Annals of the New York Academy of Sciences

Cover image for Vol. 1100 Biogerontology: Mechanisms and Interventions

April 2007

Volume 1100 Biogerontology: Mechanisms and Interventions

Pages xiii–xiii, 1–565

  1. Preface

    1. Top of page
    2. Preface
    3. Part I. Aging, Longevity, and Evolution
    4. Part II. Immunity, Aging, and Diseases
    5. Part III. Molecular and Cellular Aging
    6. Part IV. Aging Interventions
    7. Index of Contributors
    1. Preface : Biogerontology: Mechanisms and Interventions (page xiii)

      Suresh I. S. Rattan and Serif Akman

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.000

  2. Part I. Aging, Longevity, and Evolution

    1. Top of page
    2. Preface
    3. Part I. Aging, Longevity, and Evolution
    4. Part II. Immunity, Aging, and Diseases
    5. Part III. Molecular and Cellular Aging
    6. Part IV. Aging Interventions
    7. Index of Contributors
    1. Genetics of Healthy Aging in Europe : The EU-Integrated Project GEHA (GEnetics of Healthy Aging) (pages 21–45)

      CLAUDIO FRANCESCHI, VLADYSLAV BEZRUKOV, HÉLÈNE BLANCHÉ, LARS BOLUND, KAARE CHRISTENSEN, GIOVANNA DE BENEDICTIS, LUCA DEIANA, EFSTHATIOS GONOS, ANTTI HERVONEN, HUANNING YANG, BERNARD JEUNE, TOM B. L. KIRKWOOD, PETER KRISTENSEN, ALBERTA LEON, PIER GIUSEPPE PELICCI, LEENA PELTONEN, MICHEL POULAIN, IRENE MAEVE REA, JOSÉ REMACLE, JEAN MARIE ROBINE, STEFAN SCHREIBER, EWA SIKORA, PIETERNELLA ELINE SLAGBOOM, LIANA SPAZZAFUMO, MARIA ANTONIETTA STAZI, OLIVIER TOUSSAINT and JAMES W. VAUPEL

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.003

    2. Cross-Talk between Aging and Cancer : The Epigenetic Language (pages 60–74)

      MARIO F. FRAGA, RUBEN AGRELO and MANEL ESTELLER

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.005

  3. Part II. Immunity, Aging, and Diseases

    1. Top of page
    2. Preface
    3. Part I. Aging, Longevity, and Evolution
    4. Part II. Immunity, Aging, and Diseases
    5. Part III. Molecular and Cellular Aging
    6. Part IV. Aging Interventions
    7. Index of Contributors
    1. Regulation of Human Life Histories : The Role of the Inflammatory Host Response (pages 84–97)

      DAVID VAN BODEGOM, LINDA MAY, HANS J. MEIJ and RUDI G. J. WESTENDORP

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.007

    2. Do Membrane Rafts Contribute to Human Immunosenescence? (pages 98–110)

      ANDRU TOMOIU, ANIS LARBI, CARL FORTIN, GILLES DUPUIS and TAMAS FULOP Jr

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.008

    3. Zinc and Inflammatory/Immune Response in Aging (pages 111–122)

      SONYA VASTO, EUGENIO MOCCHEGIANI, MARCO MALAVOLTA, IRENE CUPPARI, FLORINDA LISTÌ, DOMENICO NUZZO, VITO DITTA, GIUSEPPINA CANDORE and CALOGERO CARUSO

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.009

    4. Genetics of Inflammation in Age-Related Atherosclerosis : Its Relevance to Pharmacogenomics (pages 123–131)

      MARIA PAOLA GRIMALDI, SONYA VASTO, CARMELA RITA BALISTRERI, DANIELE DI CARLO, MARCO CARUSO, EGLE INCALCATERRA, DOMENICO LIO, CALOGERO CARUSO and GIUSEPPINA CANDORE

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.010

    5. PECAM-1/CD31 in Infarction and Longevity (pages 132–139)

      FLORINDA LISTÌ, CALOGERO CARUSO, CARMELA RITA BALISTRERI, MARIA PAOLA GRIMALDI, MARCO CARUSO, GREGORIO CAIMI, ENRICO HOFFMANN, DOMENICO LIO and GIUSEPPINA CANDORE

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.011

    6. Plasma Levels of Apolipoprotein E and Risk of Stroke in Old Age (pages 140–147)

      PETER VAN VLIET, SIMON P. MOOIJAART, ANTON J. M. DE CRAEN, PATRICK C. N. RENSEN, DIANA VAN HEEMST and RUDI G. J. WESTENDORP

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.012

    7. Plasma Levels of Apolipoprotein E and Cognitive Function in Old Age (pages 148–161)

      SIMON P. MOOIJAART, PETER VAN VLIET, DIANA VAN HEEMST, PATRICK C. N. RENSEN, JIMMY F. P. BERBÉE, JELLE JOLLES, ANTON J. M. DE CRAEN and RUDI G. J. WESTENDORP

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.013

    8. CCR5 Receptor : Biologic and Genetic Implications in Age-Related Diseases (pages 162–172)

      CARMELA RITA BALISTRERI, CALOGERO CARUSO, MARIA PAOLA GRIMALDI, FLORINDA LISTÌ, SONYA VASTO, VALENTINA ORLANDO, ANNA MARIA CAMPAGNA, DOMENICO LIO and GIUSEPPINA CANDORE

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.014

    9. Lumbar Spinal Stenosis in Elderly Patients (pages 173–178)

      HULAGU KAPTAN, OMUR KASIMCAN, KUTAY CAKIROGLU, MUSTAFA NECMI ILHAN and CELAL KILIC

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.015

    10. Comparison of Lipoprotein(a) Levels between Elderly and Middle-Aged Men with Coronary Artery Disease (pages 179–184)

      HULYA CICEK, SIBEL BAYIL, YASEMIN ZER, AHMET CELIK and ICLAL GEYIKLI

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.016

    11. Chitotriosidase Levels in Healthy Elderly Subjects (pages 185–188)

      ISMAIL KURT, DILEK ABASLI, MURAT CIHAN, MUHITTIN A. SERDAR, ABDULLAH OLGUN, ERCAN SARUHAN and M. KEMAL ERBIL

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.017

    12. Genetic Variation in the Interleukin-10 Gene Promoter and Risk of Coronary and Cerebrovascular Events : The PROSPER Study (pages 189–198)

      S. TROMPET, D. PONS, A. J. M. DE CRAEN, P. SLAGBOOM, J. SHEPHERD, G. J. BLAUW, M. B. MURPHY, S. M. COBBE, E.L.E.M. BOLLEN, B. M. BUCKLEY, I. FORD, M. HYLAND, A. GAW, P. W. MACFARLANE, C. J. PACKARD, J. NORRIE, I. J. PERRY, D. J. STOTT, B. J. SWEENEY, C. TWOMEY, R. G. J. WESTENDORP, J. W. JUKEMA and ON BEHALF OF THE PROSPER GROUP

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.018

    13. Antioxidant Enzymes and Diabetic Retinopathy (pages 199–206)

      ZUHAL YILDIRIM, N. IREM UÇGUN, NEDRET KILIÇ, E. GÜRSEL and AYLIN SEPICI-DINÇEL

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.019

    14. Pseudoexfoliation Syndrome and Trace Elements (pages 207–212)

      ZUHAL YILDIRIM, N. IREM UÇGUN, NEDRET KILIÇ, E. GÜRSEL and AYLIN SEPICI-DINÇEL

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.020

    15. The Importance of Serum Lipids in Exudative Diabetic Macular Edema in Type 2 Diabetic Patients (pages 213–217)

      NIL IREM UÇGUN, ZUHAL YILDIRIM, NEDRET KILIÇ and EMIN GÜRSEL

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.021

    16. Age-Related Paraoxonase Activity Changes in Turkish Population (pages 218–222)

      ERCAN SARUHAN, ABDULLAH OLGUN, KAMILE ÖZTÜRK, SERIF AKMAN and M. KEMAL ERBIL

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.022

    17. Evaluation of Measurement Uncertainty of Glucose in Clinical Chemistry (pages 223–226)

      B. BERÇIK İNAL, M. KOLDAŞ, H. İNAL, C. COŞKUN, A. GÜMÜŞ and Y. DÖVENTAŞ

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.023

  4. Part III. Molecular and Cellular Aging

    1. Top of page
    2. Preface
    3. Part I. Aging, Longevity, and Evolution
    4. Part II. Immunity, Aging, and Diseases
    5. Part III. Molecular and Cellular Aging
    6. Part IV. Aging Interventions
    7. Index of Contributors
    1. Mitochondrial DNA Mutations and Aging (pages 227–240)

      KIM J. KRISHNAN, LAURA C. GREAVES, AMY K. REEVE and DOUGLASS M. TURNBULL

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.024

    2. Mitochondrial DNA-Deficient Models and Aging (pages 241–245)

      ABDULLAH OLGUN and SERIF AKMAN

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.025

    3. Mitochondrial DNA Alterations in Aging (pages 246–249)

      KAMILE ÖZTÜRK, ABDULLAH OLGUN, ERCAN SARUHAN, AYDAN ERGEN, SERIF AKMAN and M. KEMAL ERBIL

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.026

    4. Alterations to Nuclear Architecture and Genome Behavior in Senescent Cells (pages 250–263)

      ISHITA S. MEHTA, MARTIN FIGGITT, CRAIG S. CLEMENTS, IAN R. KILL and JOANNA M. BRIDGER

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.027

    5. PGC-1α-Induced Mitochondrial Alterations in 3T3 Fibroblast Cells (pages 264–279)

      HUIYUN LIANG, YIDONG BAI, YOUFEN LI, ARLAN RICHARDSON and WALTER F. WARD

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.028

    6. Proteasome and Photoaging : The Effects of UV Irradiation (pages 280–290)

      ANNE-LAURE BULTEAU, MARIELLE MOREAU, CARINE NIZARD and BERTRAND FRIGUET

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.029

    7. Proteome Alterations in Rat Mitochondria Caused by Aging (pages 291–298)

      NORBERT A. DENCHER, MONIKA FRENZEL, NICOLE H. REIFSCHNEIDER, MICHIRU SUGAWA and FRANK KRAUSE

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.030

    8. A Dual Role of p21 in Stem Cell Aging (pages 333–344)

      ZHENYU JU, AAHELI ROY CHOUDHURY and K. LENHARD RUDOLPH

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.036

    9. Age-Dependent Effects on Functional Aspects in Human Satellite Cells (pages 345–352)

      S. BECCAFICO, C. PUGLIELLI, T. PIETRANGELO, R. BELLOMO, G. FANÒ and S. FULLE

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.037

    10. Quantum Dot-Based Mortalin Staining as a Visual Assay for Detection of Induced Senescence in Cancer Cells (pages 368–372)

      ZEENIA KAUL, TOMOKO YAGUCHI, HIROSHI X. CHIURA, SUNIL C. KAUL and RENU WADHWA

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.040

    11. Deuteronation and Aging (pages 400–403)

      ABDULLAH OLGUN, KAMILE ÖZTÜRK, SELDA BAYIR, SERIF AKMAN and M. KEMAL ERBIL

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.044

    12. Hemodialysis and Protein Oxidation Products (pages 404–408)

      CİHAN COŞKUN, ALEV KURAL, YASEMİN DÖVENTAŞ, MACİT KOLDAŞ, HÜMEYRA ÖZTURK, BERRİN BERÇİK İNAL and ALPER GÜMÜŞ

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.045

  5. Part IV. Aging Interventions

    1. Top of page
    2. Preface
    3. Part I. Aging, Longevity, and Evolution
    4. Part II. Immunity, Aging, and Diseases
    5. Part III. Molecular and Cellular Aging
    6. Part IV. Aging Interventions
    7. Index of Contributors
    1. Beneficial Biochemical Outcomes of Late-Onset Dietary Restriction in Rodents (pages 431–441)

      SATARO GOTO, RYOYA TAKAHASHI, ZSOLT RADAK and RAMESH SHARMA

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.048

    2. Adult-Limited Dietary Restriction Slows Gompertzian Aging in Caenorhabditis elegans (pages 442–448)

      ISABELLE LENAERTS, SYLVIE VAN EYGEN and JACQUES VAN FLETEREN

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.049

    3. Prior Chronic in Vivo Glucocorticoid Excess Leads to an Anabolic Phenotype and an Extension of Cellular Life Span of Skin Fibroblasts in Vitro (pages 449–454)

      DIMITRIS KLETSAS, HARRIS PRATSINIS, VASSILIKI GIONI, KONSTANTINOS PILICHOS, ANDREAS M. YIACOUMETTIS and STYLIANOS TSAGARAKIS

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.050

    4. The Role of Cellular Senescence in Werner Syndrome : Toward Therapeutic Intervention in Human Premature Aging (pages 455–469)

      TERENCE DAVIS, FIONA S. WYLLIE, MICHAL J. ROKICKI, MARK C. BAGLEY and DAVID KIPLING

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.051

    5. Improvement of Immune Cell Functions in Aged Mice Treated for Five Weeks with Soybean Isoflavones (pages 497–504)

      ISABEL BAEZA, NURIA M. DE CASTRO, CARMEN ALVARADO, PEDRO ÁLVAREZ, LORENA ARRANZ, JULIÁN BAYÓN and MÓNICA DE LA FUENTE

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.054

    6. Influence of Aging and Enriched Environment on Motor Activity and Emotional Responses in Mice (pages 543–552)

      CLAUSTRO ZAMBRANA, EVA M. MARCO, LORENA ARRANZ, NURIA M. De CASTRO, MARIA PAZ VIVEROS and MÓNICA DE LA FUENTE

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.060

    7. Effects of Taurine in Cellular Responses to Oxidative Stress in Young and Middle-Aged Rat Liver (pages 553–561)

      ZUHAL YILDIRIM, NEDRET KILIÇ, ÇIGDEM OZER, AYDAN BABUL, GULNUR TAKE and DENIZ ERDOGAN

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.061

  6. Index of Contributors

    1. Top of page
    2. Preface
    3. Part I. Aging, Longevity, and Evolution
    4. Part II. Immunity, Aging, and Diseases
    5. Part III. Molecular and Cellular Aging
    6. Part IV. Aging Interventions
    7. Index of Contributors
    1. Index of Contributors (pages 563–565)

      Article first published online: 18 APR 2007 | DOI: 10.1196/annals.1395.auindex_1

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