Carbon nanotubes functionalized with sodium hyaluronate restore bone repair in diabetic rat sockets
Article first published online: 29 OCT 2012
© 2012 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Volume 19, Issue 5, pages 484–493, July 2013
How to Cite
Oral Diseases (2013) 19, 484–493
- Issue published online: 28 MAY 2013
- Article first published online: 29 OCT 2012
- Accepted manuscript online: 28 SEP 2012 07:15AM EST
- Manuscript Accepted: 9 SEP 2012
- Manuscript Revised: 1 SEP 2012
- Manuscript Received: 11 MAY 2012
- tooth extraction;
- carbon nanotubes;
- sodium hyaluronate
We evaluated the effects of sodium hyaluronate (HY) and carbon nanotubes functionalized with HY (HY-CNT) on bone repair in the tooth sockets of diabetic rats.
Materials and Methods
Diabetes was induced by streptozotocin (50 mg kg−1 i.v.), and the sockets were divided into normal control, diabetic control, diabetic treated with HY (1%), and diabetic treated with HY-CNT (100 μg ml−1) groups. The sockets were analyzed according to the percentage of bone formation and the number of cell nuclei.
The percentage of bone trabeculae was lower in diabetic control animals (11.16 ± 5.10% vs 41.92 ± 6.34% in normal animals) after 14 days. Treating diabetic animals with HY or HY-CNT significantly increased the percentage of neoformed trabeculae (HY: 29.43 ± 3.29%; HY-CNT: 36.90 ± 3.07%). Moreover, the sockets of diabetic animals had an increased number of cell nuclei and HY or HY-CNT reduced this parameter.
Our results indicate that HY and HY-CNT restore bone repair in the tooth sockets of diabetic rats, suggesting that these biomaterials are potential adjuvant therapies for the management of diabetes.