Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

September 2003

Volume 998 MYASTHENIA GRAVIS AND RELATED DISORDERS: Biochemical Basis for Disease of the Neuromuscular Junction

Pages xiii–xiv, 1–548

  1. Frontmatter

    1. Top of page
    2. Frontmatter
    3. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part I. Structure and Function of the Neuromuscular Junction: Physiology and Neurotransmitter Release
    4. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part II. Structure and Function of the Neuromuscular Junction: Structure and Function of the Acetylcholine Receptor
    5. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part III. Structure and Function of the Neuromuscular Junction: Genetic Biochemical Disorders
    6. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part IV. Autoimmunity: General Concepts
    7. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part V. Immunology of Autoimmune Disorders Involving the Neuron and Presynaptic Nerve Terminal
    8. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VI. Immunology of Postsynaptic Autoimmune Disorders: The Thymus
    9. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VII. Immunology of Postsynaptic Autoimmune Disorders: T Cells and Immunoregulation
    10. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VIII. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Human Disease
    11. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part IX. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Experimental Myasthenia
    12. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part X. Epidemiology and Measurements in Myasthenia Gravis
    13. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part XI. Current Diagnosis and Treatment: Pre- and Postsynaptic Immune Syndromes
    14. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part XII. Future Therapies in Myasthenia
    1. Introduction (pages xiii–xiv)

      MARK A. AGIUS

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.001

  2. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part I. Structure and Function of the Neuromuscular Junction: Physiology and Neurotransmitter Release

    1. Top of page
    2. Frontmatter
    3. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part I. Structure and Function of the Neuromuscular Junction: Physiology and Neurotransmitter Release
    4. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part II. Structure and Function of the Neuromuscular Junction: Structure and Function of the Acetylcholine Receptor
    5. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part III. Structure and Function of the Neuromuscular Junction: Genetic Biochemical Disorders
    6. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part IV. Autoimmunity: General Concepts
    7. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part V. Immunology of Autoimmune Disorders Involving the Neuron and Presynaptic Nerve Terminal
    8. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VI. Immunology of Postsynaptic Autoimmune Disorders: The Thymus
    9. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VII. Immunology of Postsynaptic Autoimmune Disorders: T Cells and Immunoregulation
    10. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VIII. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Human Disease
    11. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part IX. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Experimental Myasthenia
    12. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part X. Epidemiology and Measurements in Myasthenia Gravis
    13. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part XI. Current Diagnosis and Treatment: Pre- and Postsynaptic Immune Syndromes
    14. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part XII. Future Therapies in Myasthenia
    1. Ca2+ Channels and Synaptic Transmission at the Adult, Neonatal, and P/Q-Type Deficient Neuromuscular Junction (pages 11–17)

      SILVANA NUDLER, JOAQUIN PIRIZ, FRANCISCO J. URBANO, MARCELO D. ROSATO-SIRI, ERIKA S. PIEDRAS RENTERIA and OSVALDO D. UCHITEL

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.003

    2. Protein Ubiquitylation and Synaptic Function (pages 33–40)

      OTTAVIO CREMONA, CHIARA COLLESI and ELISABETTA RAITERI

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.006

  3. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part II. Structure and Function of the Neuromuscular Junction: Structure and Function of the Acetylcholine Receptor

    1. Top of page
    2. Frontmatter
    3. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part I. Structure and Function of the Neuromuscular Junction: Physiology and Neurotransmitter Release
    4. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part II. Structure and Function of the Neuromuscular Junction: Structure and Function of the Acetylcholine Receptor
    5. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part III. Structure and Function of the Neuromuscular Junction: Genetic Biochemical Disorders
    6. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part IV. Autoimmunity: General Concepts
    7. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part V. Immunology of Autoimmune Disorders Involving the Neuron and Presynaptic Nerve Terminal
    8. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VI. Immunology of Postsynaptic Autoimmune Disorders: The Thymus
    9. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VII. Immunology of Postsynaptic Autoimmune Disorders: T Cells and Immunoregulation
    10. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VIII. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Human Disease
    11. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part IX. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Experimental Myasthenia
    12. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part X. Epidemiology and Measurements in Myasthenia Gravis
    13. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part XI. Current Diagnosis and Treatment: Pre- and Postsynaptic Immune Syndromes
    14. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part XII. Future Therapies in Myasthenia
    1. Synapse-Specific Gene Expression at the Neuromuscular Junction (pages 53–65)

      ALEXANDRE MÉJAT, AYMERIC RAVEL-CHAPUIS, MARIE VANDROMME and LAURENT SCHAEFFER

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.008

    2. Regulation of Nicotinic Acetylcholine Receptor Assembly (pages 66–80)

      CHRISTIAN P. WANAMAKER, JOHN C. CHRISTIANSON and WILLIAM N. GREEN

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.009

    3. The Binding Site of Acetylcholine Receptor : From Synthetic Peptides to Solution and Crystal Structure (pages 93–100)

      SARA FUCHS, RONI KASHER, MOSHE BALASS, TALI SCHERF, MICHAL HAREL, MATI FRIDKIN, JOEL L. SUSSMAN and EPHRAIM KATCHALSKI-KATZIR

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.011

    4. Agonist-Induced Transitions of the Acetylcholine Receptor (pages 101–113)

      ROBERT H. FAIRCLOUGH, MARK A. AGIUS, ESWARI GUDIPATI, LAURA SILVIAN, BRENT HAMAOKA, CHRISTOPHER C. BELTZNER, MIKE Y. LIN, ANTHONY R. CHUANG and DAVID P. RICHMAN

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.012

  4. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part III. Structure and Function of the Neuromuscular Junction: Genetic Biochemical Disorders

    1. Top of page
    2. Frontmatter
    3. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part I. Structure and Function of the Neuromuscular Junction: Physiology and Neurotransmitter Release
    4. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part II. Structure and Function of the Neuromuscular Junction: Structure and Function of the Acetylcholine Receptor
    5. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part III. Structure and Function of the Neuromuscular Junction: Genetic Biochemical Disorders
    6. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part IV. Autoimmunity: General Concepts
    7. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part V. Immunology of Autoimmune Disorders Involving the Neuron and Presynaptic Nerve Terminal
    8. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VI. Immunology of Postsynaptic Autoimmune Disorders: The Thymus
    9. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VII. Immunology of Postsynaptic Autoimmune Disorders: T Cells and Immunoregulation
    10. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VIII. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Human Disease
    11. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part IX. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Experimental Myasthenia
    12. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part X. Epidemiology and Measurements in Myasthenia Gravis
    13. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part XI. Current Diagnosis and Treatment: Pre- and Postsynaptic Immune Syndromes
    14. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part XII. Future Therapies in Myasthenia
    1. Structural Abnormalities of the AChR Caused by Mutations Underlying Congenital Myasthenic Syndromes (pages 114–124)

      DAVID BEESON, RICHARD WEBSTER, JOHN EALING, REBECCA CROXEN, SHARON BROWNLOW, MARTIN BRYDSON, JOHN NEWSOM-DAVIS, CLARKE SLATER, CHRIS HATTON, CHRIS SHELLEY, DAVID COLQUHOUN and ANGELA VINCENT

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.013

    2. Mechanistic Diversity Underlying Fast Channel Congenital Myasthenic Syndromes (pages 128–137)

      STEVEN M. SINE, HAI-LONG WANG, KINJI OHNO, XIN-MING SHEN, WON YONG LEE and ANDREW G. ENGEL

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.015

  5. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part IV. Autoimmunity: General Concepts

    1. Top of page
    2. Frontmatter
    3. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part I. Structure and Function of the Neuromuscular Junction: Physiology and Neurotransmitter Release
    4. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part II. Structure and Function of the Neuromuscular Junction: Structure and Function of the Acetylcholine Receptor
    5. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part III. Structure and Function of the Neuromuscular Junction: Genetic Biochemical Disorders
    6. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part IV. Autoimmunity: General Concepts
    7. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part V. Immunology of Autoimmune Disorders Involving the Neuron and Presynaptic Nerve Terminal
    8. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VI. Immunology of Postsynaptic Autoimmune Disorders: The Thymus
    9. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VII. Immunology of Postsynaptic Autoimmune Disorders: T Cells and Immunoregulation
    10. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VIII. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Human Disease
    11. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part IX. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Experimental Myasthenia
    12. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part X. Epidemiology and Measurements in Myasthenia Gravis
    13. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part XI. Current Diagnosis and Treatment: Pre- and Postsynaptic Immune Syndromes
    14. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part XII. Future Therapies in Myasthenia
  6. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part V. Immunology of Autoimmune Disorders Involving the Neuron and Presynaptic Nerve Terminal

    1. Top of page
    2. Frontmatter
    3. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part I. Structure and Function of the Neuromuscular Junction: Physiology and Neurotransmitter Release
    4. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part II. Structure and Function of the Neuromuscular Junction: Structure and Function of the Acetylcholine Receptor
    5. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part III. Structure and Function of the Neuromuscular Junction: Genetic Biochemical Disorders
    6. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part IV. Autoimmunity: General Concepts
    7. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part V. Immunology of Autoimmune Disorders Involving the Neuron and Presynaptic Nerve Terminal
    8. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VI. Immunology of Postsynaptic Autoimmune Disorders: The Thymus
    9. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VII. Immunology of Postsynaptic Autoimmune Disorders: T Cells and Immunoregulation
    10. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VIII. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Human Disease
    11. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part IX. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Experimental Myasthenia
    12. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part X. Epidemiology and Measurements in Myasthenia Gravis
    13. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part XI. Current Diagnosis and Treatment: Pre- and Postsynaptic Immune Syndromes
    14. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part XII. Future Therapies in Myasthenia
    1. Pathogenic Autoantibodies in the Lambert-Eaton Myasthenic Syndrome (pages 187–195)

      BETHAN LANG, ASHWIN PINTO, FEDERICA GIOVANNINI, JOHN NEWSOM-DAVIS and ANGELA VINCENT

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.019

    2. HLA-B8 in Patients with the Lambert-Eaton Myasthenic Syndrome Reduces Likelihood of Associated Small Cell Lung Carcinoma (pages 200–201)

      PAUL W. WIRTZ, NICK WILLCOX, BART O. ROEP, BETHAN LANG, AXEL R. WINTZEN, JOHN NEWSOM-DAVIS and JAN J. VERSCHUUREN

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.021

    3. Autoimmune Disorders of Neuronal Potassium Channels (pages 202–210)

      JOHN NEWSOM-DAVIS, CAMILLA BUCKLEY, LINDA CLOVER, IAN HART, PAUL MADDISON, ERDEM TÜZÜM and ANGELA VINCENT

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.022

    4. Humoral and Cellular Autoimmune Responses in Stiff Person Syndrome (pages 215–222)

      TOBIAS LOHMANN, MARCO LONDEI, MOHAMMED HAWA and R. DAVID G. LESLIE

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.024

  7. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VI. Immunology of Postsynaptic Autoimmune Disorders: The Thymus

    1. Top of page
    2. Frontmatter
    3. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part I. Structure and Function of the Neuromuscular Junction: Physiology and Neurotransmitter Release
    4. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part II. Structure and Function of the Neuromuscular Junction: Structure and Function of the Acetylcholine Receptor
    5. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part III. Structure and Function of the Neuromuscular Junction: Genetic Biochemical Disorders
    6. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part IV. Autoimmunity: General Concepts
    7. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part V. Immunology of Autoimmune Disorders Involving the Neuron and Presynaptic Nerve Terminal
    8. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VI. Immunology of Postsynaptic Autoimmune Disorders: The Thymus
    9. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VII. Immunology of Postsynaptic Autoimmune Disorders: T Cells and Immunoregulation
    10. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VIII. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Human Disease
    11. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part IX. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Experimental Myasthenia
    12. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part X. Epidemiology and Measurements in Myasthenia Gravis
    13. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part XI. Current Diagnosis and Treatment: Pre- and Postsynaptic Immune Syndromes
    14. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part XII. Future Therapies in Myasthenia
    1. The Role of Thymomas in the Development of Myasthenia Gravis (pages 223–236)

      ALEXANDER MARX, HANS KONRAD MÜLLER-HERMELINK and PHILIPP STRÖBEL

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.025

    2. Scenarios for Autoimmunization of T and B Cells in Myasthenia Gravis (pages 237–256)

      H. SHIONO, I. ROXANIS, W. ZHANG, G. P. SIMS, A. MEAGER, L. W. JACOBSON, J-L. LIU, I. MATTHEWS, Y-L. WONG, M. BONIFATI, K. MICKLEM, D. I. STOTT, J. A. TODD, D. BEESON, A. VINCENT and N. WILLCOX

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.026

    3. A New Model Linking Intrathymic Acetylcholine Receptor Expression and the Pathogenesis of Myasthenia Gravis (pages 257–265)

      ARNOLD I. LEVINSON, YI ZHENG, GLEN GAULTON, JONNI MOORE, C. HANK PLETCHER, DECHENG SONG and LISA M. WHEATLEY

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.027

    4. Human Myoid Cells Protect Thymocytes from Apoptosis (pages 266–269)

      ROZEN Le PANSE-RUSKONÉ and SONIA BERRIH-AKNIN

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.028

    5. Analysis of SjTREC Levels in Thymus from MG Patients and Normal Children (pages 270–274)

      LAURA PASSERINI, PIA BERNASCONI, FULVIO BAGGI, FERDINANDO CORNELIO and RENATO MANTEGAZZA

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.029

    6. Analysis of CD4+CD25+ Cell Population in the Thymus from Myasthenia Gravis Patients (pages 275–277)

      A. BALANDINA, A. SAOUDI, P. DARTEVELLE and S. BERRIH-AKNIN

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.030

    7. Expression of Transforming Growth Factor-β1 in Thymus of Myasthenia Gravis Patients : Correlation with Pathological Abnormalities (pages 278–283)

      PIA BERNASCONI, LAURA PASSERINI, ANDREA ANNONI, FEDERICA UBIALI, CRISTIANA MARCOZZI, PAOLO CONFALONIERI, FERDINANDO CORNELIO and RENATO MANTEGAZZA

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.031

  8. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VII. Immunology of Postsynaptic Autoimmune Disorders: T Cells and Immunoregulation

    1. Top of page
    2. Frontmatter
    3. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part I. Structure and Function of the Neuromuscular Junction: Physiology and Neurotransmitter Release
    4. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part II. Structure and Function of the Neuromuscular Junction: Structure and Function of the Acetylcholine Receptor
    5. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part III. Structure and Function of the Neuromuscular Junction: Genetic Biochemical Disorders
    6. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part IV. Autoimmunity: General Concepts
    7. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part V. Immunology of Autoimmune Disorders Involving the Neuron and Presynaptic Nerve Terminal
    8. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VI. Immunology of Postsynaptic Autoimmune Disorders: The Thymus
    9. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VII. Immunology of Postsynaptic Autoimmune Disorders: T Cells and Immunoregulation
    10. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VIII. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Human Disease
    11. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part IX. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Experimental Myasthenia
    12. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part X. Epidemiology and Measurements in Myasthenia Gravis
    13. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part XI. Current Diagnosis and Treatment: Pre- and Postsynaptic Immune Syndromes
    14. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part XII. Future Therapies in Myasthenia
    1. T Cells and Cytokines in the Pathogenesis of Acquired Myasthenia Gravis (pages 284–307)

      MONICA MILANI, NORMA OSTLIE, WEI WANG and BIANCA M. CONTI-FINE

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.032

    2. Circulating CD4+CD25+ and CD4+CD25 T Cells in Myasthenia Gravis (pages 318–319)

      Y. HUANG, R. PIRSKANEN, R. CISCOMBE, H. LINK and A-K. LEFVERT

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.034

    3. Rationale for a T Cell Receptor Peptide Therapy in Myasthenia Gravis (pages 320–323)

      F. JAMBOU, M. MENESTRIER, I. KLINGEL-SCHMITT, S. CAILLAT-ZUCMAN, A. AÏSSAOUI, S. BERRIH-AKNIN and S. COHEN-KAMINSKY

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.035

  9. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VIII. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Human Disease

    1. Top of page
    2. Frontmatter
    3. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part I. Structure and Function of the Neuromuscular Junction: Physiology and Neurotransmitter Release
    4. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part II. Structure and Function of the Neuromuscular Junction: Structure and Function of the Acetylcholine Receptor
    5. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part III. Structure and Function of the Neuromuscular Junction: Genetic Biochemical Disorders
    6. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part IV. Autoimmunity: General Concepts
    7. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part V. Immunology of Autoimmune Disorders Involving the Neuron and Presynaptic Nerve Terminal
    8. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VI. Immunology of Postsynaptic Autoimmune Disorders: The Thymus
    9. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VII. Immunology of Postsynaptic Autoimmune Disorders: T Cells and Immunoregulation
    10. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VIII. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Human Disease
    11. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part IX. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Experimental Myasthenia
    12. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part X. Epidemiology and Measurements in Myasthenia Gravis
    13. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part XI. Current Diagnosis and Treatment: Pre- and Postsynaptic Immune Syndromes
    14. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part XII. Future Therapies in Myasthenia
    1. Antibodies in Myasthenia Gravis and Related Disorders (pages 324–335)

      ANGELA VINCENT, JOHN McCONVILLE, MARIA ELENA FARRUGIA, JOHN BOWEN, PAUL PLESTED, TERESA TANG, AMELIA EVOLI, IAN MATTHEWS, GARY SIMS, PAOLA DALTON, LESLIE JACOBSON, AGATA POLIZZI, FRANS BLAES, BETHAN LANG, DAVID BEESON, NICK WILLCOX, JOHN NEWSOM-DAVIS and WERNER HOCH

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.036

    2. Use of Peptide:HLA Class II Complexes to Study Specific T Cells in Autoimmune Myasthenia Gravis (pages 339–342)

      UDAY KISHORE, WEI ZHANG, LOUISE CORLETT, PATRICK WATERS, NICOLAS GLAICHENHAUS and NICK WILLCOX

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.038

    3. Pathogenesis of Myositis and Myasthenia Associated with Titin and Ryanodine Receptor Antibodies (pages 343–350)

      GEIR OLVE SKEIE, FREDRIK ROMI, JOHAN A. AARLI, PÅL TORE BENTSEN and NILS ERIK GILHUS

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.039

    4. Antibodies in Sera of Patients with Late-Onset Myasthenia Gravis Recognize the PEVK Domain of Titin (pages 351–355)

      MIRTA MIHOVILOVIC, EMMA CIAFALONI, JENNIFER BUTTERWORTH-ROBINETTE, JIAN-PING JIN, JANICE MASSEY and DONALD B. SANDERS

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.040

    5. Identification of Disease-Specific Autoantibodies in Seronegative Myasthenia Gravis (pages 356–358)

      EMANUELA BARTOCCIONI, MARIAPAOLA MARINO, AMELIA EVOLI, MARCUS A. RUEGG, FLAVIA SCUDERI and CARLO PROVENZANO

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.041

    6. Susceptibility of Ocular Tissues to Autoimmune Diseases (pages 362–374)

      HENRY J. KAMINSKI, ZHUYI LI, CHELLIAH RICHMONDS, ROBERT L. RUFF and LINDA KUSNER

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.043

  10. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part IX. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Experimental Myasthenia

    1. Top of page
    2. Frontmatter
    3. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part I. Structure and Function of the Neuromuscular Junction: Physiology and Neurotransmitter Release
    4. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part II. Structure and Function of the Neuromuscular Junction: Structure and Function of the Acetylcholine Receptor
    5. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part III. Structure and Function of the Neuromuscular Junction: Genetic Biochemical Disorders
    6. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part IV. Autoimmunity: General Concepts
    7. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part V. Immunology of Autoimmune Disorders Involving the Neuron and Presynaptic Nerve Terminal
    8. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VI. Immunology of Postsynaptic Autoimmune Disorders: The Thymus
    9. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VII. Immunology of Postsynaptic Autoimmune Disorders: T Cells and Immunoregulation
    10. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VIII. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Human Disease
    11. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part IX. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Experimental Myasthenia
    12. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part X. Epidemiology and Measurements in Myasthenia Gravis
    13. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part XI. Current Diagnosis and Treatment: Pre- and Postsynaptic Immune Syndromes
    14. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part XII. Future Therapies in Myasthenia
    1. Induction of Myasthenia Gravis in HLA Transgenic Mice by Immunization with Human Acetylcholine Receptors (pages 375–378)

      HUAN YANG, ELZBIETA GOLUSZKO, CHELLA DAVID, DAVID K. OKITA, BIANCA CONTI-FINE, TEH-SHENG CHAN, MATHILDE A. POUSSIN and PREMKUMAR CHRISTADOSS

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.044

    2. Production and Characterization of a T Cell Receptor Transgenic Mouse Recognizing the Immunodominant Epitope of the Torpedo californica Acetylcholine Receptor (pages 379–383)

      ALEXEI MIAGKOV, ADRIAN A. LOBITO, BINGZHI YANG, MARCELA F. LOPES, ROBERT N. ADAMS, GREGORY R. PALARDY, MICHELE M. JOHNSON, HUGH I. McFARLAND, MICHAEL J. LENARDO and DANIEL B. DRACHMAN

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.045

    3. Epitope Repertoire of Th1 and Th2 Cells Reactive with the Mouse Muscle AChR α Subunit in C57Bl/6 Mice (pages 384–387)

      WEI WANG, MONICA MILANI, DAVID OKITA, NORMA OSTLIE and BIANCA M. CONTI-FINE

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.046

    4. Immunization with Rat-, but Not Torpedo-Derived 97–116 Peptide of the AChR α-Subunit Induces Experimental Myasthenia Gravis in Lewis Rat (pages 391–394)

      FULVIO BAGGI, ANDREA ANNONI, FEDERICA UBIALI, RENATO LONGHI, MONICA MILANI, RENATO MANTEGAZZA, FERDINANDO CORNELIO and CARLO ANTOZZI

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.048

    5. Effect on T Cell Recognition and Immunogenicity of Alanine-Substituted Peptides Corresponding to 97–116 Sequence of the Rat AChR α-Subunit (pages 395–398)

      FULVIO BAGGI, ANDREA ANNONI, FEDERICA UBIALI, RENATO LONGHI, RENATO MANTEGAZZA, FERDINANDO CORNELIO and CARLO ANTOZZI

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.049

    6. Characterization of a Fully Human IgG1 Reconstructed from an Anti-AChR Fab (pages 399–400)

      MAURICE H. W. STASSEN, BARBIE M. MACHIELS, EFROSINI FOSTIERI, SOCRATES J. TZARTOS, SONIA BERRIH-AKNIN, EUGÈNE BOSMANS, PAUL W. H. I. PARREN and MARC H. De BAETS

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.050

    7. Roles of Complex Gangliosides at the Neuromuscular Junction (pages 401–403)

      R. W.M. BULLENS, G. M. O'HANLON, E. WAGNER, P. C. MOLENAAR, KOICHI FURUKAWA, KEIKO FURUKAWA, J. J. PLOMP and H. J. WILLISON

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.051

  11. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part X. Epidemiology and Measurements in Myasthenia Gravis

    1. Top of page
    2. Frontmatter
    3. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part I. Structure and Function of the Neuromuscular Junction: Physiology and Neurotransmitter Release
    4. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part II. Structure and Function of the Neuromuscular Junction: Structure and Function of the Acetylcholine Receptor
    5. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part III. Structure and Function of the Neuromuscular Junction: Genetic Biochemical Disorders
    6. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part IV. Autoimmunity: General Concepts
    7. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part V. Immunology of Autoimmune Disorders Involving the Neuron and Presynaptic Nerve Terminal
    8. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VI. Immunology of Postsynaptic Autoimmune Disorders: The Thymus
    9. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VII. Immunology of Postsynaptic Autoimmune Disorders: T Cells and Immunoregulation
    10. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VIII. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Human Disease
    11. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part IX. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Experimental Myasthenia
    12. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part X. Epidemiology and Measurements in Myasthenia Gravis
    13. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part XI. Current Diagnosis and Treatment: Pre- and Postsynaptic Immune Syndromes
    14. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part XII. Future Therapies in Myasthenia
    1. Myasthenia Gravis (MG): Epidemiological Data and Prognostic Factors (pages 413–423)

      RENATO MANTEGAZZA, FULVIO BAGGI, CARLO ANTOZZI, PAOLO CONFALONIERI, LUCIA MORANDI, PIA BERNASCONI, FRANCESCA ANDREETTA, ORNELLA SIMONCINI, ANGELA CAMPANELLA, ETTORE BEGHI and FERDINANDO CORNELIO

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.054

    2. Myasthenia Gravis in Individuals over 40 (pages 424–431)

      JOHAN A. AARLI, FREDRIK ROMI, GEIR OLVE SKEIE and NILS ERIK GILHUS

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.055

    3. Standards of Measurements in Myasthenia Gravis (pages 445–452)

      P. GAJDOS, T. SHARSHAR and S. CHEVRET

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.058

  12. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part XI. Current Diagnosis and Treatment: Pre- and Postsynaptic Immune Syndromes

    1. Top of page
    2. Frontmatter
    3. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part I. Structure and Function of the Neuromuscular Junction: Physiology and Neurotransmitter Release
    4. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part II. Structure and Function of the Neuromuscular Junction: Structure and Function of the Acetylcholine Receptor
    5. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part III. Structure and Function of the Neuromuscular Junction: Genetic Biochemical Disorders
    6. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part IV. Autoimmunity: General Concepts
    7. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part V. Immunology of Autoimmune Disorders Involving the Neuron and Presynaptic Nerve Terminal
    8. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VI. Immunology of Postsynaptic Autoimmune Disorders: The Thymus
    9. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VII. Immunology of Postsynaptic Autoimmune Disorders: T Cells and Immunoregulation
    10. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VIII. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Human Disease
    11. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part IX. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Experimental Myasthenia
    12. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part X. Epidemiology and Measurements in Myasthenia Gravis
    13. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part XI. Current Diagnosis and Treatment: Pre- and Postsynaptic Immune Syndromes
    14. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part XII. Future Therapies in Myasthenia
    1. Three Forms of Immune Myasthenia (pages 453–456)

      MARK A. AGIUS, DAVID P. RICHMAN, ROBERT H. FAIRCLOUGH, JOHAN AARLI, NILS ERIK GILHUS and FREDRIK ROMI

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.059

    2. Development of a Thymectomy Trial in Nonthymomatous Myasthenia Gravis Patients Receiving Immunosuppressive Therapy (pages 473–480)

      GIL I. WOLFE, HENRY J. KAMINSKI, ALFRED JARETZKI III, ANTHONY SWAN and JOHN NEWSOM-DAVIS

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.061

    3. Thymectomy and Antimuscle Antibodies in Nonthymomatous Myasthenia Gravis (pages 481–490)

      FREDRIK ROMI, NILS E. GILHUS, JAN E. VARHAUG, ANDREAS MYKING, GEIR O. SKEIE and JOHAN A. AARLI

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.062

    4. Prognostic Factors of Thymectomy in Patients with Myasthenia Gravis : A Cohort of 132 Patients (pages 491–493)

      JOSÉ FRANCISCO TÉLLEZ-ZENTENO, JOSE MARÍA REMES-TROCHE, GUILLERMO GARCÍA-RAMOS, BRUNO ESTAÑOL and JUAN GARDUÑO-ESPINOZA

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.063

    5. Mycophenolate Mofetil for Myasthenia Gravis A Double-Blind, Placebo-Controlled Pilot Study (pages 494–499)

      MATTHEW N. MERIGGIOLI, JULIE ROWIN, JUDITH G. RICHMAN and SUE LEURGANS

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.064

  13. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part XII. Future Therapies in Myasthenia

    1. Top of page
    2. Frontmatter
    3. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part I. Structure and Function of the Neuromuscular Junction: Physiology and Neurotransmitter Release
    4. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part II. Structure and Function of the Neuromuscular Junction: Structure and Function of the Acetylcholine Receptor
    5. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part III. Structure and Function of the Neuromuscular Junction: Genetic Biochemical Disorders
    6. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part IV. Autoimmunity: General Concepts
    7. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part V. Immunology of Autoimmune Disorders Involving the Neuron and Presynaptic Nerve Terminal
    8. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VI. Immunology of Postsynaptic Autoimmune Disorders: The Thymus
    9. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VII. Immunology of Postsynaptic Autoimmune Disorders: T Cells and Immunoregulation
    10. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part VIII. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Human Disease
    11. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part IX. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Experimental Myasthenia
    12. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part X. Epidemiology and Measurements in Myasthenia Gravis
    13. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part XI. Current Diagnosis and Treatment: Pre- and Postsynaptic Immune Syndromes
    14. Myasthenia Gravis and Related Disorders: Biochemical Basis for Disease of the Neuromuscular Junction: Part XII. Future Therapies in Myasthenia
    1. Treatment of Autoimmune Disease by Adoptive Cellular Gene Therapy (pages 512–519)

      INGO H. TARNER, ANTHONY J. SLAVIN, JACQUELINE McBRIDE, ALENKA LEVICNIK, RICHARD SMITH, GARRY P. NOLAN, CHRISTOPHER H. CONTAG and C. GARRISON FATHMAN

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.067

    2. Suppression of Myasthenia Gravis by Antigen-Specific Mucosal Tolerance and Modulation of Cytokines and Costimulatory Factors (pages 533–536)

      MIRIAM C. SOUROUJON, PRASANTA K. MAITI, TALI FEFERMAN, SIN-HYEOG IM, LILY RAVEH and SARA FUCHS

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.069

    3. Future Therapeutic Strategies in Autoimmune Myasthenia Gravis (pages 539–548)

      LOUKIA PSARIDI-LINARDAKI, AVGI MAMALAKI and SOCRATES J. TZARTOS

      Article first published online: 24 JAN 2006 | DOI: 10.1196/annals.1254.071

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