These two authors contribute equally to the study.
Associations between CD14 −159 C>T polymorphism and chronic/aggressive periodontitis susceptibility
Version of Record online: 21 MAR 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Volume 19, Issue 8, pages 805–811, November 2013
How to Cite
Oral Diseases (2013) 19, 805–811
- Issue online: 18 OCT 2013
- Version of Record online: 21 MAR 2013
- Accepted manuscript online: 6 MAR 2013 12:38AM EST
- Manuscript Accepted: 5 JAN 2013
- Manuscript Revised: 29 NOV 2012
- Manuscript Received: 5 OCT 2012
- National Natural Science Foundation of China. Grant Numbers: 30973361, 81170981, 81230022, 81200808
- Ph.D. Programs Foundation of Ministry of Education of China. Grant Number: 20113234110003
- Priority Academic Program Development of JiangSu Higher Education Institutions (PAPD)
- CD14 ;
CD14 is a causative gene for periodontitis. However, conflicting results had been achieved when evaluating the associations between CD14 −159 C>T and periodontitis, which warranted us to conduct this meta-analysis.
Material and Methods
A meta-analysis based on eight relevant case–control studies was conducted to address this issue. Odds ratios (OR) with 95% confidence intervals (CIs) were applied to test the association. The statistical heterogeneity across studies was assessed by Chi-square-based Q-test.
Retrieved studies regarding CD14 −159 C>T and periodontitis susceptibility were put into the final analysis. Overall and subgroup analyses were performed. Finally, we did not find that this polymorphism could contribute to modified risk of periodontitis or in stratified analysis by ethnicity and type of disease. However, this polymorphism was associated with decreased risk of mild to moderate periodontitis (TT vs CC, OR = 0.42, 95% CI = 0.21–0.81, CT/CC vs TT, OR = 1.91, 95% CI = 1.09–3.35) but not severe periodontitis.
The present meta-analysis provided confirmative evidence that CD14 −159 C>T was involved in the development of periodontitis.