This study was supported by NIH grant (4 R44H L079726-02), by NIA grant 1R21AG035128 and NIH grant 1RO1HL103961. This work was also supported by a Science Award from the Center for Integration of Medicine and Innovative Technology (CIMIT).
Cardiac Ablation Catheter Guidance by Means of a Single Equivalent Moving Dipole Inverse Algorithm
Article first published online: 28 FEB 2013
©2013, The Authors. Journal compilation ©2013 Wiley Periodicals, Inc.
Pacing and Clinical Electrophysiology
Volume 36, Issue 7, pages 811–822, July 2013
How to Cite
LEE, K., LV, W., TER-OVANESYAN, E., BARLEY, M. E., VOYSEY, G. E., GALEA, A. M., HIRSCHMAN, G. B., LEROY, K., MARINI, R. P., BARRETT, C., ARMOUNDAS, A. A. and COHEN, R. J. (2013), Cardiac Ablation Catheter Guidance by Means of a Single Equivalent Moving Dipole Inverse Algorithm. Pacing and Clinical Electrophysiology, 36: 811–822. doi: 10.1111/pace.12114
- Issue published online: 1 JUL 2013
- Article first published online: 28 FEB 2013
- Manuscript Accepted: 6 JAN 2013
- Manuscript Revised: 14 DEC 2012
- Manuscript Received: 19 JUN 2012
- NIH. Grant Numbers: 4 R44H L079726-02, 1RO1HL103961
- NIA. Grant Number: 1R21AG035128
- single equivalent moving dipole;
- catheter guidance
We developed and evaluated a novel system for guiding radiofrequency catheter ablation therapy of ventricular tachycardia. This guidance system employs an inverse solution guidance algorithm (ISGA) using a single equivalent moving dipole (SEMD) localization method. The method and system were evaluated in both a saline tank phantom model and in vivo animal (swine) experiments.
A catheter with two platinum electrodes spaced 3 mm apart was used as the dipole source in the phantom study. A 40-Hz sinusoidal signal was applied to the electrode pair. In the animal study, four to eight electrodes were sutured onto the right ventricle. These electrodes were connected to a stimulus generator delivering 1-ms duration pacing pulses. Signals were recorded from 64 electrodes, located either on the inner surface of the saline tank or on the body surface of the pig, and then processed by the ISGA to localize the physical or bioelectrical SEMD.
In the phantom studies, the guidance algorithm was used to advance a catheter tip to the location of the source dipole. The distance from the final position of the catheter tip to the position of the target dipole was 2.22 ± 0.78 mm in real space and 1.38 ± 0.78 mm in image space (computational space). The ISGA successfully tracked the locations of electrodes sutured on the ventricular myocardium and the movement of an endocardial catheter placed in the animal's right ventricle.
In conclusion, we successfully demonstrated the feasibility of using an SEMD inverse algorithm to guide a cardiac ablation catheter.