Annals of the New York Academy of Sciences

© The New York Academy of Sciences

Cover image for Vol. 1052 The Future of Hormone Therapy: What Basic Science and Clinical Studies Teach Us

June 2005

Volume 1052 The Future of Hormone Therapy: What Basic Science and Clinical Studies Teach Us

Pages ix–x, 1–260

    1. Introduction (pages ix–x)

      MEHARVAN SINGH and JAMES W. SIMPKINS

      Article first published online: 18 JAN 2006 | DOI: 10.1196/annals.1347.021

    2. Part I. What Is the Appropriate Population of Women to Study/Treat When Considering Hormone/Estrogen Therapy? (page 1)

      Article first published online: 18 JAN 2006 | DOI: 10.1196/annals.1347.022

    3. Surgical Menopause, Estrogen, and Cognitive Function in Women: What Do the Findings Tell Us? (pages 3–10)

      BARBARA B. SHERWIN

      Article first published online: 18 JAN 2006 | DOI: 10.1196/annals.1347.001

    4. Menopausal Hot Flashes and Development of Cognitive Impairment (pages 11–26)

      ANNA RATKA

      Article first published online: 18 JAN 2006 | DOI: 10.1196/annals.1347.002

    5. Depression, the Perimenopause, and Estrogen Therapy (pages 27–40)

      PETER J. SCHMIDT

      Article first published online: 18 JAN 2006 | DOI: 10.1196/annals.1347.003

    6. Part II. What Is the Ideal Therapeutic Window for Hormone/Estrogen Therapy? (page 41)

      Article first published online: 18 JAN 2006 | DOI: 10.1196/annals.1347.023

    7. Is the Estrogen Controversy Over? Deconstructing the Women's Health Initiative Study: A Critical Evaluation of the Evidence (pages 43–56)

      S.MITCHELL HARMAN, FREDERICK NAFTOLIN, ELIOT A. BRINTON and DEBRA R. JUDELSON

      Article first published online: 18 JAN 2006 | DOI: 10.1196/annals.1347.004

    8. Investigative Models for Determining Hormone Therapy-Induced Outcomes in Brain: Evidence in Support of a Healthy Cell Bias of Estrogen Action (pages 57–74)

      ROBERTA DIAZ BRINTON

      Article first published online: 18 JAN 2006 | DOI: 10.1196/annals.1347.005

    9. Estrogen: A Neuroprotective or Proinflammatory Hormone? Emerging Evidence from Reproductive Aging Models (pages 75–90)

      FARIDA SOHRABJI

      Article first published online: 18 JAN 2006 | DOI: 10.1196/annals.1347.006

    10. Part III. What Are Appropriate Formulations of Hormone/Estrogen Therapy? (page 91)

      Article first published online: 18 JAN 2006 | DOI: 10.1196/annals.1347.024

    11. Clinical Pharmacology and Differential Cognitive Efficacy of Estrogen Preparations (pages 93–115)

      CAREY E. GLEASON, CYNTHIA M. CARLSSON, STERLING JOHNSON, CRAIG ATWOOD and SANJAY ASTHANA

      Article first published online: 18 JAN 2006 | DOI: 10.1196/annals.1347.007

  2. The Future of Hormone Therapy: What Basic Science and Clinical Studies Teach Us: Part III. What Are Appropriate Formulations of Hormone/Estrogen Therapy?

    1. Top of page
    2. The Future of Hormone Therapy: What Basic Science and Clinical Studies Teach Us: Part III. What Are Appropriate Formulations of Hormone/Estrogen Therapy?
    1. Development of 17α-Estradiol as a Neuroprotective Therapeutic Agent: Rationale and Results from a Phase I Clinical Study (pages 116–135)

      JAMES A. DYKENS, WALTER H. MOOS and NEIL HOWELL

      Article first published online: 18 JAN 2006 | DOI: 10.1196/annals.1347.008

    1. Estrogen and the Brain: Beyond ER-α, ER-β, and 17β-Estradiol (pages 136–144)

      C.DOMINIQUE TORAN-ALLERAND

      Article first published online: 18 JAN 2006 | DOI: 10.1196/annals.1347.009

    2. Mechanisms of Progesterone-Induced Neuroprotection (pages 145–151)

      MEHARVAN SINGH

      Article first published online: 18 JAN 2006 | DOI: 10.1196/annals.1347.010

    3. The Case for Progesterone (pages 152–169)

      DONALD G. STEIN

      Article first published online: 18 JAN 2006 | DOI: 10.1196/annals.1347.011

    4. Part IV. What Is the Most Appropriate Design for Clinical Trials That Address the Efficacy of Hormone/Estrogen Therapy? (page 171)

      Article first published online: 18 JAN 2006 | DOI: 10.1196/annals.1347.025

    5. Methodological Issues in Estrogen Treatment Trials for Alzheimer's Disease (pages 173–181)

      RUTH A. MULNARD

      Article first published online: 18 JAN 2006 | DOI: 10.1196/annals.1347.014

    6. A Systematic Review of Clinical Trials of Hormone Therapy on Cognitive Function: Effects of Age at Initiation and Progestin Use (pages 182–197)

      PAULINE M. MAKI

      Article first published online: 18 JAN 2006 | DOI: 10.1196/annals.1347.012

    7. Part V. What Are Appropriate Surrogate Markers of Neurological Decline and What Experimental Models Are Best to Assess the Efficacy of Hormone/Estrogen Therapy? (pages 199–200)

      Article first published online: 18 JAN 2006 | DOI: 10.1196/annals.1347.026

    8. Estrogen Bows to a New Master: The Role of Gonadotropins in Alzheimer Pathogenesis (pages 201–209)

      KATE M. WEBBER, GEMMA CASADESUS, MICHAEL W. MARLATT, GEORGE PERRY, CLIVE R. HAMLIN, CRAIG S. ATWOOD, RICHARD L. BOWEN and MARK A. SMITH

      Article first published online: 18 JAN 2006 | DOI: 10.1196/annals.1347.020

    9. Estradiol Prevents Neural Tau Hyperphosphorylation Characteristic of Alzheimer's Disease (pages 210–224)

      MARGARITA ALVAREZ-DE-LA-ROSA, IVALDO SILVA, JON NILSEN, M. M. PÉREZ, LUIS MIGUEL GARCÍA-SEGURA, JESÚS ÁVILA and FREDERICK NAFTOLIN

      Article first published online: 18 JAN 2006 | DOI: 10.1196/annals.1347.016

    10. Estrogens and Cerebrovascular Stroke: What Do Animal Models Teach Us? (pages 225–232)

      PHYLLIS M. WISE

      Article first published online: 18 JAN 2006 | DOI: 10.1196/annals.1347.017

    11. Role of Nonfeminizing Estrogens in Brain Protection from Cerebral Ischemia: An Animal Model of Alzheimer's Disease Neuropathology (pages 233–242)

      JAMES W. SIMPKINS, YI WEN, EVELYN PEREZ, SHAOHUA YANG and XIAOFEI WANG

      Article first published online: 18 JAN 2006 | DOI: 10.1196/annals.1347.019

    12. Impact of Metabolism on the Safety of Estrogen Therapy (pages 243–257)

      KATALIN PROKAI-TATRAI and LASZLO PROKAI

      Article first published online: 18 JAN 2006 | DOI: 10.1196/annals.1347.018

    13. Summary (pages 259–260)

      MEHARVAN SINGH and JAMES W. SIMPKINS

      Article first published online: 18 JAN 2006 | DOI: 10.1196/annals.1347.027

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