Relationship between breast milk sCD14, TGF-β1 and total IgA in the first month and development of eczema during infancy
Version of Record online: 11 APR 2013
© 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd
Pediatric Allergy and Immunology
Volume 24, Issue 4, pages 352–360, June 2013
How to Cite
Relationship between breast milk sCD14, TGF-β1 and total IgA in the first month and development of eczema during infancy. Pediatr Allergy Immunol 2013: 00., , , , .
- Issue online: 21 MAY 2013
- Version of Record online: 11 APR 2013
- Manuscript Accepted: 6 MAR 2013
- Jack Brockhoff Foundation
- Murdoch Children's Research Institute (MCRI)
- Ilhan Food Allergy Foundation
- Ministry of Higher Education, Malaysia and Universiti Putra Malaysia
- University of Melbourne Baillieu Scholarship
- National Institute for Health Research Comprehensive Biomedical Research Centre
- Victorian Government's Operational Infrastructure Support Program
- Murdoch Children's Research Institute Postgraduate Scholarship
- breast milk;
- immunomodulatory factors;
- total IgA
The overall beneficial effects of breastfeeding for infants have been well documented, but its role in allergy prevention is controversial.
We investigated the relationship between breast milk immunomodulatory factors and subsequent development of eczema and atopic sensitization in the first year of life.
Day 7 and 28 breast milk samples were collected from mothers carrying infants at high risk of allergic disease. Aqueous-phase breast milk samples were assayed for TGF-β1, sCD14 and total IgA. Infants were assessed for the presence of eczema and atopic sensitization at 12 months of age. The levels of breast milk TGF-β1, sCD14 and total IgA were compared in infants who subsequently developed eczema and sensitization in the first year and those who did not.
The levels of breast milk sCD14, total IgA, and TGF-β1 at either day 7 or 28 were not associated with subsequent development of eczema or atopic sensitization during the first year of life.
Levels of breast milk immune parameters were not associated with eczema outcomes or sensitization in infants at 12 months. This suggests that apparent immunological effects on breast milk immunomodulatory factors may not necessarily lead to clinical benefits, and these immune markers may not be critical determinants of allergic disease in infancy.