Annals of the New York Academy of Sciences

© The New York Academy of Sciences

Cover image for Vol. 1245 Animal Models: Their Value in Predicting Drug Efficacy and Toxicity

December 2011

Volume 1245 Animal Models: Their Value in Predicting Drug Efficacy and Toxicity

Pages 1–64, E1–E5

  1. Original Articles

    1. Top of page
    2. Original Articles
    1. Have animal models of disease helped or hindered the drug discovery process? (pages 1–2)

      Ann Jacqueline Hunter

      Article first published online: 29 DEC 2011 | DOI: 10.1111/j.1749-6632.2011.06375.x

    2. Current models and strategies in the development of antiobesity drugs (pages 3–6)

      James S. Kinsey-Jones and Kevin G. Murphy

      Article first published online: 29 DEC 2011 | DOI: 10.1111/j.1749-6632.2011.06343.x

    3. Relevance of angiotensin II-induced aortic pathologies in mice to human aortic aneurysms (pages 7–10)

      Dennis Bruemmer, Alan Daugherty, Hong Lu and Debra L. Rateri

      Article first published online: 29 DEC 2011 | DOI: 10.1111/j.1749-6632.2011.06332.x

    4. Novel, nonreflex tests detect analgesic action in rodents at clinically relevant concentrations (pages 11–13)

      Nick Andrews, Sinead Harper, Yasmin Issop and Andrew S. C. Rice

      Article first published online: 29 DEC 2011 | DOI: 10.1111/j.1749-6632.2011.06342.x

    5. Animal welfare and the 3Rs in European biomedical research (pages 14–16)

      Dominic J. Wells

      Article first published online: 29 DEC 2011 | DOI: 10.1111/j.1749-6632.2011.06335.x

    6. Best practices for the use of animals in toxicological research and testing (pages 17–20)

      William S. Stokes

      Article first published online: 29 DEC 2011 | DOI: 10.1111/j.1749-6632.2011.06334.x

    7. Progress toward generating informative porcine biomedical models using induced pluripotent stem cells (pages 21–23)

      Franklin West and Steven Stice

      Article first published online: 29 DEC 2011 | DOI: 10.1111/j.1749-6632.2011.06337.x

    8. A knockout mouse resource for the biomedical research community (pages 24–26)

      K. C. Kent Lloyd

      Article first published online: 29 DEC 2011 | DOI: 10.1111/j.1749-6632.2011.06311.x

    9. Minimizing strain influences in a genetically modified mouse phenotyping platform (pages 27–30)

      Michael D. Hayward, Olesia Buiakova and David S. Grass

      Article first published online: 29 DEC 2011 | DOI: 10.1111/j.1749-6632.2011.06333.x

    10. The blessings and curses of C57BL/6 substrains in mouse genetic studies (pages 31–33)

      Camron D. Bryant

      Article first published online: 29 DEC 2011 | DOI: 10.1111/j.1749-6632.2011.06325.x

    11. Modeling inflammation and microvascular dysfunction (pages 34–35)

      Felicity N.E. Gavins

      Article first published online: 29 DEC 2011 | DOI: 10.1111/j.1749-6632.2011.06344.x

    12. TRPV1 and TRPA1 channels in inflammatory pain: elucidating mechanisms (pages 36–37)

      Susan D. Brain

      Article first published online: 29 DEC 2011 | DOI: 10.1111/j.1749-6632.2011.06326.x

    13. Imaging of endocrine gene expression in a humanized transgenic rat (pages 38–39)

      Julian R.E. Davis

      Article first published online: 29 DEC 2011 | DOI: 10.1111/j.1749-6632.2011.06341.x

    14. Systems biology of the heart: hype or hope? (pages 40–43)

      T. Alexander Quinn and Peter Kohl

      Article first published online: 29 DEC 2011 | DOI: 10.1111/j.1749-6632.2011.06327.x

    15. Is it time for in silico simulation of drug cardiac side effects? (pages 44–47)

      Gary R. Mirams and Denis Noble

      Article first published online: 29 DEC 2011 | DOI: 10.1111/j.1749-6632.2011.06324.x

    16. Human stem cell-derived cardiomyocytes for pharmacological and toxicological modeling (pages 48–49)

      Sian E. Harding

      Article first published online: 29 DEC 2011 | DOI: 10.1111/j.1749-6632.2011.06328.x

    17. Humanized mice as a preclinical tool for infectious disease and biomedical research (pages 50–54)

      Leonard D. Shultz, Michael A. Brehm, Sina Bavari and Dale L. Greiner

      Article first published online: 29 DEC 2011 | DOI: 10.1111/j.1749-6632.2011.06310.x

    18. Humanized mice for the study of type 1 and type 2 diabetes (pages 55–58)

      Dale L. Greiner, Michael A. Brehm, Vishnu Hosur, David M. Harlan, Alvin C. Powers and Leonard D. Shultz

      Article first published online: 29 DEC 2011 | DOI: 10.1111/j.1749-6632.2011.06318.x

    19. Deconstructing hepatitis C virus infection in humanized mice (pages 59–62)

      Marcus Dorner and Alexander Ploss

      Article first published online: 29 DEC 2011 | DOI: 10.1111/j.1749-6632.2011.06317.x

    20. Animal models got you puzzled?: think pig (pages 63–64)

      Eric M. Walters, Yuksel Agca, Venkataseshu Ganjam and Tim Evans

      Article first published online: 29 DEC 2011 | DOI: 10.1111/j.1749-6632.2011.06345.x

    21. Systems pharmacology of complex diseases (pages E1–E5)

      Jens Hansen, Shan Zhao and Ravi Iyengar

      Article first published online: 31 JAN 2012 | DOI: 10.1111/j.1749-6632.2011.06382.x

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