These authors contributed equally and joint senior authors.
Interaction between glutathione S-transferase variants, maternal smoking and childhood wheezing changes with age
Article first published online: 3 JUN 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Pediatric Allergy and Immunology
Volume 24, Issue 5, pages 501–508, August 2013
How to Cite
Interaction between glutathione s-transferase variants, maternal smoking and childhood wheezing changes with age. Pediatr Allergy Immunol 2013: 24: 501–508., , , , .
- Issue published online: 23 JUL 2013
- Article first published online: 3 JUN 2013
- Manuscript Accepted: 20 APR 2013
Figure S1. Consort figure showing participant flow.
Figure S2. The effect of maternal smoking on wheezing at different ages. The error bar and grey shading represent 95% CIs.
Figure S3. Smoking-age interaction stratified by GST genotype a) GSTP1(AA vs. AGGG), b) GSTM1 (−/−vs.+/−&+/+) c) GSTT1 (−/−vs. +/− & +/+) The error bar and grey shading represent 95% CIs.
Table S1. Genotyping success rate for GSTP1 rs1695, GSTM1 null and GSTT1 null, and number of subjects in each group.
Table S2. Demographic characteristics of children included and excluded from the study.
Table S3. Prevalence of current wheeze (%) at ages 1, 3, 5, 8 and 11 yr stratified by GST genotypes GSTP1 (rs1695), GSTM1 (null) and GSTT1 (null).
Table S4. Prevalence of current wheeze (%) at age 1, 3, 5, 8 and 11 yr stratified by GSTP1 genotypes and maternal smoking.
Table S5. Prevalence of current wheeze (%) at age 1, 3, 5, 8 and 11 yr stratified by GSTM1 genotypes and maternal smoking.
Table S6. Prevalence of current wheeze (%) at age1, 3, 5, 8 and 11 yr stratified by GSTT1 genotypes and maternal smoking.
Table S7. GEE models of the relationship between ETS exposure in infancy and current wheeze.
Table S8. The effect of time on the interaction between GST variants and environmental tobacco smoke (ETS) exposure in infancy in relation to the development of wheezing throughout childhood (ages 1, 3, 5, 8 and 11 yr
Data S1. Methods.
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