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Carbon nanotubes functionalized with sodium hyaluronate restore bone repair in diabetic rat sockets


Correspondence: Anderson José Ferreira, DDS, PhD, Department of Morphology, Federal University of Minas Gerais, Av. Antônio Carlos, 6627 - 31.270-901 – Belo Horizonte, MG, Brazil. Tel: (55-31) 3409-2811, Fax: (55-31) 3409-2810, E-mail:



We evaluated the effects of sodium hyaluronate (HY) and carbon nanotubes functionalized with HY (HY-CNT) on bone repair in the tooth sockets of diabetic rats.

Materials and Methods

Diabetes was induced by streptozotocin (50 mg kg−1 i.v.), and the sockets were divided into normal control, diabetic control, diabetic treated with HY (1%), and diabetic treated with HY-CNT (100 μg ml−1) groups. The sockets were analyzed according to the percentage of bone formation and the number of cell nuclei.


The percentage of bone trabeculae was lower in diabetic control animals (11.16 ± 5.10% vs 41.92 ± 6.34% in normal animals) after 14 days. Treating diabetic animals with HY or HY-CNT significantly increased the percentage of neoformed trabeculae (HY: 29.43 ± 3.29%; HY-CNT: 36.90 ± 3.07%). Moreover, the sockets of diabetic animals had an increased number of cell nuclei and HY or HY-CNT reduced this parameter.


Our results indicate that HY and HY-CNT restore bone repair in the tooth sockets of diabetic rats, suggesting that these biomaterials are potential adjuvant therapies for the management of diabetes.