Magnesium Adjunctive Therapy in Atrial Arrhythmias
Article first published online: 3 JUN 2013
©2013, The Authors. Journal compilation ©2013 Wiley Periodicals, Inc.
Pacing and Clinical Electrophysiology
Volume 36, Issue 10, pages 1308–1318, October 2013
How to Cite
GANGA, H. V., NOYES, A., WHITE, C. M. and KLUGER, J. (2013), Magnesium Adjunctive Therapy in Atrial Arrhythmias. Pacing and Clinical Electrophysiology, 36: 1308–1318. doi: 10.1111/pace.12189
Conflict of Interest: None.
- Issue published online: 8 OCT 2013
- Article first published online: 3 JUN 2013
- Manuscript Accepted: 10 APR 2013
- Manuscript Revised: 2 APR 2013
- Manuscript Received: 14 FEB 2013
- atrial fibrillation
Magnesium (Mg) is an important intracellular ion with cardiac metabolism and electrophysiologic properties. A large percentage of patients with arrhythmias have an intracellular Mg deficiency, which is out of line with serum Mg concentrations, and this may explain the rationale for Mg's benefits as an atrial antiarrhythmic agent. A current limitation of antiarrhythmic therapy is that the potential for cardiac risk offsets some of the benefits of therapy. Mg enhances the balance of benefits to harms by enhancing atrial antiarrhythmic efficacy and reducing antiarrhythmic proarrhythmia potential as well as providing direct antiarrhythmic efficacy when used as monotherapy in patients undergoing cardiothoracic surgery.