Annals of the New York Academy of Sciences

Cover image for Vol. 1011 Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease

April 2004

Volume 1011 Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease

Pages ix–ix, 1–349

  1. Frontmatter

    1. Top of page
    2. Frontmatter
    3. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Overview
    4. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part I. Human Evolutionary History and Mitochondrial Diseases
    5. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part II. Mitochondrial Function and Diseases
    6. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part III. Mitochondrial Transcription Factor
    7. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part IV. Mechanism of Mitochondrial Damage
    8. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part V. Oxidative Stress and Apoptosis
    9. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VI. Mitochondria and Diabetes
    10. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VII. Diagnosis and Treatment of Mitochondrial Diseases
    11. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VIII. Short Communications
    1. Preface (page ix)

      HONG KYU LEE

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1293.036

  2. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Overview

    1. Top of page
    2. Frontmatter
    3. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Overview
    4. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part I. Human Evolutionary History and Mitochondrial Diseases
    5. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part II. Mitochondrial Function and Diseases
    6. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part III. Mitochondrial Transcription Factor
    7. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part IV. Mechanism of Mitochondrial Damage
    8. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part V. Oxidative Stress and Apoptosis
    9. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VI. Mitochondria and Diabetes
    10. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VII. Diagnosis and Treatment of Mitochondrial Diseases
    11. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VIII. Short Communications
    1. Overview (pages 1–6)

      HONG KYU LEE

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1293.001

  3. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part I. Human Evolutionary History and Mitochondrial Diseases

    1. Top of page
    2. Frontmatter
    3. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Overview
    4. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part I. Human Evolutionary History and Mitochondrial Diseases
    5. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part II. Mitochondrial Function and Diseases
    6. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part III. Mitochondrial Transcription Factor
    7. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part IV. Mechanism of Mitochondrial Damage
    8. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part V. Oxidative Stress and Apoptosis
    9. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VI. Mitochondria and Diabetes
    10. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VII. Diagnosis and Treatment of Mitochondrial Diseases
    11. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VIII. Short Communications
    1. Mitochondrial Genome Single Nucleotide Polymorphisms and Their Phenotypes in the Japanese (pages 7–20)

      MASASHI TANAKA, TAKESHI TAKEYASU, NORIYUKI FUKU, GUO LI-JUN and MIYUKI KURATA

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1293.002

    2. Mitochondrial DNA Variation in the Aboriginal Populations of the Altai-Baikal Region: Implications for the Genetic History of North Asia and America (pages 21–35)

      ILIA A. ZAKHAROV, MIROSLAVA V. DERENKO, BORIS A. MALIARCHUK, IRINA K. DAMBUEVA, CHODURAA M. DORZHU and SERGEY Y. RYCHKOV

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1293.003

  4. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part II. Mitochondrial Function and Diseases

    1. Top of page
    2. Frontmatter
    3. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Overview
    4. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part I. Human Evolutionary History and Mitochondrial Diseases
    5. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part II. Mitochondrial Function and Diseases
    6. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part III. Mitochondrial Transcription Factor
    7. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part IV. Mechanism of Mitochondrial Damage
    8. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part V. Oxidative Stress and Apoptosis
    9. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VI. Mitochondria and Diabetes
    10. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VII. Diagnosis and Treatment of Mitochondrial Diseases
    11. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VIII. Short Communications
    1. Mitochondrial ALDH2 Deficiency as an Oxidative Stress (pages 36–44)

      SHIGEO OHTA, IKUROH OHSAWA, KOUZIN KAMINO, FUJIKO Ando and HIROSHI SHIMOKATA

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1293.004

    2. Mitochondrial Reactive Oxygen Species Generation and Calcium Increase Induced by Visible Light in Astrocytes (pages 45–56)

      MEI-JIE JOU, SHUO-BIN JOU, MEI-JIN GUO, HONG-YUEH WU and TSUNG-I PENG

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1293.005

  5. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part III. Mitochondrial Transcription Factor

    1. Top of page
    2. Frontmatter
    3. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Overview
    4. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part I. Human Evolutionary History and Mitochondrial Diseases
    5. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part II. Mitochondrial Function and Diseases
    6. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part III. Mitochondrial Transcription Factor
    7. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part IV. Mechanism of Mitochondrial Damage
    8. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part V. Oxidative Stress and Apoptosis
    9. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VI. Mitochondria and Diabetes
    10. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VII. Diagnosis and Treatment of Mitochondrial Diseases
    11. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VIII. Short Communications
    1. Mitochondrial Nucleoid and Transcription Factor A (pages 61–68)

      TOMOTAKE KANKI, HIROSHI NAKAYAMA, NARIE SASAKI, KOJI TAKIO, TANFIS ISTIAQ ALAM, NAOTAKA HAMASAKI and DONGCHON KANG

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1293.007

    2. Regulation and Role of the Mitochondrial Transcription Factor in the Diabetic Rat Heart (pages 78–85)

      YOSHIHIKO NISHIO, AKIO KANAZAWA, YOSHIO NAGAI, HIDETOSHI INAGAKI and ATSUNORI KASHIWAGI

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1293.009

  6. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part IV. Mechanism of Mitochondrial Damage

    1. Top of page
    2. Frontmatter
    3. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Overview
    4. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part I. Human Evolutionary History and Mitochondrial Diseases
    5. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part II. Mitochondrial Function and Diseases
    6. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part III. Mitochondrial Transcription Factor
    7. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part IV. Mechanism of Mitochondrial Damage
    8. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part V. Oxidative Stress and Apoptosis
    9. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VI. Mitochondria and Diabetes
    10. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VII. Diagnosis and Treatment of Mitochondrial Diseases
    11. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VIII. Short Communications
    1. The Mitochondrial Production of Reactive Oxygen Species in Relation to Aging and Pathology (pages 86–100)

      MARIA LUISA GENOVA, MILENA MERLO PICH, ANDREA BERNACCHIA, CRISTINA BIANCHI, ANNALISA BIONDI, CARLA BOVINA, ANNA IDA FALASCA, GABRIELLA FORMIGGINI, GIOVANNA PARENTI CASTELLI and GIORGIO LENAZ

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1293.010

    2. Biological Significance of the Defense Mechanisms against Oxidative Damage in Nucleic Acids Caused by Reactive Oxygen Species: From Mitochondria to Nuclei (pages 101–111)

      YUSAKU NAKABEPPU, DAISUKE TSUCHIMOTO, AKIMASA ICHINOE, MIZUKI OHNO, YASUHITO IDE, SEIKI HIRANO, DAISUKE YOSHIMURA, YOHEI TOMINAGA, MASATO FURUICHI and KUNIHIKO SAKUMI

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1293.011

  7. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part V. Oxidative Stress and Apoptosis

    1. Top of page
    2. Frontmatter
    3. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Overview
    4. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part I. Human Evolutionary History and Mitochondrial Diseases
    5. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part II. Mitochondrial Function and Diseases
    6. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part III. Mitochondrial Transcription Factor
    7. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part IV. Mechanism of Mitochondrial Damage
    8. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part V. Oxidative Stress and Apoptosis
    9. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VI. Mitochondria and Diabetes
    10. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VII. Diagnosis and Treatment of Mitochondrial Diseases
    11. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VIII. Short Communications
    1. Mitochondrial DNA Mutation and Depletion Increase the Susceptibility of Human Cells to Apoptosis (pages 133–145)

      CHUN-YI LIU, CHENG-FENG LEE, CHIUNG-HUI HONG and YAU-HUEI WEI

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1293.014

    2. Resistance of ρ0 Cells against Apoptosis (pages 146–153)

      MYUNG-SHIK LEE, JA-YOUNG KIM and SUN YOUNG PARK

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1293.015

    3. Role of Oxidative Stress in Pancreatic β-Cell Dysfunction (pages 168–176)

      YOSHITAKA KAJIMOTO and HIDEAKI KANETO

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1293.017

  8. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VI. Mitochondria and Diabetes

    1. Top of page
    2. Frontmatter
    3. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Overview
    4. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part I. Human Evolutionary History and Mitochondrial Diseases
    5. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part II. Mitochondrial Function and Diseases
    6. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part III. Mitochondrial Transcription Factor
    7. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part IV. Mechanism of Mitochondrial Damage
    8. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part V. Oxidative Stress and Apoptosis
    9. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VI. Mitochondria and Diabetes
    10. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VII. Diagnosis and Treatment of Mitochondrial Diseases
    11. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VIII. Short Communications
    1. Accumulation of Somatic Mutation in Mitochondrial DNA and Atherosclerosis in Diabetic Patients (pages 193–204)

      TAKASHI NOMIYAMA, YASUSHI TANAKA, LIANSHAN PIAO, NOBUTAKA HATTORI, HIROSHI UCHINO, HIROTAKA WATADA, RYUZO KAWAMORI and SHIGEO OHTA

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1293.020

    2. Changes of Mitochondrial DNA Content in the Male Offspring of Protein-Malnourished Rats (pages 205–216)

      HYEONG KYU PARK, CHENG JI JIN, YOUNG MIN CHO, DO JOON PARK, CHAN SOO SHIN, KYONG SOO PARK, SEONG YEON KIM, BO YOUN CHO and HONG KYU LEE

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1293.021

  9. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VII. Diagnosis and Treatment of Mitochondrial Diseases

    1. Top of page
    2. Frontmatter
    3. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Overview
    4. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part I. Human Evolutionary History and Mitochondrial Diseases
    5. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part II. Mitochondrial Function and Diseases
    6. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part III. Mitochondrial Transcription Factor
    7. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part IV. Mechanism of Mitochondrial Damage
    8. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part V. Oxidative Stress and Apoptosis
    9. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VI. Mitochondria and Diabetes
    10. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VII. Diagnosis and Treatment of Mitochondrial Diseases
    11. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VIII. Short Communications
    1. Mitochondrial Encephalomyopathies: Diagnostic Approach (pages 217–231)

      SALVATORE DIMAURO, STACEY TAY and MICHELANGELO MANCUSO

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1293.022

    2. Mitochondrial Encephalomyopathies: Therapeutic Approach (pages 232–245)

      SALVATORE DIMAURO, MICHELANGELO MANCUSO and ALI NAINI

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1293.023

    3. Genetic and Functional Analysis of Mitochondrial DNA-Encoded Complex I Genes (pages 272–283)

      YIDONG BAI, PEIQING HU, JEONG SOON PARK, JIAN-HONG DENG, XIUFENG SONG, ANNE CHOMYN, TAKAO YAGI and GIUSEPPE ATTARDI

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1293.026

  10. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VIII. Short Communications

    1. Top of page
    2. Frontmatter
    3. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Overview
    4. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part I. Human Evolutionary History and Mitochondrial Diseases
    5. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part II. Mitochondrial Function and Diseases
    6. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part III. Mitochondrial Transcription Factor
    7. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part IV. Mechanism of Mitochondrial Damage
    8. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part V. Oxidative Stress and Apoptosis
    9. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VI. Mitochondria and Diabetes
    10. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VII. Diagnosis and Treatment of Mitochondrial Diseases
    11. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part VIII. Short Communications
    1. Quantitative PCR Analysis of Mitochondrial DNA Content in Patients with Mitochondrial Disease (pages 304–309)

      REN-KUI BAI, CHERNG-LIH PERNG, CHANG-HUNG HSU and LEE-JUN C. WONG

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1293.029

    2. Somatic Mitochondrial DNA Mutations in Oral Cancer of Betel Quid Chewers (pages 310–316)

      DUAN-JUN TAN, JULIA CHANG, WOAN-LING CHEN, LESLEY J. AGRESS, KUN-TU YEH, BAOTYAN WANG and LEE-JUN C. WONG

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1293.030

    3. Association of the Mitochondrial DNA 16189 T to C Variant with Lacunar Cerebral Infarction: Evidence from a Hospital-Based Case-Control Study (pages 317–324)

      CHIA-WEI LIOU, TSU-KUNG LIN, FENG-MEI HUANG, TZU-LING CHEN, CHENG-FENG LEE, YAO-CHUNG CHUANG, TENG-YEOW TAN, KU-CHOU CHANG and YAU-HUEI WEI

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1293.031

    4. Mechanisms of Cell Death Induced by Cadmium and Arsenic (pages 325–331)

      SHIRO JIMI, MASANOBU UCHIYAMA, AYA TAKAKI, JYUNJI SUZUMIYA and SYUJI HARA

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1293.032

    5. Investigation of Common Mitochondrial Point Mutations in Korea (pages 339–344)

      SEON-JOO KWON, SUNG-SUP PARK, JONG-MIN KIM, TAE-BEOM AHN, SEUNG HYUN KIM, JUHAN KIM, SUNG-HYUN LEE, CHOONG-KUN HA, MOO-YOUNG AHN and BEOM S. JEON

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1293.034

    6. Leber's Hereditary Optic Neuropathy: The Spectrum of Mitochondrial DNA Mutations in Iranian Patients (pages 345–349)

      M HOUSHMAND, F SHARIFPANAH, A TABASI, M-H SANATI, M VAKILIAN, SH LAVASANI and S JOUGHEHDOUST

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1293.035

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