Evaluation of the expression of p53, MDM2, and SUMO-1 in oral lichen planus

Authors

  • MG Oliveira Alves,

    Corresponding author
    1. Department of Biosciences and Oral Diagnosis, São José dos Campos Dental School, UNESP – Univ Estadual Paulista, São José dos Campos, São Paulo, Brazil
    • Correspondence: Mônica Ghislaine Oliveira Alves, Department of Biosciences and Oral Diagnosis, São José dos Campos Dental School, UNESP – Univ Estadual Paulista, 777 Engenheiro Francisco José Longo Avenue, São Dimas, São José dos Campos, São Paulo 12245-000, Brazil. Tel: +55 1232072962/+55 1281278200, Fax: +55 1239479010; E-mail: mgoliveiraalves@gmail.com

    Search for more papers by this author
  • I Balducci,

    1. Department of Social Science and Pediatric Dentisty, São José dos Campos Dental School, UNESP – Univ Estadual Paulista, São José dos Campos, São Paulo, Brazil
    Search for more papers by this author
  • Y Rodarte Carvalho,

    1. Department of Biosciences and Oral Diagnosis, São José dos Campos Dental School, UNESP – Univ Estadual Paulista, São José dos Campos, São Paulo, Brazil
    Search for more papers by this author
  • LAG Cabral,

    1. Department of Biosciences and Oral Diagnosis, São José dos Campos Dental School, UNESP – Univ Estadual Paulista, São José dos Campos, São Paulo, Brazil
    Search for more papers by this author
  • FD Nunes,

    1. Department of Oral Pathology, School of Dentistry, University of São Paulo, São Paulo, São Paulo, Brazil
    Search for more papers by this author
  • JD Almeida

    1. Department of Biosciences and Oral Diagnosis, São José dos Campos Dental School, UNESP – Univ Estadual Paulista, São José dos Campos, São Paulo, Brazil
    Search for more papers by this author

Abstract

Objective

The objective of this study was to compare the expression of proteins p53, MDM2, and SUMO-1 in oral lichen planus (OLP) lesions, epithelial dysplasia, and squamous cell carcinoma.

Materials and Methods

The sample consisted of the following five groups of cheek mucosa lesions: normal mucosa (NM), inflammatory fibrous hyperplasia (IFH), lichen planus, epithelial dysplasia, and squamous cell carcinoma. The tissue samples were stained with hematoxylin-eosin and submitted to immunohistochemistry using anti-p53, anti-MDM2, and anti-SUMO-1 antibodies.

Results

The results of this study demonstrated similar expression of p53 and MDM2 between OLP, oral epithelial dysplasia and, to a lesser extent, between OLP and oral squamous cell carcinoma (OSCC). However, for SUMO-1 a similar expression was observed in OLP, NM, and IFH.

Conclusions

The results demonstrated overexpression of important proteins (p53 and MDM2) related to regulatory mechanisms of apoptosis in OLP, suggesting that there is a favorable environment for malignant transformation. The expression of SUMO-1 in OLP was similar to NM and IFH, suggesting that alterations of this protein occur at later stages of carcinogenesis, because important overexpression occurred in oral epithelial dysplasia and OSCC.

Ancillary