Xiaowen Zhang and Baoqing Sun contributed equally to this work.
Local atopy is more relevant than serum sIgE in reflecting allergy in childhood adenotonsillar hypertrophy
Article first published online: 3 JUN 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Pediatric Allergy and Immunology
Volume 24, Issue 5, pages 422–426, August 2013
How to Cite
Local atopy is more relevant than serum sIgE in reflecting allergy in childhood adenotonsillar hypertrophy. Pediatr Allergy Immunol 2013: 24: 422–426., , , , , .
- Issue published online: 23 JUL 2013
- Article first published online: 3 JUN 2013
- Manuscript Accepted: 3 MAY 2013
- Guangdong Natural Sciences Foundation. Grant Number: 9151001003000001
- China National Natural Science Foundation. Grant Number: 81271066
- adenotonsillar hypertrophy;
- local atopy;
- specific IgE;
There was a lack of convincing evidence supporting the influence of allergy on the adenotonsillar hypertrophy (ATH). We investigated the presence of specific IgE (sIgE) in the serum and adenotonsillar tissues in children with ATH.
A Pharmacia ImmunoCAP system was used to test sIgE against 31 allergens in the serum in 83 children with ATH before adenotonsillectomy. sIgE against 15 representative allergens were detected in adenotonsillar tissues from 20 of those children.
A total of 51 (61.45%) children had positive serum sIgE. 20 children with ATH had positive sIgE to more than two allergens at both tonsils and adenoids, although half of them were serum sIgE negative. The percentage of subjects with positive sIgE expression in adenoids and tonsils was 50.0% and 42.9%, respectively, among the subjects with positive serum sIgE expression. Of subjects with negative serum sIgE expression, local sIgE was detected in 36.0% of adenoids and 43.8% of tonsils, respectively. The rate of sIgE presence in local tissue (adenoids or tonsils) was significantly higher than that seen in the serum.
This study provided evidence that there was an important role for allergic inflammation in the ATH. The inconsistency in sIgE expression between adenotonsillar and serum suggests a role of local atopy in childhood ATH.