Annals of the New York Academy of Sciences

Cover image for Vol. 1067 Understanding and Modulating Aging

May 2006

Volume 1067 Understanding and Modulating Aging

Pages xv–xvi, 1–509

  1. Preface

    1. Top of page
    2. Preface
    3. Part I. Aging: Ideas and Challenges
    4. Part II. Aging Organisms, Organs, and Tissues
    5. Part III. Aging Cells, Organelles, and Macromolecules
    6. Part IV. Gerontogenesis and Longevity Assurance
    7. Part V. Interventions, Preventions, and Therapies
    8. Part VI. Novel Technologies, Strategies, and Possibilities
    9. Index of Contributors
    1. Understanding and Modulating Aging (pages xv–xvi)

      Suresh I. S. Rattan, Peter Kristensen and Brian F. C. Clark

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.001

  2. Part I. Aging: Ideas and Challenges

    1. Top of page
    2. Preface
    3. Part I. Aging: Ideas and Challenges
    4. Part II. Aging Organisms, Organs, and Tissues
    5. Part III. Aging Cells, Organelles, and Macromolecules
    6. Part IV. Gerontogenesis and Longevity Assurance
    7. Part V. Interventions, Preventions, and Therapies
    8. Part VI. Novel Technologies, Strategies, and Possibilities
    9. Index of Contributors
    1. Methionine Sulfoxide Reductases : Relevance to Aging and Protection against Oxidative Stress (pages 37–44)

      FILIPE CABREIRO, CÉDRIC R. PICOT, BERTRAND FRIGUET and ISABELLE PETROPOULOS

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.006

    2. Human Immunosenescence : Does It Have an Infectious Component? (pages 56–65)

      G. PAWELEC, S. KOCH, C. FRANCESCHI and A. WIKBY

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.009

  3. Part II. Aging Organisms, Organs, and Tissues

    1. Top of page
    2. Preface
    3. Part I. Aging: Ideas and Challenges
    4. Part II. Aging Organisms, Organs, and Tissues
    5. Part III. Aging Cells, Organelles, and Macromolecules
    6. Part IV. Gerontogenesis and Longevity Assurance
    7. Part V. Interventions, Preventions, and Therapies
    8. Part VI. Novel Technologies, Strategies, and Possibilities
    9. Index of Contributors
    1. OXPHOS Supercomplexes : Respiration and Life-Span Control in the Aging Model Podospora anserina (pages 106–115)

      FRANK KRAUSE, CHRISTIAN Q. SCHECKHUBER, ALEXANDRA WERNER, SASCHA REXROTH, NICOLE H. REIFSCHNEIDER, NORBERT A. DENCHER and HEINZ D. OSIEWACZ

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.013

    2. Unraveling Age-Dependent Variation of the Mitochondrial Proteome (pages 116–119)

      NORBERT A. DENCHER, SATARO GOTO, NICOLE H. REIFSCHNEIDER, MICHIRU SUGAWA and FRANK KRAUSE

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.014

    3. Using Caenorhabditis elegans as a Model for Aging and Age-Related Diseases (pages 120–128)

      ANDERS OLSEN, MAITHILI C. VANTIPALLI and GORDON J. LITHGOW

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.015

    4. Naïve T Cells in the Elderly : Are They Still There? (pages 152–157)

      GERALD PFISTER, DANIELA WEISKOPF, LUTFAN LAZUARDI, RANIA D. KOVAIOU, DANIEL P. CIOCA, MICHAEL KELLER, BERND LORBEG, WALTHER PARSON and BEATRIX GRUBECK-LOEBENSTEIN

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.018

    5. Brain Lipopigment Accumulation in Normal and Pathological Aging (pages 158–163)

      DAN RIGA, SORIN RIGA, FLORIN HALALAU and FRANCISC SCHNEIDER

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.019

    6. Aging and Orchidectomy Modulate Expression of VEGF Receptors (Flt-1 and Flk-1) on Corpus Cavernosum of the Rat (pages 164–172)

      DELMINDA NEVES, JANETE SANTOS, NUNO TOMADA, HENRIQUE ALMEIDA and PEDRO VENDEIRA

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.020

  4. Part III. Aging Cells, Organelles, and Macromolecules

    1. Top of page
    2. Preface
    3. Part I. Aging: Ideas and Challenges
    4. Part II. Aging Organisms, Organs, and Tissues
    5. Part III. Aging Cells, Organelles, and Macromolecules
    6. Part IV. Gerontogenesis and Longevity Assurance
    7. Part V. Interventions, Preventions, and Therapies
    8. Part VI. Novel Technologies, Strategies, and Possibilities
    9. Index of Contributors
    1. DNA Damage by Free Radical Production by Aminoguanidine (pages 191–199)

      GEORGE SUJI and SUBRAMANIUM SIVAKAMI

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.023

    2. Effect of Lipid Restriction on Mitochondrial Free Radical Production and Oxidative DNA Damage (pages 200–209)

      ALBERTO SANZ, PILAR CARO, JOSE GOMEZ SANCHEZ and GUSTAVO BARJA

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.024

    3. Structural and Functional Differences between Mouse Mot-1 and Mot-2 Proteins That Differ in Two Amino Acids (pages 220–223)

      CUSTER C. DEOCARIS, KAZUHIKO YAMASAKI, SUNIL C. KAUL and RENU WADHWA

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.027

    4. Proteasomal Oscillation during Mild Heat Shock in Aging Human Skin Fibroblasts (pages 224–227)

      DAVID CHRISTIAN KRAFT, CUSTER C. DEOCARIS and SURESH I. S. RATTAN

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.028

    5. Aging of Murine Mesenchymal Stem Cells (pages 235–242)

      CHRISTINE FEHRER, GERHARD LASCHOBER and GÜNTER LEPPERDINGER

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.030

    6. Prevention of Accelerated Cell Aging in the Werner Syndrome (pages 243–247)

      TERENCE DAVIS, MICHÈLE F. HAUGHTON, CHRISTOPHER J. JONES and DAVID KIPLING

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.031

    7. Oxidative Stress Induces Intralysosomal Accumulation of Alzheimer Amyloid β-Protein in Cultured Neuroblastoma Cells (pages 248–251)

      LIN ZHENG, KARIN ROBERG, FREDRIK JERHAMMAR, JAN MARCUSSON and ALEXEI TERMAN

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.032

  5. Part IV. Gerontogenesis and Longevity Assurance

    1. Top of page
    2. Preface
    3. Part I. Aging: Ideas and Challenges
    4. Part II. Aging Organisms, Organs, and Tissues
    5. Part III. Aging Cells, Organelles, and Macromolecules
    6. Part IV. Gerontogenesis and Longevity Assurance
    7. Part V. Interventions, Preventions, and Therapies
    8. Part VI. Novel Technologies, Strategies, and Possibilities
    9. Index of Contributors
    1. The Genetics of Human Longevity (pages 252–263)

      MIRIAM CAPRI, STEFANO SALVIOLI, FEDERICA SEVINI, SILVANA VALENSIN, LAURA CELANI, DANIELA MONTI, GRAHAM PAWELEC, GIOVANNA DE BENEDICTIS, EFSTATHIOS S. GONOS and CLAUDIO FRANCESCHI

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.033

    2. Search for Genetic Factors Associated with Susceptibility to Multiple Sclerosis (pages 264–269)

      GIUSI IRMA FORTE, PAOLO RAGONESE, GIUSEPPE SALEMI, LETIZIA SCOLA, GIUSEPPINA CANDORE, MARCO D'AMELIO, ANTONIO CRIVELLO, NORMA DI BENEDETTO, DOMENICO NUZZO, ANTONIO GIACALONE, DOMENICO LIO and CALOGERO CARUSO

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.034

    3. Opposite Role of Pro-Inflammatory Alleles in Acute Myocardial Infarction and Longevity : Results of Studies Performed in a Sicilian Population (pages 270–275)

      GIUSEPPINA CANDORE, CARMELA RITA BALISTRERI, MARIA PAOLA GRIMALDI, FLORINDA LISTÌ, SONYA VASTO, MARCO CARUSO, GREGORIO CAIMI, ENRICO HOFFMANN, GIUSEPPINA COLONNA-ROMANO, DOMENICO LIO, GIUSEPPE PAOLISSO, CLAUDIO FRANCESCHI and CALOGERO CARUSO

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.035

    4. Association between +1059G/C CRP Polymorphism and Acute Myocardial Infarction in a Cohort of Patients from Sicily : A Pilot Study (pages 276–281)

      CARMELA RITA BALISTRERI, SONYA VASTO, FLORINDA LISTÌ, MARIA PAOLA GRIMALDI, DOMENICO LIO, GIUSEPPINA COLONNA-ROMANO, MARCO CARUSO, GREGORIO CAIMI, ENRICO HOFFMANN, CALOGERO CARUSO and GIUSEPPINA CANDORE

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.036

    5. Inflammation, Longevity, and Cardiovascular Diseases : Role of Polymorphisms of TLR4 (pages 282–287)

      GIUSEPPINA CANDORE, ALESSANDRA AQUINO, CARMELA RITA BALISTRERI, MATTEO BULATI, DANIELE DI CARLO, MARIA PAOLA GRIMALDI, FLORINDA LISTÌ, VALENTINA ORLANDO, SONYA VASTO, MARCO CARUSO, GIUSEPPINA COLONNA-ROMANO, DOMENICO LIO and CALOGERO CARUSO

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.037

    6. Frequency of Polymorphisms of Signal Peptide of TGF-β1 and −1082G/A SNP at the Promoter Region of Il-10 Gene in Patients with Carotid Stenosis (pages 288–293)

      ANTONIO CRIVELLO, ANTONIO GIACALONE, LETIZIA SCOLA, GIUSI IRMA FORTE, DOMENICO NUZZO, ROBERTINA GIACCONI, CATIA CIPRIANO, GIUSEPPINA CANDORE, EUGENIO MOCCHEGIANI, GIUSEPPINA COLONNA ROMANO, DOMENICO LIO and CALOGERO CARUSO

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.038

    7. Reduced Expression Levels of the Senescence Biomarker Clusterin/Apolipoprotein J in Lymphocytes from Healthy Centenarians (pages 294–300)

      IOANNIS P. TROUGAKOS, CHARIKLIA PETROPOULOU, CLAUDIO FRANCESCHI and EFSTATHIOS S. GONOS

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.039

    8. Heat-Shock Protein 70 Genes and Human Longevity : A View from Denmark (pages 301–308)

      RIPUDAMAN SINGH, STEEN KØLVRAA, PETER BROSS, KAARE CHRISTENSEN, NIELS GREGERSEN, QIHUA TAN, UFFE BIRK JENSEN, HANS EIBERG and SURESH I. S. RATTAN

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.040

    9. Possible Associations between Successful Aging and Polymorphic Markers in the Werner Gene Region (pages 309–310)

      MARI SILD, CEMILE KOCA, METTE H. BENDIXEN, HENRIK FREDERIKSEN, MATT McGUE, STEEN KØLVRAA, KAARE CHRISTENSEN and BJØRN NEXØ

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.041

    10. Identification of Genes Involved in Healthy Aging and Longevity (pages 317–322)

      JENS WEIBEL, MORTEN DRÆBY SØRENSEN and PETER KRISTENSEN

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.043

  6. Part V. Interventions, Preventions, and Therapies

    1. Top of page
    2. Preface
    3. Part I. Aging: Ideas and Challenges
    4. Part II. Aging Organisms, Organs, and Tissues
    5. Part III. Aging Cells, Organelles, and Macromolecules
    6. Part IV. Gerontogenesis and Longevity Assurance
    7. Part V. Interventions, Preventions, and Therapies
    8. Part VI. Novel Technologies, Strategies, and Possibilities
    9. Index of Contributors
    1. Prevention and Treatment of Skin Aging (pages 323–331)

      JERRY L. McCULLOUGH and KRISTEN M. KELLY

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.044

    2. Kinetin-Induced Differentiation of Normal Human Keratinocytes Undergoing Aging in Vitro (pages 332–336)

      ULRICH BERGE, PETER KRISTENSEN and SURESH I. S. RATTAN

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.045

    3. Epidermal and Dermal Characteristics in Skin Equivalent after Systemic and Topical Application of Skin Care Ingredients (pages 337–342)

      JANA VICANOVA, CHARBEL BOUEZ, SOPHIE LACROIX, LARS LINDMARK and ODILE DAMOUR

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.046

    4. MAP Kinases and Heat Shock–Induced Hormesis in Human Fibroblasts during Serial Passaging in Vitro (pages 343–348)

      ELISE R. NIELSEN, YVONNE E.G. ESKILDSEN-HELMOND and SURESH I.S. RATTAN

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.048

    5. Age-Related Effects of Dexamethasone Administration in Adrenal Zona Reticularis (pages 354–360)

      HENRIQUE ALMEIDA, LILIANA MATOS, JORGE FERREIRA and DELMINDA NEVES

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.050

    6. Processing, Lysis, and Elimination of Brain Lipopigments in Rejuvenation Therapies (pages 383–387)

      SORIN RIGA, DAN RIGA, FRANCISC SCHNEIDER and FLORIN HALALAU

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.054

    7. Redox Status Impairment in Liver and Kidney of Prematurely Senescent Mice : Effectiveness of DTS Phytotherapeutic Compound (pages 408–413)

      F. MAROTTA, F. LORENZETTI, M. HARADA, S. K. ONO-NITA, E. MINELLI and P. MARANDOLA

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.058

    8. A Dietary Supplement Improves Outcome in an Experimental Influenza Model in Old Mice (pages 414–419)

      J. CERVI, F. MAROTTA, C. BATER, K. MASULAIR, E. MINELLI, M. HARADA and P. MARANDOLA

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.059

    9. Exercise and Hormesis : Activation of Cellular Antioxidant Signaling Pathway (pages 425–435)

      LI LI JI, MARIA-CARMEN GOMEZ-CABRERA and JOSE VINA

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.061

  7. Part VI. Novel Technologies, Strategies, and Possibilities

    1. Top of page
    2. Preface
    3. Part I. Aging: Ideas and Challenges
    4. Part II. Aging Organisms, Organs, and Tissues
    5. Part III. Aging Cells, Organelles, and Macromolecules
    6. Part IV. Gerontogenesis and Longevity Assurance
    7. Part V. Interventions, Preventions, and Therapies
    8. Part VI. Novel Technologies, Strategies, and Possibilities
    9. Index of Contributors
    1. Selective PPAR Agonists for the Treatment of Type 2 Diabetes (pages 448–453)

      JAN O. NEHLIN, JOHN P. MOGENSEN, INGRID PETTERSON, LONE JEPPESEN, JAN FLECKNER, ERIK M. WULFF and PER SAUERBERG

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.064

    2. RNA Regulation in Mammals (pages 461–468)

      MACIEJ SZYMANSKI and JAN BARCISZEWSKI

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.066

    3. Phage-Displayed Antibodies for the Detection of Glycated Proteasome in Aging Cells (pages 474–478)

      REGINA GONZALEZ-DOSAL, MORTEN DRÆBY SØRENSEN, BRIAN F.C. CLARK, SURESH I. S. RATTAN and PETER KRISTENSEN

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.068

    4. Techniques Used in Studies of Age-Related DNA Methylation Changes (pages 479–487)

      TOMASZ K. WOJDACZ and LISE LOTTE HANSEN

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.069

    5. Geroprotection by Glycerol : Insights to Its Mechanisms and Clinical Potentials (pages 488–492)

      CUSTER C. DEOCARIS, BHUPAL G. SHRESTHA, DAVID C. KRAFT, KAZUHIKO YAMASAKI, SUNIL C. KAUL, SURESH I. S. RATTAN and RENU WADHWA

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.070

    6. Age-Dependent Effects of in Vitro Radiofrequency Exposure (Mobile Phone) on CD95+ T Helper Human Lymphocytes (pages 493–499)

      MIRIAM CAPRI, STEFANO SALVIOLI, SERENA ALTILIA, FEDERICA SEVINI, DANIEL REMONDINI, PIETRO MESIRCA, FERDINANDO BERSANI, DANIELA MONTI and CLAUDIO FRANCESCHI

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.071

    7. Severe Acute Respiratory Syndrome (SARS) : Development of Diagnostics and Antivirals (pages 500–505)

      MORTEN DRÆBY SØRENSEN, BRIAN SØRENSEN, REGINA GONZALEZ-DOSAL, CONNIE JENNING MELCHJORSEN, JENS WEIBEL, JING WANG, CHEN WIE JUN, YANG HUANMING and PETER KRISTENSEN

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.072

  8. Index of Contributors

    1. Top of page
    2. Preface
    3. Part I. Aging: Ideas and Challenges
    4. Part II. Aging Organisms, Organs, and Tissues
    5. Part III. Aging Cells, Organelles, and Macromolecules
    6. Part IV. Gerontogenesis and Longevity Assurance
    7. Part V. Interventions, Preventions, and Therapies
    8. Part VI. Novel Technologies, Strategies, and Possibilities
    9. Index of Contributors
    1. Index of Contributors (pages 507–509)

      Article first published online: 10 MAY 2006 | DOI: 10.1196/annals.1354.653

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