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Early life IgE responses in children living in the tropics: A prospective analysis

Authors

  • Josefina Zakzuk,

    1. Institute for Immunological Research, University of Cartagena, Cartagena, Colombia
    2. Foundation for the Development of Medical and Biological Sciences (Fundemeb), Cartagena, Colombia
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  • Nathalie Acevedo,

    1. Institute for Immunological Research, University of Cartagena, Cartagena, Colombia
    2. Foundation for the Development of Medical and Biological Sciences (Fundemeb), Cartagena, Colombia
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  • Liliana Cifuentes,

    1. Department of Dermatology and Allergy, Christine Kuehne Center for Allergy Research and Education (CK-CARE), Munich University of Technology (TUM), Munich, Germany
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  • Adriana Bornacelly,

    1. Institute for Immunological Research, University of Cartagena, Cartagena, Colombia
    2. Foundation for the Development of Medical and Biological Sciences (Fundemeb), Cartagena, Colombia
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  • Jorge Sánchez,

    1. Institute for Immunological Research, University of Cartagena, Cartagena, Colombia
    2. Foundation for the Development of Medical and Biological Sciences (Fundemeb), Cartagena, Colombia
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  • Velky Ahumada,

    1. Institute for Immunological Research, University of Cartagena, Cartagena, Colombia
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  • Johannes Ring,

    1. Department of Dermatology and Allergy, Christine Kuehne Center for Allergy Research and Education (CK-CARE), Munich University of Technology (TUM), Munich, Germany
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  • Markus Ollert,

    1. Department of Dermatology and Allergy, Christine Kuehne Center for Allergy Research and Education (CK-CARE), Munich University of Technology (TUM), Munich, Germany
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  • Luis Caraballo

    Corresponding author
    1. Institute for Immunological Research, University of Cartagena, Cartagena, Colombia
    2. Foundation for the Development of Medical and Biological Sciences (Fundemeb), Cartagena, Colombia
    • Correspondence

      Luis Caraballo, MD, PhD, Institute for Immunological Research, University of Cartagena, Campus de Zaragocilla, Edificio Biblioteca, Piso 1, Cartagena de Indias, Colombia.

      Tel.: +57 310 352 7373

      Fax: +575 669 8491

      E-mail: lcaraballog@unicartagena.edu.co

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Abstract

Background

There are few birth cohort studies analyzing IgE sensitization in the tropics.

Objectives

We aimed to describe the evolution of total IgE and specific IgE responses to house-dust mite (HDM) allergens and Ascaris in a birth cohort (Risk Factors for Asthma and Allergy in the Tropics, FRAAT), analyzing their relationships with wheezing.

Methods

Total and specific IgE were measured by ImmunoCap in mothers and children at four different time points (S1–S4) between 0 and 42 months. Parasite infection was evaluated by stool examination.

Results

Maternal total IgE (aOR: 2.43, 95% CI: 1.09–5.43; p = 0.03) and socio-demographic factors were associated with high cord blood (CB) total IgE. High CB total IgE was positively associated with higher Blomia tropicalis and Ascaris-specific IgE values during lifetime, but protected from recurrent wheezing (aOR: 0.26, 95% CI: 0.08–0.88, p = 0.03). Prevalence rates of IgE sensitization were high; at around 3 yr old, they were 33.3, 18.6, and 26.5% for B. tropicalis, Dermatophagoides pteronyssinus, and Ascaris, respectively. Indicators of unhygienic conditions were risk factors for HDM and Ascaris sensitization in children. A weak statistical association between B. tropicalis-specific IgE and ever wheezing was found (aOR: 1.47 95% CI: 1.00–2.28, p = 0.05).

Conclusions

In a socioeconomically deprived community from the tropics, sensitization to HDM allergens was very frequent at early life, especially to B. tropicalis. In contrast to expected according to the hygiene hypothesis, unhygienic/poverty conditions were risk factors for allergen sensitization. High CB total IgE levels were a risk factor for allergen sensitization but protected from recurrent wheezing.

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