Annals of the New York Academy of Sciences

Cover image for Vol. 1160 Relaxin and Related Peptides Fifth International Conference

April 2009

Volume 1160 Relaxin and Related Peptides Fifth International Conference

Pages xiii–xiv, 1–396

  1. Preface

    1. Top of page
    2. Preface
    3. In Tribute
    4. Part I. Relaxin and Related Peptides: Structure and Function
    5. Part II. Relaxin Family Receptors
    6. Part III. Relaxin and Related Peptides: Receptor Signaling
    7. Part IV. Reproductive Functions of Relaxin and Related Peptides
    8. Part V. Physiology of Insulin-Like Peptide 3
    9. Part VI. Neurobiology of Relaxin and Relaxin-Related Peptides
    10. Part VII. Cardiac Actions of Relaxin
    11. Part VIII. Renal and Vascular Actions of Relaxin
    12. Part IX. Actions of Relaxin on the Extracellular Matrix
    13. Part X. Relaxin and Cancer
    14. Part XI. Relaxin Clinical Trials
    15. Index of Contributors
    1. Preface (pages xiii–xiv)

      Gillian D. Bryant-Greenwood

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2009.04665.x

  2. In Tribute

    1. Top of page
    2. Preface
    3. In Tribute
    4. Part I. Relaxin and Related Peptides: Structure and Function
    5. Part II. Relaxin Family Receptors
    6. Part III. Relaxin and Related Peptides: Receptor Signaling
    7. Part IV. Reproductive Functions of Relaxin and Related Peptides
    8. Part V. Physiology of Insulin-Like Peptide 3
    9. Part VI. Neurobiology of Relaxin and Relaxin-Related Peptides
    10. Part VII. Cardiac Actions of Relaxin
    11. Part VIII. Renal and Vascular Actions of Relaxin
    12. Part IX. Actions of Relaxin on the Extracellular Matrix
    13. Part X. Relaxin and Cancer
    14. Part XI. Relaxin Clinical Trials
    15. Index of Contributors
    1. In Tribute : Bernard G. Steinetz, Jr.: A Most Tenacious Relaxinologist (pages 1–4)

      O. David Sherwood

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03798.x

  3. Part I. Relaxin and Related Peptides: Structure and Function

    1. Top of page
    2. Preface
    3. In Tribute
    4. Part I. Relaxin and Related Peptides: Structure and Function
    5. Part II. Relaxin Family Receptors
    6. Part III. Relaxin and Related Peptides: Receptor Signaling
    7. Part IV. Reproductive Functions of Relaxin and Related Peptides
    8. Part V. Physiology of Insulin-Like Peptide 3
    9. Part VI. Neurobiology of Relaxin and Relaxin-Related Peptides
    10. Part VII. Cardiac Actions of Relaxin
    11. Part VIII. Renal and Vascular Actions of Relaxin
    12. Part IX. Actions of Relaxin on the Extracellular Matrix
    13. Part X. Relaxin and Cancer
    14. Part XI. Relaxin Clinical Trials
    15. Index of Contributors
    1. Structure and Activity in the Relaxin Family of Peptides (pages 5–10)

      Geoffrey W. Tregear, Ross A. D. Bathgate, Mohammed Akhter Hossain, Feng Lin, Suode Zhang, Fazel Shabanpoor, Daniel J. Scott, Sherie Ma, Andrew L. Gundlach, Chrishan S. Samuel and John D. Wade

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2009.03955.x

    2. The Chemical Synthesis of Relaxin and Related Peptides : A Historical Perspective (pages 11–15)

      John D. Wade, Feng Lin, M. Akhter Hossain, Fazel Shabanpoor, Suode Zhang and Geoffrey W. Tregear

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2009.03951.x

    3. De Novo Design and Synthesis of Cyclic and Linear Peptides to Mimic the Binding Cassette of Human Relaxin (pages 16–19)

      Mohammed Akhter Hossain, Ross A. D. Bathgate, Geoffery Tregear and John D. Wade

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2009.03840.x

    4. You have free access to this content
      Structural Insights into the Function of Relaxins (pages 20–26)

      K. Johan Rosengren, Ross A. D. Bathgate, David J. Craik, Norelle L. Daly, Linda M. Haugaard-Jönsson, Mohammed Akhter Hossain and John D. Wade

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2009.03833.x

    5. Structural Properties of Relaxin Chimeras : NMR Characterization of the R3/I5 Relaxin Peptide (pages 27–30)

      Linda M. Haugaard-Jönsson, Mohammed Akhter Hossain, Norelle L. Daly, Ross A. D. Bathgate, John D. Wade, David J. Craik and K. Johan Rosengren

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03805.x

    6. Probing the Functional Domains of Relaxin-3 and the Creation of a Selective Antagonist for RXFP3/GPCR135 over Relaxin Receptor RXFP1/LGR7 (pages 31–37)

      Changlu Liu, Chester Kuei, Steven Sutton, Jonathan Shelton, Jessica Zhu, Diane Nepomuceno, Mohammed Akhter Hossain, John D. Wade, Ross A. D. Bathgate, Pascal Bonaventure and Timothy Lovenberg

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03790.x

    7. Degradation of Relaxin Family Peptides by Insulin-Degrading Enzyme (pages 38–41)

      Robert G. Bennett, Dean G. Heimann and Frederick G. Hamel

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03782.x

    8. Relaxin Family Genes in Humans and Teleosts : Bioinformatic Analyses and Expression of Three RLN Genes in Teleosts (pages 42–44)

      Sergey Yegorov, Sara V. Good-Avila, Laura Parry and Brian C. Wilson

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2009.03842.x

  4. Part II. Relaxin Family Receptors

    1. Top of page
    2. Preface
    3. In Tribute
    4. Part I. Relaxin and Related Peptides: Structure and Function
    5. Part II. Relaxin Family Receptors
    6. Part III. Relaxin and Related Peptides: Receptor Signaling
    7. Part IV. Reproductive Functions of Relaxin and Related Peptides
    8. Part V. Physiology of Insulin-Like Peptide 3
    9. Part VI. Neurobiology of Relaxin and Relaxin-Related Peptides
    10. Part VII. Cardiac Actions of Relaxin
    11. Part VIII. Renal and Vascular Actions of Relaxin
    12. Part IX. Actions of Relaxin on the Extracellular Matrix
    13. Part X. Relaxin and Cancer
    14. Part XI. Relaxin Clinical Trials
    15. Index of Contributors
    1. Structural Basis of Allosteric Ligand–Receptor Interactions in the Insulin/Relaxin Peptide Family : Implications for Other Receptor Tyrosine Kinases and G-Protein-Coupled Receptors (pages 45–53)

      Pierre De Meyts, Lisbeth Gauguin, Angela Manegold Svendsen, Mazen Sarhan, Louise Knudsen, Jane Nøhr and Vladislav V. Kiselyov

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2009.03837.x

    2. Dimerization and Negative Cooperativity in the Relaxin Family Peptide Receptors (pages 54–59)

      Angela Manegold Svendsen, Milka Vrecl, Louise Knudsen, Anders Heding, John D. Wade, Ross A. D. Bathgate, Pierre De Meyts and Jane Nøhr

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2009.03835.x

    3. Mechanisms of Relaxin Receptor (LGR7/RXFP1) Expression and Function (pages 60–66)

      András Kern and Gillian D. Bryant-Greenwood

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03826.x

    4. Resolving the Unconventional Mechanisms Underlying RXFP1 and RXFP2 Receptor Function (pages 67–73)

      Brigham J. Hartley, Daniel J. Scott, Gabrielle E. Callander, Tracey N. Wilkinson, Despina E. Ganella, Chze K. Kong, Sharon Layfield, Tania Ferraro, Emma J. Petrie and Ross A. D. Bathgate

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2009.03949.x

    5. Modeling the Primary Hormone-Binding Site of RXFP1 and RXFP2 (pages 74–77)

      Daniel J. Scott, Geoffrey W. Tregear and Ross A. D. Bathgate

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2009.03950.x

    6. Activation of Relaxin-Related Receptors by Short, Linear Peptides Derived from a Collagen-Containing Precursor (pages 78–86)

      Ronen Shemesh, Chen Hermesh, Amir Toporik, Zurit Levine, Amit Novik, Assaf Wool, Yossef Kliger, Avi Rosenberg, Ross A. D. Bathgate and Yossi Cohen

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2009.03827.x

    7. Development of Lanthanide-Labeled Human INSL3 as an Alternative Probe to Radioactively Labeled INSL3 for Use in Bioassays (pages 87–90)

      Fazel Shabanpoor, Richard A. Hughes, Ross A. D. Bathgate, Frances Separovic and John D. Wade

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2009.03839.x

    8. Relaxin Receptor LGR7 (RXFP1) Is Regulated by Estrogen (pages 91–92)

      Priya Maseelall, Jeff Gardner, Andrea Wojtczuk, Gerson Weiss and Laura T. Goldsmith

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2009.04048.x

  5. Part III. Relaxin and Related Peptides: Receptor Signaling

    1. Top of page
    2. Preface
    3. In Tribute
    4. Part I. Relaxin and Related Peptides: Structure and Function
    5. Part II. Relaxin Family Receptors
    6. Part III. Relaxin and Related Peptides: Receptor Signaling
    7. Part IV. Reproductive Functions of Relaxin and Related Peptides
    8. Part V. Physiology of Insulin-Like Peptide 3
    9. Part VI. Neurobiology of Relaxin and Relaxin-Related Peptides
    10. Part VII. Cardiac Actions of Relaxin
    11. Part VIII. Renal and Vascular Actions of Relaxin
    12. Part IX. Actions of Relaxin on the Extracellular Matrix
    13. Part X. Relaxin and Cancer
    14. Part XI. Relaxin Clinical Trials
    15. Index of Contributors
    1. The “Hot Wires” of the Relaxin-Like Factor (Insl3) (pages 93–98)

      Christian Schwabe and Erika E. Büllesbach

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03779.x

    2. Roles of the Receptor, the Ligand, and the Cell in the Signal Transduction Pathways Utilized by the Relaxin Family Peptide Receptors 1–3 (pages 99–104)

      Roger J. Summers, Ross A. D. Bathgate, John D. Wade, Emma T. Van Der Westhuizen and Michelle L. Halls

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2009.03828.x

    3. Addition of a Carboxy-Terminal Green Fluorescent Protein Does Not Alter the Binding and Signaling Properties of Relaxin Family Peptide Receptor 3 (pages 105–107)

      Emma T. Van Der Westhuizen, John D. Wade, Patrick M. Sexton and Roger J. Summers

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03818.x

    4. Relaxin Activates Multiple cAMP Signaling Pathway Profiles in Different Target Cells (pages 108–111)

      Michelle L. Halls, Tim D. Hewitson, Xiao-Lei Moore, Xiao-Jun Du, Ross A. D. Bathgate and Roger J. Summers

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03814.x

    5. RXFP1 Couples to the Gαi3-Gβγ-PI3K-PKCζ Pathway via the Final 10 Amino Acids of the Receptor C-terminal Tail (pages 117–120)

      Michelle L. Halls, Maria Papaioannou, John D. Wade, Bronwyn A. Evans, Ross A. D. Bathgate and Roger J. Summers

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03813.x

  6. Part IV. Reproductive Functions of Relaxin and Related Peptides

    1. Top of page
    2. Preface
    3. In Tribute
    4. Part I. Relaxin and Related Peptides: Structure and Function
    5. Part II. Relaxin Family Receptors
    6. Part III. Relaxin and Related Peptides: Receptor Signaling
    7. Part IV. Reproductive Functions of Relaxin and Related Peptides
    8. Part V. Physiology of Insulin-Like Peptide 3
    9. Part VI. Neurobiology of Relaxin and Relaxin-Related Peptides
    10. Part VII. Cardiac Actions of Relaxin
    11. Part VIII. Renal and Vascular Actions of Relaxin
    12. Part IX. Actions of Relaxin on the Extracellular Matrix
    13. Part X. Relaxin and Cancer
    14. Part XI. Relaxin Clinical Trials
    15. Index of Contributors
    1. Relaxin in Human Pregnancy (pages 130–135)

      Laura T. Goldsmith and Gerson Weiss

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03800.x

    2. Identification of Relaxin-Responsive Cells in the Human Choriodecidua at Term (pages 136–137)

      Jaime S. Horton, Sandra Y. Yamamoto and Gillian D. Bryant-Greenwood

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03786.x

    3. Relaxin in Endometriosis (pages 138–139)

      Sara S. Morelli, Felice Petraglia, Gerson Weiss, Stefano Luisi, Pasquale Florio and Laura T. Goldsmith

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03792.x

    4. Relaxin Supports Implantation and Early Pregnancy in the Marmoset Monkey (pages 140–146)

      Almuth Einspanier, Kai Lieder, Bettina Husen, Katja Ebert, Susanne Lier, Ralf Einspanier, Elaine Unemori and Martina Kemper

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2009.03947.x

    5. Expression of LGR7 in the Primate Corpus Luteum Implicates the Corpus Luteum as a Relaxin Target Organ (pages 147–151)

      Priya B. Maseelall, Aimee Seungdamrong, Gerson Weiss, Andrea S. Wojtczuk, Robert Donnelly, Richard L. Stouffer and Laura T. Goldsmith

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2009.03946.x

    6. Milk-Borne Relaxin and the Lactocrine Hypothesis for Maternal Programming of Neonatal Tissues (pages 152–157)

      Carol A. Bagnell, Bernard G. Steinetz and Frank F. Bartol

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2009.03834.x

    7. Relaxin and Maternal Lactocrine Programming of Neonatal Uterine Development (pages 158–163)

      Frank F. Bartol, Anne A. Wiley and Carol A. Bagnell

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03820.x

    8. Biological Activity of Relaxin in Porcine Milk (pages 164–168)

      Amy-Lynn Frankshun, Teh-Yuan Ho, Bernard G. Steinetz, Frank F. Bartol and Carol A. Bagnell

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03822.x

    9. Evaluation of Systemic Relaxin Blood Profiles in Horses as a Means of Assessing Placental Function in High-Risk Pregnancies and Responsiveness to Therapeutic Strategies (pages 169–178)

      Peter L. Ryan, David L. Christiansen, Richard M. Hopper, Carol A. Bagnell, Wendy E. Vaala and Michelle M. Leblanc

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03802.x

    10. Relaxin Concentrations in Serum and Urine of Endangered and Crazy Mixed-Up Species : New Methods, Uses, and Findings (pages 179–185)

      B. Steinetz, S. Lasano, F. De Haas van Dorsser, S. Glickman, D. Bergfelt, R. Santymire, N. Songsassen and W. Swanson

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03824.x

    11. Conceptus Numbers Do Not Affect Blood Concentrations of Relaxin in the Rabbit (pages 186–187)

      Phillip Fields and Michael Fields

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03811.x

    12. Perinatal Zearalenone Exposure Affects RXFP1, RXFP2, and Morphoregulatory Gene Expression in the Neonatal Porcine Uterus (pages 188–189)

      Joseph C. Chen, Anne A. Wiley, Johannes Kauffold, Martin Wähner, Frank F. Bartol and Carol A. Bagnell

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03815.x

    13. Laser Microdissection of Neonatal Porcine Endometrium for Tissue-Specific Evaluation of Relaxin Receptor (RXFP1) Expression in Response to Perinatal Zearalenone Exposure (pages 190–191)

      Anne A. Wiley, Johannes Kauffold, Martin Wähner, Bethany Crean-Harris, Dori J. Miller, Carol A. Bagnell and Frank F. Bartol

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03821.x

    14. RXFP1 Is Expressed on the Sperm Acrosome, and Relaxin Stimulates the Acrosomal Reaction of Human Spermatozoa (pages 192–193)

      Lisa Gianesello, Alberto Ferlin, Massimo Menegazzo, Anastasia Pepe and Carlo Foresta

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03789.x

    15. Identification of Boar Testis as a Source and Target Tissue of Relaxin (pages 194–196)

      Tetsuya Kohsaka, Shinichi Kato, Si Qin, Itaru Minagawa, Keiichiro Yogo, Tatsuo Kawarasaki and Hiroshi Sasada

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03809.x

  7. Part V. Physiology of Insulin-Like Peptide 3

    1. Top of page
    2. Preface
    3. In Tribute
    4. Part I. Relaxin and Related Peptides: Structure and Function
    5. Part II. Relaxin Family Receptors
    6. Part III. Relaxin and Related Peptides: Receptor Signaling
    7. Part IV. Reproductive Functions of Relaxin and Related Peptides
    8. Part V. Physiology of Insulin-Like Peptide 3
    9. Part VI. Neurobiology of Relaxin and Relaxin-Related Peptides
    10. Part VII. Cardiac Actions of Relaxin
    11. Part VIII. Renal and Vascular Actions of Relaxin
    12. Part IX. Actions of Relaxin on the Extracellular Matrix
    13. Part X. Relaxin and Cancer
    14. Part XI. Relaxin Clinical Trials
    15. Index of Contributors
    1. INSL3/RXFP2 Signaling in Testicular Descent : Mice and Men (pages 197–204)

      Shu Feng, Alberto Ferlin, Anne Truong, Ross Bathgate, John D. Wade, Sean Corbett, Shuo Han, Mounia Tannour-Louet, Dolores J. Lamb, Carlo Foresta and Alexander I. Agoulnik

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2009.03841.x

    2. Mutations in INSL3 and RXFP2 Genes in Cryptorchid Boys (pages 213–214)

      Alberto Ferlin, Daniela Zuccarello, Andrea Garolla, Riccardo Selice, Cinzia Vinanzi, Francesco Ganz, Gian Franco Zanon, Biagio Zuccarello and Carlo Foresta

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03784.x

    3. New Roles for INSL3 in Adults : Regulation of Bone Metabolism and Association of RXFP2 Gene Mutations with Osteoporosis (pages 215–218)

      Alberto Ferlin, Anastasia Pepe, Lisa Gianesello, Andrea Garolla, Shu Feng, Arianna Facciolli, Roy Morello, Alexander I. Agoulnik and Carlo Foresta

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03787.x

    4. INSL3 Plays a Role in the Balance between Bone Formation and Resorption (pages 219–220)

      Anastasia Pepe, Alberto Ferlin, Lisa Gianesello, Arianna Facciolli, Alexander I. Agoulnik and Carlo Foresta

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03785.x

    5. Role of Relaxin in Human Osteoclastogenesis (pages 221–225)

      Arianna Facciolli, Alberto Ferlin, Lisa Gianesello, Anastasia Pepe and Carlo Foresta

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03788.x

  8. Part VI. Neurobiology of Relaxin and Relaxin-Related Peptides

    1. Top of page
    2. Preface
    3. In Tribute
    4. Part I. Relaxin and Related Peptides: Structure and Function
    5. Part II. Relaxin Family Receptors
    6. Part III. Relaxin and Related Peptides: Receptor Signaling
    7. Part IV. Reproductive Functions of Relaxin and Related Peptides
    8. Part V. Physiology of Insulin-Like Peptide 3
    9. Part VI. Neurobiology of Relaxin and Relaxin-Related Peptides
    10. Part VII. Cardiac Actions of Relaxin
    11. Part VIII. Renal and Vascular Actions of Relaxin
    12. Part IX. Actions of Relaxin on the Extracellular Matrix
    13. Part X. Relaxin and Cancer
    14. Part XI. Relaxin Clinical Trials
    15. Index of Contributors
    1. Relaxin Family Peptides and Receptors in Mammalian Brain : Anatomical Insights and Diverse Functional Possibilities (pages 226–235)

      Andrew L. Gundlach, Sherie Ma, Qian Sang, Pei-Juan Shen, Loretta Piccenna, Katayoun Sedaghat, Craig M. Smith, Ross A. D. Bathgate, Andrew J. Lawrence, Geoffrey W. Tregear, John D. Wade, David I. Finkelstein, Pascal Bonaventure, Changlu Liu, Timothy W. Lovenberg and Steve W. Sutton

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2009.03956.x

    2. Behavioral Phenotyping of Mixed Background (129S5:B6) Relaxin-3 Knockout Mice (pages 236–241)

      Craig M. Smith, Andrew J. Lawrence, Steve W. Sutton and Andrew L. Gundlach

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2009.03953.x

    3. Metabolic and Neuroendocrine Responses to RXFP3 Modulation in the Central Nervous System (pages 242–249)

      Steven W. Sutton, Jonathan Shelton, Craig Smith, John Williams, Sujin Yun, Timothy Motley, Chester Kuei, Pascal Bonaventure, Andrew Gundlach, Changlu Liu and Timothy Lovenberg

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03812.x

    4. Relaxin-3 and Its Role in Neuroendocrine Function (pages 250–255)

      Barbara M. C. McGowan, Sarah A. Stanley, Mohammad A. Ghatei and Stephen R. Bloom

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03796.x

    5. Distribution of Relaxin-3 mRNA and Immunoreactivity and RXFP3-Binding Sites in the Brain of the Macaque, Macaca fascicularis (pages 256–258)

      Sherie Ma, Pei-Juan Shen, Qian Sang, Jose L. Lanciego and Andrew L. Gundlach

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2009.03954.x

    6. Verification of a Relaxin-3 Knockout/LacZ Reporter Mouse as a Model of Relaxin-3 Deficiency (pages 259–260)

      Craig M. Smith, Pei-Juan Shen, Sherie Ma, Steve W. Sutton and Andrew L. Gundlach

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2009.03952.x

    7. Development and Optimization of MicroRNA against Relaxin-3 (pages 261–264)

      Gabrielle E. Callander, Walter G. Thomas and Ross A. D. Bathgate

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03816.x

    8. An in Vitro Study of the Protective Effect of Relaxin on Brain Tissue under Ischemic Stress (pages 265–268)

      Brian C. Wilson and Rebecca Rappaport

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03806.x

  9. Part VII. Cardiac Actions of Relaxin

    1. Top of page
    2. Preface
    3. In Tribute
    4. Part I. Relaxin and Related Peptides: Structure and Function
    5. Part II. Relaxin Family Receptors
    6. Part III. Relaxin and Related Peptides: Receptor Signaling
    7. Part IV. Reproductive Functions of Relaxin and Related Peptides
    8. Part V. Physiology of Insulin-Like Peptide 3
    9. Part VI. Neurobiology of Relaxin and Relaxin-Related Peptides
    10. Part VII. Cardiac Actions of Relaxin
    11. Part VIII. Renal and Vascular Actions of Relaxin
    12. Part IX. Actions of Relaxin on the Extracellular Matrix
    13. Part X. Relaxin and Cancer
    14. Part XI. Relaxin Clinical Trials
    15. Index of Contributors
    1. Prominent Role of Relaxin in Improving Postinfarction Heart Remodeling : Clues from in Vivo and in Vitro Studies with Genetically Engineered Relaxin-Producing Myoblasts (pages 269–277)

      Daniele Bani, Silvia Nistri, Lucia Formigli, Elisabetta Meacci, Fabio Francini and Sandra Zecchi-Orlandini

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03781.x

    2. Reversal of Cardiac Fibrosis and Related Dysfunction by Relaxin : Experimental Findings (pages 278–284)

      Xiao-Jun Du, Qi Xu, Edna Lekgabe, Xiao-Ming Gao, Helen Kiriazis, Xiao-Lei Moore, Anthony M. Dart, Geoffrey W. Tregear, Ross A. D. Bathgate and Chrishan S. Samuel

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03780.x

    3. α1-Adrenergic Activation Upregulates Expression of Relaxin Receptor RXFP1 in Cardiomyocytes (pages 285–286)

      Xiao-Lei Moore, Alice Hong and Xiao-Jun Du

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03791.x

    4. Relaxin Promotes Matrix Metalloproteinase-2 and Decreases Wnt/β-Catenin Expression in the Neonatal Porcine Heart (pages 287–288)

      Teh-Yuan Ho, Megan A. Dilts, Frank F. Bartol and Carol A. Bagnell

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03810.x

  10. Part VIII. Renal and Vascular Actions of Relaxin

    1. Top of page
    2. Preface
    3. In Tribute
    4. Part I. Relaxin and Related Peptides: Structure and Function
    5. Part II. Relaxin Family Receptors
    6. Part III. Relaxin and Related Peptides: Receptor Signaling
    7. Part IV. Reproductive Functions of Relaxin and Related Peptides
    8. Part V. Physiology of Insulin-Like Peptide 3
    9. Part VI. Neurobiology of Relaxin and Relaxin-Related Peptides
    10. Part VII. Cardiac Actions of Relaxin
    11. Part VIII. Renal and Vascular Actions of Relaxin
    12. Part IX. Actions of Relaxin on the Extracellular Matrix
    13. Part X. Relaxin and Cancer
    14. Part XI. Relaxin Clinical Trials
    15. Index of Contributors
    1. Relaxin: An Endogenous Renoprotective Factor? (pages 289–293)

      Tim D. Hewitson and Chrishan S. Samuel

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03795.x

    2. Investigations into the Inhibitory Effects of Relaxin on Renal Myofibroblast Differentiation (pages 294–299)

      Chrishan S. Samuel, Ishanee Mookerjee, Michelle L. Halls, Roger J. Summers, Elaine Chew, Ross A. D. Bathgate, Geoffrey W. Tregear and Tim D. Hewitson

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03823.x

    3. Effects of Relaxin on Development of Mesangial Proliferative Nephritis (pages 300–303)

      Naoki Ikegaya, Takuya Yoshida, Tetsuya Kohsaka, Ayumi Suzuki, Natsuki Kobayashi, Tatsuo Yamamoto, Yoshihide Fujigaki, Akira Hishida and Hiromichi Kumagai

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2009.03831.x

    4. Role of Relaxin in Maternal Systemic and Renal Vascular Adaptations during Gestation (pages 304–312)

      Jonathan T. McGuane, Julianna E. Debrah, Dan O. Debrah, J. Peter Rubin, Mark Segal, Sanjeev G. Shroff and Kirk P. Conrad

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2009.03829.x

  11. Part IX. Actions of Relaxin on the Extracellular Matrix

    1. Top of page
    2. Preface
    3. In Tribute
    4. Part I. Relaxin and Related Peptides: Structure and Function
    5. Part II. Relaxin Family Receptors
    6. Part III. Relaxin and Related Peptides: Receptor Signaling
    7. Part IV. Reproductive Functions of Relaxin and Related Peptides
    8. Part V. Physiology of Insulin-Like Peptide 3
    9. Part VI. Neurobiology of Relaxin and Relaxin-Related Peptides
    10. Part VII. Cardiac Actions of Relaxin
    11. Part VIII. Renal and Vascular Actions of Relaxin
    12. Part IX. Actions of Relaxin on the Extracellular Matrix
    13. Part X. Relaxin and Cancer
    14. Part XI. Relaxin Clinical Trials
    15. Index of Contributors
    1. Relaxin's Involvement in Extracellular Matrix Homeostasis : Two Diverse Lines of Evidence (pages 329–335)

      Timothy E. Cooney, Justine M. Schober, John D. Lubahn and Elisa M. Konieczko

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03801.x

    2. Role of Relaxin in Regulation of Fibrosis in the Lung : Implications for Airway Remodeling in Asthma (pages 342–347)

      Mimi L. K. Tang, Chrishan S. Samuel and Simon G. Royce

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03825.x

    3. Relaxin Reduces Fibrosis in Models of Progressive and Established Hepatic Fibrosis (pages 348–349)

      Robert G. Bennett, Dean G. Heimann and Dean J. Tuma

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03783.x

    4. Evaluation of Relaxin's Antifibrotic Action by SELDI-TOF Mass Spectrometry-Based Profiling of Relaxin Knockout Mice, a Model of Progressive Fibrosis (pages 350–352)

      Eleni Giannakis, Mary Macris, Linda Chan, Geoffrey W. Tregear, Chrishan S. Samuel and John D. Wade

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2009.03957.x

  12. Part X. Relaxin and Cancer

    1. Top of page
    2. Preface
    3. In Tribute
    4. Part I. Relaxin and Related Peptides: Structure and Function
    5. Part II. Relaxin Family Receptors
    6. Part III. Relaxin and Related Peptides: Receptor Signaling
    7. Part IV. Reproductive Functions of Relaxin and Related Peptides
    8. Part V. Physiology of Insulin-Like Peptide 3
    9. Part VI. Neurobiology of Relaxin and Relaxin-Related Peptides
    10. Part VII. Cardiac Actions of Relaxin
    11. Part VIII. Renal and Vascular Actions of Relaxin
    12. Part IX. Actions of Relaxin on the Extracellular Matrix
    13. Part X. Relaxin and Cancer
    14. Part XI. Relaxin Clinical Trials
    15. Index of Contributors
    1. Lysosomal Acid Hydrolases of the Cathepsin Family Are Novel Targets of INSL3 in Human Thyroid Carcinoma Cells (pages 361–366)

      Joanna Bialek, Sabine Hombach-Klonisch, Barbara Fiebig, Ekkehard Weber, Cuong Hoang-Vu and Thomas Klonisch

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2009.03832.x

    2. Estrogen and TCDD Influence RLN2 Gene Activity in Estrogen Receptor-Positive Human Breast Cancer Cells (pages 367–373)

      Silke Kietz, Shu Feng, Alexander Agoulnik and Sabine Hombach-Klonisch

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2009.03836.x

    3. Relaxin Signaling in Uterine Fibroids (pages 374–378)

      Zhen Li, Jennifer K. Burzawa, Anne Troung, Shu Feng, Irina U. Agoulnik, Xiaowen Tong, Matthew L. Anderson, Ertug Kovanci, Aleksandar Rajkovic and Alexander I. Agoulnik

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03803.x

    4. Relaxin/RXFP1 Signaling in Prostate Cancer Progression (pages 379–380)

      Shu Feng, Irina U. Agoulnik, Zhen Li, Hee Dong Han, Gabriel Lopez-Berestein, Anil Sood, Michael M. Ittmann and Alexander I. Agoulnik

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03793.x

  13. Part XI. Relaxin Clinical Trials

    1. Top of page
    2. Preface
    3. In Tribute
    4. Part I. Relaxin and Related Peptides: Structure and Function
    5. Part II. Relaxin Family Receptors
    6. Part III. Relaxin and Related Peptides: Receptor Signaling
    7. Part IV. Reproductive Functions of Relaxin and Related Peptides
    8. Part V. Physiology of Insulin-Like Peptide 3
    9. Part VI. Neurobiology of Relaxin and Relaxin-Related Peptides
    10. Part VII. Cardiac Actions of Relaxin
    11. Part VIII. Renal and Vascular Actions of Relaxin
    12. Part IX. Actions of Relaxin on the Extracellular Matrix
    13. Part X. Relaxin and Cancer
    14. Part XI. Relaxin Clinical Trials
    15. Index of Contributors
    1. Scientific Rationale and Design of a Phase I Safety Study of Relaxin in Women with Severe Preeclampsia (pages 381–384)

      Elaine Unemori, Baha Sibai and Sam L Teichman

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2009.03838.x

    2. A Randomized, Double-Blind, Placebo-Controlled Trial of Relaxin for Cervical Ripening in Post-Delivery Date Pregnancies (pages 385–386)

      Gerson Weiss, Sam Teichman, Dennis Stewart, David Nader, Susan Wood and Elaine Unemori

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03794.x

    3. First Clinical Experience with Intravenous Recombinant Human Relaxin in Compensated Heart Failure (pages 387–392)

      Thomas Dschietzig, Sam Teichman, Elaine Unemori, Susy Wood, Julia Boehmer, Christoph Richter, Gert Baumann and Karl Stangl

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2008.03819.x

  14. Index of Contributors

    1. Top of page
    2. Preface
    3. In Tribute
    4. Part I. Relaxin and Related Peptides: Structure and Function
    5. Part II. Relaxin Family Receptors
    6. Part III. Relaxin and Related Peptides: Receptor Signaling
    7. Part IV. Reproductive Functions of Relaxin and Related Peptides
    8. Part V. Physiology of Insulin-Like Peptide 3
    9. Part VI. Neurobiology of Relaxin and Relaxin-Related Peptides
    10. Part VII. Cardiac Actions of Relaxin
    11. Part VIII. Renal and Vascular Actions of Relaxin
    12. Part IX. Actions of Relaxin on the Extracellular Matrix
    13. Part X. Relaxin and Cancer
    14. Part XI. Relaxin Clinical Trials
    15. Index of Contributors
    1. Index of Contributors (pages 393–396)

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1749-6632.2009.04666.x

SEARCH

SEARCH BY CITATION