Annals of the New York Academy of Sciences

Cover image for Vol. 1019 Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable

June 2004

Volume 1019 Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable

Pages xv–xvi, 1–592

  1. Frontmatter

    1. Top of page
    2. Frontmatter
    3. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part I. The Nervous System
    4. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part II. The Cardiovascular System
    5. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part III. The Immune System
    6. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IV. Cancer
    7. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part V. Protein Damage
    8. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VI. DNA Damage
    9. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VII. Hormones and Signaling
    10. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VIII. Oxidative Stress
    11. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IX. Nutrition
    12. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part X. Exercise
    13. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XI. Exceptional Longevity
    14. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XII. Ethical and Sociological Issues
    15. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XIII. Other Topics
    1. Preface (pages xv–xvi)

      AUBREY D.N.J. DE GREY

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.111

  2. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part I. The Nervous System

    1. Top of page
    2. Frontmatter
    3. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part I. The Nervous System
    4. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part II. The Cardiovascular System
    5. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part III. The Immune System
    6. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IV. Cancer
    7. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part V. Protein Damage
    8. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VI. DNA Damage
    9. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VII. Hormones and Signaling
    10. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VIII. Oxidative Stress
    11. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IX. Nutrition
    12. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part X. Exercise
    13. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XI. Exceptional Longevity
    14. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XII. Ethical and Sociological Issues
    15. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XIII. Other Topics
    1. Challenging the Amyloid Cascade Hypothesis: Senile Plaques and Amyloid-β as Protective Adaptations to Alzheimer Disease (pages 1–4)

      HYOUNG-GON LEE, GEMMA CASADESUS, XIONGWEI ZHU, ATSUSHI TAKEDA, GEORGE PERRY and MARK A. SMITH

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.001

    2. The Role of Viruses and of APOE in Dementia (pages 15–18)

      R F Itzhaki, C B Dobson, S J Shipley and M A Wozniak

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.003

    3. The Biphasic Relationship between Regional Brain Senile Plaque and Neurofibrillary Tangle Distributions: Modification by Age, Sex, and APOE Polymorphism (pages 24–28)

      ELIZABETH H. CORDER, ESTIFANOS GHEBREMEDHIN, MILES G. TAYLOR, DIETMAR R. THAL, THOMAS G. OHM and HEIKO BRAAK

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.005

    4. Decay of Mitochondrial Metabolic Competence in the Aging Cerebellum (pages 29–32)

      CARLO BERTONI-FREDDARI, PATRIZIA FATTORETTI, BELINDA GIORGETTI, MORENO SOLAZZI, MARTA BALIETTI, GIUSEPPINA DI STEFANO and TIZIANA CASOLI

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.006

    5. Cytochrome Oxidase Activity in Hippocampal Synaptic Mitochondria during Aging: A Quantitative Cytochemical Investigation (pages 33–36)

      CARLO BERTONI-FREDDARI, PATRIZIA FATTORETTI, BELINDA GIORGETTI, MORENO SOLAZZI, MARTA BALIETTI, TIZIANA CASOLI and GIUSEPPINA DI STEFANO

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.007

    6. Vitamin E Deficiency and Aging Effect on Expression Levels of GAP-43 and MAP-2 in Selected Areas of the Brain (pages 37–40)

      TIZIANA CASOLI, GIUSEPPINA DI STEFANO, ALESSIA DELFINO, PATRIZIA FATTORETTI and CARLO BERTONI-FREDDARI

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.008

    7. Chronic Aluminum Administration to Old Rats Results in Increased Levels of Brain Metal Ions and Enlarged Hippocampal Mossy Fibers (pages 44–47)

      PATRIZIA FATTORETTI, CARLO BERTONI-FREDDARI, MARTA BALIETTI, BELINDA GIORGETTI, MORENO SOLAZZI and PAOLO ZATTA

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.010

    8. Motor and Cognitive Recovery Induced by Bone Marrow Stem Cells Grafted to Striatum and Hippocampus of Impaired Aged Rats: Functional and Therapeutic Considerations (pages 48–52)

      CARIDAD I. FERNÁNDEZ, ESTEBAN ALBERTI, YISSEL MENDOZA, LISIS MARTÍNEZ, JAIME COLLAZO, JUAN C. ROSILLO and JOSÉ Y. BAUZA

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.011

    9. Digital Transcriptome Analysis in the Aging Cerebellum (pages 58–63)

      MAGDALENA C. POPESCO, ADRIENNE FROSTHOLM, KATARZYNA REJNIAK and ANDREJ ROTTER

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.013

    10. Antiaging Treatments Have Been Legally Prescribed for Approximately Thirty Years (pages 64–69)

      SVETLANA V. UKRAINTSEVA, KONSTANTIN G. ARBEEV, ANATOLY I. MICHALSKY and ANATOLY I. YASHIN

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.014

  3. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part II. The Cardiovascular System

    1. Top of page
    2. Frontmatter
    3. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part I. The Nervous System
    4. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part II. The Cardiovascular System
    5. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part III. The Immune System
    6. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IV. Cancer
    7. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part V. Protein Damage
    8. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VI. DNA Damage
    9. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VII. Hormones and Signaling
    10. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VIII. Oxidative Stress
    11. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IX. Nutrition
    12. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part X. Exercise
    13. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XI. Exceptional Longevity
    14. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XII. Ethical and Sociological Issues
    15. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XIII. Other Topics
    1. Response of the Senescent Heart to Stress: Clinical Therapeutic Strategies and Quest for Mitochondrial Predictors of Biological Age (pages 78–84)

      FRANKLIN ROSENFELDT, FRANCIS MILLER, PHILLIP NAGLEY, ANTHONY HADJ, SILVANA MARASCO, DEAHNE QUICK, FREYA SHEERAN, MICHELLE WOWK and SALVATORE PEPE

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.016

    2. Impairment of the Transcriptional Responses to Oxidative Stress in the Heart of Aged C57BL/6 Mice (pages 85–95)

      MICHAEL G. EDWARDS, DEEPAYAN SARKAR, ROGER KLOPP, JASON D. MORROW, RICHARD WEINDRUCH and TOMAS A. PROLLA

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.017

  4. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part III. The Immune System

    1. Top of page
    2. Frontmatter
    3. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part I. The Nervous System
    4. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part II. The Cardiovascular System
    5. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part III. The Immune System
    6. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IV. Cancer
    7. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part V. Protein Damage
    8. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VI. DNA Damage
    9. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VII. Hormones and Signaling
    10. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VIII. Oxidative Stress
    11. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IX. Nutrition
    12. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part X. Exercise
    13. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XI. Exceptional Longevity
    14. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XII. Ethical and Sociological Issues
    15. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XIII. Other Topics
    1. Interleukin-7: An Interleukin for Rejuvenating the Immune System (pages 116–122)

      RICHARD ASPINALL, SIAN HENSON, JEFFREY PIDO-LOPEZ and PA TAMBA NGOM

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.021

    2. Zinc, Immune Plasticity, Aging, and Successful Aging: Role of Metallothionein (pages 127–134)

      EUGENIO MOCCHEGIANI, ROBERTINA GIACCONI, ELISA MUTI, CINZIA ROGO, MASSIMO BRACCI, MARIO MUZZIOLI, CATIA CIPRIANO and MARCO MALAVOLTA

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.023

    3. Looking for Immunological Risk Genotypes (pages 141–146)

      CALOGERO CARUSO, ALESSANDRA AQUINO, GIUSEPPINA CANDORE, LETIZIA SCOLA, GIUSEPPINA COLONNA-ROMANO and DOMENICO LIO

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.025

  5. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IV. Cancer

    1. Top of page
    2. Frontmatter
    3. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part I. The Nervous System
    4. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part II. The Cardiovascular System
    5. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part III. The Immune System
    6. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IV. Cancer
    7. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part V. Protein Damage
    8. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VI. DNA Damage
    9. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VII. Hormones and Signaling
    10. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VIII. Oxidative Stress
    11. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IX. Nutrition
    12. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part X. Exercise
    13. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XI. Exceptional Longevity
    14. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XII. Ethical and Sociological Issues
    15. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XIII. Other Topics
    1. Total Deletion of in Vivo Telomere Elongation Capacity: An Ambitious but Possibly Ultimate Cure for All Age-Related Human Cancers (pages 147–170)

      AUBREY D. N. J. DE GREY, F CHARLES CAMPBELL, INDERJEET DOKAL, LESLIE J. FAIRBAIRN, GERRY J. GRAHAM, COLIN A. B. JAHODA and ANDREW C. G. PORTERG

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.026

    2. Insights into Aging Obtained from p53 Mutant Mouse Models (pages 171–177)

      MELISSA DUMBLE, CATHERINE GATZA, STUART TYNER, SUNDARESAN VENKATACHALAM and LAWRENCE A. DONEHOWER

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.027

    3. Engineering Anticancer T Cells for Extended Functional Longevity (pages 178–185)

      GRAHAM PAWELEC, ERMINIA MARIANI, JULIE McLEOD, ARIE BEN-YEHUDA, TAMAS FÜLÖP, MARTIN ARINGER and YVONNE BARNETT

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.028

    4. Telomerase Expression Is Differentially Regulated in Birds of Differing Life Span (pages 186–190)

      MARK F. HAUSSMANN, DAVID W. WINKLER, CHARLES E. HUNTINGTON, IAN C. T. NISBET and CAROL M. VLECK

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.029

    5. The Aging/Precancerous Gastric Mucosa: A Pilot Nutraceutical Trial (pages 195–199)

      F MAROTTA, R BARRETO, H TAJIRI, J BERTUCCELLI, P SAFRAN, C YOSHIDA and E FESCE

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.031

    6. Cancer as “Rejuvenescence” (pages 200–205)

      SVETLANA V. UKRAINTSEVA and ANATOLY I. YASHINA

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.032

  6. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part V. Protein Damage

    1. Top of page
    2. Frontmatter
    3. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part I. The Nervous System
    4. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part II. The Cardiovascular System
    5. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part III. The Immune System
    6. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IV. Cancer
    7. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part V. Protein Damage
    8. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VI. DNA Damage
    9. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VII. Hormones and Signaling
    10. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VIII. Oxidative Stress
    11. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IX. Nutrition
    12. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part X. Exercise
    13. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XI. Exceptional Longevity
    14. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XII. Ethical and Sociological Issues
    15. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XIII. Other Topics
    1. Protective Effects of Mutant Ubiquitin in Transgenic Mice (pages 215–218)

      D A GRAY, M TSIRIGOTIS, J BRUN, M TANG, M ZHANG, M BEYERS and J WOULFE

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.035

    2. Algae Extract Protection Effect on Oxidized Protein Level in Human Stratum Corneum (pages 219–222)

      CARINE NIZARD, SYLVIE POGGIOLI, CATHERINE HEUSÈLE, ANNE-LAURE BULTEAU, MARIELLE MOREAU, ALEX SAUNOIS, SYLVIANNE SCHNEBERT, CHRISTIAN MAHÉ and BERTRAND FRIGUET

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.036

    3. Heat Shock Protein 47 Expression in Aged Normal Human Fibroblasts: Modulation by Salix alba Extract (pages 223–227)

      CARINE NIZARD, EMMANUELLE NOBLESSE, CÉCILLE BOISDÉ, MARIELLE MOREAU, ANNE-MARIE FAUSSAT, SYLVIANNE SCHNEBERT and CHRISTIAN MAHÉ

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.037

    4. RAGE: A New Pleiotropic Antagonistic Gene? (pages 228–231)

      A SIMM, B BARTLING and R-E SILBER

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.038

  7. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VI. DNA Damage

    1. Top of page
    2. Frontmatter
    3. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part I. The Nervous System
    4. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part II. The Cardiovascular System
    5. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part III. The Immune System
    6. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IV. Cancer
    7. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part V. Protein Damage
    8. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VI. DNA Damage
    9. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VII. Hormones and Signaling
    10. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VIII. Oxidative Stress
    11. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IX. Nutrition
    12. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part X. Exercise
    13. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XI. Exceptional Longevity
    14. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XII. Ethical and Sociological Issues
    15. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XIII. Other Topics
    1. Genetic Correction of Mitochondrial Diseases: Using the Natural Migration of Mitochondrial Genes to the Nucleus in Chlorophyte Algae as a Model System (pages 232–239)

      DIEGO GONZÁLEZ-HALPHEN, SOLEDAD FUNES, XOCHITL PÉREZ-MARTÍNEZ, ADRIÁN REYES-PRIETO, M GONZALO CLAROS, EDGAR DAVIDSON and MICHAEL P. KING

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.039

    2. Where and When Do Somatic mtDNA Mutations Occur? (pages 240–244)

      KONSTANTIN KHRAPKO, KONSTANTIN EBRALIDSE and YEVGENYA KRAYTSBERG

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.040

    3. Genomic Instability, Aging, and Cellular Senescence (pages 245–255)

      RITA A. BUSUTTIL, MARTIJN DOLLÉ, JUDITH CAMPISI and JAN VIJGA

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.041

    4. Camptothecin Sensitivity in Werner Syndrome Fibroblasts as Assessed by the COMET Technique (pages 256–259)

      J LOWE, A SHEERIN, K JENNERT-BURSTON, D BURTON, E L OSTLER, J BIRD, M H L GREEN and R G A FARAGHER

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.042

    5. Lysosomal Redox-Active Iron Is Important for Oxidative Stress-Induced DNA Damage (pages 285–288)

      TINO KURZ, ALAN LEAKE, THOMAS VON ZGLINICKI and ULF T. BRUNK

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.048

  8. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VII. Hormones and Signaling

    1. Top of page
    2. Frontmatter
    3. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part I. The Nervous System
    4. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part II. The Cardiovascular System
    5. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part III. The Immune System
    6. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IV. Cancer
    7. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part V. Protein Damage
    8. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VI. DNA Damage
    9. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VII. Hormones and Signaling
    10. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VIII. Oxidative Stress
    11. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IX. Nutrition
    12. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part X. Exercise
    13. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XI. Exceptional Longevity
    14. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XII. Ethical and Sociological Issues
    15. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XIII. Other Topics
    1. Functional Efficiency of the Senescent Cells: Replace or Restore? (pages 309–316)

      SANG CHUL PARK, KYUNG A. CHO, IK SOON JANG, KYUNG TAE KIM and SUNG JIN RYU

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.052

    2. Secretion of Melatonin in Healthy Elderly Subjects: A Longitudinal Study (pages 326–329)

      N M K NG YING KIN, N P V NAIR, G SCHWARTZ, J X THAVUNDAYIL and L ANNABLE

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.055

    3. The Proinflammatory Phenotype of Senescent Cells: The p53-Mediated ICAM-1 Expression (pages 330–332)

      DIMITRIS KLETSAS, HARRIS PRATSINIS, GIORGOS MARIATOS, PANAYOTIS ZACHARATOS and VASSILIS G. GORGOULIS

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.056

  9. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VIII. Oxidative Stress

    1. Top of page
    2. Frontmatter
    3. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part I. The Nervous System
    4. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part II. The Cardiovascular System
    5. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part III. The Immune System
    6. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IV. Cancer
    7. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part V. Protein Damage
    8. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VI. DNA Damage
    9. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VII. Hormones and Signaling
    10. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VIII. Oxidative Stress
    11. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IX. Nutrition
    12. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part X. Exercise
    13. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XI. Exceptional Longevity
    14. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XII. Ethical and Sociological Issues
    15. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XIII. Other Topics
    1. Short-Term Caloric Restriction and Sites of Oxygen Radical Generation in Kidney and Skeletal Muscle Mitochondria (pages 333–342)

      RICARDO GREDILLA, SHARON PHANEUF, COLIN SELMAN, SUMA KENDAIAH, CHRISTIAAN LEEUWENBURGH and GUSTAVO BARJA

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.057

    2. Glutathione Metabolism during Aging and in Alzheimer Disease (pages 346–349)

      HONGLEI LIU, HONG WANG, SWAPNA SHENVI, TORY M. HAGEN and RUI-MING LIU

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.059

    3. Senescence Marker Protein-30 as a Novel Antiaging Molecule (pages 360–364)

      DONGYUN FENG, YOSHITAKA KONDO, AKIHITO ISHIGAMI, MASASHI KURAMOTO, TAKEO MACHIDA and NAOKI MARUYAMA

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.062

    4. Iron Accumulation during Cellular Senescence (pages 365–367)

      DAVID W. KILLILEA, STEPHANIE L. WONG, HENDRY S. CAHAYA, HANI ATAMNA and BRUCE N. AMES

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.063

    5. No Increase in Senescence-Associated β-Galactosidase Activity in Werner Syndrome Fibroblasts after Exposure to H2O2 (pages 375–378)

      JOÃO PEDRO de MAGALHÃES, VALÉRIE MIGEOT, VÉRONIQUE MAINFROID, FRANÇOISE de LONGUEVILLE, JOSÉ REMACLE and OLIVIER TOUSSAINT

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.066

    6. Aging and Vitamin E Deficiency Are Responsible for Altered RNA Pathways (pages 379–382)

      MANUELA MALATESTA, CARLO BERTONI-FREDDARI, PATRIZIA FATTORETTI, BEATRICE BALDELLI, STANISLAV FAKAN and GIANCARLO GAZZANELLI

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.067

    7. Senescence Marker Protein-30 Knockout Mouse as an Aging Model (pages 383–387)

      NAOKI MARUYAMA, AKIHITO ISHIGAMI, MASASHI KURAMOTO, SETSUKO HANDA, SACHIHO KUBO, TOSHIYUKI IMASAWA, KUNIAKI SEYAMA, TATSUO SHIMOSAWA and YASUSHI KASAHARA

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.068

  10. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IX. Nutrition

    1. Top of page
    2. Frontmatter
    3. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part I. The Nervous System
    4. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part II. The Cardiovascular System
    5. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part III. The Immune System
    6. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IV. Cancer
    7. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part V. Protein Damage
    8. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VI. DNA Damage
    9. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VII. Hormones and Signaling
    10. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VIII. Oxidative Stress
    11. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IX. Nutrition
    12. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part X. Exercise
    13. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XI. Exceptional Longevity
    14. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XII. Ethical and Sociological Issues
    15. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XIII. Other Topics
    1. Development of Calorie Restriction Mimetics as a Prolongevity Strategy (pages 412–423)

      DONALD K. INGRAM, R MICHAEL ANSON, RAFAEL DE CABO, JACEK MAMCZARZ, MIN ZHU, JULIE MATTISON, MARK A. LANE and GEORGE S. ROTH

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.074

    2. An Appetite for Death (pages 434–435)

      JALAL KOOCHMESHGI

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.078

    3. Long-Lived αMUPA Transgenic Mice Exhibit Increased Mitochondrion-Mediated Apoptotic Capacity (pages 439–442)

      OREN TIROSH, BETTY SCHWARTZ, IGOR ZUSMAN, GEORGE KOSSOY, SHLOMO YAHAV and RUTH MISKIN

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.080

    4. Effect of Caloric Restriction on the 24-Hour Plasma DHEAS and Cortisol Profiles of Young and Old Male Rhesus Macaques (pages 443–447)

      H F. URBANSKI, J L DOWNS, V T GARYFALLOU, J A MATTISON, M A LANE, G S ROTH and D K INGRAM

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.081

  11. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part X. Exercise

    1. Top of page
    2. Frontmatter
    3. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part I. The Nervous System
    4. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part II. The Cardiovascular System
    5. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part III. The Immune System
    6. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IV. Cancer
    7. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part V. Protein Damage
    8. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VI. DNA Damage
    9. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VII. Hormones and Signaling
    10. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VIII. Oxidative Stress
    11. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IX. Nutrition
    12. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part X. Exercise
    13. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XI. Exceptional Longevity
    14. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XII. Ethical and Sociological Issues
    15. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XIII. Other Topics
    1. Aging, Exercise, and Cardioprotection (pages 462–470)

      SCOTT K. POWERS, JOHN QUINDRY and KARYN HAMILTON

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.084

    2. Regular Exercise: An Effective Means to Reduce Oxidative Stress in Old Rats (pages 471–474)

      SATARO GOTO, ZSOLT RADÁK, CSABA NYAKAS, HAE YOUNG CHUNG, HISASHI NAITO, RYOYA TAKAHASHI, HIDEKO NAKAMOTO and RYOICHI ABEA

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.085

    3. Mechanisms in Muscle Atrophy in Immobilization and Aging (pages 475–478)

      MARINA BAR-SHAI, ELI CARMELI, RAYMOND COLEMAN and ABRAHAM Z. REZNICK

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.086

  12. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XI. Exceptional Longevity

    1. Top of page
    2. Frontmatter
    3. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part I. The Nervous System
    4. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part II. The Cardiovascular System
    5. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part III. The Immune System
    6. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IV. Cancer
    7. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part V. Protein Damage
    8. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VI. DNA Damage
    9. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VII. Hormones and Signaling
    10. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VIII. Oxidative Stress
    11. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IX. Nutrition
    12. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part X. Exercise
    13. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XI. Exceptional Longevity
    14. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XII. Ethical and Sociological Issues
    15. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XIII. Other Topics
    1. Cardiovascular Disease Delay in Centenarian Offspring: Role of Heat Shock Proteins (pages 502–505)

      DELLARA F. TERRY, MAEGAN McCORMICK, STACY ANDERSEN, JAEMI PENNINGTON, EMILY SCHOENHOFEN, ELIZABETH PALAIMA, MARIA BAUSERO, KISHIKO OGAWA, THOMAS T. PERLS and ALEXZANDER ASEA

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.092

    2. Does Exceptional Human Longevity Come with a High Cost of Infertility?: Testing the Evolutionary Theories of Aging (pages 513–517)

      NATALIA S. GAVRILOVA, LEONID A. GAVRILOV, VICTORIA G. SEMYONOVA and GALINA N. EVDOKUSHKINA

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.095

  13. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XII. Ethical and Sociological Issues

    1. Top of page
    2. Frontmatter
    3. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part I. The Nervous System
    4. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part II. The Cardiovascular System
    5. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part III. The Immune System
    6. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IV. Cancer
    7. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part V. Protein Damage
    8. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VI. DNA Damage
    9. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VII. Hormones and Signaling
    10. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VIII. Oxidative Stress
    11. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IX. Nutrition
    12. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part X. Exercise
    13. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XI. Exceptional Longevity
    14. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XII. Ethical and Sociological Issues
    15. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XIII. Other Topics
  14. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XIII. Other Topics

    1. Top of page
    2. Frontmatter
    3. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part I. The Nervous System
    4. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part II. The Cardiovascular System
    5. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part III. The Immune System
    6. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IV. Cancer
    7. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part V. Protein Damage
    8. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VI. DNA Damage
    9. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VII. Hormones and Signaling
    10. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part VIII. Oxidative Stress
    11. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part IX. Nutrition
    12. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part X. Exercise
    13. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XI. Exceptional Longevity
    14. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XII. Ethical and Sociological Issues
    15. Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable: Part XIII. Other Topics
    1. The Arrest of Biological Time as a Bridge to Engineered Negligible Senescence (pages 559–563)

      JERRY LEMLER, STEVEN B. HARRIS, CHARLES PLATT and TODD M. HUFFMAN

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.104

    2. Apolipoprotein E Genotype and Age at Menopause (pages 564–567)

      JALAL KOOCHMESHGI, SEYED MEHDI HOSSEINI-MAZINANI, SEYED MORTEZA SEIFATI, NASRIN HOSEIN-PUR-NOBARI and LADAN TEIMOORI-TOOLABI

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.105

    3. How an Individual Fecundity Pattern Looks in Drosophila and Medflies (pages 577–580)

      V N NOVOSELTSEV, R ARKING, J R CAREY, J A NOVOSELTSEVA and A I YASHINb

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1297.108

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