The role of adipocytes in the modulation of iron metabolism in obesity

Authors

  • S. Coimbra,

    1. Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal
    2. CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Gandra-PRD, Portugal
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    • S. Coimbra and C. Catarino share equal contribution to the article.
  • C. Catarino,

    Corresponding author
    1. Laboratório de Bioquímica, Departamento de Ciências Biológicas, Faculdade de Farmácia (FFUP), Universidade do Porto, Porto, Portugal
    • Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal
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    • S. Coimbra and C. Catarino share equal contribution to the article.
  • A. Santos-Silva

    1. Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal
    2. Laboratório de Bioquímica, Departamento de Ciências Biológicas, Faculdade de Farmácia (FFUP), Universidade do Porto, Porto, Portugal
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Address for correspondence: Dr C Catarino, Laboratório de Bioquímica, Departamento de Ciências Biológicas, Faculdade de Farmácia da Universidade do Porto (FFUP), Rua Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal.

E-mail: cristinacatarino@ff.up.pt; tinacris_cat@hotmail.com

Summary

A tight relationship between iron deficiency and obesity is known to exist. The chronic low-grade inflammation that characterizes obesity enhances hepcidin production, the principal regulator of iron availability. Adipose tissue is known to secret interleukin-6 and leptin that triggers hepcidin production. It was found that adipose tissue also expresses hepcidin and hemojuvelin, a regulator of hepcidin production. These recent findings suggest that adipose tissue may have an important role in erythropoiesis particularly on obesity that is still poorly clarified. This paper discusses these findings and how they can modulate erythropoiesis.

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