, MATHEW L. THAKUR and ERIC WICKSTROM

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1281.015

  7. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part VI. Antisense Targets and Combination Strategies

    1. Top of page
    2. Frontmatter
    3. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part I. Antisense, Chemistry, Sequence Specificity, and Prodrug
    4. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part II. Interference RNA and Gene Repair
    5. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part III. Antisense Delivery and Gene Therapy
    6. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part IV. CpG Immune Modulators
    7. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part V. DNA Chips, Enhancer Decoys, Triple-Helix, Imaging Gene Expression, and Morpholino Antisense
    8. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part VI. Antisense Targets and Combination Strategies
    9. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part VII. Antisense Drug Development
  8. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part VII. Antisense Drug Development

    1. Top of page
    2. Frontmatter
    3. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part I. Antisense, Chemistry, Sequence Specificity, and Prodrug
    4. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part II. Interference RNA and Gene Repair
    5. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part III. Antisense Delivery and Gene Therapy
    6. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part IV. CpG Immune Modulators
    7. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part V. DNA Chips, Enhancer Decoys, Triple-Helix, Imaging Gene Expression, and Morpholino Antisense
    8. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part VI. Antisense Targets and Combination Strategies
    9. Therapeutic Oligonucleotides: Antisense, RNAi, Triple-Helix, Gene Repair, Enhancer Decoys, CpG and DNA Chips: Part VII. Antisense Drug Development
    1. Clinical Studies in Patients with Solid Tumors using a Second-Generation Antisense Oligonucleotide (GEM®231) Targeted against Protein Kinase A Type I (pages 252–262)

      S. MANI, S. GOEL, M. NESTEROVA, R. M. MARTIN, J. M. GRINDEL, M. L. ROTHENBERG, R. ZHANG, G. TORTORA and Y. S. CHO-CHUNG

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1281.028

    2. Concluding Remarks (page 271)

      ALAN M. GEWIRTZ

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1281.031

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