Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

June 2003

Volume 994 THE MELANOCORTIN SYSTEM

Pages xi–xii, 1–383

  1. Frontmatter

    1. Top of page
    2. Frontmatter
    3. The Melanocortin System: Part II. Peripheral Non-Pigmentary Actions of Melanocortins
    4. The Melanocortin System: Part I. Melanocortin Structure/Function and Melanocortin Agonists/Antagonists
    5. The Melanocortin System: Part II. Peripheral Non-Pigmentary Actions of Melanocortins
    6. The Melanocortin System: Part III. CNS Physiology
    7. The Melanocortin System: Part IV. The Pigmentary System
    1. Preface (pages xi–xii)

      ROGER D. CONE

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03155.x

  2. The Melanocortin System: Part II. Peripheral Non-Pigmentary Actions of Melanocortins

    1. Top of page
    2. Frontmatter
    3. The Melanocortin System: Part II. Peripheral Non-Pigmentary Actions of Melanocortins
    4. The Melanocortin System: Part I. Melanocortin Structure/Function and Melanocortin Agonists/Antagonists
    5. The Melanocortin System: Part II. Peripheral Non-Pigmentary Actions of Melanocortins
    6. The Melanocortin System: Part III. CNS Physiology
    7. The Melanocortin System: Part IV. The Pigmentary System
  3. The Melanocortin System: Part I. Melanocortin Structure/Function and Melanocortin Agonists/Antagonists

    1. Top of page
    2. Frontmatter
    3. The Melanocortin System: Part II. Peripheral Non-Pigmentary Actions of Melanocortins
    4. The Melanocortin System: Part I. Melanocortin Structure/Function and Melanocortin Agonists/Antagonists
    5. The Melanocortin System: Part II. Peripheral Non-Pigmentary Actions of Melanocortins
    6. The Melanocortin System: Part III. CNS Physiology
    7. The Melanocortin System: Part IV. The Pigmentary System
    1. Exploring the Stereostructural Requirements of Peptide Ligands for the Melanocortin Receptors (pages 12–20)

      VICTOR J. HRUBY, MINYING CAI, PAOLO GRIECO, GUOXIA HAN, MALCOLM KAVARANA and DEV TRIVEDI

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03157.x

    2. Melanocortin Receptors: Ligands and Proteochemometrics Modeling (pages 21–26)

      J. E.S. WIKBERG, F. MUTULIS, I. MUTULE, S. VEIKSINA, M. LAPINSH, R. PETROVSKA and P. PRUSIS

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03158.x

    3. Loops and Links: Structural Insights into the Remarkable Function of the Agouti-Related Protein (pages 27–35)

      GLENN L. MILLHAUSER, JOE C. McNULTY, PILGRIM J. JACKSON, DARREN A. THOMPSON, GREGORY S. BARSH and IRA GANTZ

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03159.x

    4. Melanocortin Tetrapeptides Modified at the N-Terminus, His, Phe, Arg, and Trp Positions (pages 36–48)

      JERRY RYAN HOLDER and CARRIE HASKELL-LUEVANO

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03160.x

    5. Molecular Genetics of Human Obesity-Associated MC4R Mutations (pages 49–57)

      CECILE LUBRANO-BERTHELIER, MARTHA CAVAZOS, BEATRICE DUBERN, ASTRID SHAPIRO, CATHERINE LE STUNFF, SUMEI ZHANG, FRANCK PICART, CEDRIC GOVAERTS, PHILIPPE FROGUEL, PIERRE BOUGNÈRES, KARINE CLEMENT and CHRISTIAN VAISSE

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03161.x

    6. α-MSH and Desacetyl-α-MSH Signaling through Melanocortin Receptors (pages 58–65)

      KATHLEEN G. MOUNTJOY, CHIA-SHAN JENNY WU, JILLIAN CORNISH and KAREN E. CALLON

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03162.x

    7. Syndecan-3 Modulates Food Intake by Interacting with the Melanocortin/AgRP Pathway (pages 66–73)

      OFER REIZES, STEPHEN C. BENOIT, APRIL D. STRADER, DEBORAH J. CLEGG, SHAILAJA AKUNURU and RANDY J. SEELEY

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03163.x

    8. Functional Role, Structure, and Evolution of the Melanocortin-4 Receptor (pages 74–83)

      HELGI B. SCHIÖTH, MALIN C. LAGERSTRÖM, HAJIME WATANOBE, LOGI JONSSON, ANNA VALERIA VERGONI, ANETA RINGHOLM, JON O. SKARPHEDINSSON, GUDRUN V. SKULADOTTIR, JANIS KLOVINS and ROBERT FREDRIKSSON

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03164.x

    9. Anti-Inflammatory Potential of Melanocortin Receptor-Directed Drugs (pages 84–89)

      A. SKOTTNER, C. POST, A. OCKLIND, E. SEIFERT, E. LIUTKEVICIUS, R. MESKYS, A. PILINKIENE, G. BIZIULEVICIENE and T. LUNDSTEDT

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03165.x

    10. MT-II Induces Penile Erection via Brain and Spinal Mechanisms (pages 90–95)

      HUNTER WESSELLS, VICTOR J. HRUBY, JOHN HACKETT, GUOXIA HAN, PREETI BALSE-SRINIVASAN and TODD W. VANDERAH

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03166.x

    11. PT-141: A Melanocortin Agonist for the Treatment of Sexual Dysfunction (pages 96–102)

      P. B. MOLINOFF, A. M. SHADIACK, D. EARLE, L. E. DIAMOND and C. Y. QUON

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03167.x

    12. Body Weight Regulation by Selective MC4 Receptor Agonists and Antagonists (pages 103–110)

      ALAN C. FOSTER, MARGARET JOPPA, STACY MARKISON, KATHY R. GOGAS, BETH A. FLECK, BRIAN J. MURPHY, MEIRA WOLFF, MARY J. CISMOWSKI, NICHOLAS LING, VAL S. GOODFELLOW, CHEN CHEN, JOHN SAUNDERS and PAUL J. CONLON

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03168.x

  4. The Melanocortin System: Part II. Peripheral Non-Pigmentary Actions of Melanocortins

    1. Top of page
    2. Frontmatter
    3. The Melanocortin System: Part II. Peripheral Non-Pigmentary Actions of Melanocortins
    4. The Melanocortin System: Part I. Melanocortin Structure/Function and Melanocortin Agonists/Antagonists
    5. The Melanocortin System: Part II. Peripheral Non-Pigmentary Actions of Melanocortins
    6. The Melanocortin System: Part III. CNS Physiology
    7. The Melanocortin System: Part IV. The Pigmentary System
    1. Expression, Desensitization, and Internalization of the ACTH Receptor (MC2R) (pages 111–117)

      ADRIAN J.L. CLARK, ASMA H. BAIG, LUKE NOON, FRANCESCA M. SWORDS, LASZLO HUNYADY and PETER J. KING

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03169.x

    2. New Insights into the Functions of α-MSH and Related Peptides in the Immune System (pages 133–140)

      THOMAS A. LUGER, THOMAS E. SCHOLZEN, THOMAS BRZOSKA and MARKUS BÖHM

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03172.x

    3. Regulation of PPARγ and Obesity by Agouti/Melanocortin Signaling in Adipocytes (pages 141–146)

      RANDALL L. MYNATT and JACQUELINE M. STEPHENS

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03173.x

    4. A Polymorphic Form of Steroidogenic Factor 1 Associated with ACTH Receptor Deficiency in Mouse Adrenal Cell Mutants (pages 147–153)

      BERNARD P. SCHIMMER, MARTHA CORDOVA, JENNIVINE TSAO and CLAUDIA FRIGERI

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03174.x

    5. Proopiomelanocortin Peptides and Sebogenesis (pages 154–161)

      LI ZHANG, MIKE ANTHONAVAGE, QIULING HUANG, WEN-HWA LI and MAGDALENA EISINGER

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03175.x

  5. The Melanocortin System: Part III. CNS Physiology

    1. Top of page
    2. Frontmatter
    3. The Melanocortin System: Part II. Peripheral Non-Pigmentary Actions of Melanocortins
    4. The Melanocortin System: Part I. Melanocortin Structure/Function and Melanocortin Agonists/Antagonists
    5. The Melanocortin System: Part II. Peripheral Non-Pigmentary Actions of Melanocortins
    6. The Melanocortin System: Part III. CNS Physiology
    7. The Melanocortin System: Part IV. The Pigmentary System
    1. The Gut Hormone Peptide YY Regulates Appetite (pages 162–168)

      RACHEL L. BATTERHAM and STEPHEN R. BLOOM

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03176.x

    2. Central Serotonin and Melanocortin Pathways Regulating Energy Homeostasis (pages 169–174)

      LORA K. HEISLER, MICHAEL A. COWLEY, TOSHIRO KISHI, LAURENCE H. TECOTT, WEI FAN, MALCOLM J. LOW, JAMES L. SMART, MARCELO RUBINSTEIN, JEFFREY B. TATRO, JEFFREY M. ZIGMAN, ROGER D. CONE and JOEL K. ELMQUIST

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03177.x

    3. Electrophysiological Actions of Peripheral Hormones on Melanocortin Neurons (pages 175–186)

      MICHAEL A. COWLEY, ROGER D. CONE, PABLO ENRIORI, INGRID LOUISELLE, SARAH M. WILLIAMS and ANNE E. EVANS

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03178.x

    4. Agouti-Related Protein: Appetite or Reward? (pages 187–191)

      PAWEL K. OLSZEWSKI, KATHIE WICKWIRE, MICHELLE M. WIRTH, ALLEN S. LEVINE and SILVIA Q. GIRAUDO

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03179.x

    5. State-Dependent Modulation of Feeding Behavior by Proopiomelanocortin-Derived β-Endorphin (pages 192–201)

      MALCOLM J. LOW, MICHAEL D. HAYWARD, SUZANNE M. APPLEYARD and MARCELO RUBINSTEIN

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03180.x

    6. Putative Targets of CNS Melanocortin Receptor Activity (pages 211–217)

      CLIFFORD R. LAMAR, WENDI GARDNER, AMY BRAZDA and ROBERT A. KESTERSON

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03182.x

    7. Engineering the Melanocortin-4 Receptor to Control Gs Signaling in Vivo (pages 225–232)

      SUPRIYA SRINIVASAN, CHRISTIAN VAISSE and BRUCE R. CONKLIN

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03184.x

    8. Mutations in the Human Proopiomelanocortin Gene (pages 233–239)

      HEIKO KRUDE, HEIKE BIEBERMANN and ANNETTE GRÜTERS

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03185.x

    9. The Central Melanocortin System and Fever (pages 246–257)

      JEFFREY B. TATRO and PARTHA S. SINHA

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03187.x

    10. The Role of the Melanocortin-3 Receptor in Cachexia (pages 258–266)

      DANIEL L. MARKS and ROGER D. CONE

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03188.x

    11. Melanocortin System and Eating Disorders (pages 267–274)

      ROGER A.H. ADAN, JACQUELIEN J.G. HILLEBRAND, CORINE De RIJKE, WOUTER NIJENHUIS, TOM VINK, KEITH M. GARNER and MARTIEN J.H. KAS

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03189.x

    12. Melanocortin Signaling and Anorexia in Chronic Disease States (pages 275–281)

      BRENT E. WISSE, MICHAEL W. SCHWARTZ and DAVID E. CUMMINGS

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03190.x

    13. α-Melanocyte-Stimulating Hormone Is a Peripheral, Integrative Regulator of Glucose and Fat Metabolism (pages 282–287)

      MILES B. BRENNAN, JESSICA LYNN COSTA, STACY FORBES, PEGGY REED, STEPHANIE BUI and UTE HOCHGESCHWENDER

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03191.x

  6. The Melanocortin System: Part IV. The Pigmentary System

    1. Top of page
    2. Frontmatter
    3. The Melanocortin System: Part II. Peripheral Non-Pigmentary Actions of Melanocortins
    4. The Melanocortin System: Part I. Melanocortin Structure/Function and Melanocortin Agonists/Antagonists
    5. The Melanocortin System: Part II. Peripheral Non-Pigmentary Actions of Melanocortins
    6. The Melanocortin System: Part III. CNS Physiology
    7. The Melanocortin System: Part IV. The Pigmentary System
    1. Accessory Proteins for Melanocortin Signaling : Attractin and Mahogunin (pages 288–298)

      LIN HE, ADAM G. ELDRIDGE, PETER K. JACKSON, TERESA M. GUNN and GREGORY S. BARSH

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03192.x

    2. DNA Polymorphism and Selection at the Melanocortin-1 Receptor Gene in Normally Pigmented Southern African Individuals (pages 299–306)

      PREMILA R. JOHN, KATERYNA MAKOVA, WEN-HSIUNG LI, TREFOR JENKINS and MICHELE RAMSAY

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03193.x

    3. Evolutionary Genetics of the Melanocortin-1 Receptor in Vertebrates (pages 307–312)

      NICHOLAS I. MUNDY, JOANNE KELLY, EMMALIZE THERON and KIM HAWKINS

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03194.x

    4. Sequence Characterization of Teleost Fish Melanocortin Receptors (pages 319–330)

      DARREN W. LOGAN, ROBERT J. BRYSON-RICHARDSON, MARTIN S. TAYLOR, PETER CURRIE and IAN J. JACKSON

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03196.x

    5. Pigmentary Switches in Domestic Animal Species (pages 331–338)

      H. KLUNGLAND and D. I. VÅGE

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03197.x

    6. Defining the Quantitative Contribution of the Melanocortin 1 Receptor (MC1R) to Variation in Pigmentary Phenotype (pages 339–347)

      T. HA, L. NAYSMITH, K. WATERSTON, C. OH, R. WELLER and J. L. REES

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03198.x

    7. Genetic Association and Cellular Function of MC1R Variant Alleles in Human Pigmentation (pages 348–358)

      R. A. STURM, D. L. DUFFY, N. F. BOX, R. A. NEWTON, A. G. SHEPHERD, W. CHEN, L. H. MARKS, J. H. LEONARD and N. G. MARTIN

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03199.x

    8. Significance of the Melanocortin 1 Receptor in Regulating Human Melanocyte Pigmentation, Proliferation, and Survival (pages 359–365)

      ANA LUISA KADEKARO, HIROMI KANTO, RENNY KAVANAGH and ZALFA A. ABDEL-MALEK

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03200.x

    9. Avian Melanocortin System: α-MSH May Act as an Autocrine/Paracrine Hormone : A Minireview (pages 366–372)

      SAKAE TAKEUCHI, SUMIO TAKAHASHI, RONALD OKIMOTO, HELGI B. SCHIÖTH and TIMOTHY BOSWELL

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03201.x

    10. P-Locus Is a Target for the Melanogenic Effects of MC-1R Signaling : A Possible Control Point for Facultative Pigmentation (pages 373–377)

      JANIS ANCANS, NIAMH FLANAGAN, MARTIN J. HOOGDUIJN and ANTHONY J. THODY

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03202.x

    11. DOTA α-Melanocyte-Stimulating Hormone Analogues for Imaging Metastatic Melanoma Lesions (pages 378–383)

      SYLVIE FROIDEVAUX, MARTINE CALAME-CHRISTE, LAZAR SUMANOVSKI, HEIDI TANNER and ALEX N. EBERLE

      Article first published online: 24 JAN 2006 | DOI: 10.1111/j.1749-6632.2003.tb03203.x

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