Get access

Cardiac Ablation Catheter Guidance by Means of a Single Equivalent Moving Dipole Inverse Algorithm

Authors


  • This study was supported by NIH grant (4 R44H L079726-02), by NIA grant 1R21AG035128 and NIH grant 1RO1HL103961. This work was also supported by a Science Award from the Center for Integration of Medicine and Innovative Technology (CIMIT).

Address for reprints: Richard J. Cohen, M.D., Ph.D., Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 45 Carleton Street, Room E25-335, Cambridge, MA 02139. Fax: 617-253-3019; e-mail: rjcohen@mit.edu

Abstract

Background

We developed and evaluated a novel system for guiding radiofrequency catheter ablation therapy of ventricular tachycardia. This guidance system employs an inverse solution guidance algorithm (ISGA) using a single equivalent moving dipole (SEMD) localization method. The method and system were evaluated in both a saline tank phantom model and in vivo animal (swine) experiments.

Methods

A catheter with two platinum electrodes spaced 3 mm apart was used as the dipole source in the phantom study. A 40-Hz sinusoidal signal was applied to the electrode pair. In the animal study, four to eight electrodes were sutured onto the right ventricle. These electrodes were connected to a stimulus generator delivering 1-ms duration pacing pulses. Signals were recorded from 64 electrodes, located either on the inner surface of the saline tank or on the body surface of the pig, and then processed by the ISGA to localize the physical or bioelectrical SEMD.

Results

In the phantom studies, the guidance algorithm was used to advance a catheter tip to the location of the source dipole. The distance from the final position of the catheter tip to the position of the target dipole was 2.22 ± 0.78 mm in real space and 1.38 ± 0.78 mm in image space (computational space). The ISGA successfully tracked the locations of electrodes sutured on the ventricular myocardium and the movement of an endocardial catheter placed in the animal's right ventricle.

Conclusion

In conclusion, we successfully demonstrated the feasibility of using an SEMD inverse algorithm to guide a cardiac ablation catheter.

Get access to the full text of this article

Ancillary