Beyond survival; influences of blood pressure, cerebral perfusion and anesthesia on neurodevelopment

Authors

  • Mary Ellen McCann,

    Corresponding author
    1. Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA
    • Correspondence

      Mary Ellen McCann, Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA

      Email: mary.mccann@childrens.harvard.edu

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  • Anton N.J. Schouten

    1. Department of Anesthesiology, Intensive care and Emergency Medicine, University Medical Center, Utrecht, The Netherlands
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Summary

Neonates have a higher perioperative mortality risk largely due to the degree of prior illness of the infants, the complexity of their surgeries, and infant physiology. It is important to consider contributing anesthetic factors during the perioperative period that may affect cerebral perfusion and neurocognitive outcome, such as alterations in hemodynamics and ventilation. Limitations of blood pressure as a marker for cerebral perfusion are discussed, as well as the effect of hypocapnia on the brain.

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