• 1
    Pabst O. New concepts in the generation and functions of IgA. Nat Rev Immunol 2012: 12: 82132.
  • 2
    Stokes CR, Taylor B, Turner MW. Association of house-dust and grass-pollen allergies with specific IgA antibody deficiency. Lancet 1974: 2: 4858.
  • 3
    Aghamohammadi A, Cheraghi T, Gharagozlou M, et al. IgA deficiency: correlation between clinical and immunological phenotypes. J Clin Immunol 2009: 29: 1306.
  • 4
    Kaufman HS, Hobbs JR. Immunoglobulin deficiencies in an atopic population. Lancet 1970: 2: 10613.
  • 5
    Taylor B, Norman AP, Orgel HA, Stokes CR, Turner MW, Soothill JF. Transient IgA deficiency and pathogenesis of infantile atopy. Lancet 1973: 2: 1113.
  • 6
    Ludviksson BR, Eiriksson TH, Ardal B, Sigfusson A, Valdimarsson H. Correlation between serum immunoglobulin A concentrations and allergic manifestations in infants. J Pediatr 1992: 121: 237.
  • 7
    Challacombe SJ, Tomasi TB Jr. Systemic tolerance and secretory immunity after oral immunization. J Exp Med 1980: 152: 145972.
  • 8
    Francis JN, James LK, Paraskevopoulos G, et al. Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity. J Allergy Clin Immunol 2008: 121: 11205 e1122.
  • 9
    Pilette C, Nouri-Aria KT, Jacobson MR, et al. Grass pollen immunotherapy induces an allergen-specific IgA2 antibody response associated with mucosal TGF-beta expression. J Immunol 2007: 178: 465866.
  • 10
    Scadding GW, Shamji MH, Jacobson MR, et al. Sublingual grass pollen immunotherapy is associated with increases in sublingual Foxp3-expressing cells and elevated allergen-specific immunoglobulin G4, immunoglobulin A and serum inhibitory activity for immunoglobulin E-facilitated allergen binding to B cells. Clin Exp Allergy 2010: 40: 598606.
  • 11
    Lemon-Mule H, Sampson HA, Sicherer SH, Shreffler WG, Noone S, Nowak-Wegrzyn A. Immunologic changes in children with egg allergy ingesting extensively heated egg. J Allergy Clin Immunol 2008: 122: 97783 e971.
  • 12
    Weemaes C, Klasen I, Goertz J, Beldhuis-Valkis M, Olafsson O, Haraldsson A. Development of immunoglobulin A in infancy and childhood. Scand J Immunol 2003: 58: 6428.
  • 13
    Schauer U, Stemberg F, Rieger CH, et al. Establishment of age-dependent reference values for IgA subclasses. Clin Chim Acta 2003: 328: 12933.
  • 14
    Hidvegi E, Cserhati E, Kereki E, Savilahti E, Arato A. Serum immunoglobulin E, IgA, and IgG antibodies to different cow's milk proteins in children with cow's milk allergy: association with prognosis and clinical manifestations. Pediatr Allergy Immunol 2002: 13: 25561.
  • 15
    Isolauri E, Suomalainen H, Kaila M, et al. Local immune response in patients with cow milk allergy: follow-up of patients retaining allergy or becoming tolerant. J Pediatr 1992: 120: 915.
  • 16
    Hochwallner H, Schulmeister U, Swoboda I, et al. Patients suffering from non-IgE-mediated cow's milk protein intolerance cannot be diagnosed based on IgG subclass or IgA responses to milk allergens. Allergy 2011: 66: 12017.
  • 17
    Sletten GB, Halvorsen R, Egaas E, Halstensen TS. Changes in humoral responses to beta-lactoglobulin in tolerant patients suggest a particular role for IgG4 in delayed, non-IgE-mediated cow's milk allergy. Pediatr Allergy Immunol 2006: 17: 43543.
  • 18
    Savilahti EM, Saarinen KM, Savilahti E. Specific antibodies to cow's milk proteins in infants: effect of early feeding and diagnosis of cow's milk allergy. Eur J Nutr 2010: 49: 5014.
  • 19
    Sletten GB, Halvorsen R, Egaas E, Halstensen TS. Casein-specific immunoglobulins in cow's milk allergic patient subgroups reveal a shift to IgA dominance in tolerant patients. Pediatr Allergy Immunol 2007: 18: 7180.
  • 20
    Firer MA, Hoskings CS, Hill DJ. Humoral immune response to cow's milk in children with cow's milk allergy. Relationship to the time of clinical response to cow's milk challenge. Int Arch Allergy Appl Immunol 1987: 84: 1737.
  • 21
    Shek LP, Bardina L, Castro R, Sampson HA, Beyer K. Humoral and cellular responses to cow milk proteins in patients with milk-induced IgE-mediated and non-IgE-mediated disorders. Allergy 2005: 60: 9129.
  • 22
    Kukkonen AK, Savilahti EM, Haahtela T, Savilahti E, Kuitunen M. Ovalbumin-specific immunoglobulins A and G levels at age 2 years are associated with the occurrence of atopic disorders. Clin Exp Allergy 2011: 41: 141421.
  • 23
    Kolopp-Sarda MN, Moneret-Vautrin DA, Gobert B, et al. Polyisotypic antipeanut-specific humoral responses in peanut-allergic individuals. Clin Exp Allergy 2001: 31: 4753.
  • 24
    Kulis M, Saba K, Kim EH, et al. Increased peanut-specific IgA levels in saliva correlate with food challenge outcomes after peanut sublingual immunotherapy. J Allergy Clin Immunol 2012: 129: 115962.
  • 25
    Bahceciler NN, Arikan C, Taylor A, et al. Impact of sublingual immunotherapy on specific antibody levels in asthmatic children allergic to house dust mites. Int Arch Allergy Immunol 2005: 136: 28794.
  • 26
    Jutel M, Akdis M, Budak F, et al. IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy. Eur J Immunol 2003: 33: 120514.
  • 27
    Nouri-Aria KT, Wachholz PA, Francis JN, et al. Grass pollen immunotherapy induces mucosal and peripheral IL-10 responses and blocking IgG activity. J Immunol 2004: 172: 32529.
  • 28
    Philips JR, Brouwer W, Edwards M, Mahler S, Ruhno J, Collins AM. The effectiveness of different rat IgG subclasses as IgE-blocking antibodies in the rat basophil leukaemia cell model. Immunol Cell Biol 1999: 77: 1216.
  • 29
    Mothes N, Heinzkill M, Drachenberg KJ, et al. Allergen-specific immunotherapy with a monophosphoryl lipid A-adjuvanted vaccine: reduced seasonally boosted immunoglobulin E production and inhibition of basophil histamine release by therapy-induced blocking antibodies. Clin Exp Allergy 2003: 33: 1198208.
  • 30
    Strait RT, Mahler A, Hogan S, Khodoun M, Shibuya A, Finkelman FD. Ingested allergens must be absorbed systemically to induce systemic anaphylaxis. J Allergy Clin Immunol 2011: 127: 9829 e981.
  • 31
    Schwarze J, Cieslewicz G, Joetham A, et al. Antigen-specific immunoglobulin-A prevents increased airway responsiveness and lung eosinophilia after airway challenge in sensitized mice. Am J Respir Crit Care Med 1998: 158: 51925.
  • 32
    Kett K, Scott H, Fausa O, Brandtzaeg P. Secretory immunity in celiac disease: cellular expression of immunoglobulin A subclass and joining chain. Gastroenterology 1990: 99: 38692.
  • 33
    Karlsson MR, Rugtveit J, Brandtzaeg P. Allergen-responsive CD4 + CD25 +  regulatory T cells in children who have outgrown cow's milk allergy. J Exp Med 2004: 199: 167988.
  • 34
    Boyce JA, Assa'ad A, Burks AW, et al. Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol 2010: 126 (Suppl. 6): S158.
  • 35
    Stapel SO, Asero R, Ballmer-Weber BK, et al. Testing for IgG4 against foods is not recommended as a diagnostic tool: EAACI Task Force Report. Allergy 2008: 63: 7936.
  • 36
    Cerutti A. The regulation of IgA class switching. Nat Rev Immunol 2008: 8: 42134.
  • 37
    Garcia-Nieto RM, Rico-Mata R, Arias-Negrete S, Avila EE. Degradation of human secretory IgA1 and IgA2 by Entamoeba histolytica surface-associated proteolytic activity. Parasitol Int 2008: 57: 41723.
  • 38
    Noma T, Yamaguchi K, Yoshizawa I, et al. T cell mediation of abnormally low production of ovalbumin-specific immunoglobulin A in patients allergic to eggs. Pediatr Res 1996: 39: 32935.