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An evaluation of vitamin E and pycnogenol in children suffering from oral mucositis during cancer chemotherapy


Correspondence: Heena Khurana, NCR Hostel, CSMMU, Lucknow, Uttar Pradesh-226003, India. Tel: 09793080381, Fax: 0522 2651806, E-mail:



The purpose of the present study was to evaluate and compare the effectiveness of Vitamin E (E) and Pycnogenol (P) in treatment of Chemotherapy-Related Oral Mucositis (ChROM) in children.

Materials and Methods

A total of 72 children, aged between 6 and 15 years, with ChROM were selected and randomly divided into three groups after assessment of oral mucositis (OM) by WHO grading system. Glycerine (control), E, and P were topically applied in group I, II, and III, respectively, and the prognosis of OM was assessed by functional, objective, and subjective parameters.


Patients of group II and III showed significant improvement when ChROM was analyzed through scoring systems – WHO grading, Oral Mucositis Assessment Scale (OMAS), and Children's International Mucositis Evaluation Scale (ChIMES) as compared to group I (P < 0.001); however, there was no significant difference between groups II and III.


Both the drugs E and P per se are effective for treatment of OM with P being not effective for the treatment of severe mucositis (grade 4). Combination of E and P and additional agents may be tried for better results.