Get access

Focal dermal hypoplasia: updates

Authors

  • L Wang,

    1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityChengdu, Sichuan, China
    Search for more papers by this author
  • X Jin,

    1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityChengdu, Sichuan, China
    Search for more papers by this author
  • X Zhao,

    1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityChengdu, Sichuan, China
    Search for more papers by this author
  • D Liu,

    1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityChengdu, Sichuan, China
    Search for more papers by this author
  • T Hu,

    1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityChengdu, Sichuan, China
    Search for more papers by this author
  • W Li,

    1. Department of Dermatology, West China Hospital of Stomatology, Sichuan UniversityChengdu, Sichuan, China
    Search for more papers by this author
  • L Jiang,

    1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityChengdu, Sichuan, China
    Search for more papers by this author
  • H Dan,

    Corresponding author
    1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityChengdu, Sichuan, China
    • Correspondence: Hongxia Dan and Xin Zeng, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No.14, Section 3, Ren Min Nan Lu, Chengdu, Sichuan, 610041, China. Tel: +86 28 85503484, Fax: +86 28 85405251, E-mail: hxdan@foxmail.com; zengxin22@163.com

    Search for more papers by this author
  • X Zeng,

    Corresponding author
    1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityChengdu, Sichuan, China
    • Correspondence: Hongxia Dan and Xin Zeng, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No.14, Section 3, Ren Min Nan Lu, Chengdu, Sichuan, 610041, China. Tel: +86 28 85503484, Fax: +86 28 85405251, E-mail: hxdan@foxmail.com; zengxin22@163.com

    Search for more papers by this author
  • Q Chen

    1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityChengdu, Sichuan, China
    Search for more papers by this author

Abstract

Focal dermal hypoplasia (FDH), or Goltz–Gorlin syndrome, is a rare syndrome and may result in multisystem disorders. Several reviews of FDH have been published. However, the last comprehensive review of this disorder appeared more than 20 years ago. To date, a number of new clinical manifestations have been reported and considerable knowledge has accumulated regarding etiology and pathogenetic mechanisms. The purpose of this review is to gather these more recent data and to provide organized and reliable information. So we reviewed 159 cases of FDH that had been reported from 1990 to 2012, summarized the new discoveries, and suggested a potential standard for the diagnosis of FDH. We also reported on a Chinese girl with FDH, who was clinically and histologically in accord with FDH, as an example.

Ancillary