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Figure S1. Consort figure showing participant flow.

Figure S2. The effect of maternal smoking on wheezing at different ages. The error bar and grey shading represent 95% CIs.

Figure S3. Smoking-age interaction stratified by GST genotype a) GSTP1(AA vs. AGGG), b) GSTM1 (/vs.+/−&+/+) c) GSTT1 (/vs. +/− & +/+) The error bar and grey shading represent 95% CIs.

Table S1. Genotyping success rate for GSTP1 rs1695, GSTM1 null and GSTT1 null, and number of subjects in each group.

Table S2. Demographic characteristics of children included and excluded from the study.

Table S3. Prevalence of current wheeze (%) at ages 1, 3, 5, 8 and 11 yr stratified by GST genotypes GSTP1 (rs1695), GSTM1 (null) and GSTT1 (null).

Table S4. Prevalence of current wheeze (%) at age 1, 3, 5, 8 and 11 yr stratified by GSTP1 genotypes and maternal smoking.

Table S5. Prevalence of current wheeze (%) at age 1, 3, 5, 8 and 11 yr stratified by GSTM1 genotypes and maternal smoking.

Table S6. Prevalence of current wheeze (%) at age1, 3, 5, 8 and 11 yr stratified by GSTT1 genotypes and maternal smoking.

Table S7. GEE models of the relationship between ETS exposure in infancy and current wheeze.

Table S8. The effect of time on the interaction between GST variants and environmental tobacco smoke (ETS) exposure in infancy in relation to the development of wheezing throughout childhood (ages 1, 3, 5, 8 and 11 yr

Data S1. Methods.

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