Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

December 2004

Volume 1030 Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets

Pages xiii–xiii, 1–669

  1. Frontmatter

    1. Top of page
    2. Frontmatter
    3. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part I. Cell Signaling Pathways in Health and Disease
    4. Article: Part I. Cell Signaling Pathways in Health and Disease
    5. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part I. Cell Signaling Pathways in Health and Disease
    6. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part II. MAP Kinase Pathways as Therapeutic Targets
    7. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part III. Signal Transduction Pathways in Neurodegenerative Diseases
    8. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part IV. Apoptotic Signaling Pathways
    9. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part V. Chemopreventive Agents Interfering with Cell Signaling Pathways
    10. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VI. Gene Expression Mechanisms as Therapeutic Targets
    11. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VII. Transcriptional Control Mechanisms as Therapeutic Targets
    12. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VIII. Chromatin Structure as a Therapeutic Target
    1. Preface (page xiii)

      MARC DIEDERICH

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.001

  2. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part I. Cell Signaling Pathways in Health and Disease

    1. Top of page
    2. Frontmatter
    3. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part I. Cell Signaling Pathways in Health and Disease
    4. Article: Part I. Cell Signaling Pathways in Health and Disease
    5. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part I. Cell Signaling Pathways in Health and Disease
    6. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part II. MAP Kinase Pathways as Therapeutic Targets
    7. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part III. Signal Transduction Pathways in Neurodegenerative Diseases
    8. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part IV. Apoptotic Signaling Pathways
    9. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part V. Chemopreventive Agents Interfering with Cell Signaling Pathways
    10. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VI. Gene Expression Mechanisms as Therapeutic Targets
    11. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VII. Transcriptional Control Mechanisms as Therapeutic Targets
    12. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VIII. Chromatin Structure as a Therapeutic Target
    1. A Beginner's Guide to NF-κB Signaling Pathways (pages 1–13)

      SYLVIE DELHALLE, ROMAIN BLASIUS, MARIO DICATO and MARC DIEDERICH

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.002

    2. Spontaneous Generation of Reactive Oxygen Species in the Mixture of Cyanide and Glycerol (pages 43–51)

      YANG-SOOK CHUN, EUN-JIN YEO, HWA-JIN SUH and JONG-WAN PARK

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.006

    3. Design and Characterization of a New Class of Inhibitors of Ras Activation (pages 52–61)

      SONIA COLOMBO, FRANCESCO PERI, RENATA TISI, FRANCESCO NICOTRA and ENZO MARTEGANI

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.007

    4. Endogenous Oxidative Stress Induces Distinct Redox Forms of Tumor Necrosis Factor Receptor-1 in Melanoma Cells (pages 62–68)

      S DOMINICI, L PIERI, A PAOLICCHI, V DE TATA, F ZUNINO and A POMPELLA

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.008

    5. Epidermal Growth Factor Receptor as a Novel Therapeutic Target in Anaplastic Thyroid Carcinomas (pages 69–77)

      C ENSINGER, G SPIZZO, P MOSER, I TSCHOERNER, R PROMMEGGER, M GABRIEL, G MIKUZ and K W SCHMID

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.009

    6. Analysis of the Effects of Different Alcohols on MCF-7 Human Breast Cancer Cells (pages 78–85)

      NICOLAS ETIQUE, DOMINIQUE CHARDARD, AMAND CHESNEL, STEPHANE FLAMENT and ISABELLE GRILLIER-VUISSOZ

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.010

    7. Redox Signaling by Ionizing Radiation in Mouse Liver (pages 86–94)

      JEUNG HEE AN, JIYOUNG KIM and JINSIL SEONG

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.011

  3. Article: Part I. Cell Signaling Pathways in Health and Disease

    1. Top of page
    2. Frontmatter
    3. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part I. Cell Signaling Pathways in Health and Disease
    4. Article: Part I. Cell Signaling Pathways in Health and Disease
    5. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part I. Cell Signaling Pathways in Health and Disease
    6. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part II. MAP Kinase Pathways as Therapeutic Targets
    7. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part III. Signal Transduction Pathways in Neurodegenerative Diseases
    8. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part IV. Apoptotic Signaling Pathways
    9. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part V. Chemopreventive Agents Interfering with Cell Signaling Pathways
    10. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VI. Gene Expression Mechanisms as Therapeutic Targets
    11. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VII. Transcriptional Control Mechanisms as Therapeutic Targets
    12. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VIII. Chromatin Structure as a Therapeutic Target
    1. Three-Dimensional Bioreactor Cultures: A Useful Dynamic Model for the Study of Cellular Interactions (pages 103–115)

      SPIRO M. KONSTANTINOV, MINA M. MINDOVA, PANAYOT T. GOSPODINOV and PENKA I. GENOVA

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.013

  4. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part I. Cell Signaling Pathways in Health and Disease

    1. Top of page
    2. Frontmatter
    3. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part I. Cell Signaling Pathways in Health and Disease
    4. Article: Part I. Cell Signaling Pathways in Health and Disease
    5. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part I. Cell Signaling Pathways in Health and Disease
    6. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part II. MAP Kinase Pathways as Therapeutic Targets
    7. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part III. Signal Transduction Pathways in Neurodegenerative Diseases
    8. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part IV. Apoptotic Signaling Pathways
    9. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part V. Chemopreventive Agents Interfering with Cell Signaling Pathways
    10. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VI. Gene Expression Mechanisms as Therapeutic Targets
    11. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VII. Transcriptional Control Mechanisms as Therapeutic Targets
    12. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VIII. Chromatin Structure as a Therapeutic Target
    1. Platelet-Activating Factor Receptor Signals in Rat Osteoblasts during Spaceflight (pages 116–120)

      YASUHIRO KUMEI, SADAO MORITA, HIROSHI NAKAMURA, HIDEO AKIYAMA, HISAKO KATANO, HITOYATA SHIMOKAWA and KEI'ICHI OHYA

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.014

    2. Osteoblast Responsiveness to 1α,25-Dihydroxyvitamin D3 during Spaceflight (pages 121–124)

      YASUHIRO KUMEI, SADAO MORITA, HIROSHI NAKAMURA, HISAKO KATANO, KEI'ICHI OHYA, HITOYATA SHIMOKAWA, CLARENCE F. SAMS and PEGGY A. WHITSON

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.015

    3. Low-Grade Inflammation with Aging Has Consequences for T-Lymphocyte Signaling (pages 125–133)

      ANIS LARBI, GILLES DUPUIS, NADINE DOUZIECH, ABDELOUAHED KHALIL and TAMÀS FÜLÖP JR

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.016

    4. Effects of Oxalate on IMCD Cells: A Line of Mouse Inner Medullary Collecting Duct Cells (pages 144–149)

      PAUL D. MARONI, SWEATY KOUL, RANDALL B. MEACHAM, PARAMJIT S. CHANDHOKE and HARI K. KOUL

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.018

    5. Hypergravity Stimulates Osteoblast Phenotype Expression: A Therapeutic Hint for Disuse Bone Atrophy (pages 158–161)

      SADAO MORITA, HIROSHI NAKAMURA, YASUHIRO KUMEI, HITOYATA SHIMOKAWA, KEIICHI OHYA and KENICHI SHINOMIYA

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.020

    6. CXCR4 Activation Induces Epidermal Growth Factor Receptor Transactivation in an Ovarian Cancer Cell Line (pages 162–169)

      CAROLA PORCILE, ADRIANA BAJETTO, SIMONE BARBERO, PAOLO PIRANI and GENNARO SCHETTINI

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.021

    7. Radiation-Induced Alteration of Pain-Related Signals in an Animal Model with Bone Invasion from Cancer (pages 179–186)

      JINSIL SEONG, HEE CHUL PARK, JIYOUNG KIM, UN JUNG KIM and BAE WHAN LEE

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.023

    8. Analysis of the Signal Transduction Pathway Leading to Human Immunodeficiency Virus-1-Induced Interferon Regulatory Factor-1 Upregulation (pages 187–195)

      MARCO SGARBANTI, GIULIA MARSILI, ANNA LISA REMOLI, BARBARA RIDOLFI, EMILIA STELLACCI, ALESSANDRA BORSETTI, BARBARA ENSOLI and ANGELA BATTISTINI

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.024

  5. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part II. MAP Kinase Pathways as Therapeutic Targets

    1. Top of page
    2. Frontmatter
    3. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part I. Cell Signaling Pathways in Health and Disease
    4. Article: Part I. Cell Signaling Pathways in Health and Disease
    5. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part I. Cell Signaling Pathways in Health and Disease
    6. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part II. MAP Kinase Pathways as Therapeutic Targets
    7. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part III. Signal Transduction Pathways in Neurodegenerative Diseases
    8. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part IV. Apoptotic Signaling Pathways
    9. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part V. Chemopreventive Agents Interfering with Cell Signaling Pathways
    10. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VI. Gene Expression Mechanisms as Therapeutic Targets
    11. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VII. Transcriptional Control Mechanisms as Therapeutic Targets
    12. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VIII. Chromatin Structure as a Therapeutic Target
    1. The Phosphotyrosine Phosphatase η Mediates Somatostatin Inhibition of Glioma Proliferation via the Dephosphorylation of ERK1/2 (pages 264–274)

      ALESSANDRO MASSA, FEDERICA BARBIERI, CINZIA AIELLO, RODOLFO IULIANO, SARA ARENA, ALESSANDRA PATTAROZZI, ALESSANDRO CORSARO, VALENTINA VILLA, ALFREDO FUSCO, GIANLUIGI ZONA, RENATO SPAZIANTE, GENNARO SCHETTINI and TULLIO FLORIO

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.033

  6. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part III. Signal Transduction Pathways in Neurodegenerative Diseases

    1. Top of page
    2. Frontmatter
    3. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part I. Cell Signaling Pathways in Health and Disease
    4. Article: Part I. Cell Signaling Pathways in Health and Disease
    5. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part I. Cell Signaling Pathways in Health and Disease
    6. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part II. MAP Kinase Pathways as Therapeutic Targets
    7. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part III. Signal Transduction Pathways in Neurodegenerative Diseases
    8. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part IV. Apoptotic Signaling Pathways
    9. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part V. Chemopreventive Agents Interfering with Cell Signaling Pathways
    10. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VI. Gene Expression Mechanisms as Therapeutic Targets
    11. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VII. Transcriptional Control Mechanisms as Therapeutic Targets
    12. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VIII. Chromatin Structure as a Therapeutic Target
    1. Increased Mitochondrial and Nuclear Gene Expression of Cytochrome Oxidase Subunits I and IV in Neuronal Aging (pages 303–309)

      PATRIZIA FATTORETTI, CARLO BERTONI-FREDDARI, BELINDA GIORGETTI and MARTA BALIETTI

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.038

    2. BACE1 Overexpression Regulates Amyloid Precursor Protein Cleavage and Interaction with the ShcA Adapter (pages 330–338)

      EMANUELA REPETTO, CLAUDIO RUSSO, VALENTINA VENEZIA, MARIO NIZZARI, ROGER M. NITSCH and GENNARO SCHETTINI

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.041

    3. Apoptotic Cell Death and Amyloid Precursor Protein Signaling in Neuroblastoma SH-SY5Y Cells (pages 339–347)

      VALENTINA VENEZIA, CLAUDIO RUSSO, EMANUELA REPETTO, MARIO NIZZARI, ELISABETTA VIOLANI, PIA CARLO, BIANCA MARCHETTI and GENNARO SCHETTINI

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.042

  7. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part IV. Apoptotic Signaling Pathways

    1. Top of page
    2. Frontmatter
    3. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part I. Cell Signaling Pathways in Health and Disease
    4. Article: Part I. Cell Signaling Pathways in Health and Disease
    5. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part I. Cell Signaling Pathways in Health and Disease
    6. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part II. MAP Kinase Pathways as Therapeutic Targets
    7. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part III. Signal Transduction Pathways in Neurodegenerative Diseases
    8. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part IV. Apoptotic Signaling Pathways
    9. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part V. Chemopreventive Agents Interfering with Cell Signaling Pathways
    10. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VI. Gene Expression Mechanisms as Therapeutic Targets
    11. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VII. Transcriptional Control Mechanisms as Therapeutic Targets
    12. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VIII. Chromatin Structure as a Therapeutic Target
    1. The Antiapoptotic Protein ICBP90 Is a Target for Protein Kinase 2 (pages 355–360)

      CHRISTIAN BRONNER, MARIE-ALINE TROTZIER, ODILE FILHOL, CLAUDE COCHET, CÉCILE ROCHETTE-EGLY, MARIE SCHÖLLER-GUINARD, JEAN-PAUL KLEIN and MARC MOUSLI

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.044

    2. Expression of the Insulin-Like Growth Factor-I Receptor and Proapoptotic Bax and Bak Proteins in Human Colorectal Cancer (pages 377–383)

      MARIUSZ KODA, JOANNA RESZEC, MARIOLA SULKOWSKA, LUIZA KANCZUGA-KODA and STANISLAW SULKOWSKI

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.047

    3. Inhibition of B16 Mouse Melanoma Cell Growth and Induction of Apoptotic Cell Death with 8-Chloroadenosine-3′,5′-monophosphate and Tiazofurin (pages 384–392)

      LELA B. KORIĆANAC, DANIJELA V. TODOROVIĆ, NATAŠA M. POPOVIĆ, MIROSLAV A. DEMAJO, SABERA D. RUŽDIJIĆ and ALEKSANDRA M. RISTI-FIRA

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.048

    4. Alterations in Protein Expression in HL-60 Cells during Etoposide-Induced Apoptosis Modulated by the Caspase Inhibitor ZVAD.fmk (pages 393–402)

      RUTA NAVAKAUSKIENE, GRAZINA TREIGYTE, JURATE SAVICKIENE, ARUNAS GINEITIS and KARL-ERIC MAGNUSSON

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.0049

    5. Mitochondria of Human Spermatozoa Are Preferentially Susceptible to Apoptosis (pages 403–409)

      UWE PAASCH, SONJA GRUNEWALD, SYLVIA DATHE and HANS-JUERGEN GLANDER

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.050

    6. Expression of Cell Proliferation and Apoptosis Markers in Papillomas and Cancers of Conjunctiva and Eyelid (pages 419–426)

      JOANNA RESZEC, MARIOLA SULKOWSKA, MARIUSZ KODA, LUIZA KANCZUGA-KODA and STANISLAW SULKOWSKI

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.052

  8. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part V. Chemopreventive Agents Interfering with Cell Signaling Pathways

    1. Top of page
    2. Frontmatter
    3. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part I. Cell Signaling Pathways in Health and Disease
    4. Article: Part I. Cell Signaling Pathways in Health and Disease
    5. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part I. Cell Signaling Pathways in Health and Disease
    6. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part II. MAP Kinase Pathways as Therapeutic Targets
    7. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part III. Signal Transduction Pathways in Neurodegenerative Diseases
    8. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part IV. Apoptotic Signaling Pathways
    9. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part V. Chemopreventive Agents Interfering with Cell Signaling Pathways
    10. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VI. Gene Expression Mechanisms as Therapeutic Targets
    11. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VII. Transcriptional Control Mechanisms as Therapeutic Targets
    12. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VIII. Chromatin Structure as a Therapeutic Target
    1. Curcumin Stability and Its Effect on Glutathione S-Transferase P1-1 mRNA Expression in K562 Cells (pages 442–448)

      ROMAIN BLASIUS, ANNELYSE DUVOIX, FRANCK MORCEAU, MICHAËL SCHNEKENBURGER, SYLVIE DELHALLE, ESTELLE HENRY, MARIO DICATO and MARC DIEDERICH

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.055

    2. Prevention Against Oxidative Stress of Eukaryotic Cell Membranes by Selenium Compounds of the Rat (pages 458–461)

      A KYRIAKOPOULOS, K BUKALIS, D ROETHLEIN, B HOPPE, A GRAEBERT and D BEHNE

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.057

    3. Effect of Dietary Restriction on DNA Synthesis in Vitamin E-Deficient Rats (pages 462–467)

      FAUSTO MORONI, RINA RECCHIONI, FIORELLA MARCHESELLI, PATRIZIA FATTORETTI and CARLO BERTONI-FREDDARI

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.058

  9. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VI. Gene Expression Mechanisms as Therapeutic Targets

    1. Top of page
    2. Frontmatter
    3. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part I. Cell Signaling Pathways in Health and Disease
    4. Article: Part I. Cell Signaling Pathways in Health and Disease
    5. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part I. Cell Signaling Pathways in Health and Disease
    6. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part II. MAP Kinase Pathways as Therapeutic Targets
    7. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part III. Signal Transduction Pathways in Neurodegenerative Diseases
    8. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part IV. Apoptotic Signaling Pathways
    9. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part V. Chemopreventive Agents Interfering with Cell Signaling Pathways
    10. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VI. Gene Expression Mechanisms as Therapeutic Targets
    11. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VII. Transcriptional Control Mechanisms as Therapeutic Targets
    12. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VIII. Chromatin Structure as a Therapeutic Target
    1. Alternatively Spliced Protein Variants as Potential Therapeutic Targets for Male Infertility and Contraception (pages 468–478)

      MARGARIDA FARDILHA, WENJUAN WU, ROSÁLIA SÁ, SARA FIDALGO, CRISTINA SOUSA, CATARINA MOTA, ODETE A.B. DA CRUZ E SILVA and EDGAR F. DA CRUZ E SILVA

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.059

    2. Comparison of Gene Expression in Intra-Abdominal and Subcutaneous Fat: A Study of Men with Morbid Obesity and Nonobese Men Using Microarray and Proteomics (pages 508–536)

      ABDOMINAL OBESITY STUDY GROUP, FINN EDLER VON EYBEN, JENS PETER KROUSTRUP, JENS FROMHOLT LARSEN and JULIO CELIS

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.063

  10. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VII. Transcriptional Control Mechanisms as Therapeutic Targets

    1. Top of page
    2. Frontmatter
    3. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part I. Cell Signaling Pathways in Health and Disease
    4. Article: Part I. Cell Signaling Pathways in Health and Disease
    5. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part I. Cell Signaling Pathways in Health and Disease
    6. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part II. MAP Kinase Pathways as Therapeutic Targets
    7. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part III. Signal Transduction Pathways in Neurodegenerative Diseases
    8. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part IV. Apoptotic Signaling Pathways
    9. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part V. Chemopreventive Agents Interfering with Cell Signaling Pathways
    10. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VI. Gene Expression Mechanisms as Therapeutic Targets
    11. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VII. Transcriptional Control Mechanisms as Therapeutic Targets
    12. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VIII. Chromatin Structure as a Therapeutic Target
    1. GATA-1: Friends, Brothers, and Coworkers (pages 537–554)

      FRANCK MORCEAU, MICHAEL SCHNEKENBURGER, MARIO DICATO and MARC DIEDERICH

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.064

    2. Tetramethoxy Hydroxyflavone p7F Downregulates Inflammatory Mediators via the Inhibition of Nuclear Factor κB (pages 555–568)

      HEE-GU LEE, HYOSON KIM, WON-KEUN OH, KYUNG-AE YU, YONG-KYUNG CHOE, JONG-SEOG AHN, DONG-SOO KIM, SOO-HYUN KIM, CHARLES A. DINARELLO, KILHYOUN KIM and DO-YOUNG YOON

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.065

    3. Effects of Curcumin (Diferuloylmethane) on Nuclear Factor κB Signaling in Interleukin-1β-Stimulated Chondrocytes (pages 578–586)

      GUNDULA SCHULZE-TANZIL, ALI MOBASHERI, JUDITH SENDZIK, THILO JOHN and MEHDI SHAKIBAEI

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.067

  11. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VIII. Chromatin Structure as a Therapeutic Target

    1. Top of page
    2. Frontmatter
    3. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part I. Cell Signaling Pathways in Health and Disease
    4. Article: Part I. Cell Signaling Pathways in Health and Disease
    5. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part I. Cell Signaling Pathways in Health and Disease
    6. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part II. MAP Kinase Pathways as Therapeutic Targets
    7. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part III. Signal Transduction Pathways in Neurodegenerative Diseases
    8. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part IV. Apoptotic Signaling Pathways
    9. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part V. Chemopreventive Agents Interfering with Cell Signaling Pathways
    10. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VI. Gene Expression Mechanisms as Therapeutic Targets
    11. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VII. Transcriptional Control Mechanisms as Therapeutic Targets
    12. Signal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets: Part VIII. Chromatin Structure as a Therapeutic Target
    1. From Electrophysiology to Chromatin: A Bottom-Up Approach to Angelman Syndrome (pages 599–611)

      BERNARD DAN, LAURENT SERVAIS, STEWART G. BOYD, JOSEPH WAGSTAFF and GUY CHERON

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.070

    2. Repetitive Treatments of Colon HT-29 Cells with Diallyl Disulfide Induce a Prolonged Hyperacetylation of Histone H3 K14 (pages 612–621)

      NATHALIE DRUESNE, ANTHONY PAGNIEZ, CAMILLE MAYEUR, MURIEL THOMAS, CLAIRE CHERBUY, PIERRE-HENRI DUÉE, PAULE MARTEL and CATHERINE CHAUMONTET

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.071

    3. Defining the Chemotherapeutic Targets of Histone Deacetylase Inhibitors (pages 627–635)

      BRIAN GABRIELLI, ROBYN WARRENER, ANDREW BURGESS and HEATHER BEAMISH

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.073

    4. Role of Acetylases and Deacetylase Inhibitors in IRF-1-Mediated HIV-1 Long Terminal Repeat Transcription (pages 636–643)

      GIULIA MARSILI, ANNA LISA REMOLI, MARCO SGARBANTI and ANGELA BATTISTINI

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.074

    5. Histone Structures: Targets for Modifications by Molecular Assemblies (pages 644–655)

      JAMES M. NICHOLSON, CHRISTOPHER M. WOOD, COLIN D. REYNOLDS, ALAN BROWN, STANLEY J. LAMBERT, LAURENT CHANTALAT and JOHN P. BALDWIN

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.075

    6. HDAC-3 Participates in the Repression of e2f-Dependent Gene Transcription in Primary Differentiated Neurons (pages 656–660)

      IRINA PANTELEEVA, CAROLINE ROUAUX, YVES LARMET, STÉPHANIE BOUTILLIER, JEAN-PHILIPPE LOEFFLER and ANNE-LAURENCE BOUTILLIER

      Article first published online: 12 JAN 2006 | DOI: 10.1196/annals.1329.076

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