Annals of the New York Academy of Sciences

Cover image for Vol. 1098 Oral‐Based Diagnostics

March 2007

Volume 1098 Oral-Based Diagnostics

Pages xiii–xv, 1–519

  1. Dedication to Irwin Mandel

    1. Top of page
    2. Dedication to Irwin Mandel
    3. Introduction
    4. Part I. Biochemistry/Physiology of Saliva: Implications for Diagnostics
    5. Part II. Drug and Small Molecule Detection in Saliva
    6. Part III. Meeting Unmet Needs in Diagnostics
    7. Part IV. Oral Samples/Oral Diseases
    8. Part V. Molecular and Protein Markers of Disease
    9. Part VI. Horizons in Oral Diagnostics
    10. Part VII. Short Papers
    11. Index of Contributors
    1. Dedication to Irwin Mandel (page xiii)

      Malamud Daniel

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.045

  2. Introduction

    1. Top of page
    2. Dedication to Irwin Mandel
    3. Introduction
    4. Part I. Biochemistry/Physiology of Saliva: Implications for Diagnostics
    5. Part II. Drug and Small Molecule Detection in Saliva
    6. Part III. Meeting Unmet Needs in Diagnostics
    7. Part IV. Oral Samples/Oral Diseases
    8. Part V. Molecular and Protein Markers of Disease
    9. Part VI. Horizons in Oral Diagnostics
    10. Part VII. Short Papers
    11. Index of Contributors
    1. Introduction (pages xiv–xv)

      Daniel Malamud and R. Sam Niedbala

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.046

  3. Part I. Biochemistry/Physiology of Saliva: Implications for Diagnostics

    1. Top of page
    2. Dedication to Irwin Mandel
    3. Introduction
    4. Part I. Biochemistry/Physiology of Saliva: Implications for Diagnostics
    5. Part II. Drug and Small Molecule Detection in Saliva
    6. Part III. Meeting Unmet Needs in Diagnostics
    7. Part IV. Oral Samples/Oral Diseases
    8. Part V. Molecular and Protein Markers of Disease
    9. Part VI. Horizons in Oral Diagnostics
    10. Part VII. Short Papers
    11. Index of Contributors
    1. Implications for Diagnostics in the Biochemistry and Physiology of Saliva (pages 1–6)

      ARIE v. NIEUW AMERONGEN, ANTOON J. M. LIGTENBERG and ENNO C. I. VEERMAN

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.033

    2. Salivary Proteome and Its Genetic Polymorphisms (pages 22–50)

      FRANK G. OPPENHEIM, ERDJAN SALIH, WALTER L. SIQUEIRA, WEIMIN ZHANG and EVA J. HELMERHORST

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.030

  4. Part II. Drug and Small Molecule Detection in Saliva

    1. Top of page
    2. Dedication to Irwin Mandel
    3. Introduction
    4. Part I. Biochemistry/Physiology of Saliva: Implications for Diagnostics
    5. Part II. Drug and Small Molecule Detection in Saliva
    6. Part III. Meeting Unmet Needs in Diagnostics
    7. Part IV. Oral Samples/Oral Diseases
    8. Part V. Molecular and Protein Markers of Disease
    9. Part VI. Horizons in Oral Diagnostics
    10. Part VII. Short Papers
    11. Index of Contributors
    1. Salivary α-Amylase in Biobehavioral Research : Recent Developments and Applications (pages 122–144)

      DOUGLAS A. GRANGER, KATIE T. KIVLIGHAN, MONA El-SHEIKH, ELANA B. GORDIS and LAURA R. STROUD

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.008

  5. Part III. Meeting Unmet Needs in Diagnostics

    1. Top of page
    2. Dedication to Irwin Mandel
    3. Introduction
    4. Part I. Biochemistry/Physiology of Saliva: Implications for Diagnostics
    5. Part II. Drug and Small Molecule Detection in Saliva
    6. Part III. Meeting Unmet Needs in Diagnostics
    7. Part IV. Oral Samples/Oral Diseases
    8. Part V. Molecular and Protein Markers of Disease
    9. Part VI. Horizons in Oral Diagnostics
    10. Part VII. Short Papers
    11. Index of Contributors
    1. Visualization and Other Emerging Technologies as Change Makers for Oral Cancer Prevention (pages 167–183)

      MIRIAM P. ROSIN, CATHERINE F. POH, MARTIAL GUILLARD, P. MICHELE WILLIAMS, LEWEI ZHANG and CALUM MacAULAY

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.039

    2. Genomic Targets in Saliva (pages 184–191)

      BERNHARD G. ZIMMERMANN, NOH JIN PARK and DAVID T. WONG

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.002

    3. Saliva and the Clinical Pathology Laboratory (pages 192–199)

      MICHAEL A. PESCE and STEVEN L. SPITALNIK

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.032

  6. Part IV. Oral Samples/Oral Diseases

    1. Top of page
    2. Dedication to Irwin Mandel
    3. Introduction
    4. Part I. Biochemistry/Physiology of Saliva: Implications for Diagnostics
    5. Part II. Drug and Small Molecule Detection in Saliva
    6. Part III. Meeting Unmet Needs in Diagnostics
    7. Part IV. Oral Samples/Oral Diseases
    8. Part V. Molecular and Protein Markers of Disease
    9. Part VI. Horizons in Oral Diagnostics
    10. Part VII. Short Papers
    11. Index of Contributors
    1. Oral Diseases : From Detection to Diagnostics (pages 200–203)

      ANTOON J. M. LIGTENBERG, JOHANNES J. De SOET, ENNO C. I. VEERMAN and ARIE v. NIEUW AMERONGEN

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.040

    2. A Novel Caries Risk Test (pages 204–215)

      PAUL C. DENNY, PATRICIA A. DENNY, JONA TAKASHIMA, JOYCE GALLIGAN and MAHVASH NAVAZESH

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.009

    3. Oral Fluid–Based Biomarkers of Alveolar Bone Loss in Periodontitis (pages 230–251)

      JANET S. KINNEY, CHRISTOPH A. RAMSEIER and WILLIAM V. GIANNOBILE

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.028

    4. Human Breath Odors and Their Use in Diagnosis (pages 252–266)

      CHRIS L. WHITTLE, STEVEN FAKHARZADEH, JASON EADES and GEORGE PRETI

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.011

  7. Part V. Molecular and Protein Markers of Disease

    1. Top of page
    2. Dedication to Irwin Mandel
    3. Introduction
    4. Part I. Biochemistry/Physiology of Saliva: Implications for Diagnostics
    5. Part II. Drug and Small Molecule Detection in Saliva
    6. Part III. Meeting Unmet Needs in Diagnostics
    7. Part IV. Oral Samples/Oral Diseases
    8. Part V. Molecular and Protein Markers of Disease
    9. Part VI. Horizons in Oral Diagnostics
    10. Part VII. Short Papers
    11. Index of Contributors
    1. Oxytocin : Behavioral Associations and Potential as a Salivary Biomarker (pages 312–322)

      C. SUE CARTER, HOSSEIN POURNAJAFI-NAZARLOO, KRISTIN M. KRAMER, TONI E. ZIEGLER, ROSEMARY WHITE-TRAUT, DEBORAH BELLO and DORIE SCHWERTZ

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.006

    2. Human Saliva Proteome Analysis (pages 323–329)

      SHEN HU, JOSEPH A. LOO and DAVID T. WONG

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.015

  8. Part VI. Horizons in Oral Diagnostics

    1. Top of page
    2. Dedication to Irwin Mandel
    3. Introduction
    4. Part I. Biochemistry/Physiology of Saliva: Implications for Diagnostics
    5. Part II. Drug and Small Molecule Detection in Saliva
    6. Part III. Meeting Unmet Needs in Diagnostics
    7. Part IV. Oral Samples/Oral Diseases
    8. Part V. Molecular and Protein Markers of Disease
    9. Part VI. Horizons in Oral Diagnostics
    10. Part VII. Short Papers
    11. Index of Contributors
    1. SPR Imaging-Based Salivary Diagnostics System for the Detection of Small Molecule Analytes (pages 335–344)

      ELAIN FU, TIMOTHY CHINOWSKY, KJELL NELSON, KYLE JOHNSTON, THAYNE EDWARDS, KRISTEN HELTON, MICHAEL GROW, JOHN W. MILLER and PAUL YAGER

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.026

    2. Saliva-Based Diagnostics Using 16S rRNA Microarrays and Microfluidics (pages 345–361)

      E. MICHELLE STARKE, JAMES C. SMOOT, JER-HORNG WU, WEN-TSO LIU, DARRELL CHANDLER and DAVID A. STAHL

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.007

    3. Integrated Microfluidic Platform for Oral Diagnostics (pages 362–374)

      AMY E. HERR, ANSON V. HATCH, WILLIAM V. GIANNOBILE, DANIEL J. THROCKMORTON, HUU M. TRAN, JAMES S. BRENNAN and ANUP K. SINGH

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.004

    4. Development of a Microfluidic Device for Detection of Pathogens in Oral Samples Using Upconverting Phosphor Technology (UPT) (pages 375–388)

      WILLIAM R. ABRAMS, CHERYL A. BARBER, KURT McCANN, GARY TONG, ZONGYUAN CHEN, MICHAEL G. MAUK, JING WANG, ALEX VOLKOV, PETE BOURDELLE, PAUL L. A. M. CORSTJENS, MICHEL ZUIDERWIJK, KEITH KARDOS, SHANG LI, HANS J. TANKE, R. SAM NIEDBALA, DANIEL MALAMUD and HAIM BAU

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.020

    5. Microsensor Arrays for Saliva Diagnostics (pages 389–400)

      DAVID R. WALT, TIMOTHY M. BLICHARZ, RYAN B. HAYMAN, DAVID M. RISSIN, MICHAELA BOWDEN, WALTER L. SIQUEIRA, EVA J. HELMERHORST, NERLINE GRAND-PIERRE, FRANK G. OPPENHEIM, JASVINDER S. BHATIA, FRÉDÉRIC F. LITTLE and JEROME S. BRODY

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.031

    6. Lab-on-a-Chip Methods for Point-of-Care Measurements of Salivary Biomarkers of Periodontitis (pages 411–428)

      NICOLAOS CHRISTODOULIDES, PIERRE N. FLORIANO, CRAIG S. MILLER, JEFFREY L. EBERSOLE, SANGHAMITRA MOHANTY, PRIYA DHARSHAN, MICHAEL GRIFFIN, ALEXIS LENNART, KARRI L. MICHAEL BALLARD, CHARLES P. KING JR, M. CHRIS LANGUB, RICHARD J. KRYSCIO, MARK V. THOMAS and JOHN T. McDEVITT

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.035

  9. Part VII. Short Papers

    1. Top of page
    2. Dedication to Irwin Mandel
    3. Introduction
    4. Part I. Biochemistry/Physiology of Saliva: Implications for Diagnostics
    5. Part II. Drug and Small Molecule Detection in Saliva
    6. Part III. Meeting Unmet Needs in Diagnostics
    7. Part IV. Oral Samples/Oral Diseases
    8. Part V. Molecular and Protein Markers of Disease
    9. Part VI. Horizons in Oral Diagnostics
    10. Part VII. Short Papers
    11. Index of Contributors
    1. A Microfluidic System for Saliva-Based Detection of Infectious Diseases (pages 429–436)

      ZONGYUAN CHEN, MICHAEL G. MAUK, JING WANG, WILLIAM R. ABRAMS, PAUL L. A. M. CORSTJENS, R. SAM NIEDBALA, DANIEL MALAMUD and HAIM H. BAU

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.024

    2. Rapid Assay Format for Multiplex Detection of Humoral Immune Responses to Infectious Disease Pathogens (HIV, HCV, and TB) (pages 437–445)

      PAUL L. A. M. CORSTJENS, ZONGYUANG CHEN, MICHEL ZUIDERWIJK, HAIM H. BAU, WILLIAM R. ABRAMS, DANIEL MALAMUD, R. SAM NIEDBALA and HANS J. TANKE

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.016

    3. Patterns of Salivary Estradiol and Progesterone across the Menstrual Cycle (pages 446–450)

      BEATRICE K. GANDARA, LINDA LERESCHE and LLOYD MANCL

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.022

    4. Layered Peptide Arrays : A Diverse Technique for Antibody Screening of Clinical Samples (pages 451–453)

      GALLYA GANNOT, MICHAEL A. TANGREA, RODRIGO F. CHUAQUI, JOHN W. GILLESPIE and MICHAEL R. EMMERT-BUCK

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.041

    5. Lab-on-a-Chip Technologies for Oral-Based Cancer Screening and Diagnostics : Capabilities, Issues, and Prospects (pages 467–475)

      MICHAEL G. MAUK, BARRY L. ZIOBER, ZONGYUAN CHEN, JASON A. THOMPSON and HAIM H. BAU

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.025

    6. Evaluation of UPlink–RSV : Prototype Rapid Antigen Test for Detection of Respiratory Syncytial Virus Infection (pages 476–485)

      VIJAYA K. MOKKAPATI, R. SAM NIEDBALA, KEITH KARDOS, RONELITO J. PEREZ, MING GUO, HANS J. TANKE and PAUL L. A. M. CORSTJENS

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.021

    7. Immunoassay-Based Diagnostic Point-of-Care Technology for Oral Specimen (pages 486–489)

      SARVAN MUNJAL, PETER MIETHE, LUTZ NETUSCHIL, FRIEDHELM STRUCK, KURT MAIER and CLAUS BAUERMEISTER

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.017

    8. Evaluation of Immunoassay-Based MMP-8 Detection in Gingival Crevicular Fluid on a Point-of-Care Platform (pages 490–492)

      S. K. MUNJAL, N. PRESCHER, F. STRUCK, T. SORSA, K. MAIER and L. NETUSCHIL

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.018

    9. Rapid Quantitative Chairside Test for Active MMP-8 in Gingival Crevicular Fluid : First Clinical Data (pages 493–495)

      N PRESCHER, K MAIER, S. K. MUNJAL, T. SORSA, C.-D BAUERMEISTER, F STRUCK and L NETUSCHIL

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.019

    10. Salivary Biomarkers Associated with Alveolar Bone Loss (pages 496–497)

      F.A. SCANNAPIECO, PBY NG, K. HOVEY, E. HAUSMANN, A. HUTSON and J WACTAWSKI-WENDE

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.034

    11. Salivary Protein/Peptide Profiling with SELDI-TOF-MS (pages 498–503)

      RAYMOND SCHIPPER, ARNOUD LOOF, JOLAN De GROOT, LUCIEN HARTHOORN, WAANDER Van HEERDE and ERIC DRANSFIELD

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.010

    12. Acquired Enamel Pellicle and Its Potential Role in Oral Diagnostics (pages 504–509)

      W. L. SIQUEIRA, E. J. HELMERHORST, W. ZHANG, E. SALIH and F. G. OPPENHEIM

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.023

    13. Gender-Specific Differences in Salivary Biomarker Responses to Acute Psychological Stress (pages 510–515)

      NORIYASU TAKAI, MASAKI YAMAGUCHI, TOSHIAKI ARAGAKI, KENJI ETO, KENJI UCHIHASHI and YASUO NISHIKAWA

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1384.014

  10. Index of Contributors

    1. Top of page
    2. Dedication to Irwin Mandel
    3. Introduction
    4. Part I. Biochemistry/Physiology of Saliva: Implications for Diagnostics
    5. Part II. Drug and Small Molecule Detection in Saliva
    6. Part III. Meeting Unmet Needs in Diagnostics
    7. Part IV. Oral Samples/Oral Diseases
    8. Part V. Molecular and Protein Markers of Disease
    9. Part VI. Horizons in Oral Diagnostics
    10. Part VII. Short Papers
    11. Index of Contributors
    1. Index of Contributors (pages 517–519)

      Article first published online: 2 APR 2007 | DOI: 10.1196/annals.1379.1865

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