Asthma severity, polymorphisms in 20p13 and their interaction with tobacco smoke exposure
Version of Record online: 20 JAN 2013
© 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd
Pediatric Allergy and Immunology
Volume 24, Issue 1, pages 10–18, February 2013
How to Cite
Bukvic, B. K., Blekic, M., Simpson, A., Marinho, S., Curtin, J. A., Hankinson, J., Aberle, N. and Custovic, A. (2013), Asthma severity, polymorphisms in 20p13 and their interaction with tobacco smoke exposure. Pediatric Allergy and Immunology, 24: 10–18. doi: 10.1111/pai.12019
- Issue online: 20 JAN 2013
- Version of Record online: 20 JAN 2013
- Manuscript Accepted: 1 OCT 2012
Table E1. SNPs selected for genotypingon ATRN gene.
Table E2. SNPsselected for genotypingon GFR4 gene.
Table E3. SNPsselected for genotypingon ADAM33 gene.
Table E4. SNPs selected for genotypingon SIGLEC1 gene.
Table E5. SNPs selected for genotypingon HSPA12B gene.
Table E6. Association between genetic variants in the region 20p13-p12 and lung function measures amongst asthmatic children.
Table E7. Significant interactions between genetic variants in 20p13-p12 and early-life environmental tobacco smoke exposure in relation to asthma.
Table E8. Significant interactions between genetic variants in 20p13-p12 and early-life ETS exposure in relation to lung function amongst children with asthma.
Figure E1. Linkage disequilibrium plot for analysed SNPs in region 20p13-12p showing pairwise r2 values.
Figure E2. Interaction between genetic variant in ATRNand early-life ETS exposure in relation to asthma:Early-life ETS exposure significantly increases the risk of asthma amongst carriers of G allele on rs3848809, with no effect of ETS exposure on asthma risk amongst A allele homozygotes.
Figure E3. Interaction between genetic variant in ADAM33 and early-life ETS exposure in relation to FEF50: Homozygotes for G allele on rs512625 have lower FEF50 if they are exposed to ETS, with no effect of ETS exposure amongst carriers of A allele.
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