Significant reduction of homocysteine level with multiple B vitamins in atrophic glossitis patients
Article first published online: 7 NOV 2012
© 2012 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Volume 19, Issue 5, pages 519–524, July 2013
How to Cite
Oral Diseases (2013) 19, 519–524
- Issue published online: 28 MAY 2013
- Article first published online: 7 NOV 2012
- Accepted manuscript online: 18 OCT 2012 06:02AM EST
- Manuscript Accepted: 12 OCT 2012
- Manuscript Revised: 7 OCT 2012
- Manuscript Received: 30 AUG 2012
- atrophic glossitis;
- vitamin B12;
- folic acid;
This study evaluated whether supplementations of different vitamins and iron could reduce the serum homocysteine levels in 91 atrophic glossitis (AG) patients.
Materials and Methods
Atrophic glossitis (AG) patients with concomitant deficiencies of vitamin B12 only (n = 39, group I), folic acid only (n = 10, group II), iron only (n = 9, group III), or vitamin B12 plus iron (n = 19, group IV) were treated with vitamin BC capsules plus deficient hematinics. AG patients without definite hematinic deficiencies (n = 14, group V) were treated with vitamin BC capsules only. The blood homocysteine and hematinic levels at baseline and after treatment till all oral symptoms had disappeared were measured and compared by paired t-test.
Supplementations with vitamin BC capsules plus corresponding deficient hematinics for groups I, II, III, IV patients and with vitamin BC capsules only for group V patients could reduce the high serum homocysteine levels to significantly lower levels after a mean treatment period of 8.3–11.6 months (all P-values < 0.05).
Supplementations with vitamin BC capsules plus corresponding deficient hematinics or with vitamin BC capsules only can reduce the high serum homocysteine levels to significantly lower levels in AG patients.