Role of human papillomavirus infection and other factors in patients with head and neck squamous cell carcinoma
Article first published online: 17 APR 2013
© 2013 John Wiley & Sons A/S
Volume 20, Issue 3, pages 288–293, April 2014
How to Cite
Oral Diseases (2014) 20, 288–293
- Issue published online: 14 MAR 2014
- Article first published online: 17 APR 2013
- Accepted manuscript online: 8 APR 2013 07:06AM EST
- Manuscript Accepted: 20 MAR 2013
- Manuscript Revised: 26 FEB 2013
- Manuscript Received: 7 JAN 2013
- high-risk human papillomavirus;
- head and neck squamous cell carcinoma;
To analyse the association between high-risk human papillomavirus (HR-HPV) and other risk factors in the aetiology of head and neck squamous cell carcinoma (HNSCC) in an Asian population.
This study is a cross-sectional analysis of 80 patients who were diagnosed with HNSCC. Patients' demographics, dietary habit, medical and social history were obtained. Surgical specimens from these patients were then histologically analysed using H&E stain and immunohistochemistry (IHC) for the presence of HR-HPV primary antibody.
High-risk human papillomavirus was detected in 41 patients, representing 51.3% of the 80 paraffin-embedded tissues of HNSCC; 27.5% of these were weak positive, 10.0% medium positive and 13.8% were strongly positive for the HR-HPV on IHC. The tongue lesions had the highest HR-HPV infection of 72.2%. No association existed between HR-HPV and patient's demographics, dietary habit and other predisposing factors.
The place of HR-HPV as a possible aetiological factor for HNSCC has further been established from this study.