Annals of the New York Academy of Sciences

Cover image for Vol. 1057 Reversal of Aging: Resetting the Pineal Clock

December 2005

Volume 1057 Reversal of Aging: Resetting the Pineal Clock

Pages xi–xxii, 1–571

  1. Article: Frontmatter

    1. Top of page
    2. Article: Frontmatter
    3. Article: Reversal of Aging: Resetting the Pineal Clock
    4. Article: Part I. The Earthly Cage of Aging: Can We Escape from It? Theories, Concepts, Views, Proposals
    5. Article: Part II. Molecular, Cellular, and Organistic Mechanisms of Aging: Suggestions, Proposals, Experimental and Clinical Evidence
    6. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or “Curin” Aging
    7. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or Curing Aging
    8. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or “Curin” Aging
    9. Article: Part IV. Aging and Regeneration of the Central and Peripheral Nervous Systems—Mechanisms and Interventions: Preventative and Regenerative Medicine and Bioengineering Interventions
    10. Article: Part V. The Pineal Life Clock—Experimental and Clinical Activities of Melatonin: Significance and Perspectives
    11. Article: Part VI. Replacement Therapies of a Failing Body: Clinical Evidence of Restorative Medicine
    12. Article: Part VII. Striving for Health—Anti-aging Medicine and Its Presence in the World: The Witnesses and Pioneers of a Rapidly Changing and Aging Western Population
  2. Article: Reversal of Aging: Resetting the Pineal Clock

    1. Top of page
    2. Article: Frontmatter
    3. Article: Reversal of Aging: Resetting the Pineal Clock
    4. Article: Part I. The Earthly Cage of Aging: Can We Escape from It? Theories, Concepts, Views, Proposals
    5. Article: Part II. Molecular, Cellular, and Organistic Mechanisms of Aging: Suggestions, Proposals, Experimental and Clinical Evidence
    6. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or “Curin” Aging
    7. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or Curing Aging
    8. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or “Curin” Aging
    9. Article: Part IV. Aging and Regeneration of the Central and Peripheral Nervous Systems—Mechanisms and Interventions: Preventative and Regenerative Medicine and Bioengineering Interventions
    10. Article: Part V. The Pineal Life Clock—Experimental and Clinical Activities of Melatonin: Significance and Perspectives
    11. Article: Part VI. Replacement Therapies of a Failing Body: Clinical Evidence of Restorative Medicine
    12. Article: Part VII. Striving for Health—Anti-aging Medicine and Its Presence in the World: The Witnesses and Pioneers of a Rapidly Changing and Aging Western Population
  3. Article: Part I. The Earthly Cage of Aging: Can We Escape from It? Theories, Concepts, Views, Proposals

    1. Top of page
    2. Article: Frontmatter
    3. Article: Reversal of Aging: Resetting the Pineal Clock
    4. Article: Part I. The Earthly Cage of Aging: Can We Escape from It? Theories, Concepts, Views, Proposals
    5. Article: Part II. Molecular, Cellular, and Organistic Mechanisms of Aging: Suggestions, Proposals, Experimental and Clinical Evidence
    6. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or “Curin” Aging
    7. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or Curing Aging
    8. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or “Curin” Aging
    9. Article: Part IV. Aging and Regeneration of the Central and Peripheral Nervous Systems—Mechanisms and Interventions: Preventative and Regenerative Medicine and Bioengineering Interventions
    10. Article: Part V. The Pineal Life Clock—Experimental and Clinical Activities of Melatonin: Significance and Perspectives
    11. Article: Part VI. Replacement Therapies of a Failing Body: Clinical Evidence of Restorative Medicine
    12. Article: Part VII. Striving for Health—Anti-aging Medicine and Its Presence in the World: The Witnesses and Pioneers of a Rapidly Changing and Aging Western Population
    1. Genetic Contribution to Aging: Deleterious and Helpful Genes Define Life Expectancy (pages 50–63)

      J I LAO, C MONTORIOL, I MORER and K BEYER

      Version of Record online: 23 JAN 2006 | DOI: 10.1196/annals.1356.003

    2. The Nitric Oxide Theory of Aging Revisited (pages 64–84)

      S M. McCANN, C MASTRONARDI, A DE LAURENTIIS and V RETTORI

      Version of Record online: 23 JAN 2006 | DOI: 10.1196/annals.1356.064

    3. Immunoregulation of Cellular Life Span (pages 85–111)

      MARGUERITE KAY

      Version of Record online: 23 JAN 2006 | DOI: 10.1196/annals.1356.005

    4. Aging as a Mitochondria-Mediated Atavistic Program: Can Aging Be Switched Off? (pages 145–164)

      VLADIMIR P. SKULACHEV and VALTER D. LONGO

      Version of Record online: 23 JAN 2006 | DOI: 10.1196/annals.1356.009

  4. Article: Part II. Molecular, Cellular, and Organistic Mechanisms of Aging: Suggestions, Proposals, Experimental and Clinical Evidence

    1. Top of page
    2. Article: Frontmatter
    3. Article: Reversal of Aging: Resetting the Pineal Clock
    4. Article: Part I. The Earthly Cage of Aging: Can We Escape from It? Theories, Concepts, Views, Proposals
    5. Article: Part II. Molecular, Cellular, and Organistic Mechanisms of Aging: Suggestions, Proposals, Experimental and Clinical Evidence
    6. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or “Curin” Aging
    7. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or Curing Aging
    8. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or “Curin” Aging
    9. Article: Part IV. Aging and Regeneration of the Central and Peripheral Nervous Systems—Mechanisms and Interventions: Preventative and Regenerative Medicine and Bioengineering Interventions
    10. Article: Part V. The Pineal Life Clock—Experimental and Clinical Activities of Melatonin: Significance and Perspectives
    11. Article: Part VI. Replacement Therapies of a Failing Body: Clinical Evidence of Restorative Medicine
    12. Article: Part VII. Striving for Health—Anti-aging Medicine and Its Presence in the World: The Witnesses and Pioneers of a Rapidly Changing and Aging Western Population
  5. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or “Curin” Aging

    1. Top of page
    2. Article: Frontmatter
    3. Article: Reversal of Aging: Resetting the Pineal Clock
    4. Article: Part I. The Earthly Cage of Aging: Can We Escape from It? Theories, Concepts, Views, Proposals
    5. Article: Part II. Molecular, Cellular, and Organistic Mechanisms of Aging: Suggestions, Proposals, Experimental and Clinical Evidence
    6. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or “Curin” Aging
    7. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or Curing Aging
    8. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or “Curin” Aging
    9. Article: Part IV. Aging and Regeneration of the Central and Peripheral Nervous Systems—Mechanisms and Interventions: Preventative and Regenerative Medicine and Bioengineering Interventions
    10. Article: Part V. The Pineal Life Clock—Experimental and Clinical Activities of Melatonin: Significance and Perspectives
    11. Article: Part VI. Replacement Therapies of a Failing Body: Clinical Evidence of Restorative Medicine
    12. Article: Part VII. Striving for Health—Anti-aging Medicine and Its Presence in the World: The Witnesses and Pioneers of a Rapidly Changing and Aging Western Population
    1. Central and Peripheral Effects of Insulin/IGF-1 Signaling in Aging and Cancer: Antidiabetic Drugs as Geroprotectors and Anticarcinogens (pages 220–234)

      VLADIMIR N. ANISIMOV, LEV M. BERSTEIN, IRINA G. POPOVICH, MARK A. ZABEZHINSKI, PETER A. EGORMIN, MARGARITA L. TYNDYK, IVAN V. ANIKIN, ANNA V. SEMENCHENKO and ANATOLI I. YASHIN

      Version of Record online: 23 JAN 2006 | DOI: 10.1196/annals.1356.017

  6. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or Curing Aging

    1. Top of page
    2. Article: Frontmatter
    3. Article: Reversal of Aging: Resetting the Pineal Clock
    4. Article: Part I. The Earthly Cage of Aging: Can We Escape from It? Theories, Concepts, Views, Proposals
    5. Article: Part II. Molecular, Cellular, and Organistic Mechanisms of Aging: Suggestions, Proposals, Experimental and Clinical Evidence
    6. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or “Curin” Aging
    7. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or Curing Aging
    8. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or “Curin” Aging
    9. Article: Part IV. Aging and Regeneration of the Central and Peripheral Nervous Systems—Mechanisms and Interventions: Preventative and Regenerative Medicine and Bioengineering Interventions
    10. Article: Part V. The Pineal Life Clock—Experimental and Clinical Activities of Melatonin: Significance and Perspectives
    11. Article: Part VI. Replacement Therapies of a Failing Body: Clinical Evidence of Restorative Medicine
    12. Article: Part VII. Striving for Health—Anti-aging Medicine and Its Presence in the World: The Witnesses and Pioneers of a Rapidly Changing and Aging Western Population
    1. The Phenomenon of the Switching of Estrogen Effects and Joker Function of Glucose: Similarities and Relation to Age-Associated Pathology and Approaches to Correction (pages 235–246)

      LEV M. BERSTEIN, EVGENIA V. TSYRLINA, DMITRY A. VASILYEV, TATJANA E. POROSHINA and RINA G. KOVALENKO

      Version of Record online: 23 JAN 2006 | DOI: 10.1196/annals.1356.018

  7. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or “Curin” Aging

    1. Top of page
    2. Article: Frontmatter
    3. Article: Reversal of Aging: Resetting the Pineal Clock
    4. Article: Part I. The Earthly Cage of Aging: Can We Escape from It? Theories, Concepts, Views, Proposals
    5. Article: Part II. Molecular, Cellular, and Organistic Mechanisms of Aging: Suggestions, Proposals, Experimental and Clinical Evidence
    6. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or “Curin” Aging
    7. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or Curing Aging
    8. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or “Curin” Aging
    9. Article: Part IV. Aging and Regeneration of the Central and Peripheral Nervous Systems—Mechanisms and Interventions: Preventative and Regenerative Medicine and Bioengineering Interventions
    10. Article: Part V. The Pineal Life Clock—Experimental and Clinical Activities of Melatonin: Significance and Perspectives
    11. Article: Part VI. Replacement Therapies of a Failing Body: Clinical Evidence of Restorative Medicine
    12. Article: Part VII. Striving for Health—Anti-aging Medicine and Its Presence in the World: The Witnesses and Pioneers of a Rapidly Changing and Aging Western Population
    1. Immunomodulation by Immunopeptides and Autoantibodies in Aging, Autoimmunity, and Infection (pages 247–259)

      J J MARCHALONIS, S F SCHLUTER, R T SEPULVEDA, R R WATSON and D F LARSON

      Version of Record online: 23 JAN 2006 | DOI: 10.1196/annals.1356.019

  8. Article: Part IV. Aging and Regeneration of the Central and Peripheral Nervous Systems—Mechanisms and Interventions: Preventative and Regenerative Medicine and Bioengineering Interventions

    1. Top of page
    2. Article: Frontmatter
    3. Article: Reversal of Aging: Resetting the Pineal Clock
    4. Article: Part I. The Earthly Cage of Aging: Can We Escape from It? Theories, Concepts, Views, Proposals
    5. Article: Part II. Molecular, Cellular, and Organistic Mechanisms of Aging: Suggestions, Proposals, Experimental and Clinical Evidence
    6. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or “Curin” Aging
    7. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or Curing Aging
    8. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or “Curin” Aging
    9. Article: Part IV. Aging and Regeneration of the Central and Peripheral Nervous Systems—Mechanisms and Interventions: Preventative and Regenerative Medicine and Bioengineering Interventions
    10. Article: Part V. The Pineal Life Clock—Experimental and Clinical Activities of Melatonin: Significance and Perspectives
    11. Article: Part VI. Replacement Therapies of a Failing Body: Clinical Evidence of Restorative Medicine
    12. Article: Part VII. Striving for Health—Anti-aging Medicine and Its Presence in the World: The Witnesses and Pioneers of a Rapidly Changing and Aging Western Population
    1. Age at Onset: An Essential Variable for the Definition of Genetic Risk Factors for Sporadic Alzheimer's Disease (pages 260–278)

      KATRIN BEYER, JOSÉ I. LAO, PILAR LATORRE and AURELIO ARIZA

      Version of Record online: 23 JAN 2006 | DOI: 10.1111/j.1749-6632.2005.tb06138.x

    2. Hormones Are Key Actors in Gene X Environment Interactions Programming the Vulnerability to Parkinson's Disease: Glia as a Common Final Pathway (pages 296–318)

      BIANCA MARCHETTI, PIER ANDREA SERRA, FRANCESCA L'EPISCOPO, CATALDO TIROLO, SALVO CANIGLIA, NUCCIO TESTA, SERENA CIONI, FLORINDA GENNUSO, GAIA ROCCHITTA, MARIA SPERANZA DESOLE, MARIA CLORINDA MAZZARINO, EGIDIO MIELE and MARIA CONCETTA MORALE

      Version of Record online: 23 JAN 2006 | DOI: 10.1196/annals.1356.023

  9. Article: Part V. The Pineal Life Clock—Experimental and Clinical Activities of Melatonin: Significance and Perspectives

    1. Top of page
    2. Article: Frontmatter
    3. Article: Reversal of Aging: Resetting the Pineal Clock
    4. Article: Part I. The Earthly Cage of Aging: Can We Escape from It? Theories, Concepts, Views, Proposals
    5. Article: Part II. Molecular, Cellular, and Organistic Mechanisms of Aging: Suggestions, Proposals, Experimental and Clinical Evidence
    6. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or “Curin” Aging
    7. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or Curing Aging
    8. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or “Curin” Aging
    9. Article: Part IV. Aging and Regeneration of the Central and Peripheral Nervous Systems—Mechanisms and Interventions: Preventative and Regenerative Medicine and Bioengineering Interventions
    10. Article: Part V. The Pineal Life Clock—Experimental and Clinical Activities of Melatonin: Significance and Perspectives
    11. Article: Part VI. Replacement Therapies of a Failing Body: Clinical Evidence of Restorative Medicine
    12. Article: Part VII. Striving for Health—Anti-aging Medicine and Its Presence in the World: The Witnesses and Pioneers of a Rapidly Changing and Aging Western Population
    1. Clinical Perspectives for the Use of Melatonin as a Chronobiotic and Cytoprotective Agent (pages 327–336)

      DANIEL P. CARDINALI, ANALÍA M. FURIO and MARÍA P. REYES

      Version of Record online: 23 JAN 2006 | DOI: 10.1196/annals.1356.025

    2. Melatonin Influences on the Neuroendocrine-Reproductive Axis (pages 337–364)

      BEATRIZ DÍAZ LÓPEZ, E DÍAZ RODRÍGUEZ, COLMENERO URQUIJO and C FERNÁNDEZ ÁLVAREZ

      Version of Record online: 23 JAN 2006 | DOI: 10.1196/annals.1356.026

    3. Caloric Restriction Mimetics: The Next Phase (pages 365–371)

      GEORGE S. ROTH, MARK A. LANE and DONALD K. INGRAM

      Version of Record online: 23 JAN 2006 | DOI: 10.1196/annals.1356.027

    4. Mechanisms Regulating Melatonin Synthesis in the Mammalian Pineal Organ (pages 372–383)

      CHRISTOF SCHOMERUS and HORST-WERNER KORF

      Version of Record online: 23 JAN 2006 | DOI: 10.1196/annals.1356.028

    5. Effects of Melatonin in Age-Related Macular Degeneration (pages 384–392)

      CHANGXIAN YI, XIAOYAN PAN, HONG YAN, MENGXIANG GUO and WALTER PIERPAOLI

      Version of Record online: 23 JAN 2006 | DOI: 10.1196/annals.1356.029

    6. Effects of Melatonin in Perimenopausal and Menopausal Women: Our Personal Experience (pages 393–402)

      G BELLIPANNI, F DI MARZO, F BLASI and A DI MARZO

      Version of Record online: 23 JAN 2006 | DOI: 10.1196/annals.1356.030

  10. Article: Part VI. Replacement Therapies of a Failing Body: Clinical Evidence of Restorative Medicine

    1. Top of page
    2. Article: Frontmatter
    3. Article: Reversal of Aging: Resetting the Pineal Clock
    4. Article: Part I. The Earthly Cage of Aging: Can We Escape from It? Theories, Concepts, Views, Proposals
    5. Article: Part II. Molecular, Cellular, and Organistic Mechanisms of Aging: Suggestions, Proposals, Experimental and Clinical Evidence
    6. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or “Curin” Aging
    7. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or Curing Aging
    8. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or “Curin” Aging
    9. Article: Part IV. Aging and Regeneration of the Central and Peripheral Nervous Systems—Mechanisms and Interventions: Preventative and Regenerative Medicine and Bioengineering Interventions
    10. Article: Part V. The Pineal Life Clock—Experimental and Clinical Activities of Melatonin: Significance and Perspectives
    11. Article: Part VI. Replacement Therapies of a Failing Body: Clinical Evidence of Restorative Medicine
    12. Article: Part VII. Striving for Health—Anti-aging Medicine and Its Presence in the World: The Witnesses and Pioneers of a Rapidly Changing and Aging Western Population
    1. Use of Telomerase to Create Bioengineered Tissues (pages 479–491)

      JERRY W. SHAY and WOODRING E. WRIGHT

      Version of Record online: 23 JAN 2006 | DOI: 10.1196/annals.1356.037

    2. Mind-Body Medicine: Stress and Its Impact on Overall Health and Longevity (pages 492–505)

      L VITETTA, B ANTON, F CORTIZO and A SALI

      Version of Record online: 23 JAN 2006 | DOI: 10.1111/j.1749-6632.2005.tb06153.x

  11. Article: Part VII. Striving for Health—Anti-aging Medicine and Its Presence in the World: The Witnesses and Pioneers of a Rapidly Changing and Aging Western Population

    1. Top of page
    2. Article: Frontmatter
    3. Article: Reversal of Aging: Resetting the Pineal Clock
    4. Article: Part I. The Earthly Cage of Aging: Can We Escape from It? Theories, Concepts, Views, Proposals
    5. Article: Part II. Molecular, Cellular, and Organistic Mechanisms of Aging: Suggestions, Proposals, Experimental and Clinical Evidence
    6. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or “Curin” Aging
    7. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or Curing Aging
    8. Article: Part III. Biomolecular Interventions Suitable for Interpreting, Preventing, or “Curin” Aging
    9. Article: Part IV. Aging and Regeneration of the Central and Peripheral Nervous Systems—Mechanisms and Interventions: Preventative and Regenerative Medicine and Bioengineering Interventions
    10. Article: Part V. The Pineal Life Clock—Experimental and Clinical Activities of Melatonin: Significance and Perspectives
    11. Article: Part VI. Replacement Therapies of a Failing Body: Clinical Evidence of Restorative Medicine
    12. Article: Part VII. Striving for Health—Anti-aging Medicine and Its Presence in the World: The Witnesses and Pioneers of a Rapidly Changing and Aging Western Population
    1. Can We Delay Aging? The Biology and Science of Aging (pages 525–535)

      B ANTON, L VITETTA, F CORTIZO and A SALI

      Version of Record online: 23 JAN 2006 | DOI: 10.1196/annals.1356.040

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