• CD14 ;
  • polymorphism;
  • periodontitis;
  • meta


CD14 is a causative gene for periodontitis. However, conflicting results had been achieved when evaluating the associations between CD14 −159 C>T and periodontitis, which warranted us to conduct this meta-analysis.

Material and Methods

A meta-analysis based on eight relevant case–control studies was conducted to address this issue. Odds ratios (OR) with 95% confidence intervals (CIs) were applied to test the association. The statistical heterogeneity across studies was assessed by Chi-square-based Q-test.


Retrieved studies regarding CD14 −159 C>T and periodontitis susceptibility were put into the final analysis. Overall and subgroup analyses were performed. Finally, we did not find that this polymorphism could contribute to modified risk of periodontitis or in stratified analysis by ethnicity and type of disease. However, this polymorphism was associated with decreased risk of mild to moderate periodontitis (TT vs CC, OR = 0.42, 95% CI = 0.21–0.81, CT/CC vs TT, OR = 1.91, 95% CI = 1.09–3.35) but not severe periodontitis.


The present meta-analysis provided confirmative evidence that CD14 −159 C>T was involved in the development of periodontitis.