Annals of the New York Academy of Sciences

Cover image for Vol. 1119 Molecular Mechanisms and Models of Aging

November 2007

Volume 1119 Molecular Mechanisms and Models of Aging

Pages xi–xii, 1–312

  1. Preface

    1. Top of page
    2. Preface
    3. Part I. Overview of Mammalian Aging and Senescence
    4. Part II. Cell Signaling and Replicative Senescence
    5. Part III. Biomarkers of Aging
    6. Part IV. DNA Repair and Aging
    7. Part V. Free Radicals, Oxidative Stress, Proteolysis and Proteins Maintenance
    8. Part VI. Intervention
    9. Part VII. Molecular Links between Aging and Cancer
    10. Part VIII. Age-Related Diseases
    11. Part IX. Model Organisms
    12. Part X. Evolutionary and Epidemiological Aspects of Aging
    13. Index of Contributors
    1. Preface (pages xi–xii)

      Efstathios S. Gonos, Ioannis P. Trougakos and Niki Chondrogianni

      Article first published online: 28 NOV 2007 | DOI: 10.1196/annals.1404.032

  2. Part I. Overview of Mammalian Aging and Senescence

    1. Top of page
    2. Preface
    3. Part I. Overview of Mammalian Aging and Senescence
    4. Part II. Cell Signaling and Replicative Senescence
    5. Part III. Biomarkers of Aging
    6. Part IV. DNA Repair and Aging
    7. Part V. Free Radicals, Oxidative Stress, Proteolysis and Proteins Maintenance
    8. Part VI. Intervention
    9. Part VII. Molecular Links between Aging and Cancer
    10. Part VIII. Age-Related Diseases
    11. Part IX. Model Organisms
    12. Part X. Evolutionary and Epidemiological Aspects of Aging
    13. Index of Contributors
  3. Part II. Cell Signaling and Replicative Senescence

    1. Top of page
    2. Preface
    3. Part I. Overview of Mammalian Aging and Senescence
    4. Part II. Cell Signaling and Replicative Senescence
    5. Part III. Biomarkers of Aging
    6. Part IV. DNA Repair and Aging
    7. Part V. Free Radicals, Oxidative Stress, Proteolysis and Proteins Maintenance
    8. Part VI. Intervention
    9. Part VII. Molecular Links between Aging and Cancer
    10. Part VIII. Age-Related Diseases
    11. Part IX. Model Organisms
    12. Part X. Evolutionary and Epidemiological Aspects of Aging
    13. Index of Contributors
    1. Exposure of Human Diploid Fibroblasts to Hypoxia Extends Proliferative Life Span (pages 9–19)

      EFTHYMIOS POULIOS, IOANNIS P. TROUGAKOS, NIKI CHONDROGIANNI and EFSTATHIOS S. GONOS

      Article first published online: 28 NOV 2007 | DOI: 10.1196/annals.1404.025

    2. Cyclin D1 Overexpression Permits the Reproducible Detection of Senescent Human Vascular Smooth Muscle Cells (pages 20–31)

      DOMINICK G. A. BURTON, ANGELA N. SHEERIN, ELIZABETH L. OSTLER, KAYE SMITH, PETER J. GILES, JILL LOWE, WILLIAM RHYS-WILLIAMS, DAVID G. KIPLING and RICHARD G. A. FARAGHER

      Article first published online: 28 NOV 2007 | DOI: 10.1196/annals.1404.026

  4. Part III. Biomarkers of Aging

    1. Top of page
    2. Preface
    3. Part I. Overview of Mammalian Aging and Senescence
    4. Part II. Cell Signaling and Replicative Senescence
    5. Part III. Biomarkers of Aging
    6. Part IV. DNA Repair and Aging
    7. Part V. Free Radicals, Oxidative Stress, Proteolysis and Proteins Maintenance
    8. Part VI. Intervention
    9. Part VII. Molecular Links between Aging and Cancer
    10. Part VIII. Age-Related Diseases
    11. Part IX. Model Organisms
    12. Part X. Evolutionary and Epidemiological Aspects of Aging
    13. Index of Contributors
    1. Morphological Changes Associated with Aging : Age Spots and the Microinflammatory Model of Skin Aging (pages 32–39)

      EARL GOYARTS, NEELAM MUIZZUDDIN, DANIEL MAES and PAOLO U. GIACOMONI

      Article first published online: 28 NOV 2007 | DOI: 10.1196/annals.1404.006

    2. Molecular Mechanisms of Skin Aging : State of the Art (pages 40–50)

      E. MAKRANTONAKI and C. C. ZOUBOULIS

      Article first published online: 28 NOV 2007 | DOI: 10.1196/annals.1404.027

  5. Part IV. DNA Repair and Aging

    1. Top of page
    2. Preface
    3. Part I. Overview of Mammalian Aging and Senescence
    4. Part II. Cell Signaling and Replicative Senescence
    5. Part III. Biomarkers of Aging
    6. Part IV. DNA Repair and Aging
    7. Part V. Free Radicals, Oxidative Stress, Proteolysis and Proteins Maintenance
    8. Part VI. Intervention
    9. Part VII. Molecular Links between Aging and Cancer
    10. Part VIII. Age-Related Diseases
    11. Part IX. Model Organisms
    12. Part X. Evolutionary and Epidemiological Aspects of Aging
    13. Index of Contributors
    1. Effect of the Histone Deacetylase Inhibitor Trichostatin A in Human Peripheral Blood Lymphocytes as a Function of Donor Age (pages 64–71)

      T. G. SOURLINGAS, K. P. KYPREOU, G. N. TOPAKAS, I. N. KARCHILAKI, C. STAVROPOULOS-GIOKAS and K. E. SEKERI-PATARYAS

      Article first published online: 28 NOV 2007 | DOI: 10.1196/annals.1404.014

  6. Part V. Free Radicals, Oxidative Stress, Proteolysis and Proteins Maintenance

    1. Top of page
    2. Preface
    3. Part I. Overview of Mammalian Aging and Senescence
    4. Part II. Cell Signaling and Replicative Senescence
    5. Part III. Biomarkers of Aging
    6. Part IV. DNA Repair and Aging
    7. Part V. Free Radicals, Oxidative Stress, Proteolysis and Proteins Maintenance
    8. Part VI. Intervention
    9. Part VII. Molecular Links between Aging and Cancer
    10. Part VIII. Age-Related Diseases
    11. Part IX. Model Organisms
    12. Part X. Evolutionary and Epidemiological Aspects of Aging
    13. Index of Contributors
    1. Transient Increased Extracellular Release of H2O2 during Establishment of UVB-Induced Premature Senescence (pages 72–77)

      CELINE BORLON, ALINE CHRETIEN, FLORENCE DEBACQ-CHAINIAUX and OLIVIER TOUSSAINT

      Article first published online: 28 NOV 2007 | DOI: 10.1196/annals.1404.002

    2. Protein Oxidative Modifications and Replicative Senescence of WI-38 Human Embryonic Fibroblasts (pages 88–96)

      EMAD KHAIRY AHMED, CÉDRIC R. PICOT, ANNE-LAURE BULTEAU and BERTRAND FRIGUET

      Article first published online: 28 NOV 2007 | DOI: 10.1196/annals.1404.020

    3. Lipofuscin : Formation, Distribution, and Metabolic Consequences (pages 97–111)

      TOBIAS JUNG, NICOLLE BADER and TILMAN GRUNE

      Article first published online: 28 NOV 2007 | DOI: 10.1196/annals.1404.008

  7. Part VI. Intervention

    1. Top of page
    2. Preface
    3. Part I. Overview of Mammalian Aging and Senescence
    4. Part II. Cell Signaling and Replicative Senescence
    5. Part III. Biomarkers of Aging
    6. Part IV. DNA Repair and Aging
    7. Part V. Free Radicals, Oxidative Stress, Proteolysis and Proteins Maintenance
    8. Part VI. Intervention
    9. Part VII. Molecular Links between Aging and Cancer
    10. Part VIII. Age-Related Diseases
    11. Part IX. Model Organisms
    12. Part X. Evolutionary and Epidemiological Aspects of Aging
    13. Index of Contributors
    1. Stress-Mediated Hormetic Modulation of Aging, Wound Healing, and Angiogenesis in Human Cells (pages 112–121)

      SURESH I. S. RATTAN, HENRIK SEJERSEN, RICARDO A. FERNANDES and WEIWEI LUO

      Article first published online: 28 NOV 2007 | DOI: 10.1196/annals.1404.005

    2. Zinc, Metallothioneins, and Longevity: : Effect of Zinc Supplementation: Zincage Study (pages 129–146)

      EUGENIO MOCCHEGIANI, ROBERTINA GIACCONI, CATIA CIPRIANO, LAURA COSTARELLI, ELISA MUTI, SILVIA TESEI, CINZIA GIULI, ROBERTA PAPA, FIORELLA MARCELLINI, ERMINIA MARIANI, LOTHAR RINK, GEORGE HERBEIN, AUDREY VARIN, TAMAS FULOP, DANIELA MONTI, JOLANTA JAJTE, GEORGE DEDOUSSIS, EFSTATHIOS S. GONOS, IOANNIS P. TROUGAKOS and MARCO MALAVOLTA

      Article first published online: 28 NOV 2007 | DOI: 10.1196/annals.1404.030

    3. Ghrelin Receptor (GHS-R1A) Agonists Show Potential as Interventive Agents during Aging (pages 147–164)

      ROY G. SMITH, YUXIANG SUN, HONG JIANG, ROSIE ALBARRAN-ZECKLER and NIKOLAI TIMCHENKO

      Article first published online: 28 NOV 2007 | DOI: 10.1196/annals.1404.023

  8. Part VII. Molecular Links between Aging and Cancer

    1. Top of page
    2. Preface
    3. Part I. Overview of Mammalian Aging and Senescence
    4. Part II. Cell Signaling and Replicative Senescence
    5. Part III. Biomarkers of Aging
    6. Part IV. DNA Repair and Aging
    7. Part V. Free Radicals, Oxidative Stress, Proteolysis and Proteins Maintenance
    8. Part VI. Intervention
    9. Part VII. Molecular Links between Aging and Cancer
    10. Part VIII. Age-Related Diseases
    11. Part IX. Model Organisms
    12. Part X. Evolutionary and Epidemiological Aspects of Aging
    13. Index of Contributors
    1. Functional Significance of Minor Structural and Expression Changes in Stress Chaperone Mortalin (pages 165–175)

      CUSTER C. DEOCARIS, NASHI WIDODO, TETSURO ISHII, SUNIL C. KAUL and RENU WADHWA

      Article first published online: 28 NOV 2007 | DOI: 10.1196/annals.1404.007

    2. GRO-α : A Potential Marker for Cancer and Aging Silenced by RNA Interference (pages 176–189)

      SABINE FIMMEL, LENA DEVERMANN, ANKE HERRMANN and CHRISTOS ZOUBOULIS

      Article first published online: 28 NOV 2007 | DOI: 10.1196/annals.1404.016

  9. Part VIII. Age-Related Diseases

    1. Top of page
    2. Preface
    3. Part I. Overview of Mammalian Aging and Senescence
    4. Part II. Cell Signaling and Replicative Senescence
    5. Part III. Biomarkers of Aging
    6. Part IV. DNA Repair and Aging
    7. Part V. Free Radicals, Oxidative Stress, Proteolysis and Proteins Maintenance
    8. Part VI. Intervention
    9. Part VII. Molecular Links between Aging and Cancer
    10. Part VIII. Age-Related Diseases
    11. Part IX. Model Organisms
    12. Part X. Evolutionary and Epidemiological Aspects of Aging
    13. Index of Contributors
    1. Role of TLR4 Polymorphisms in Inflammatory Responses : Implications for Unsuccessful Aging (pages 203–207)

      CARMELA RITA BALISTRERI, GIUSEPPINA CANDORE, FLORINDA LISTÌ, TERESA FAZIO, SIMONA GANGI, EGLE INCALCATERRA, MARCO CARUSO, MAURIZIO LI VECCHI, DOMENICO LIO and CALOGERO CARUSO

      Article first published online: 28 NOV 2007 | DOI: 10.1196/annals.1404.003

    2. ProNGF, Sortilin, and Age-related Neurodegeneration (pages 208–215)

      RAYA AL-SHAWI, ANGELA HAFNER, SOYON CHUN, SABA RAZA, KEITH CRUTCHER, CHRISTOPHER THRASIVOULOU, PAUL SIMONS and TIMOTHY COWEN

      Article first published online: 28 NOV 2007 | DOI: 10.1196/annals.1404.024

    3. Identification of Fasting-induced Genes in the Rat Hypothalamus : Relationship with Neuroprotection (pages 216–226)

      TAKUYA CHIBA, SATOSHI FUJITA, HARUAKI KUBOTA, DAISUKE INOUE, AYA MIZUNO, TOSHIMITSU KOMATSU, HARUYOSHI YAMAZA, YOSHIKAZU HIGAMI and ISAO SHIMOKAWA

      Article first published online: 28 NOV 2007 | DOI: 10.1196/annals.1404.013

    4. Acute Myocardial Infarction and Proinflammatory Gene Variants (pages 227–242)

      FEDERICO LICASTRO, MARTINA CHIAPELLI, CLAUDIO MARCELLO CALDARERA, CALOGERO CARUSO, DOMENICO LIO and ELIZABETH H. CORDER

      Article first published online: 28 NOV 2007 | DOI: 10.1196/annals.1404.004

    5. Bone Mineral Density in Ukrainian Women of Different Age (pages 243–252)

      V. V. POVOROZNYUK, N. I. DZEROVICH and T. A. KARASEVSKAYA

      Article first published online: 28 NOV 2007 | DOI: 10.1196/annals.1404.019

  10. Part IX. Model Organisms

    1. Top of page
    2. Preface
    3. Part I. Overview of Mammalian Aging and Senescence
    4. Part II. Cell Signaling and Replicative Senescence
    5. Part III. Biomarkers of Aging
    6. Part IV. DNA Repair and Aging
    7. Part V. Free Radicals, Oxidative Stress, Proteolysis and Proteins Maintenance
    8. Part VI. Intervention
    9. Part VII. Molecular Links between Aging and Cancer
    10. Part VIII. Age-Related Diseases
    11. Part IX. Model Organisms
    12. Part X. Evolutionary and Epidemiological Aspects of Aging
    13. Index of Contributors
    1. Modulating Longevity in Drosophila by Over- and Underexpression of Glutamate-Cysteine Ligase (pages 260–273)

      JAMES M. LUCHAK, LEENA PRABHUDESAI, RAJINDAR S. SOHAL, SVETLANA N. RADYUK and WILLIAM C. ORR

      Article first published online: 28 NOV 2007 | DOI: 10.1196/annals.1404.000

    2. Modeling Werner Syndrome in Drosophila melanogaster : Hyper-recombination in Flies Lacking WRN-like Exonuclease (pages 274–288)

      LYNNE S. COX, DAVID J. CLANCY, IVAN BOUBRIAK and ROBERT D. C. SAUNDERS

      Article first published online: 28 NOV 2007 | DOI: 10.1196/annals.1404.009

    3. Protein Synthesis Is a Novel Determinant of Aging in Caenorhabditis elegans (pages 289–295)

      POPI SYNTICHAKI, KOSTOULA TROULINAKI and NEKTARIOS TAVERNARAKIS

      Article first published online: 28 NOV 2007 | DOI: 10.1196/annals.1404.001

  11. Part X. Evolutionary and Epidemiological Aspects of Aging

    1. Top of page
    2. Preface
    3. Part I. Overview of Mammalian Aging and Senescence
    4. Part II. Cell Signaling and Replicative Senescence
    5. Part III. Biomarkers of Aging
    6. Part IV. DNA Repair and Aging
    7. Part V. Free Radicals, Oxidative Stress, Proteolysis and Proteins Maintenance
    8. Part VI. Intervention
    9. Part VII. Molecular Links between Aging and Cancer
    10. Part VIII. Age-Related Diseases
    11. Part IX. Model Organisms
    12. Part X. Evolutionary and Epidemiological Aspects of Aging
    13. Index of Contributors
    1. Nonpathological Senescence Arises from Unsuitable External Influences (pages 306–309)

      ALEXANDER V. KHALYAVKIN and ANATOLI I. YASHIN

      Article first published online: 28 NOV 2007 | DOI: 10.1196/annals.1404.022

  12. Index of Contributors

    1. Top of page
    2. Preface
    3. Part I. Overview of Mammalian Aging and Senescence
    4. Part II. Cell Signaling and Replicative Senescence
    5. Part III. Biomarkers of Aging
    6. Part IV. DNA Repair and Aging
    7. Part V. Free Radicals, Oxidative Stress, Proteolysis and Proteins Maintenance
    8. Part VI. Intervention
    9. Part VII. Molecular Links between Aging and Cancer
    10. Part VIII. Age-Related Diseases
    11. Part IX. Model Organisms
    12. Part X. Evolutionary and Epidemiological Aspects of Aging
    13. Index of Contributors
    1. Index of Contributors (pages 311–312)

      Article first published online: 28 NOV 2007 | DOI: 10.1196/annals.1404.auindex_1

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