[Correction added on 21 April 2014, after first online publication: the title has been shortened]
The association between foodborne and orofecal pathogens and allergic sensitisation — EuroPrevall study
Article first published online: 10 DEC 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Pediatric Allergy and Immunology
Volume 25, Issue 3, pages 250–256, May 2014
How to Cite
The association between foodborne and orofecal pathogens and allergic sensitisation — EuroPrevall study. Pediatr Allergy Immunol 2014: 25: 250–256., , , , , , , , , , , , , , , , .
- Issue published online: 21 APR 2014
- Article first published online: 10 DEC 2013
- Manuscript Accepted: 27 OCT 2013
- EU through EuroPrevall. Grant Number: FP6-FOOD-CT-2005-514000
- HK Research Grant Council. Grant Number: CUHK 477110
- hepatitis A;
- specific IgE;
- skin prick testing;
- T. gondii
An inverse association between markers of exposure to foodborne and orofecal pathogens and allergic sensitization has been reported. However, the findings of epidemiological studies have not been consistent. This study investigated the relationship between antibodies to hepatitis A, Toxoplasma gondii and salmonella and allergic sensitization to food and aeroallergens in children from different geographical areas.
Specific IgE and/or skin prick testing against food and aeroallergens were measured in children from 6 to 12 years of age residing in Greece, the Netherlands, China, India and Russia. Seropositivity to the three pathogens was measured, and data on potential confounders were collected using questionnaire.
Data from 800 children (126 from Athens; 248 from Utrecht; 110 from Hong Kong; 119 from urban Tomsk; and 197 from rural Tomsk) could be analysed. The highest percentage of positive serology to salmonella was found in Hong Kong (46.4%), to T. gondii in urban Tomsk (13.4%) and to hepatitis A in Athens (71.2%). Although not significant, T. gondii seropositivity tends to be negatively associated, and hepatitis A seropositivity tends to be positively associated with allergic sensitization.
Inconsistent associations were observed between allergic sensitization to food and aeroallergens and markers of exposure to two common foodborne pathogens. The association with T. gondii tends to be negative, consistent with the ‘hygiene hypothesis’, but the association with hepatitis A tends to be positive. Taken together, there is no clear evidence that past exposure to foodborne and orofecal pathogens protects against allergic sensitization to food or aeroallergens.